In vitro antibiotic synergy in extensively drug-resistant Acinetobacter baumannii: The effect of testing by time-kill, checkerboard, and etest methods

Antimicrobial Agents and Chemotherapy

Volumn 55, Issue 1, 2011, Pages 436-438

  Tan, Thean Yen ^a   Lim, Tze Peng ^b   Lee, Winnie Hui Ling ^b   Sasikala, Suranthran ^a   Hsu, Li Yang ^c   Kwa, Andrea Lay Hoon ^b  

^a CHANGI GENERAL HOSPITAL   (Singapore)

^b SINGAPORE GENERAL HOSPITAL   (Singapore)

^c NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

POLYMYXIN B; RIFAMPICIN; TIGECYCLINE;

ACINETOBACTER BAUMANNII; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL;

ACINETOBACTER BAUMANNII; ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; DRUG SYNERGISM; MICROBIAL SENSITIVITY TESTS; MINOCYCLINE; POLYMYXIN B; RIFAMPIN;

EID: 78650663301     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00850-10     Document Type: Article

References (20)

1. Bonapace, C. R., R. L. White, L. V. Friedrich, and J. A. Bosso. 2000. Evaluation of antibiotic synergy against Acinetobacter baumannii: a comparison with Etest, time-kill, and checkerboard methods. Diagn. Microbiol. Infect. Dis. 38:43-50.
2. Chen, T. L., L. K. Siu, R. C. Wu, M. F. Shaio, L. Y. Huang, C. P. Fung, C. M. Lee, and W. L. Cho. 2007. Comparison of one-tube multiplex PCR, automated ribotyping and intergenic spacer (ITS) sequencing for rapid identification of Acinetobacter baumannii. Clin. Microbiol. Infect. 13:801-806.
3. Clinical and Laboratory Standards Institute. 2009. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard, 8th ed., vol. 29. Clinical and Laboratory Standards Institute, Wayne, PA.
4. Clinical and Laboratory Standards Institute. 2010. Performance standards for antimicrobial susceptibility testing; 20th informational supplement. CLSI document M100-S20, vol. 30. Clinical and Laboratory Standards Institute, Wayne, PA.
5. Falagas, M. E., and D. E. Karageorgopoulos. 2008. Pandrug resistance (PDR), extensive drug resistance (XDR), and multidrug resistance (MDR) among Gram-negative bacilli: need for international harmonization in terminology. Clin. Infect. Dis. 46:1121-1122.
6. Giske, C. G., D. L. Monnet, O. Cars, and Y. Carmeli. 2008. Clinical and economic impact of common multidrug-resistant gram-negative bacilli. Antimicrob. Agents Chemother. 52:813-821.
7. Gumbo, T., A. Louie, M. R. Deziel, W. Liu, L. M. Parsons, M. Salfinger, and G. L. Drusano. 2007. Concentration-dependent Mycobacterium tuberculosis killing and prevention of resistance by rifampin. Antimicrob. Agents Chemother. 51:3781-3788.
8. Ko, K. S., J. Y. Suh, K. T. Kwon, S. I. Jung, K. H. Park, C. I. Kang, D. R. Chung, K. R. Peck, and J. H. Song. 2007. High rates of resistance to colistin and polymyxin B in subgroups of Acinetobacter baumannii isolates from Korea. J. Antimicrob. Chemother. 60:1163-1167.
9. Kwa, A. L., T. P. Lim, J. G. Low, J. Hou, A. Kurup, R. A. Prince, and V. H. Tam. 2008. Pharmacokinetics of polymyxin B1 in patients with multidrugresistant Gram-negative bacterial infections. Diagn. Microbiol. Infect. Dis. 60:163-167.
10. Lim, T. P., T. Y. Tan, W. Lee, S. Sasikala, T. T. Tan, L. Y. Hsu, and A. L. Kwa. 2009. In vitro activity of various combinations of antimicrobials against carbapenem-resistant Acinetobacter species in Singapore. J. Antibiot. (Tokyo) 62:675-679.
11. Liu, P. Y., and W. L. Wu. 1997. Use of different PCR-based DNA fingerprinting techniques and pulsed-field gel electrophoresis to investigate the epidemiology of Acinetobacter calcoaceticus-Acinetobacter baumannii complex. Diagn. Microbiol. Infect. Dis. 29:19-28.
12. Moody, J. 2004. Synergism testing: broth microdilution checkerboard and broth macrodilution methods, p. 5.12.1-5.12.23. In H. D. Isenberg (ed.), Clinical microbiology procedures handbook, vol. 2. American Society for Microbiology, Washington, DC.
13. National Committee for Clinical Laboratory Standards. 1999. Methods for determining bactericidal activity of antimicrobial agents. Approved guideline M26-A, vol. 19. NCCLS, Wayne, PA.
14. Odds, F. C. 2003. Synergy, antagonism, and what the chequerboard puts between them. J. Antimicrob. Chemother. 52:1.
15. Pachon-Ibanez, M. E., F. Docobo-Perez, R. Lopez-Rojas, J. Dominguez-Herrera, M. E. Jimenez-Mejias, A. Garcia-Curiel, C. Pichardo, L. Jimenez, and J. Pachon. 2010. Efficacy of rifampin and its combinations with imipenem, sulbactam, and colistin in experimental models of infection caused by imipenem-resistant Acinetobacter baumannii. Antimicrob. Agents Chemother. 54:1165-1172.
16. Pankey, G. A., and D. S. Ashcraft. 2009. The detection of synergy between meropenem and polymyxin B against meropenem-resistant Acinetobacter baumannii using Etest and time-kill assay. Diagn. Microbiol. Infect. Dis. 63:228-232.
17. Peleg, A. Y., H. Seifert, and D. L. Paterson. 2008. Acinetobacter baumannii: emergence of a successful pathogen. Clin. Microbiol. Rev. 21:538-582.
18. Rodvold, K. A., M. H. Gotfried, M. Cwik, J. M. Korth-Bradley, G. Dukart, and E. J. Ellis-Grosse. 2006. Serum, tissue and body fluid concentrations of tigecycline after a single 100 mg dose. J. Antimicrob. Chemother. 58:1221-1229.
19. Taccone, F. S., H. Rodriguez-Villalobos, D. De Backer, V. De Moor, J. Deviere, J. L. Vincent, and F. Jacobs. 2006. Successful treatment of septic shock due to pan-resistant Acinetobacter baumannii using combined antimicrobial therapy including tigecycline. Eur. J. Clin. Microbiol. Infect. Dis. 25:257-260.
20. White, R. L., D. S. Burgess, M. Manduru, and J. A. Bosso. 1996. Comparison of three different in vitro methods of detecting synergy: time-kill, checkerboard, and E test. Antimicrob. Agents Chemother. 40:1914-1918.