Cellular comparison of sinus mucosa vs polyp tissue from a single sinus cavity in chronic rhinosinusitis

International Forum of Allergy and Rhinology

Volumn 5, Issue 1, 2015, Pages 14-27

  Ho, Jacqueline ^a   Bailey, Michelle ^a,b   Zaunders, John ^a,b   Mrad, Nadine ^a   Sacks, Raymond ^a,c   Sewell, William ^a,d   Harvey, Richard J ^a,c  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c MACQUARIE UNIVERSITY   (Australia)

^d GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Chronic rhinosinusitis; Flow cytometry; Human; Lymphocytes; Mucosa; Nasal polyp; Sinonasal; Sinus; Tissue; Type 2 innate lymphoid cells

Indexed keywords

ADULT; CELL SEPARATION; CHRONIC DISEASE; CROSS-SECTIONAL STUDY; DENDRITIC CELL; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; LYMPHOCYTE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBPOPULATION; MALE; NOSE MUCOSA; NOSE POLYP; PATHOLOGY; PLASMA CELL; RHINITIS; SINUSITIS; TH2 CELL;

ADULT; CELL SEPARATION; CHRONIC DISEASE; CROSS-SECTIONAL STUDIES; DENDRITIC CELLS; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNITY, INNATE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBSETS; LYMPHOCYTES; MALE; NASAL MUCOSA; NASAL POLYPS; PLASMA CELLS; RHINITIS; SINUSITIS; TH2 CELLS;

EID: 84920157424     PISSN: 20426976     EISSN: 20426984     Source Type: Journal    
DOI: 10.1002/alr.21417     Document Type: Article

References (54)

1. Fokkens WJ, Lund VJ, Mullol J, et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology. 2012;50:1-12.
2. Huvenne W, van Bruaene N, Zhang N, et al. Chronic rhinosinusitis with and without nasal polyps: what is the difference? Curr Allergy Asthma Rep. 2009;9:213-220.
3. Hsu J, Peters AT. Pathophysiology of chronic rhinosinusitis with nasal polyp. Am J Rhinol Allergy. 2011;25:285-290.
4. Kamil A, Ghaffar O, Lavigne F, Taha R, Renzi PM, Hamid Q. Comparison of inflammatory cell profile and Th2 cytokine expression in the ethmoid sinuses, maxillary sinuses, and turbinates of atopic subjects with chronic sinusitis. Otolaryngol Head Neck Surg. 1998;118:804-809.
5. Ardehali MM, Amali A, Bakhshaee M, Madani Z. Histopathologic characteristics of inferior turbinate vs ethmoidal polyp in chronic rhinosinusitis. Ann DiagnPathol. 2011;15:233-236.
6. Bernstein JM, Gorfien J, Noble B, Yankaskas JR. Nasal polyposis: immunohistochemistry and bioelectrical findings (a hypothesis for the development of nasal polyps). J Allergy ClinImmunol. 1997;99:165-175.
7. Luong A, Shaw J, Fakhri S, Citardi M. Inflamed sinus mucosa has different cytokine profile than nasal polyps in patients with chronic rhinosinusitis. Paper/poster presented at: 56th Annual Meeting of the American Rhinologic Society; September 25, 2010; Boston, MA.
8. Shaw JL, Fakhri S, Citardi MJ, et al. IL-33-responsive innate lymphoid cells are an important source of IL-13 in chronic rhinosinusitis with nasal polyps. Am J RespirCrit Care Med. 2013;188:432-439.
9. Mjosberg JM, Trifari S, Crellin NK, et al. Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161. Nat Immunol. 2011;12:1055-1062.
10. Kirsche H, Niederfuhr A, Deutschle T, Fuchs C, Riechelmann H. Ratio of myeloid and plasmacytoid dendritic cells and TH2 skew in CRS with nasal polyps. Allergy. 2010;65:24-31.
11. Pant H, Hughes A, Miljkovic D, et al. Accumulation of effector memory CD8+ T cells in nasal polyps. Am J Rhinol Allergy. 2013;27:e117-e126.
12. Hulse KE, Norton JE, Suh L, et al. Chronic rhinosinusitis with nasal polyps is characterized by B-cell inflammation and EBV-induced protein 2 expression. J Allergy ClinImmunol. 2013;131:1075-1083, 1083.e1-1083.e7.
13. Cho KS, Kim CS, Lee HS, Seo SK, Park HY, Roh HJ. Role of interferon-producing t cells in the pathogenesis of chronic rhinosinusitis with nasal polyps associated with staphylococcal superantigen. J Otolaryngol Head Neck Surg. 2010;39:600-605.
14. Monticelli LA, Sonnenberg GF, Abt MC, et al. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat Immunol. 2011;12:1045-1054.
15. Wills-Karp M, Finkelman FD. Innate lymphoid cells wield a double-edged sword. Nat Immunol. 2011;12:1025-1027.
16. Hartmann E, Graefe H, Hopert A, et al. Analysis of plasmacytoid and myeloid dendritic cells in nasal epithelium. Clin Vaccine Immunol. 2006;13:1278-1286.
17. Sozzani S, Vermi W, Del Prete A, Facchetti F. Trafficking properties of plasmacytoid dendritic cells in health and disease. Trends Immunol. 2010;31:270-277.
18. Swiecki M, Colonna M. Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance. Immunol Rev. 2010;234:142-162.
19. Stoop AE, van der Heijden HA, Biewenga J, van der Baan S. Eosinophils in nasal polyps and nasal mucosa: an immunohistochemical study. J Allergy ClinImmunol. 1993;91:616-622.
20. Sanchez-Segura A, Antonio Brieva J, Rodríguez C. Regulation of immunoglobulin secretion by plasma cells infiltrating nasal polyps. Laryngoscope. 2000;110:1183-1188.
21. Psaltis AJ, Schlosser RJ, Yawn JR, Henriquez O, Mulligan JK. Characterization of B-cell subpopulations in patients with chronic rhinosinusitis. Int Forum Allergy Rhinol. 2013;3:621-629.
22. Park SY, Shin MG, Kim HR, et al. Alteration of mitochondrial DNA sequence and copy number in nasal polyp tissue. Mitochondrion. 2009;9:318-325.
23. Kim TH, Lee SH, Lee HM, et al. D2-40 immunohistochemical assessment of lymphangiogenesis in normal and edematous sinus mucosa and nasal polyp. Laryngoscope. 2007;117:442-446.
24. Takabayashi T, Kato A, Peters AT, et al. Excessive fibrin deposition in nasal polyps caused by fibrinolytic impairment through reduction of tissue plasminogen activator expression. Am J RespirCrit Care Med. 2013;187:49-57.
25. Nagarkar DR, Poposki JA, Tan BK, et al. Thymic stromal lymphopoietin activity is increased in nasal polyps of patients with chronic rhinosinusitis. J Allergy ClinImmunol. 2013;132:593-600.e12.
26. Peterson S, Poposki JA, Nagarkar DR, et al. Increased expression of CC chemokine ligand 18 in patients with chronic rhinosinusitis with nasal polyps. J Allergy ClinImmunol. 2012;129:119-127.e9.
27. Poposki JA, Uzzaman A, Nagarkar DR, et al. Increased expression of the chemokine CCL23 in eosinophilic chronic rhinosinusitis with nasal polyps. J Allergy ClinImmunol. 2011;128:73-81.e4.
28. Richer SL, Truong-Tran AQ, Conley DB, et al. Epithelial genes in chronic rhinosinusitis with and without nasal polyps. Am J Rhinol. 2008;22:228-234.
29. Platt MP, Soler ZM, Kao SY, Metson R, Stankovic KM. Topographic gene expression in the sinonasal cavity of patients with chronic sinusitis with polyps. Otolaryngol Head Neck Surg. 2011;145:171-175.
30. Plager DA, Kahl JC, Asmann YW, et al. Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis. PLoS One. 2010;5:e11450.
31. Li JY, Fang SY. Allergic profiles in unilateral nasal polyps of bilateral chronic rhinosinusitis. Am J Rhinol. 2008;22:111-114.
32. Zaravinos A, Bizakis J, Spandidos DA. RKIP and BRAF aberrations in human nasal polyps and the adjacent turbinate mucosae. Cancer Lett. 2008;264:288-298.
33. Hao J, Pang YT, Wang DY. Diffuse mucosal inflammation in nasal polyps and adjacent middle turbinate. Otolaryngol Head Neck Surg. 2006;134:267-275.
34. Jahnsen FL, Haraldsen G, Aanesen JP, Haye R, Brandtzaeg P. Eosinophil infiltration is related to increased expression of vascular cell adhesion molecule-1 in nasal polyps. Am J Respir Cell Mol Biol. 1995;12:624-632.
35. Stoop AE, van der Heijden HA, Biewenga J, van der Baan S. Lymphocytes and nonlymphoid cells in human nasal polyps. J Allergy ClinImmunol. 1991;87:470-475.
36. Linke R, Pries R, Konnecke M, et al. Increased activation and differentiated localization of native and phosphorylated STAT3 in nasal polyps. Int Arch Allergy Immunol. 2013;162:290-298.
37. Wu CC, Lee TJ, Chang PH, et al. Similar cellular proliferation activities in nasal polyps and adjacent inferior turbinate. Am J Otolaryngol. 2012;33:14-19.
38. Gu Z, Cao Z, Jin M. Expression and role of acidic mammalian chitinase and eotaxin-3 in chronic rhinosinusitis with nasal polyps. J Otolaryngol Head Neck Surg. 2011;40:64-69.
39. Wang JH, Kwon HJ, Jang YJ. Staphylococcus aureus increases cytokine and matrix metalloproteinase expression in nasal mucosae of patients with chronic rhinosinusitis and nasal polyps. Am J Rhinol Allergy. 2010;24:422-427.
40. Eweiss A, Dogheim Y, Hassab M, Tayel H, Hammad Z. VCAM-1 and eosinophilia in diffuse sino-nasal polyps. Eur Arch Otorhinolaryngol. 2009;266:377-383.
41. Fundova P, Filipovsky T, Funda DP, et al. Expression of IGF-1R and iNOS in nasal polyps; epithelial cell homeostasis and innate immune mechanisms in pathogenesis of nasal polyposis. Folia Microbiol (Praha). 2008;53:558-562.
42. Kato A, Peters A, Suh L, et al. Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps. J Allergy ClinImmunol. 2008;121:1385-1392.e2.
43. Qiu ZF, Han DM, Zhang L, et al. Expression of survivin and enhanced polypogenesis in nasal polyps. Am J Rhinol. 2008;22:106-110.
44. Wang JH, Kwon HJ, Chung YS, Lee BJ, Jang YJ. Infection rate and virus-induced cytokine secretion in experimental rhinovirus infection in mucosal organ culture: comparison between specimens from patients with chronic rhinosinusitis with nasal polyps and those from normal subjects. Arch Otolaryngol Head Neck Surg. 2008;134:424-427.
45. Chen YS, Westhofen M, Lorenzen J. Telomerase in nasal polyps. Am J Rhinol. 2007;21:354-358.
46. Danielsen A, Tynning T, Brokstad KA, Olofsson J, Davidsson A. Interleukin 5, IL6, IL12, IFN-gamma, RANTES and Fractalkine in human nasal polyps, turbinate mucosa and serum. Eur Arch Otorhinolaryngol. 2006;263:282-289.
47. Iino Y, Miyazawa T, Kakizaki K, et al. Expression of ecalectin, a novel eosinophil chemoattractant, in nasal polyps. ActaOtolaryngol (Stockh). 2006;126:43-50.
48. Morinaka S, Nakamura H. Immunocytochemical distribution of the c-H-ras protein in nasal polyps: Localization to the terminal bars. AurisNasus Larynx. 2000;27:131-135.
49. Morinaka S, Nakamura H. Inflammatory cells in nasal mucosa and nasal polyps. AurisNasus Larynx. 2000;27:59-64.
50. Coste A, Lefaucheur JP, Wang QP, et al. Expression of the transforming growth factor beta isoforms in inflammatory cells of nasal polyps. Arch Otolaryngol Head Neck Surg. 1998;124:1361-1366.
51. Coste A, Rateau JG, Roudot-Thoraval F, et al. Increased epithelial cell proliferation in nasal polyps. Arch Otolaryngol Head Neck Surg. 1996;122:432-436.
52. Coste A, Wang QP, Roudot-Thoraval F, et al. Epithelial cell proliferation in nasal polyps could be up-regulated by platelet-derived growth factor. Laryngoscope. 1996;106(5 Pt 1):578-583.
53. Bernstein JM, Yankaskas JR. Increased ion transport in cultured nasal polyp epithelial cells. Arch Otolaryngol Head Neck Surg. 1994;120:993-996.
54. Uneri C, Ozturk O, Polat S, Yuksel M, Haklar G. Determination of reactive oxygen species in nasal polyps. Rhinology. 2005;43:185-189.