In vitro synergy of polymyxins with other antibiotics for Acinetobacter baumannii: A systematic review and meta-analysis

International Journal of Antimicrobial Agents

Volumn 45, Issue 1, 2015, Pages 8-18

  Ni, Wentao ^a   Shao, Xiaodi ^a   Di, Xiuzhen ^a   Cui, Junchang ^a   Wang, Rui ^a   Liu, Youning ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Acinetobacter baumannii; Antibiotic combination; Polymyxin; Synergy

Indexed keywords

AMIKACIN; ANTIBIOTIC AGENT; AZITHROMYCIN; CARBAPENEM DERIVATIVE; CEFEPIME; CEFTAZIDIME; CEFTOBIPROLE; CEFTRIAXONE; CLARITHROMYCIN; COLISTIN; DAPTOMYCIN; DORIPENEM; DOXYCYCLINE; FOSFOMYCIN; IMIPENEM; LEVOFLOXACIN; LINEZOLID; MEROPENEM; MINOCYCLINE; POLYMYXIN; POLYMYXIN B; POLYPEPTIDE ANTIBIOTIC AGENT; RIFAMPICIN; SULBACTAM; SULTAMICILLIN; TEICOPLANIN; TELAVANCIN; TIGECYCLINE; UNINDEXED DRUG; VANCOMYCIN; ANTIINFECTIVE AGENT;

ACINETOBACTER BAUMANNII; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; DILUTION; DRUG ANTAGONISM; DRUG POTENTIATION; EPSILOMETER TEST; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; OUTCOME ASSESSMENT; DRUG EFFECTS; HUMAN; META ANALYSIS; MICROBIAL VIABILITY; PHYSIOLOGY; TIME;

ACINETOBACTER BAUMANNII; ANTI-BACTERIAL AGENTS; DRUG SYNERGISM; HUMANS; MICROBIAL VIABILITY; POLYMYXINS; TIME FACTORS;

EID: 84920402534     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2014.10.002     Document Type: Short Survey

References (110)

1. T.D. Gootz, and A. Marra Acinetobacter baumannii: an emerging multidrug-resistant threat Expert Rev Anti Infect Ther 6 2008 309 325
2. N.C. Gordon, and D.W. Wareham Multidrug-resistant Acinetobacter baumannii: mechanisms of virulence and resistance Int J Antimicrob Agents 35 2010 219 226
3. E.V. Lemos, F.P. de la Hoz, T.R. Einarson, W.F. McGhan, E. Quevedo, and C. Castañeda Carbapenem resistance and mortality in patients with Acinetobacter baumannii infection: systematic review and meta-analysis Clin Microbiol Infect 20 2014 416 423
4. P.J. Bergen, C.B. Landersdorfer, H.J. Lee, J. Li, and R.L. Nation 'Old' antibiotics for emerging multidrug-resistant bacteria Curr Opin Infect Dis 25 2012 626 633
5. D. Yahav, L. Farbman, L. Leibovici, and M. Paul Colistin: new lessons on an old antibiotic Clin Microbiol Infect 18 2012 18 29
6. N. Petrosillo, E. Ioannidou, and M.E. Falagas Colistin monotherapy vs. combination therapy: evidence from microbiological, animal and clinical studies Clin Microbiol Infect 14 2008 816 827
7. O. Zusman, T. Avni, L. Leibovici, A. Adler, L. Friberg, and T. Stergiopoulou Systematic review and meta-analysis of in vitro synergy of polymyxins and carbapenems Antimicrob Agents Chemother 57 2013 5104 5111
8. J.P.T. Higgins, S.G. Thompson, J.J. Deeks, and D.G. Altman Measuring inconsistency in meta-analyses BMJ 327 2003 557 560
9. C. Tascini, F. Menichetti, S. Bozza, A. Del Favero, and F. Bistoni Evaluation of the activities of two-drug combinations of rifampicin, polymyxin B and ampicillin/sulbactam against Acinetobacter baumannii J Antimicrob Chemother 42 1998 270 271
10. G.M. Hogg, J.G. Barr, and C.H. Webb In-vitro activity of the combination of colistin and rifampicin against multidrug-resistant strains of Acinetobacter baumannii J Antimicrob Chemother 41 1998 494 495
11. E.J. Giamarellos-Bourboulis, E. Xirouchaki, and H. Giamarellou Interactions of colistin and rifampin on multidrug-resistant Acinetobacter baumannii Diagn Microbiol Infect Dis 40 2001 117 120
12. J. Yoon, C. Urban, C. Terzian, N. Mariano, and J.J. Rahal In vitro double and triple synergistic activities of polymyxin B, imipenem, and rifampin against multidrug-resistant Acinetobacter baumannii Antimicrob Agents Chemother 48 2004 753 757
13. D.W. Wareham, and D.C. Bean In-vitro activity of polymyxin B in combination with imipenem, rifampicin and azithromycin versus multidrug resistant strains of Acinetobacter baumannii producing OXA-23 carbapenemases Ann Clin Microbiol Antimicrob 5 2006 10
14. F. Timurkaynak, F. Can, O.K. Azap, M. Demirbilek, H. Arslan, and S.O. Karaman In vitro activities of non-traditional antimicrobials alone or in combination against multidrug-resistant strains of Pseudomonas aeruginosa and Acinetobacter baumannii isolated from intensive care units Int J Antimicrob Agents 27 2006 224 228
15. P.J. Petersen, P. Labthavikul, C.H. Jones, and P.A. Bradford In vitro antibacterial activities of tigecycline in combination with other antimicrobial agents determined by chequerboard and time-kill kinetic analysis J Antimicrob Chemother 57 2006 573 576
16. B. Foleno, E. Wira, K. Bush, R.K. Flamm, and B.D. Foleno Ceftobiprole in vitro interactions with doripenem, levofloxacin or colistin against Pseudomonas aeruginosa, Acinetobacter baumannii, and fluoroquinolone-resistant Escherichia coli Proceedings of the 44th Annual Meeting of the Infectious Diseases Society of America (IDSA) 12-15 October 2006, Toronto, Canada 2006 Oxford University Press Oxford, UK [poster 286]
17. C. Tascini, R. Doria, G. Gemignani, A. Leonildi, P. Malacarne, and G. Biancofiore Clinical and microbiology activity of colistin alone and in combination with rifampin or other antibiotics against MDR Gram-negative rods severe infections: four-year, single-centre experience Proceedings of the 16th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 1-4 April 2006, Nice, France 2006 Oxford, UK Wiley
18. H.S. Leu, L.H. Su, and W.J. Wang Laboratory investigation of the combination effect of imipenem/colistin and sulbactam/colistin on clinical isolates of multidrug-resistant Acinetobacter baumannii Proceedings of the 16th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 1-4 April 2006, Nice, France 2006 Wiley Oxford, UK
19. G. Biancofiore, C. Tascini, M. Bisa, G. Gemignani, M.L. Bindi, and A. Leonildi Colistin, meropenem and rifampin in a combination therapy for multi-drug-resistant Acinetobacter baumannii multifocal infection. A case report Minerva Anestesiol 73 2007 181 185
20. M.F. Tripodi, E. Durante-Mangoni, R. Fortunato, R. Utili, and R. Zarrilli Comparative activities of colistin, rifampicin, imipenem and sulbactam/ampicillin alone or in combination against epidemic multidrug-resistant Acinetobacter baumannii isolates producing OXA-58 carbapenemases Int J Antimicrob Agents 30 2007 537 540
21. T.Y. Tan, L.S. Ng, E. Tan, and G. Huang In vitro effect of minocycline and colistin combinations on imipenem-resistant Acinetobacter baumannii clinical isolates J Antimicrob Chemother 60 2007 421 423
22. J. Li, R.L. Nation, R.J. Owen, S. Wong, D. Spelman, and C. Franklin Antibiograms of multidrug-resistant clinical Acinetobacter baumannii: promising therapeutic options for treatment of infection with colistin-resistant strains Clin Infect Dis 45 2007 594 598
23. J.Y. Song, S.Y. Kee, I.S. Hwang, Y.B. Seo, H.W. Jeong, and W.J. Kim In vitro activities of carbapenem/sulbactam combination, colistin, colistin/rifampicin combination and tigecycline against carbapenem-resistant Acinetobacter baumannii J Antimicrob Chemother 60 2007 317 322
24. M. Sands, Y. McCarter, and W. Sanchez Synergy testing of multidrug resistant Acinetobacter baumannii against tigecycline and polymyxin using an E-test methodology Eur J Clin Microbiol Infect Dis 26 2007 521 522
25. L.A. Kroeger, L.B. Hovde, I.F. Mitropoulos, J. Schafer, and J.C. Rotschafer Colistin methanesulfonate against multidrug-resistant Acinetobacter baumannii in an in vitro pharmacodynamic model Antimicrob Agents Chemother 51 2007 3431 3433
26. M.H. Scheetz, C. Qi, J.R. Warren, M.J. Postelnick, T. Zembower, and A. Obias In vitro activities of various antimicrobials alone and in combination with tigecycline against carbapenem-intermediate or -resistant Acinetobacter baumannii Antimicrob Agents Chemother 51 2007 1621 1626
27. M. Morgan, R. Chan, R. Murthy, S. Nichols, and Y. Miyasaki In vitro activity of antibiotic combinations against multidrug-resistant Acinetobacter baumannii (MDRAB) Proceedings of the 45th Annual Meeting of the Infectious Diseases Society of America (IDSA) 4-7 October 2007, San Diego, CA 2007 Oxford University Press Oxford, UK
28. H. Antonopoulou, D. Kavatha, I. Galani, Z. Chryssouli, M. Lelekis, and H. Giamarellou In vitro interaction of imipenem, sulbactam, colistin and rifampin on 18 imipenem-resistant Acinetobacter baumannii isolates Proceedings of the 17th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 31 March-4 April 2007, Munich, Germany 2007 Oxford, UK Wiley [abstract 1724-60]
29. G.A. Pankuch, G. Lin, H. Seifert, and P.C. Appelbaum Activity of meropenem with and without ciprofloxacin and colistin against Pseudomonas aeruginosa and Acinetobacter baumannii Antimicrob Agents Chemother 52 2008 333 336
30. K.C. Guelfi, M.C. Tognim, C.L. Cardoso, A.C. Gales, F.E. Carrara-Marrone, and L.B. Garcia In vitro evaluation of the antimicrobial activity of meropenem in combination with polymyxin B and gatifloxacin against Pseudomonas aeruginosa and Acinetobacter baumannii J Chemother 20 2008 180 185
31. E.S. Moland, D.W. Craft, S.G. Hong, S.Y. Kim, L. Hachmeister, and S.D. Sayed In vitro activity of tigecycline against multidrug-resistant Acinetobacter baumannii and selection of tigecycline-amikacin synergy Antimicrob Agents Chemother 52 2008 2940 2942
32. C.H. Lee, Y.F. Tang, L.H. Su, C.C. Chien, and J.W. Liu Antimicrobial effects of varied combinations of meropenem, sulbactam, and colistin on a multidrug-resistant Acinetobacter baumannii isolate that caused meningitis and bacteremia Microb Drug Resist 14 2008 233 237
33. D.S. Burgess, M.F. Carden, and S. Nathisuwan In vitro activity of colistin (COL) in combination with meropenem (MER), ampicillin/sulbactam (ASM), cefepime (CFP), rifampicin (RIF), doxycycline (DOX), levofloxacin (LEV), and amikacin (AMK) against multidrug-resistant (MDR) Acinetobacter baumannii (Ab) Proceedings of the 48th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 25-28 October 2008, Washington, DC 2008 ASM Press Washington, DC
34. M. Ullman, I. Mitropoulos, L. Hovde, R. Prince, and J. Rotschafer In vitro pharmacodynamic evaluation of meropenem and colistin against multi-drug resistant (MDR) Acinetobacter baumannii Proceedings of the 48th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 25-28 October 2008, Washington, DC 2008 ASM Press Washington, DC
35. R.T. Attridge, M.F. Carden, S. Padilla, S. Nathisuwan, and D.S. Burgess Colistin (COL) and rifampicin (RIF) alone and in combination against multidrug-resistant (MDR) Acinetobacter baumannii using an in vitro PK-PD model Proceedings of the 48th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 25-28 October 2008, Washington, DC 2008 ASM Press Washington, DC
36. G.A. Pankey, and D.S. Ashcraft The detection of synergy between meropenem and polymyxin B against meropenem-resistant Acinetobacter baumannii using Etest and time-kill assay Diagn Microbiol Infect Dis 63 2009 228 232
37. T.P. Lim, T.Y. Tan, W. Lee, S. Sasikala, T.T. Tan, and L.Y. Hsu In vitro activity of various combinations of antimicrobials against carbapenem-resistant Acinetobacter species in Singapore J Antibiot (Tokyo) 62 2009 675 679
38. L. Principe, S. D'Arezzo, A. Capone, N. Petrosillo, and P. Visca In vitro activity of tigecycline in combination with various antimicrobials against multidrug resistant Acinetobacter baumannii Ann Clin Microbiol Antimicrob 8 2009 18
39. L.A. Arroyo, I. Mateos, V. Gonzalez, and J. Aznar In vitro activities of tigecycline, minocycline, and colistin-tigecycline combination against multi- and pandrug-resistant clinical isolates of Acinetobacter baumannii group Antimicrob Agents Chemother 53 2009 1295 1296
40. C. Mukhopadhyay, N. Nagalakshmi, K. Chawla, G. Dutta, and I. Bairy Synergism of colistin and rifampicin in the treatment of nosocomial infections with pandrug-resistant nonfermenters: an observational study Drug Metab Rev 41 2009 47
41. D.S. Burgess, W. Srisupha-Olarn, and M.F. Carden In vitro activity of colistin in combination with ceftazidime, ceftriaxone, clarithromycin, imipenem, linezolid and vancomycin against metallo-β-lactamase Acinetobacter baumannii Proceedings of the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 12-15 September 2009, San Francisco, CA 2009 ASM Press Washington, DC [abstract 3297]
42. P. Pongpech, S. Amornnopparattanakul, S. Panapakdee, S. Fungwithaya, P. Nannha, and C. Dhiraputra Antibacterial activity of carbapenem-based combinations against multidrug-resistant Acinetobacter baumannii J Med Assoc Thai 93 2010 161 171
43. C.H. Rodriguez, A. De Ambrosio, M. Bajuk, M. Spinozzi, M. Nastro, and K. Bombicino In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones J Infect Dev Ctries 4 2010 164 167
44. M.M. Sopirala, J.E. Mangino, W.A. Gebreyes, B. Biller, T. Bannerman, and J.M. Balada-Llasat Synergy testing by Etest, microdilution checkerboard, and time-kill methods for pan-drug-resistant Acinetobacter baumannii Antimicrob Agents Chemother 54 2010 4678 4683
45. C. Urban, N. Mariano, and J.J. Rahal In vitro double and triple bactericidal activities of doripenem, polymyxin B, and rifampin against multidrug-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli Antimicrob Agents Chemother 54 2010 2732 2734
46. G.A. Pankuch, H. Seifert, and P.C. Appelbaum Activity of doripenem with and without levofloxacin, amikacin, and colistin against Pseudomonas aeruginosa and Acinetobacter baumannii Diagn Microbiol Infect Dis 67 2010 191 197
47. M.E. Pachón-Ibáñez, F. Docobo-Pérez, R. López-Rojas, J. Domínguez-Herrera, M.E. Jiménez-Mejias, and A. García-Curiel Efficacy of rifampin and its combinations with imipenem, sulbactam, and colistin in experimental models of infection caused by imipenem-resistant Acinetobacter baumannii Antimicrob Agents Chemother 54 2010 1165 1172
48. M. Dizbay, D.K. Tozlu, M.Y. Cirak, Y. Isik, K. Ozdemir, and D. Arman In vitro synergistic activity of tigecycline and colistin against XDR-Acinetobacter baumannii J Antibiot (Tokyo) 63 2010 51 53
49. B. Özbek, and A. Şentürk Postantibiotic effects of tigecycline, colistin sulfate, and levofloxacin alone or tigecycline-colistin sulfate and tigecycline-levofloxacin combinations against Acinetobacter baumannii Chemotherapy 56 2010 466 471
50. B. Özbek, and G. Ötük In vitro activities of tigecycline alone and in combination with colistin sulfate or sulbactam against carbapenem-susceptible and -resistant Acinetobacter baumannii strains isolated from intensive care units Int J Antimicrob Agents 36 2010 191 192
51. N.C. Gordon, K. Png, and D.W. Wareham Potent synergy and sustained bactericidal activity of a vancomycin-colistin combination versus multidrug-resistant strains of Acinetobacter baumannii Antimicrob Agents Chemother 54 2010 5316 5322
52. W. Srisupha-Olarn, and D. Burgess Activity of meropenem and colistin alone and in combination against multidrug resistant Acinetobacter baumannii in a pharmacokinetic-pharmacodynamic model Proceedings of the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 12-15 September 2010, Boston, MA 2010 ASM Press Washington, DC
53. C.H. Tan, B.T. Tsuji, J.B. Bulitta, A. Forrest, R.L. Nation, and J. Li Colistin & rifampicin combinations demonstrate synergy and suppression of resistance against Acinetobacter baumannii in an in vitro PK/PD model Proceedings of the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 12-15 September 2010, Boston, MA 2010 ASM Press Washington, DC
54. M.J. Dorobisz, R.K. Shields, M.H. Nguyen, Y. Doi, C.J. Clancy, and B.A. Potoski Combination therapy options for extreme drug resistant Acinetobacter (XDR-AB) not susceptible to colistin and tigecycline Proceedings of the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 12-15 September 2010, Boston, MA 2010 ASM Press Washington, DC
55. B. Korber-Irrgang, and M. Kresken In vitro activity of daptomycin combined with other antimicrobial agents against Gram-negative bacteria Proceedings of the 20th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10-13 April 2010, Vienna, Austria 2010 Wiley Oxford, UK
56. T.P. Lim, W. Lee, S. Sasikala, L.Y. Hsu, T.T. Tan, and A.L. Kwa Pharmacokinetic/pharmacodynamic modelling of polymyxin B, rifampicin and tigecycline against pandrug resistant Acinetobacter baumannii in an in vitro model Proceedings of the 20th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10-13 April 2010, Vienna, Austria 2010 Wiley Oxford, UK
57. T.P. Lim, W. Lee, S. Sasikala, L.Y. Hsu, T.H. Koh, and T.T. Tan In vitro activity of antimicrobials in combination against clinical strains of extreme drug-resistant Acinetobacter baumannii to all antibiotics including polymyxin B in Singapore Proceedings of the 20th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10-13 April 2010, Vienna, Austria 2010 Wiley Oxford, UK
58. M.E. Steed, K. Kaye, H. Salimnia, D. Marchaim, T. Chopra, and M. Rybak In vitro activity of colistin sulfate in combination with other antimicrobials against Acinetobacter baumannii Proceedings of the 20th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10-13 April 2010, Vienna, Austria 2010 Wiley Oxford, UK
59. R.K. Shields, E.J. Kwak, B.A. Potoski, Y. Doi, J.M. Adams-Haduch, and F.P. Silviera High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii: using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment regimen Diagn Microbiol Infect Dis 70 2011 246 252
60. W. Liang, X.F. Liu, J. Huang, D.M. Zhu, J. Li, and J. Zhang Activities of colistin- and minocycline-based combinations against extensive drug resistant Acinetobacter baumannii isolates from intensive care unit patients BMC Infect Dis 11 2011 109
61. W.H. Sheng, J.T. Wang, S.Y. Li, Y.C. Lin, A. Cheng, and Y.C. Chen Comparative in vitro antimicrobial susceptibilities and synergistic activities of antimicrobial combinations against carbapenem-resistant Acinetobacter species: Acinetobacter baumannii versus Acinetobacter genospecies 3 and 13TU Diagn Microbiol Infect Dis 70 2011 380 386
62. T.P. Lim, T.Y. Tan, W. Lee, S. Sasikala, T.T. Tan, and L.Y. Hsu In-vitro activity of polymyxin B, rifampicin, tigecycline alone and in combination against carbapenem-resistant Acinetobacter baumannii in Singapore PLoS One 6 2011 e18485
63. M. Hornsey, and D.W. Wareham In vivo efficacy of glycopeptide-colistin combination therapies in a Galleria mellonella model of Acinetobacter baumannii infection Antimicrob Agents Chemother 55 2011 3534 3537
64. T.Y. Tan, T.P. Lim, W.H. Lee, S. Sasikala, L.Y. Hsu, and A.L. Kwa In vitro antibiotic synergy in extensively drug-resistant Acinetobacter baumannii: the effect of testing by time-kill, checkerboard, and Etest methods Antimicrob Agents Chemother 55 2011 436 438
65. W. Santimaleeworagun, P. Wongpoowarak, P. Chayakul, S. Pattharachayakul, P. Tansakul, and K.W. Garey In vitro activity of colistin or sulbactam in combination with fosfomycin or imipenem against clinical isolates of carbapenem-resistant Acinetobacter baumannii producing OXA-23 carbapenemases Southeast Asian J Trop Med Public Health 42 2011 890 900
66. D.W. Wareham, N.C. Gordon, and M. Hornsey In vitro activity of teicoplanin combined with colistin versus multidrug-resistant strains of Acinetobacter baumannii J Antimicrob Chemother 66 2011 1047 1051
67. T.S. Wang, and J.R. Su Different activities of antimicrobial combinations against multidrug resistant Acinetobacter baumannii in vitro Chin J Microbiol Immunol (China) 31 2011 898 902
68. C.A. Speil, R.W. Rzepka, L. Shahani, S.J. Bergman, and N. Khardori Tigecycline combined with polymyxin B or rifampin against Acinetobacter baumannii in suspension and biofilm Proceedings of the 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 17-20 September 2011, Chicago, IL 2011 ASM Press Washington, DC
69. L. Principe, A. Mazzarelli, S. D'Arezzo, E. Bordi, A.D. Caro, and N. Petrosillo In vitro activity of doripenem in combination with various antimicrobials against multidrug-resistant Acinetobacter baumannii: possible options for the treatment of complicated infections Proceedings of the 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 17-20 September 2011, Chicago, IL 2011 ASM Press Washington DC
70. A. Poudyal, H. Yu, K. Davis, C. Ku, R. Nightingale, and J. Jacob Colistin and doripenem combinations demonstrate synergy and suppression of resistance against Acinetobacter baumannii at multiple inocula in an in vitro PK/PD model Proceedings of the 21st European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 7-10 May 2011, Milan, Italy 2011 Wiley Oxford, UK
71. J. Teo, T. Lim, W. Lee, S. Sasikala, D.Q. Chia, and L.Y. Hsu In vitro activity of doripenem in combination with polymyxin against multidrug-resistant Acinetobacter baumannii Proceedings of the 21st European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 7-10 May 2011, Milan, Italy 2011 Wiley Oxford, UK
72. C. Speil, R. Rzepka, and N. Khardori Activity of polymyxin B and rifampin against Acinetobacter baumannii in suspension and biofilm Proceedings of the 21st European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 7-10 May 2011, Milan, Italy 2011 Wiley Oxford, UK
73. M. Hornsey, C. Longshaw, L. Phee, and D.W. Wareham In vitro activity of telavancin in combination with colistin versus Gram-negative bacterial pathogens Antimicrob Agents Chemother 56 2012 3080 3085
74. K.R. Peck, M.J. Kim, J.Y. Choi, H.S. Kim, C.I. Kang, and Y.K. Cho In vitro time-kill studies of antimicrobial agents against blood isolates of imipenem-resistant Acinetobacter baumannii, including colistin- or tigecycline-resistant isolates J Med Microbiol 61 2012 353 360
75. M. Kempf, L. Djouhri-Bouktab, J.M. Brunel, D. Raoult, and J.M. Rolain Synergistic activity of sulbactam combined with colistin against colistin-resistant Acinetobacter baumannii Int J Antimicrob Agents 39 2012 180 181
76. A.G. Ozseven, E.S. Cetin, B.C. Aridogan, and L. Ozseven In vitro synergistic activity of carbapenems in combination with other antimicrobial agents against multidrug-resistant Acinetobacter baumannii Afr J Microbiol Res 6 2012 2985 2992
77. J. Quale, N. Shah, P. Kelly, E. Babu, M. Backer, and G. Rosas-Garcia Activity of polymyxin B and the novel polymyxin analogue CB-182,804 against contemporary Gram-negative pathogens in New York City Microb Drug Resist 18 2012 132 136
78. E. Mutlu Yilmaz, M. Sunbul, A. Aksoy, H. Yilmaz, A.K. Guney, and T. Guvenc Efficacy of tigecycline/colistin combination in a pneumonia model caused by extensively drug-resistant Acinetobacter baumannii Int J Antimicrob Agents 40 2012 332 336
79. A. Deveci, A.Y. Coban, O. Acicbe, E. Tanyel, G. Yaman, and B. Durupinar In vitro effects of sulbactam combinations with different antibiotic groups against clinical Acinetobacter baumannii isolates J Chemother 24 2012 247 252
80. Y. Miyasaki, M.A. Morgan, R.C. Chan, W.S. Nichols, K.M. Hujer, and R.A. Bonomo In vitro activity of antibiotic combinations against multidrug-resistant strains of Acinetobacter baumannii and the effects of their antibiotic resistance determinants FEMS Microbiol Lett 328 2012 26 31
81. C. Vidaillac, L. Benichou, and R.E. Duval In vitro synergy of colistin combinations against colistin-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae isolates Antimicrob Agents Chemother 56 2012 4856 4861
82. K. Kongsanae, P. Naenna, C. Dhiraputra, A. Leelarasamee, and P. Pongpech In vitro antimicrobial activity of colistin in combination with rifampicin against carbapenem-resistant Acinetobacter baumannii Int J Infect Dis 16 2012 e421
83. G.G. Rao, N.S. Ly, R.L. Soon, S. Roman, P.A. Kelchlin, and P.N. Holden Polymyxin B in combination with doripenem against Acinetobacter baumannii demonstrates high synergy and suppression of resistance Proceedings of the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 9-12 September 2012, San Francisco, CA 2012 ASM Press Washington, DC
84. M. Medeiros, and N. Lincopan Synergistic activity of polymyxin B associated with vancomycin or imipenem against OXA-143, OXA-23, OXA-58, and OXA-72-producing Acinetobacter baumannii Proceedings of the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 9-12 September 2012, San Francisco, CA 2012 ASM Press Washington, DC
85. C. Malmberg, L. Albrecht, P. Bertilsson-Forsberg, P. Lagerback, H. Seifert, and P. Komp-Lindgren Colistin in combination with daptomycin enhances the effect against Acinetobacter baumannii Proceedings of the 22nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 31 March-3 April 2011, London, UK 2012 Wiley Oxford, UK
86. H. Moraitou, O. Oikonomou, M. Makarona, S. Bartziali, G. Tsoumanis, and S. Triantafyllou Various antibiotic combination tests against MDR Acinetobacter baumannii and Klebsiella pneumoniae Proceedings of the 22nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 31 March-3 April 2011, London, UK 2012 Wiley Oxford, UK
87. T.P. Lim, W. Lee, S. Sasikala, N. Rafida, T.Y. Tan, and L.Y. Hsu High-dose doripenem and polymyxin B are bactericidal against extreme drug-resistant Acinetobacter baumannii and suppress the emergence of resistance beyond 24 hours in a hollow fibre infection mode Proceedings of the 22nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 31 March-3 April 2011, London, UK 2012 Wiley Oxford, UK
88. Y.Y. Cai, T.P. Lim, S. Sasikala, N. Rafida, T.Y. Tan, and W. Lee Comparison of a rapid multiple combination bactericidal testing method vs. conventional time-kill studies for patients infected with extreme drug-resistant Acinetobacter baumannii with decreasing susceptibilities to polymyxin B Proceedings of the 22nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 31 March-3 April 2011, London, UK 2012 Wiley Oxford, UK
89. S.A. Clock, S. Tabibi, L. Alba, C.J. Kubin, S. Whittier, and L. Saiman In vitro activity of doripenem alone and in multi-agent combinations against extensively drug-resistant Acinetobacter baumannii and Klebsiella pneumoniae Diagn Microbiol Infect Dis 76 2013 343 346
90. A. Cikman, M.R. Ceylan, M. Parlak, M.K. Karahocagil, and M. Berktas Evaluation of colistin-ampicillin/sulbactam combination efficacy in imipenem-resistant Acinetobacter baumannii strains [in Turkish] Mikrobiyol Bul 47 2013 147 151
91. B. Netto, B.J. Vieira, D.M. Hermes, V.B. Ribeiro, and A.P. Zavascki In vitro activity of non-bactericidal concentrations of polymyxin B in combination with other antimicrobials against OXA-23-producing carbapenem-resistant Acinetobacter baumannii Braz J Infect Dis 17 2013 502 504
92. L. Principe, A. Capone, A. Mazzarelli, S. D'Arezzo, E. Bordi, and A. Di Caro In vitro activity of doripenem in combination with various antimicrobials against multidrug-resistant Acinetobacter baumannii: possible options for the treatment of complicated infection Microb Drug Resist 19 2013 407 414
93. H.J. Lee, P.J. Bergen, J.B. Bulitta, B. Tsuji, A. Forrest, and R.L. Nation Synergistic activity of colistin and rifampin combination against multidrug-resistant Acinetobacter baumannii in an in vitro pharmacokinetic/pharmacodynamic model Antimicrob Agents Chemother 57 2013 3738 3745
94. W. Ni, J. Cui, B. Liang, Y. Cai, N. Bai, and X. Cai In vitro effects of tigecycline in combination with colistin (polymyxin E) and sulbactam against multidrug-resistant Acinetobacter baumannii J Antibiot (Tokyo) 66 2013 705 708
95. I. Karaoglan, Y. Zer, V.K. Bosnak, A.O. Mete, and M. Namiduru In vitro synergistic activity of colistin with tigecycline or β-lactam antibiotic/β-lactamase inhibitor combinations against carbapenem-resistant Acinetobacter baumannii J Int Med Res 41 2013 1830 1837
96. E.S. Cetin, A. Tekeli, A.G. Ozseven, E. Us, and B.C. Aridogan Determination of in vitro activities of polymyxin B and rifampin in combination with ampicillin/sulbactam or cefoperazone/sulbactam against multidrug-resistant Acinetobacter baumannii by the E-test and checkerboard methods Jpn J Infect Dis 66 2013 463 468
97. Y. Zhang, F. Chen, E. Sun, R. Ma, C. Qu, and L. Ma In vitro antibacterial activity of combinations of fosfomycin, minocycline and polymyxin B on pan-drug-resistant Acinetobacter baumannii Exp Ther Med 5 2013 1737 1739
98. J.A. O'Hara, L.A. Ambe, L.G. Casella, B.M. Townsend, M.R. Pelletier, and R.K. Ernst Activities of vancomycin-containing regimens against colistin-resistant Acinetobacter baumannii clinical strains Antimicrob Agents Chemother 57 2013 2103 2108
99. M. Hornsey, L. Phee, C. Longshaw, and D.W. Wareham In vivo efficacy of telavancin/colistin combination therapy in a Galleria mellonella model of Acinetobacter baumannii infection Int J Antimicrob Agents 41 2013 285 287
100. S. Yilmaz, M.A. Yetkin, B. Kayaaslan, A. Baştuʇ, H. Aslaner, and D. Kanyilmaz In vitro antimicrobial synergy testing of colistin with sulbactam, meropenem, tigecycline against carbapenem resistant Acinetobacter baumannii isolated from intensive care unit patients by using Etest Proceedings of the 51st Annual Meeting of the Infectious Diseases Society of America (IDSA) 2-6 October 2013, San Francisco, CA 2013 Oxford University Press Oxford, UK
101. G. Leite, C.K. Rocha, A. Levin, and S. Costa In vitro antibiotic synergistic activity against multidrug resistant Acinetobacter baumannii Proceedings of the 51st Annual Meeting of the Infectious Diseases Society of America (IDSA) 2-6 October 2013, San Francisco, CA 2013 Oxford University Press Oxford, UK
102. F.F. Arhin, M. Marquis, I. Sarmiento, and G. Moeck Activity of oritavancin combined with colistin against multi-drug resistant strains of Acinetobacter baumannii Proceedings of the 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 10-13 September 2013, Denver, CO 2013 ASM Press Washington, DC
103. N. Mansour, E. Azar, C. Afif, and Z. Daoud Synergistic combination of carbapenems and colistin against Pseudomonas aeruginosa and Acinetobacter baumannii Proceedings of the 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 10-13 September 2013, Denver, CO 2013 ASM Press Washington, DC
104. L.M. Oleksiuk, M.H. Nguyen, E.G. Press, C.L. Updike, J.A. O'Hara, and Y. Doi In vitro responses of Acinetobacter baumannii to two- and three-drug combinations following exposure to colistin and doripenem Antimicrob Agents Chemother 58 2014 1195 1199
105. M. Hagihara, S.T. Housman, D.P. Nicolau, and J.L. Kuti In vitro pharmacodynamics of polymyxin B and tigecycline alone and in combination against carbapenem-resistant Acinetobacter baumannii Antimicrob Agents Chemother 58 2014 874 879
106. H.S. Leu, J.J. Ye, M.H. Lee, L.H. Su, P.Y. Huang, and T.L. Wu Synergy of imipenem/colistin methanesulfonate combinations against imipenem-nonsusceptible multidrug-resistant Acinetobacter baumannii J Microbiol Immunol Infect 47 2014 406 411
107. M. Nastro, C.H. Rodríguez, R. Monge, J. Zintgraff, L. Neira, and M. Rebollo Activity of the colistin-rifampicin combination against colistin-resistant, carbapenemase-producing Gram-negative bacteria J Chemother 26 2014 211 216
108. V. Thamlikitkul, and S. Tiengrim In vitro activity of colistin plus sulbactam against extensive-drug-resistant Acinetobacter baumannii by checkerboard method J Med Assoc Thai 97 Suppl 3 2014 S1 S6
109. I. Galani, K. Orlandou, H. Moraitou, G. Petrikkos, and M. Souli Colistin/daptomycin: an unconventional antimicrobial combination synergistic in vitro against multidrug-resistant Acinetobacter baumannii Int J Antimicrob Agents 43 2014 370 374
110. Y. Cai, D. Chai, R. Wang, B. Liang, and N. Bai Colistin resistance of Acinetobacter baumannii: clinical reports, mechanisms and antimicrobial strategies J Antimicrob Chemother 67 2012 1607 1615