Effects of concurrent training on inflammatory markers and expression of CD4, CD8, and HLA-DR in overweight and obese adults

Journal of Exercise Science and Fitness

Volumn 12, Issue 2, 2014, Pages 55-61

  Colato, Alana ^a   Abreu, Fabiana ^a   Medeiros, Niara ^a   Lemos, Leandro ^a   Dorneles, Gilson ^a   Ramis, Thiago ^a   Vianna, Priscila ^b   Chies, José Artur ^b   Peres, Alessandra ^a,c  

^a Laboratory of Immunology and Exercise Physiology   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c UNIVERSIDADE FEDERAL DE CIÊNCIAS DA SAÚDE DE PORTO ALEGRE   (Brazil)

Author keywords

Chronic exercise; Cytokines; Inflammation; Monocytes; T lymphocytes

Indexed keywords

EID: 84920164992     PISSN: 1728869X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jesf.2014.06.002     Document Type: Article

References (54)

1. Murthy N., Mukherjee S., Ray G., et al. Dietary factors and cancer chemoprevention: an overview of obesity-related malignancies. J Postgrad Med 2009, 55:45-54.
2. Grundy S.M., Brewer H.B., Cleeman J.I., et al. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 2004, 109:433-438. American Heart Association, National Heart, Lung, and Blood Institute.
3. World Health Organization (WHO) What Is the Scale of the Obesity Problem in Your Country? WHO Global Infobase - Data for Saving Lives 2010, Available from:, [Accessed May 2011]. http://www.who.int/topics/obesity/en/.
4. Festa A., D'Agostino R., Williams K., et al. The relation of body fat mass and distribution to markers of chronic inflammation. Int J Obes Relat Metab Disord 2001, 25:1407-1415.
5. Bullo M., Garcia-Lorda P., Megias I., et al. Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression. Obes Res 2003, 1:525-531.
6. Bastard J.P., Jardel C., Bruckert E., et al. Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J Clin Endocrinol Metab 2000, 85:3338-3342.
7. Yudkin J.S., Stehouwer C.D., Emeis J.J., et al. C reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?. Arterioscler Thromb Vasc Biol 1999, 19:972-978.
8. Dusserre E., Moulin P., Vidal H. Differences in mRNA expression of the proteins secreted by the adipocytes in human subcutaneous and visceral adipose tissues. Biochim Biophys Acta 2000, 1500:88-96.
9. Weiseberg S.P., McCann D., Desai M., et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003, 112:1796-1808.
10. Esposito K., Pontillo A., Di Palo C., et al. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA 2003, 289:1799-1804.
11. Nicklas B.J., You T., Pahor M. Behavioral treatments for chronic systemic inflammation: effects of dietary weight loss and exercise training. Can J Appl Physiol 2005, 172:1199-1209.
12. Kasapis C., Thompson P.D. The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review. J Am Coll Cardiol 2005, 45:1563-1569.
13. Simonson S.R. The immune response to resistance exercise. J Strength Cond Res 2001, 15:378-384.
14. Ischander M., Zaldivar F., Eliakim A., et al. Physical activity, growth, and inflammatory mediators in BMI-matched female adolescents. Med Sci Sports Exerc 2007, 39:1131-1138.
15. Pischon T., Hankinson S., Hotamisligil S., et al. Leisuretime physical activity and reduced plasma levels of obesity-related inflammatory markers. Obes Res 2003, 11:1055-1064.
16. Straczkowski M., Kowalska I., Dzienis-Straczkowska S., et al. Changes in tumor necrosis factor a system and insulin sensitivity during an exercise training program in obese women with normal and impaired glucose tolerance. Eur J Endocrinol 2001, 145:273-280.
17. Ryan A.S., Pratley R.E., Elahi D., et al. Changes in plasma leptin and insulin action with resistive training in postmenopausal women. Int J Obes Relat Metab Disord 2000, 24:27-32.
18. Miller J.P., Pratley R.E., Goldberg A.P., et al. Strength training increases insulin action in healthy 50- to 65-year-old men. J Appl Physiol 1994, 77:1122-1127.
19. Zachwieja J.J., Toffolo G., Cobelli C., et al. Resistance exercise and growth hormone administration in older men: effects on insulin sensitivity and secretion during a stable-label intravenous glucose tolerance test. Metabolism 1996, 45:254-260.
20. Kelley G.A., Kelley K.S. Effects of aerobic exercise on c reactive protein, body composition, and maximum oxygen consumption in adults: a metaanalysis of randomized controlled trials. Metabolism 2006, 55:1500-1507.
21. Bruce R.A. Exercise testing of patients with coronary heart disease. Principles and normal standards for evaluation. Ann Clin Res 1971, 3:323-332.
22. Borg G.A.V. Psychophysical bases of perceived exertion. Med Sci Sports Exerc 1982, 14:377-381.
23. Brown L.E., Weir J.P. ASEP procedures recommendations I: accurate assessment of muscle strength and power. J Exerc Physiol Online 2001, 4:1-21.
24. American College of Sports Medicine (ACSM) ACSM's Guidelines for Exercise Testing and Prescription 2009, The Point, Baltimore, MD. 8th ed.
25. Donges C.E., Duffield R., Drinkwater E.J. Effects of resistance or aerobic exercise training on interleukin-6, c-reactive protein, and body composition. Med Sci Sports Exerc 2010, 42:304-313.
26. Balducci S., Zanuso S., Nicolucci A., et al. Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutr Metab Cardiovasc Dis 2010, 20:608-617.
27. Libardi C.A., Souza G.V., Cavaglieri C.R., et al. Effect of resistance, endurance, and concurrent training on TNF-α, IL-6, and CRP. Med Sci Sports Exerc 2012, 44:50-56.
28. Aicher B.O., Haser E.K., Freeman L.A., et al. Diet-induced weight loss in overweight or obese women and changes in high-density lipoprotein levels and function. Obesity 2012, 20:2057-2062.
29. Fisher G., Hyatt T.C., Hunter G.R., et al. Effect of diet with and without exercise training on markers of inflammation and fat distribution in overweight women. Obesity (Silver Spring) 2011, 19:1131-1136.
30. Melo C.M., Tirapegui J., Cohen D., et al. Nutritional status and energy expenditure after a programme of nutrition education and combined aerobic/resistance training in obese women. E Spen Eur E J Clin Nutr Metab 2010, 5:e180-e186.
31. Blair S.N., Kampert J.B., Kohl H.W., et al. Influences of cardiorespiratory fitness and other precursors on cardiovascular disease and all-cause mortality in men and women. JAMA 1996, 276:205-210.
32. Donnelly J.E., Blair S.N., Jakicic J.M., et al. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults. Med Sci Sports Exerc 2009, 41:459-471.
33. Gibson R. Principles of Nutritional Assessment 1990, Oxford University Press, New York, NY, 690 pp. 1st ed.
34. Wajchenberg B.L. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 2000, 21:697-738.
35. Prestes J., Shiguemoto G., Botero J.P., et al. Effects of resistance training on resistin, leptin, cytokines, and muscle force in elderly post-menopausal women. J Sports Sci 2009, 27:1607-1615.
36. Petersen A.M., Pedersen B.K. The anti-inflammatory effect of exercise. J Appl Physiol 2005, 98:1154-1162.
37. Mohamed-Ali V., Pinkney J.H., Coppack S.W. Adipose tissue as an endocrine and paracrine organ. Int J Obes Relat Metab Disord 1998, 22:1145-1158.
38. Steensberg A., Keller C., Starkie R.L., et al. IL-6 and TNF-α expression in, and release from, contracting human skeletal muscle. Am J Physiol Endocrinol Metab 2002, 283:E1272-E1278.
39. Hotamisligil G.S., Arner P., Caro J.F., et al. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 1995, 95:2409-2415.
40. Baumann H., Gauldie J. The acute phase response. Immunol Today 1994, 15:74-80.
41. Martín-Cordero L., García J.J., Hinchado M.D., et al. Habitual physical exercise improves macrophage IL-6 and TNF-α deregulated release in the obese zucker rat model of the metabolic syndrome. Neuroimmunomodulation 2011, 18:123-130.
42. de Salles B.F., Simão R., Fleck S.J., et al. Effects of resistance training on cytokines. Int J Sports Med 2010, 31:441-450.
43. Andersson J., Janssona J., Hellsten G., et al. Effects of heavy endurance physical exercise on inflammatory markers in nonathletes. Atherosclerosis 2010, 209:601-605.
44. Ahmadi N., Eshaghian S., Huizenga R., et al. Effects of intense exercise and moderate caloric restriction on cardiovascular risk factors and inflammation. Am J Med 2011, 124:978-982.
45. Snel M., van Diepen J.A., Stijnen T., et al. Immediate and long-term effects of addition of exercise to a 16-week very low calorie diet on low-grade inflammation in obese, insulin-dependent type 2 diabetic patients. Food Chem Toxicol 2011, 49:3104-3111.
46. El-Kader S.M.A. Aerobic versus resistance exercise training in modulation of insulin resistance, adipocytokines and inflammatory cytokine levels in obese type 2 diabetic patients. J Adv Res 2011, 2:179-183.
47. Smart N.A., Larsen A.I., LeMaitre J.P., et al. Effect of exercise training on interleukin-6, tumour necrosis factor alpha and functional capacity in heart failure. Cardiol Res Pract 2011, 27:532-620.
48. Buyukyazi G., Ulmanb C., Taneli F., et al. The effects of different intensity walking programs on serum blood lipids, high sensitive C reactive protein, and lipoprotein associated phospholipase A2 in premenopausal women. Science Sports 2010, 25:245-252.
49. Jae S.Y., Fernhalla B., Heffernan K.S., et al. Effects of lifestyle modifications on C-reactive protein: contribution of weight loss and improved aerobic capacity. Metabolism 2006, 55:825-831.
50. Jorge M.L.M.P., Oliveira V.N., Resende N.M., et al. The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus. Metabolism 2011, 60:1244-1252.
51. Shih K.C., Janckila A.J., Kwok C.F., et al. Effects of exercise on insulin sensitivity, inflammatory cytokines, and serum tartrate-resistant acid phosphatase 5a in obese Chinese male adolescents. Metabolism 2010, 59:144-151.
52. Fu S.C., Qin L., Leung C.K., et al. Regular moderate exercise training prevents decrease of CD4+ T-lymphocytes induced by a single bout of strenuous exercise in mice. Can J Appl Physiol 2003, 28:370-381.
53. da Nobrega A.C. The subacute effects of exercise: concept, characteristics, and clinical implications. Exerc Sport Sci Rev 2005, 33:84-87.
54. Shimizu K., Suzuki N., Imai T., et al. Monocyte and T-cell responses to exercise training in elderly subjects. J Strength Cond Res 2011, 25:2565-2572.