HLA-DQ allele competition in narcolepsy: A comment on Tafti et al. DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe

Sleep

Volumn 38, Issue 1, 2015, Pages 147-151

  Ollila, Hanna M ^a   Fernandez Vina, Marcelo ^b   Mignot, Emmanuel ^a  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cataplexy; HLA; Hypocretin; MHC; Narcolepsy

Indexed keywords

HETERODIMER; HLA DQ ANTIGEN;

ALLELE; ARTICLE; CATAPLEXY; CONTROLLED STUDY; COPY NUMBER VARIATION; ETHNIC DIFFERENCE; ETHNIC GROUP; EUROPE; GENE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HIGH RISK POPULATION; HLA DQA1 GENE; HLA DQB1 GENE; HUMAN; NARCOLEPSY; GENETIC PREDISPOSITION; GENETICS;

CATAPLEXY; GENETIC PREDISPOSITION TO DISEASE; HLA-DQ BETA-CHAINS; HUMANS; NARCOLEPSY;

EID: 84920395193     PISSN: 01618105     EISSN: 15509109     Source Type: Journal    
DOI: 10.5665/sleep.4342     Document Type: Article

References (17)

1. Tafti M, Hor H, Dauvilliers Y, et al. DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe. Sleep 2014;37:19-25.
2. Han F, Lin L, Li J, et al. HLA-DQ association and allele competition in Chinese narcolepsy. Tissue Antigens 2012;80:328-35.
3. Hong SC, Lin L, Lo B, et al. DQB1∗0301 and DQB1∗0601 modulate narcolepsy susceptibility in Koreans. Hum Immunol 2007;68:59-68.
4. Mignot E, Lin L, Rogers W, et al. Complex HLA-DR and-DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am J Hum Genet 2001;68:686-99.
5. Roh EY, Park MH, Park H, et al. Association of HLA-DR and-DQ genes with narcolepsy in Koreans: comparison with two control groups, randomly selected subjects and DRB1∗1501-DQB1∗0602-positive subjects. Hum Immunol 2006;67:749-55.
6. Sollid LM, Qiao SW, Anderson RP, Gianfrani C, Koning F. Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules. Immunogenetics 2012;64:455-60.
7. Koeleman BP, Lie BA, Undlien DE, et al. Genotype effects and epistasis in type 1 diabetes and HLA-DQ trans dimer associations with disease. Genes Immun 2004;5:381-8.
8. Kwok WW, Kovats S, Thurtle P, Nepom GT. HLA-DQ allelic polymorphisms constrain patterns of class II heterodimer formation. J Immunol 1993;150:2263-72.
9. Temme S, Zacharias M, Neumann J, et al. A novel family of human leukocyte antigen class II receptors may have its origin in archaic human species. J Biol Chem 2014;289:639-53.
10. Gyllensten UB, Erlich HA. Evolution of HLA class-II polymorphism in primates: the DQA locus. Immunol Res 1990;9:223-33.
11. Otting N, de Groot NG, Doxiadis GG, Bontrop RE. Extensive Mhc-DQB variation in humans and non-human primate species. Immunogenetics 2002;54:230-9.
12. Siebold C, Hansen BE, Wyer JR, et al. Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy. Proc Natl Acad Sci U S A 2004;101:1999-2004.
13. Hohjoh H, Terada N, Honda Y, Juji T, Tokunaga K. Negative association of the HLA-DRB1∗1502-DQB1∗0601 haplotype with human narcolepsy. Immunogenetics 2001;52:299-301.
14. Voorter CE, Lee KW, Smillie D, Tilanus MG, van den Berg-Loonen EM. Sequence-based typing of HLA-DQA1: comprehensive approach showed molecular heterogeneity. Tissue Antigens 2007;69 Suppl 1:76-81
15. Han F, Faraco J, Dong XS, et al. Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic. PLoS Genetics 2013;9:e1003880.
16. Juji T, Satake M, Honda Y, Doi Y. HLA antigens in Japanese patients with narcolepsy. All the patients were DR2 positive. Tissue Antigens 1984;24:316-9.
17. Rogers AE, Meehan J, Guilleminault C, Grumet FC, Mignot E. HLA DR15 (DR2) and DQB1∗0602 typing studies in 188 narcoleptic patients with cataplexy. Neurology 1997;48:1550-6.