메뉴 건너뛰기




Volumn 12, Issue 11, 2014, Pages 1850-1860

Antithrombotic triple therapy and coagulation activation at the site of thrombus formation: A randomized trial in healthy subjects

Author keywords

Aspirin; Dabigatran; Drug therapy, combination; Phenprocoumon; Rivaroxaban; Ticagrelor

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE; ANTICOAGULANT AGENT; ANTITHROMBIN III; ANTITHROMBIN III-PROTEASE COMPLEX; ANTITHROMBOCYTIC AGENT; BENZIMIDAZOLE DERIVATIVE; BETA ALANINE; BETA THROMBOGLOBULIN; BIOLOGICAL MARKER; DABIGATRAN; FIBRINOLYTIC AGENT; MORPHOLINE DERIVATIVE; PEPTIDE FRAGMENT; PEPTIDE HYDROLASE; PHENPROCOUMON; PROTHROMBIN; PROTHROMBIN FRAGMENT 1.2; RIVAROXABAN; THIOPHENE DERIVATIVE; THROMBIN; TICAGRELOR;

EID: 84920272003     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/jth.12726     Document Type: Article
Times cited : (6)

References (45)
  • 3
    • 84856158305 scopus 로고    scopus 로고
    • ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC)
    • Hamm CW, Bassand JP, Agewall S, Bax J, Boersma E, Bueno H, Caso P, Dudek D, Gielen S, Huber K, Ohman M, Petrie MC, Sonntag F, Uva MS, Storey RF, Wijns W, Zahger D, Guidelines ESCCfP. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 2011; 32: 2999-3054.
    • (2011) Eur Heart J , vol.32 , pp. 2999-3054
    • Hamm, C.W.1    Bassand, J.P.2    Agewall, S.3    Bax, J.4    Boersma, E.5    Bueno, H.6    Caso, P.7    Dudek, D.8    Gielen, S.9    Huber, K.10    Ohman, M.11    Petrie, M.C.12    Sonntag, F.13    Uva, M.S.14    Storey, R.F.15    Wijns, W.16    Zahger, D.17
  • 8
    • 33747052359 scopus 로고    scopus 로고
    • Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalence
    • Miyasaka Y, Barnes ME, Gersh BJ, Cha SS, Bailey KR, Abhayaratna WP, Seward JB, Tsang TS. Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalence. Circulation 2006; 114: 119-25.
    • (2006) Circulation , vol.114 , pp. 119-125
    • Miyasaka, Y.1    Barnes, M.E.2    Gersh, B.J.3    Cha, S.S.4    Bailey, K.R.5    Abhayaratna, W.P.6    Seward, J.B.7    Tsang, T.S.8
  • 12
    • 77953189870 scopus 로고    scopus 로고
    • Antithrombotic management of atrial fibrillation patients presenting with acute coronary syndrome and/or undergoing coronary stenting: executive summary-a Consensus Document of the European Society of Cardiology Working Group on Thrombosis, endorsed by the European Heart Rhythm Association (EHRA) and the European Association of Percutaneous Cardiovascular Interventions (EAPCI)
    • Lip GY, Huber K, Andreotti F, Arnesen H, Airaksinen JK, Cuisset T, Kirchhof P, Marin F, Consensus Document of European Society of Cardiology Working Group on Thrombosis. Antithrombotic management of atrial fibrillation patients presenting with acute coronary syndrome and/or undergoing coronary stenting: executive summary-a Consensus Document of the European Society of Cardiology Working Group on Thrombosis, endorsed by the European Heart Rhythm Association (EHRA) and the European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur Heart J 2010; 31: 1311-8.
    • (2010) Eur Heart J , vol.31 , pp. 1311-1318
    • Lip, G.Y.1    Huber, K.2    Andreotti, F.3    Arnesen, H.4    Airaksinen, J.K.5    Cuisset, T.6    Kirchhof, P.7    Marin, F.8
  • 14
    • 39149105940 scopus 로고    scopus 로고
    • Anticoagulant and antiplatelet therapy use in 426 patients with atrial fibrillation undergoing percutaneous coronary intervention and stent implantation implications for bleeding risk and prognosis
    • Ruiz-Nodar JM, Marin F, Hurtado JA, Valencia J, Pinar E, Pineda J, Gimeno JR, Sogorb F, Valdes M, Lip GY. Anticoagulant and antiplatelet therapy use in 426 patients with atrial fibrillation undergoing percutaneous coronary intervention and stent implantation implications for bleeding risk and prognosis. J Am Coll Cardiol 2008; 51: 818-25.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 818-825
    • Ruiz-Nodar, J.M.1    Marin, F.2    Hurtado, J.A.3    Valencia, J.4    Pinar, E.5    Pineda, J.6    Gimeno, J.R.7    Sogorb, F.8    Valdes, M.9    Lip, G.Y.10
  • 16
    • 84865863475 scopus 로고    scopus 로고
    • Bleeding after initiation of multiple antithrombotic drugs, including triple therapy, in atrial fibrillation patients following myocardial infarction and coronary intervention: a nationwide cohort study
    • Lamberts M, Olesen JB, Ruwald MH, Hansen CM, Karasoy D, Kristensen SL, Kober L, Torp-Pedersen C, Gislason GH, Hansen ML. Bleeding after initiation of multiple antithrombotic drugs, including triple therapy, in atrial fibrillation patients following myocardial infarction and coronary intervention: a nationwide cohort study. Circulation 2012; 126: 1185-93.
    • (2012) Circulation , vol.126 , pp. 1185-1193
    • Lamberts, M.1    Olesen, J.B.2    Ruwald, M.H.3    Hansen, C.M.4    Karasoy, D.5    Kristensen, S.L.6    Kober, L.7    Torp-Pedersen, C.8    Gislason, G.H.9    Hansen, M.L.10
  • 18
    • 84908272253 scopus 로고    scopus 로고
    • Antithrombotic therapy in patients with atrial fibrillation and acute coronary syndrome in the real world: data from the Berlin AFibACS Registry
    • Accessed 13 May 2014.
    • Maier B, Hegenbarth C, Theres H, Schoeller R, Schuhlen H, Behrens S. Antithrombotic therapy in patients with atrial fibrillation and acute coronary syndrome in the real world: data from the Berlin AFibACS Registry. Cardiol J 2014; DOI:10.5603/CJ.a2013.0146. URL: http://www.ncbi.nlm.nih.gov/pubmed/24142683. Accessed 13 May 2014.
    • (2014) Cardiol J
    • Maier, B.1    Hegenbarth, C.2    Theres, H.3    Schoeller, R.4    Schuhlen, H.5    Behrens, S.6
  • 20
    • 79955933219 scopus 로고    scopus 로고
    • 2011 ACCF/AHA/HRS focused updates incorporated into the ACC/AHA/ESC 2006 Guidelines for the management of patients with atrial fibrillation: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines developed in partnership with the European Society of Cardiology and in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society
    • Fuster V, Ryden LE, Cannom DS, Crijns HJ, Curtis AB, Ellenbogen KA, Halperin JL, Kay GN, Le Huezey JY, Lowe JE, Olsson SB, Prystowsky EN, Tamargo JL, Wann LS. 2011 ACCF/AHA/HRS focused updates incorporated into the ACC/AHA/ESC 2006 Guidelines for the management of patients with atrial fibrillation: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines developed in partnership with the European Society of Cardiology and in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. J Am Coll Cardiol 2011; 57: e101-98.
    • (2011) J Am Coll Cardiol , vol.57 , pp. e101-e198
    • Fuster, V.1    Ryden, L.E.2    Cannom, D.S.3    Crijns, H.J.4    Curtis, A.B.5    Ellenbogen, K.A.6    Halperin, J.L.7    Kay, G.N.8    Le Huezey, J.Y.9    Lowe, J.E.10    Olsson, S.B.11    Prystowsky, E.N.12    Tamargo, J.L.13    Wann, L.S.14
  • 24
    • 0023615865 scopus 로고
    • Investigation of the interaction of blood platelets with the coagulation system at the site of plug formation in vivo in man-effect of low-dose aspirin
    • Kyrle PA, Westwick J, Scully MF, Kakkar VV, Lewis GP. Investigation of the interaction of blood platelets with the coagulation system at the site of plug formation in vivo in man-effect of low-dose aspirin. Thromb Haemost 1987; 57: 62-6.
    • (1987) Thromb Haemost , vol.57 , pp. 62-66
    • Kyrle, P.A.1    Westwick, J.2    Scully, M.F.3    Kakkar, V.V.4    Lewis, G.P.5
  • 25
    • 79958241510 scopus 로고    scopus 로고
    • Effect of edoxaban on markers of coagulation in venous and shed blood compared with fondaparinux
    • Wolzt M, Samama MM, Kapiotis S, Ogata K, Mendell J, Kunitada S. Effect of edoxaban on markers of coagulation in venous and shed blood compared with fondaparinux. Thromb Haemost 2011; 105: 1080-90.
    • (2011) Thromb Haemost , vol.105 , pp. 1080-1090
    • Wolzt, M.1    Samama, M.M.2    Kapiotis, S.3    Ogata, K.4    Mendell, J.5    Kunitada, S.6
  • 27
    • 0020646407 scopus 로고
    • Thromboxane A2 in skin-bleeding-time blood and in clotted venous blood before and after administration of acetylsalicylic acid
    • Thorngren M, Shafi S, Born GV. Thromboxane A2 in skin-bleeding-time blood and in clotted venous blood before and after administration of acetylsalicylic acid. Lancet 1983; 1: 1075-8.
    • (1983) Lancet , vol.1 , pp. 1075-1078
    • Thorngren, M.1    Shafi, S.2    Born, G.V.3
  • 28
    • 0023945284 scopus 로고
    • Evidence for tissue factor-dependent activation of the classic extrinsic coagulation mechanism in blood obtained from bleeding time wounds
    • Weiss HJ, Lages B. Evidence for tissue factor-dependent activation of the classic extrinsic coagulation mechanism in blood obtained from bleeding time wounds. Blood 1988; 71: 629-35.
    • (1988) Blood , vol.71 , pp. 629-635
    • Weiss, H.J.1    Lages, B.2
  • 31
    • 0035889148 scopus 로고    scopus 로고
    • Blood coagulation at the site of microvascular injury: effects of low-dose aspirin
    • Undas A, Brummel K, Musial J, Mann KG, Szczeklik A. Blood coagulation at the site of microvascular injury: effects of low-dose aspirin. Blood 2001; 98: 2423-31.
    • (2001) Blood , vol.98 , pp. 2423-2431
    • Undas, A.1    Brummel, K.2    Musial, J.3    Mann, K.G.4    Szczeklik, A.5
  • 32
    • 0343603522 scopus 로고    scopus 로고
    • A novel enzyme immunoassay for plasma thrombospondin. Comparison with beta-thromboglobulin as platelet activation marker in vitro and in vivo
    • Bergseth G, Lappegard KT, Videm V, Mollnes TE. A novel enzyme immunoassay for plasma thrombospondin. Comparison with beta-thromboglobulin as platelet activation marker in vitro and in vivo. Thromb Res 2000; 99: 41-50.
    • (2000) Thromb Res , vol.99 , pp. 41-50
    • Bergseth, G.1    Lappegard, K.T.2    Videm, V.3    Mollnes, T.E.4
  • 34
    • 0027393437 scopus 로고
    • Laboratory markers of coagulation activation
    • Bauer KA. Laboratory markers of coagulation activation. Arch Pathol Lab Med 1993; 117: 71-7.
    • (1993) Arch Pathol Lab Med , vol.117 , pp. 71-77
    • Bauer, K.A.1
  • 35
    • 0014555555 scopus 로고
    • The standardized normal Ivy bleeding time and its prolongation by aspirin
    • Mielke CH Jr, Kaneshiro MM, Maher IA, Weiner JM, Rapaport SI. The standardized normal Ivy bleeding time and its prolongation by aspirin. Blood 1969; 34: 204-15.
    • (1969) Blood , vol.34 , pp. 204-215
    • Mielke, C.H.1    Kaneshiro, M.M.2    Maher, I.A.3    Weiner, J.M.4    Rapaport, S.I.5
  • 36
    • 0033117206 scopus 로고    scopus 로고
    • Inhibition of thrombin generation by simvastatin and lack of additive effects of aspirin in patients with marked hypercholesterolemia
    • Szczeklik A, Musial J, Undas A, Gajewski P, Gora P, Swadzba J, Jankowski M. Inhibition of thrombin generation by simvastatin and lack of additive effects of aspirin in patients with marked hypercholesterolemia. J Am Coll Cardiol 1999; 33: 1286-93.
    • (1999) J Am Coll Cardiol , vol.33 , pp. 1286-1293
    • Szczeklik, A.1    Musial, J.2    Undas, A.3    Gajewski, P.4    Gora, P.5    Swadzba, J.6    Jankowski, M.7
  • 37
    • 29144518504 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939-an oral, direct Factor Xa inhibitor-after multiple dosing in healthy male subjects
    • Kubitza D, Becka M, Wensing G, Voith B, Zuehlsdorf M. Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939-an oral, direct Factor Xa inhibitor-after multiple dosing in healthy male subjects. Eur J Clin Pharmacol 2005; 61: 873-80.
    • (2005) Eur J Clin Pharmacol , vol.61 , pp. 873-880
    • Kubitza, D.1    Becka, M.2    Wensing, G.3    Voith, B.4    Zuehlsdorf, M.5
  • 38
    • 18044388905 scopus 로고    scopus 로고
    • Preclinical and clinical studies with selective reversible direct P2Y12 antagonists
    • van Giezen JJ, Humphries RG. Preclinical and clinical studies with selective reversible direct P2Y12 antagonists. Semin Thromb Hemost 2005; 31: 195-204.
    • (2005) Semin Thromb Hemost , vol.31 , pp. 195-204
    • van Giezen, J.J.1    Humphries, R.G.2
  • 41
    • 0029074254 scopus 로고
    • Effects of recombinant hirudin (r-hirudin, HBW 023) on coagulation and platelet activation in vivo. Comparison with unfractionated heparin and a low-molecular-weight heparin preparation (fragmin)
    • Eichinger S, Wolzt M, Schneider B, Nieszpaur-Los M, Heinrichs H, Lechner K, Eichler HG, Kyrle PA. Effects of recombinant hirudin (r-hirudin, HBW 023) on coagulation and platelet activation in vivo. Comparison with unfractionated heparin and a low-molecular-weight heparin preparation (fragmin). Arterioscler Thromb Vasc Biol 1995; 15: 886-92.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 886-892
    • Eichinger, S.1    Wolzt, M.2    Schneider, B.3    Nieszpaur-Los, M.4    Heinrichs, H.5    Lechner, K.6    Eichler, H.G.7    Kyrle, P.A.8
  • 43
    • 84904302336 scopus 로고    scopus 로고
    • Direct thrombin inhibitors, but not the direct factor Xa inhibitor rivaroxaban, increase tissue factor-induced hypercoagulability in vitro and in vivo
    • Perzborn E, Heitmeier S, Buetehorn U, Laux V. Direct thrombin inhibitors, but not the direct factor Xa inhibitor rivaroxaban, increase tissue factor-induced hypercoagulability in vitro and in vivo. J Thromb Haemost 2014; 12: 1054-65.
    • (2014) J Thromb Haemost , vol.12 , pp. 1054-1065
    • Perzborn, E.1    Heitmeier, S.2    Buetehorn, U.3    Laux, V.4
  • 44
    • 84891762128 scopus 로고    scopus 로고
    • Impact of endogenous esterase activity on in vitro p-glycoprotein profiling of dabigatran etexilate in Caco-2 monolayers
    • Ishiguro N, Kishimoto W, Volz A, Ludwig-Schwellinger E, Ebner T, Schaefer O. Impact of endogenous esterase activity on in vitro p-glycoprotein profiling of dabigatran etexilate in Caco-2 monolayers. Drug Metab Dispos 2014; 42: 250-6.
    • (2014) Drug Metab Dispos , vol.42 , pp. 250-256
    • Ishiguro, N.1    Kishimoto, W.2    Volz, A.3    Ludwig-Schwellinger, E.4    Ebner, T.5    Schaefer, O.6
  • 45
    • 84884816920 scopus 로고    scopus 로고
    • A pharmacokinetic interaction study of ticagrelor and digoxin in healthy volunteers
    • Teng R, Butler K. A pharmacokinetic interaction study of ticagrelor and digoxin in healthy volunteers. Eur J Clin Pharmacol 2013; 69: 1801-8.
    • (2013) Eur J Clin Pharmacol , vol.69 , pp. 1801-1808
    • Teng, R.1    Butler, K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.