Low dose acetylsalicylic acid and shedding of microparticles in vivo in humans

European Journal of Clinical Investigation

Volumn 40, Issue 6, 2010, Pages 477-482

  Lubsczyk, Barbara ^a   Kollars, Marietta ^a   Hron, Gregor ^a   Kyrle, Paul A ^a,b   Weltermann, Ansgar ^c   Gartner, Verena ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Karl Landsteiner Institute of Thrombosis Research   (Austria)

^c ELISABETHINEN HOSPITAL   (Austria)

Author keywords

Acetylsalicylic acid; Coagulation; Microcirculation; Microparticles; Platelets

Indexed keywords

ACETYLSALICYLIC ACID; BETA THROMBOGLOBULIN; PHOSPHATIDYLSERINE; PLACEBO; PROTHROMBIN; PROTHROMBIN FRAGMENT 1.2; THROMBOASS; THROMBOPLASTIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD CLOTTING; BLOOD VESSEL INJURY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG MECHANISM; FLOW CYTOMETRY; HEMOSTASIS; HUMAN; HUMAN EXPERIMENT; IMMUNOASSAY; LOW DRUG DOSE; MALE; MICROCIRCULATION; NORMAL HUMAN; PLATELET MICROPARTICLE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE FUNCTION; VENOUS BLOOD;

ADULT; ASPIRIN; BETA-THROMBOGLOBULIN; BIOLOGICAL MARKERS; BLOOD COAGULATION; CELL-DERIVED MICROPARTICLES; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FLOW CYTOMETRY; HUMANS; IMMUNOASSAY; MALE; PEPTIDE FRAGMENTS; PHOSPHATIDYLSERINES; PLATELET ACTIVATION; PROSPECTIVE STUDIES; PROTHROMBIN; THROMBOPLASTIN;

EID: 77952628599     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2010.02299.x     Document Type: Article

References (19)

1. Diamant M, Tushuizen ME, Sturk A, Nieuwland R. Cellular microparticles: new players in the field of vascular disease? Eur J Clin Invest 2004 34: 392 401.
2. Freyssinet JM. Cellular microparticles: what are they bad or good for? J Thromb Haemost 2003 1: 1655 1662.
3. Barry OP, Pratico D, Lawson JA, FitzGerald GA. Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles. J Clin Invest 1997 99: 2118 2127.
4. Chou J, Mackman N, Merrill-Skoloff G, Pedersen B, Furie BC, Furie B. Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation. Blood 2004 104: 3190 3197.
5. van der Zee PM, Biro E, Ko Y, de Winter RJ, Hack CE, Sturk A et al. P-selectin-and CD63-exposing platelet microparticles reflect platelet activation in peripheral arterial disease and myocardial infarction. Clin Chem 2006 52: 657 664.
6. Chirinos JA, Heresi GA, Velasquez H, Jy W, Jimenez JJ, Ahn E et al. Elevation of endothelial microparticles, platelets, and leukocyte activation in patients with venous thromboembolism. J Am Coll Cardiol 2005 45: 1467 1471.
7. Mallat Z, Benamer H, Hugel B, Benessiano J, Steg PG, Freyssinet JM et al. Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes. Circulation 2000 101: 841 843.
8. Tesselaar ME, Romijn FP, Van Der Linden IK, Prins FA, Bertina RM, Osanto S. Microparticle-associated tissue factor activity: a link between cancer and thrombosis? J Thromb Haemost 2007 5: 520 527.
9. Falati S, Gross P, Merrill-Skoloff G, Furie BC, Furie B. Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse. Nat Med 2002 8: 1175 1181.
10. Undas A, Brummel K, Musial J, Mann KG, Szczeklik A. Blood coagulation at the site of microvascular injury: effects of low-dose aspirin. Blood 2001 98: 2423 2431.
11. Weltermann A, Wolzt M, Petersmann K, Czerni C, Graselli U, Lechner K et al. Large amounts of vascular endothelial growth factor at the site of hemostatic plug formation in vivo. Arterioscler Thromb Vasc Biol 1999 19: 1757 1760.
12. Kyrle PA, Westwick J, Scully MF, Kakkar VV, Lewis GP. Investigation of the interaction of blood platelets with the coagulation system at the site of plug formation in vivo in man-effect of low-dose aspirin. Thromb Haemost 1987 57: 62 6.
13. Mielke CH. Measurement of the bleeding time. Thromb Haemost 1984 52: 210 211.
14. Biro E, Sturk-Maquelin KN, Vogel GM, Meuleman DG, Smit MJ, Hack CE et al. Human cell-derived microparticles promote thrombus formation in vivo in a tissue factor-dependent manner. J Thromb Haemost 2003 1: 2561 2568.
15. Hathcock JJ, Rusinova E, Gentry RD, Andree H, Nemerson Y. Phospholipid regulates the activation of factor X by tissue factor/factor VIIa (TF/VIIa) via substrate and product interactions. Biochemistry 2005 44: 8187 8197.
16. Butenas S, Bouchard BA, Brummel-Ziedins KE, Parhami-Seren B, Mann KG. Tissue factor activity in whole blood. Blood 2005 105: 2764 2770.
17. Patrono C. Aspirin as an antiplatelet drug. N Engl J Med 1994 330: 1287 1294.
18. Kyrle PA, Eichler HG, Jager U, Lechner K. Inhibition of prostacyclin and thromboxane A2 generation by low-dose aspirin at the site of plug formation in man in vivo. Circulation 1987 75: 1025 1029.
19. Hron G, Kollars M, Weber H, Sagaster V, Quehenberger P, Eichinger S et al. Tissue factor-positive microparticles: cellular origin and association with coagulation activation in patients with colorectal cancer. Thromb Haemost 2007 97: 119 123.