In vitro activity of antibiotic combinations against multidrug-resistant strains of Acinetobacter baumannii and the effects of their antibiotic resistance determinants

FEMS Microbiology Letters

Volumn 328, Issue 1, 2012, Pages 26-31

  Miyasaki, Yoko ^a   Morgan, Margie A ^a   Chan, Raymond C ^a   Nichols, W Stephen ^a   Hujer, Kristine M ^b,c   Bonomo, Robert A ^b,c   Murthy, A Rekha ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acinetobacter baumannii; Antibiotic combination; Antibiotic resistance determinants; Multidrug resistance

Indexed keywords

AMINOGLYCOSIDE DERIVATIVE; BETA LACTAMASE INHIBITOR; CARBAPENEM DERIVATIVE; CEPHALOSPORIN DERIVATIVE; COLISTIN; DOXYCYCLINE; PENICILLIN G; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ACINETOBACTER BAUMANNII; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG POTENTIATION; GENE AMPLIFICATION; IN VITRO STUDY; ISOELECTRIC FOCUSING; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; CLUSTER ANALYSIS; CROSS INFECTION; DRUG INTERACTIONS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GENOTYPE; HUMANS; ISOELECTRIC FOCUSING; MICROBIAL SENSITIVITY TESTS; MOLECULAR TYPING; POLYMERASE CHAIN REACTION;

ACINETOBACTER BAUMANNII; BACTERIA (MICROORGANISMS);

EID: 84856498943     PISSN: 03781097     EISSN: 15746968     Source Type: Journal    
DOI: 10.1111/j.1574-6968.2011.02480.x     Document Type: Article

References (23)

1. Bonapace CR, White RL, Friedrich LV & Bosso JA (2000) Evaluation of antibiotic synergy against Acinetobacter baumannii: a comparison with Etest, time-kill, and checkerboard methods. Diagn Microbiol Infect Dis 38: 43-50.
2. Boucher HW, Talbot GH, Bradley JS, Edwards JE, Gilbert D, Rice LB, Scheld M, Spellberg B & Bartlett J (2009) Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis 48: 1-12.
3. Clinical and Laboratory Standards Institute (2009) Performance Standards for Antimicrobial Susceptibility Testing; Nineteenth Informational Supplement. M100-S19. Clinical and Laboratory Standards Institute, Wayne, PA.
4. Giamarellos-Bourboulis EJ, Xirouchaki E & Giamarellou H (2001) Interactions of colistin and rifampin on multidrug-resistant Acinetobacter baumannii. Diagn Microbiol Infect Dis 40: 117-120.
5. Heritier C, Poirel L & Nordmann P (2006) Cephalosporinase over-expression resulting from insertion of ISAba1 in Acinetobacter baumannii. Clin Microbiol Infect 12: 123-130.
6. Hogg GM, Barr JG & Webb CH (1998) In-vitro activity of the combination of colistin and rifampicin against multidrug-resistant strains of Acinetobacter baumannii. J Antimicrob Chemother 41: 494-495.
7. Horan TC, Andrus M & Dudeck MA (2008) CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 36: 309-332.
8. Hujer KM, Hujer AM, Hulten EA et al. (2006) Analysis of antibiotic resistance genes in multidrug-resistant Acinetobacter sp. strains from military and civilian patients treated at the Walter Reed Army Medical Center. Antimicrob Agents Chemother 50: 4114-4123.
9. Li J, Nation RL, Owen RJ, Wong S, Spelman D & Franklin C (2007) Antibiograms of multidrug-resistant clinical Acinetobacter baumannii: promising therapeutic options for treatment of infection with colistin-resistant strains. Clin Infect Dis 45: 594-598.
10. Motaouakkil S, Charra B, Hachimi A, Nejmi H, Benslama A, Elmdaghri N, Belabbes H & Benbachir M (2006) Colistin and rifampicin in the treatment of nosocomial infections from multiresistant Acinetobacter baumannii. J Infect 53: 274-278.
11. Murthy ARK, Denny R, Morgan MA, Maldonado L, Lewis M, Burnes-Bolton L, Nichols WS & Mosenifar Z (2008) Control of a hospital wide multidrug-resistant Acinetobacter baumannii outbreak. 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy/Infectious Disease Society of America 46th Annual Meeting, Washington DC, USA. Abstract # K3347.
12. Panchón-Ibáñez ME, Docobo-Pérez F, López-Rojas R, Domínguez-Herrera J, Jiménez-Mejias ME, García-Curiel A, Pichardo C, Jiménez L & Panchón J (2010) Efficacy of rifampin and its combinations with imipenem, sulbactam, and colistin in experimental models of infection caused by imipenem-resistant Acinetobacter baumannii. Antimicrob Agents Chemother 54: 1165-1172.
13. Paterson DL, Rice LB & Bonomo RA (2001) Rapid method of extraction and analysis of extended-spectrum β-lactamases from clinical strains of Klebsiella pneumoniae. Clin Microbiol Infect 7: 709-711.
14. Perez F, Hujer AM, Hujer KM, Decker BK, Rather PN & Bonomo RA (2007) Global challenge of multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother 51: 3471-3484.
15. Poirel L & Nordmann P (2006) Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology. Clin Microbiol Infect 12: 826-836.
16. Rahal JJ (2006) Novel antibiotic combinations against infections with almost completely resistant Pseudomonas aeruginosa and Acinetobacter species. Clin Infect Dis 43(suppl 2): S95-S99.
17. Saballs M, Pujol M, Tubau F, Peña C, Montero A, Domínguez MA, Gudiol F & Ariza J (2006) Rifampicin/imipenem combination in the treatment of carbapenem-resistant Acinetobacter baumannii infections. J Antimicrob Chemother 58: 697-700.
18. Song JY, Cheong HJ, Lee J, Sung AK & Kim WJ (2009) Efficacy of monotherapy and combined antibiotic therapy for carbapenem-resistant Acinetobacter baumannii pneumonia in an immunosuppressed mouse model. Int J Antimicrob Agents 33: 33-39.
19. Tan TY, Ng LS, Tan E & Huang G (2007) In vitro effect of minocycline and colistin combinations on imipenem-resistant Acinetobacter baumannii clinical strains. J Antimicrob Chemother 60: 421-423.
20. Tascini C, Menichetti F, Bozza S, Del FA & Bistoni F (1998) Evaluation of the activities of two-drug combinations of rifampicin, polymyxin B and ampicillin/sulbactam against Acinetobacter baumannii. J Antimicrob Chemother 42: 270-271.
21. Timurkaynak F, Can F, Azap OK, Demirbilek M, Arslan H & Karaman SO (2006) In vitro activities of non-traditional antimicrobials alone or in combination against multidrug-resistant strains of Pseudomonas aeruginosa and Acinetobacter baumannii isolated from intensive care units. Int J Antimicrob Agents 27: 224-228.
22. Tripodi MF, Durante-Mangoni E, Fortunato R, Utili R & Zarrilli R (2007) Comparative activities of colistin, rifampicin, imipenem and sulbactam/ampicillin alone or in combination against epidemic multidrug-resistant Acinetobacter baumannii strains producing OXA-58 carbapenemases. Int J Antimicrob Agents 30: 537-540.
23. White RL, Burgess DS, Manduru M & Bosso JA (1996) Comparison of three different in vitro methods of detecting synergy: time-kill, checkerboard, and E test. Antimicrob Agents Chemother 40: 1914-1918.