Benzophenone C - And O -glucosides from Cyclopia genistoides (Honeybush) inhibit mammalian α-glucosidase

Journal of Natural Products

Volumn 77, Issue 12, 2014, Pages 2694-2699

  Beelders, Theresa ^a,b   Brand, D Jacobus ^c   De Beer, Dalene ^b   Malherbe, Christiaan J ^b   Mazibuko, Sithandiwe E ^d   Muller, Christo J F ^d   Joubert, Elizabeth ^a,b  

^a STELLENBOSCH UNIVERSITY   (South Africa)

^b ARC INFRUITEC NIETVOORBIJ   (South Africa)

^c Central Analytical Facility (CAF) Nuclear Magnetic Resonance Unit   (South Africa)

^d SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

3 C BETA DEXTRO GLUCOPYRANOSYL 4 O BETA DEXTRO GLUCOPYRANOSYLIRIFLOPHENONE; 3 C BETA DEXTRO GLUCOPYRANOSYLMACLURIN; ACETONE; ALPHA GLUCOSIDASE INHIBITOR; BENZOPHENONE DERIVATIVE; GLUCOSIDE; PROTON; UNCLASSIFIED DRUG; 3-C-BETA-D-GLUCOPYRANOSYL-4-O-BETA-D-GLUCOPYRANOSYLIRIFLOPHENONE; 3-C-BETA-D-GLUCOPYRANOSYLMACLURIN; ALPHA GLUCOSIDASE; GLUCOSE; GLYCOSIDASE INHIBITOR;

ADIPOCYTE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYCLOPIA GENISTOIDES; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; ENZYME INHIBITION; GLUCOSE TRANSPORT; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HYDROLYSIS; IN VITRO STUDY; MASS FRAGMENTOGRAPHY; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SHRUB; ALGORITHM; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CYCLOPIA (GENUS); DRUG EFFECTS; ISOLATION AND PURIFICATION; MALE; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PLANT LEAF; SOUTH AFRICA;

CYCLOPIA GENISTOIDES; MAMMALIA; RATTUS;

ALGORITHMS; ALPHA-GLUCOSIDASES; ANIMALS; BENZOPHENONES; CYCLOPIA PLANT; GLUCOSE; GLUCOSIDES; GLYCOSIDE HYDROLASE INHIBITORS; MALE; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PLANT LEAVES; RATS; SOUTH AFRICA;

EID: 84920169124     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/np5007247     Document Type: Article

References (27)

1. Shaw, J. E.; Sicree, R. A.; Zimmet, P. Z. Diabetes Res. Clin. Pract. 2010, 87, 4-14
2. International Diabetes Federation. IDF Diabetes Atlas, 6 th ed.; International Diabetes Federation: Brussels, Belgium, 2013, (accessible at http://www.idf.org/diabetesatlas).
3. Mathers, C. D.; Loncar, D. PLoS Med. 2006, 3, e442
4. Xiao, J.; Kai, G.; Yamamoto, K.; Chen, X. Crit. Rev. Food Sci. Nutr. 2013, 53, 818-836
5. Park, H.; Hwang, K. Y.; Oh, K. H.; Kim, Y. H.; Lee, J. Y.; Kim, K. Bioorg. Med. Chem. 2008, 16, 284-292
6. Hollander, P. Diabetes Spectrum 2007, 20, 159-165
7. Boath, A. S.; Stewart, D.; McDougall, G. J. Food Chem. 2012, 135, 929-936
8. Liu, Y.; Zou, L.; Ma, L.; Chen, W.-H.; Wang, B.; Xu, Z.-L. Bioorg. Med. Chem. 2006, 14, 5683-5690
9. Feng, J.; Yang, X.-W.; Wang, R.-F. Phytochemistry 2011, 72, 242-247
10. Hu, X.; Xiao, Y.; Wu, J.; Ma, L. Arch. Pharm. Chem. Life Sci. 2011, 344, 71-77
11. Liu, Q.; Guo, T.; Li, W.; Li, D.; Feng, Z. Arch. Pharm. Chem. Life Sci. 2012, 345, 771-783
12. Joubert, E.; Joubert, M. E.; Bester, C.; De Beer, D.; De Lange, J. H. S. Afr. J. Bot. 2011, 77, 887-907
13. Vyas, A.; Syeda, K.; Ahmad, A.; Padhye, S.; Sarkar, F. H. Mini-Rev. Med. Chem. 2012, 12, 412-425
14. Kokotkiewicz, A.; Luczkiewicz, M.; Pawlowska, J.; Luczkiewicz, P.; Sowinski, P.; Witkowski, J.; Bryl, E.; Bucinski, A. Fitoterapia 2013, 90, 199-208
15. Malherbe, C. J.; Willenburg, E.; De Beer, D.; Bonnet, S. L.; Van der Westhuizen, J. H.; Joubert, E. J. Chromatogr. B 2014, 951-952C, 164-171
16. Beelders, T.; De Beer, D.; Stander, M. A.; Joubert, L. Molecules 2014, 19, 11760-11790
17. De Beer, D.; Schulze, A. E.; Joubert, E.; De Villiers, A.; Malherbe, C. J.; Stander, M. A. Molecules 2012, 17, 14602-14624
18. Kokotkiewicz, A.; Luczkiewicz, M.; Sowinski, P.; Glod, D.; Gorynski, K.; Bucinski, A. Food Chem. 2012, 133, 1373-1382
19. Jay, M. In The Flavonoids: Advances in Research since 1986; Harborne, J. B., Ed.; Chapman and Hall: London, 1993; p 85.
20. Tanaka, T.; Sueyasu, T.; Nonaka, G.-I.; Nishioka, I. Chem. Pharm. Bull. 1984, 32, 2676-2686
21. Li, H.; Song, F.; Xing, J.; Tsao, R.; Liu, Z.; Liua, S. J. Am. Soc. Mass. Spectrom. 2009, 20, 1496-1503
22. Zhang, Y.; Qian, Q.; Ge, D.; Li, Y.; Wang, X.; Chen, Q.; Gao, X.; Wang, T. J. Agric. Food Chem. 2011, 59, 11526-11533
23. Zhang, Y.; Liu, X.; Han, L.; Gao, X.; Liu, E.; Wang, T. Food Chem. 2013, 141, 2896-2905
24. Zhou, G.; Myers, R.; Li, Y.; Chen, Y.; Shen, X.; Fenyk-Melody, J.; Wu, M.; Ventre, J.; Doebber, T.; Fujii, N.; Musi, N.; Hirshman, M. F.; Goodyear, L. J.; Möller, D. E. J. Clin. Invest. 2001, 108, 1167-1174
25. Roessner, U.; Wagner, C.; Kopka, J.; Trethewey, R. N.; Willmitzer, L. Plant J. 2000, 23, 131-142
26. Azuma, T.; Kayano, S.; Matsumura, Y.; Konishi, Y.; Tanaka, Y.; Kikuzaki, H. Food Chem. 2011, 125, 471-475
27. Mazibuko, M. E. In Vitro and in Vivo Effect of Aspalathus linearis and Its Major Polyphenols on Carbohydrate and Lipid Metabolism in Insulin Resistant Models. Ph.D. Thesis, University of Zululand, KwaDlangezwa, South Africa, 2013.