Molecular characterization of Klebsiella pneumoniae Carbapenemase (KPC)-producing Enterobacteriaceae in Ontario, Canada, 2008-2011

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Tijet, Nathalie ^a   Sheth, Prameet M ^b   Lastovetska, Olga ^a   Chung, Catherine ^a   Patel, Samir N ^a,c   Melano, Roberto G ^a,c,d  

^a PUBLIC HEALTH ONTARIO   (Canada)

^b QUEEN S UNIVERSITY   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE; CARBAPENEM DERIVATIVE; CEPHALOSPORIN DERIVATIVE; COLISTIN; QUINOLONE DERIVATIVE; BACTERIAL DNA; BACTERIAL PROTEIN; CARBAPENEMASE;

ALLELE; ANTIBIOTIC RESISTANCE; ARTICLE; BETA LACTAMASE GENE; CANADA; CITROBACTER FREUNDII; CONTROLLED STUDY; DNA SEQUENCE; ENTEROBACTER CLOACAE; ENTEROBACTERIACEAE; GENE IDENTIFICATION; KLEBSIELLA PNEUMONIAE CARBAPENEMASE ENTEROBACTERIACEAE; MOLECULAR TYPING; MULTILOCUS SEQUENCE TYPING; NONHUMAN; PLASMID; POLYMERASE CHAIN REACTION; PULSED FIELD GEL ELECTROPHORESIS; RAOULTELLA; RAOULTELLA ORNITHINOLYTICA; REPLICON; SOUTHERN BLOTTING; AGED; DRUG EFFECTS; ENZYMOLOGY; FEMALE; GENETICS; HUMAN; ISOLATION AND PURIFICATION; KLEBSIELLA INFECTION; KLEBSIELLA PNEUMONIAE; MALE; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MULTIDRUG RESISTANCE; URINE;

CITROBACTER FREUNDII; ENTEROBACTER CLOACAE; ENTEROBACTERIACEAE; KLEBSIELLA PNEUMONIAE; RAOULTELLA ORNITHINOLYTICA;

AGED; BACTERIAL PROTEINS; BETA-LACTAMASES; DNA, BACTERIAL; DRUG RESISTANCE, MULTIPLE, BACTERIAL; FEMALE; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MALE; MICROBIAL SENSITIVITY TESTS; MULTILOCUS SEQUENCE TYPING; ONTARIO; PLASMIDS;

EID: 84920126436     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0116421     Document Type: Article

References (42)

1. Nordmann P, Cuzon G, Naas T (2009) The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect Dis 9: 228-236.
2. Bennett JW, Herrera ML, Lewis JS, Wickes BW, Jorgensen JH (2009) KPC-2-producing Enterobacter cloacae and Pseudomonas putida coinfection in a liver transplant recipient. Antimicrob Agents Chemother 53: 292-294.
3. Robledo IE, Aquino EE, Santé MI, Santana JL, Otero DM, et al. (2010) Detection of KPC in Acinetobacter spp. in Puerto Rico. Antimicrob Agents Chemother 54: 1354-1357.
4. Tanne JH (2012) Resistance of enterobacteria to carbapenem antibiotics is a global crisis BMJ 344: e1646.
5. Yigit H, Queenan AM, Anderson GJ, Domenech-Sanchez A, Biddle JW, et al. (2001) Novel carbapenem-hydrolyzing β-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother 45: 1151-1161.
6. Walsh TR (2010) Emerging carbapenemases: a global perspective. Int J Antimicrob Agents 36: 8-14.
7. KPC gene. Antimicrob Agents Chemother 52: 1257-1263.
8. Kitchel B, Rasheed JK, Patel JB, Srinivasan A, Navon-Venezia S, et al. (2009) Molecular epidemiology of KPC-producing Klebsiella pneumoniae isolates in the United States: clonal expansion of multilocus sequence type 258. Antimicrob Agents Chemother 53: 3365-3370.
9. Mataseje LF, Bryce E, Roscoe D, Boyd DA, Embree J, et al. (2012) Carbapenem-resistant Gram-negative bacilli in Canada 2009-10: results from the Canadian Nosocomial Infection Surveillance Program (CNISP). J Antimicrob Chemother 67: 1359-1367.
10. Denisuik AJ, Lagacé-Wiens PR, Pitout JD, Mulvey MR, Simner PJ, et al. (2013) Molecular epidemiology of extended-spectrum β-lactamase-, AmpC β-lactamase- and carbapenemase-producing Escherichia coli and Klebsiella pneumoniae isolated from Canadian hospitals over a 5 year period: CANWARD 2007-11. J Antimicrob Chemother 68: i57-65.
11. Pillai DR, Melano R, Rawte P, Lo S, Tijet N, et al. (2009) Klebsiella pneumoniae carbapenemase, Canada. Emerg Infect Dis 15: 827-829.
12. Goldfarb D, Harvey SB, Jessamine K, Jessamine P, Toye B, et al. (2009) Detection of plasmid-mediated KPC-producing Klebsiella pneumoniae in Ottawa, Canada: evidence of intrahospital transmission. J Clin Microbiol 47: 1920-1922.
13. Drancourt M, Bollet C, Carta A, Rousselier P (2001) Phylogenetic analyses of Klebsiella species delineate Klebsiella and Raoultella gen. nov., with description of Raoultella ornithinolytica comb. nov., Raoultella terrigena comb. nov. and Raoultella planticola comb. nov. Int J Syst Evol Microbiol. 51: 925-932.
14. Clinical and Laboratory Standards Institute (2014) CLSI document M100-S24 Performance Standards for Antimicrobial Susceptibility Testing: Twenty-third Informational Supplement. Pennsylvania: Clinical and Laboratory Standards Institute, Wayne, PA.
15. Dallenne C, Da Costa A, Decre D, Favier C, Arlet G (2010) Development of a set of multiplex PCR assays for the detection of genes encoding important β-lactamases in Enterobacteriaceae. J Antimicrob Chemother 65: 490-495.
16. Tijet N, Alexander DC, Richardson D, Lastovetska O, Low DE, et al. (2011) New Delhi metallo-β-lactamase, Ontario, Canada. Emerg Infect Dis 17: 306-307.
17. Tijet N, Andres P, Chung C, Lucero C; WHONET-Argentina Group, et al. (2011) rmtD2, a new allele of a 16S rRNA methylase gene, has been present in Enterobacteriaceae isolates from Argentina for more than a decade. Antimicrob Agents Chemother 55: 904-909.
18. Diancourt L, Passet V, Verhoef J, Grimont PA, Brisse S (2005) Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates. J Clin Microbiol 43: 4178-4182.
19. Hunter SB, Vauterin P, Lambert-Fair MA, Van Duyne MS, Kubota K, et al. (2005) Establishment of a universal size standard strain for use with the PulseNet standardized pulsed-field gel electrophoresis protocols: converting the national databases to the new size standard. J Clin Microbiol 43: 1045-1050.
20. Carattoli A, Bertini A, Villa L, Falbo V, Hopkins KL, et al. (2005) Identification of plasmids by PCR-based replicon typing. J Microbiol Methods 63: 219-228.
21. KPC-harboring IncI2 plasmid and its dissemination in New Jersey and New York hospitals. Antimicrob Agents Chemother 57: 5019-5025.
22. Gomez SA, Pasteran FG, Faccone D, Tijet N, Rapoport M, et al. (2011) Clonal dissemination of Klebsiella pneumoniae ST258 harbouring KPC-2 in Argentina. Clin Microbiol Infect 17: 1520-1524.
23. Barton BM, Harding GP, Zuccarelli AJ (1995) A general method for detecting and sizing large plasmids. Anal Biochem 226: 235-240.
24. NDM-1, Ontario, Canada. Clin Infect Dis 55: e109-117.
25. KPC in Raoultella spp. (R. planticola and R. ornithinolytica): report from the SENTRY Antimicrobial Surveillance Program. J Clin Microbiol 47: 4129-4130.
26. Munoz-Price LS, Poirel L, Bonomo RA, Schwaber MJ, Daikos GL, et al. (2013) Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis 13: 785-796.
27. Chan WW, Peirano G, Smyth DJ, Pitout JD (2013) The characteristics of Klebsiella pneumoniae that produce KPC-2 imported from Greece. Diagn Microbiol Infect Dis 75: 317-319.
28. Peirano G, Ahmed-Bentley J, Fuller J, Rubin JE, Pitout JD (2014) Travel-related carbapenemase-producing Gram negatives in Alberta, Canada: the first three years. J Clin Microbiol 52: 1575-1581.
29. Deleo FR, Chen L, Porcella SF, Martens CA, Kobayashi SD, et al. (2014) Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae. Proc Natl Acad Sci USA 111: 4988-4493.
30. KPC-2 by the spread of Klebsiella pneumoniae clonal complex 258 clones (ST258, ST11, ST437) and plasmids (IncFII, IncN, IncL/M) among Enterobacteriaceae species in Brazil. Antimicrob Agents Chemother 55: 3579-3583.
31. Woodford N, Turton JF, Livermore DM (2011) Multiresistant Gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance. FEMS Microbiol Rev 35: 736-755.
32. Nordberg V, Quizhpe Peralta A, Galindo T, Turlej-Rogacka A, Iversen A, et al. (2013) High proportion of intestinal colonization with successful epidemic clones of ESBL-producing Enterobacteriaceae in a neonatal intensive care unit in Ecuador. PLoS ONE 8: e76597.
33. Osterblad M, Kirveskari J, Hakanen AJ, Tissari P, Vaara M, et al. (2012) Carbapenemase-producing Enterobacteriaceae in Finland: the first years (2008-11). J Antimicrob Chemother 67: 2860-2864.
34. Sanchez-Romero I, Asensio A, Oteo J, Muñoz-Algarra M, Isidoro B, et al. (2012) Nosocomial outbreak of VIM-1-producing Klebsiella pneumoniae isolates of multilocus sequence type 15: molecular basis, clinical risk factors, and outcome. Antimicrob Agents Chemother 56: 420-427.
35. Oteo J, Saez D, Bautista V, Fernández-Romero S, Hernández-Molina JM, et al. (2013) Carbapenemase-producing Enterobacteriaceae in Spain in 2012. Antimicrob Agents Chemother 57: 6344-6347.
36. Haraoui LP, Lévesque S, Lefebvre B, Blanchette R, Tomkinson M, et al. (2013) Polyclonal outbreak of KPC-3-producing Enterobacter cloacae at a single hospital in Montreal, Quebec, Canada. J Clin Microbiol 51: 2406-2408.
37. Leung V, Loo VG, Frenette C, Domingo MC, Bourgault AM, et al. (2012) First Canadian outbreak of Enterobacteriaceae-expressing Klebsiella pneumoniae carbapenemase type 3. Can J Infect Dis Med Microbiol 23: 117-120.
38. Tzouvelekis LS, Markogiannakis A, Psichogiou M, Tassios PT, Daikos GL (2012) Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions. Clin Microbiol Rev 25: 682-707.
39. Carattoli A (2013) Plasmids and the spread of resistance. Int J Med Microbiol 303: 298-304.
40. KPC-2 gene. Emerg Infect Dis 16: 1349-1356.
41. Osborn AM, da Silva Tatley FM, Steyn LM, Pickup RW, Saunders JR (2000) Mosaic plasmids and mosaic replicons: evolutionary lessons from the analysis of genetic diversity in IncFII-related replicons. Microbiology 146: 2267-2275.
42. Walckenaer E, Poirel L, Leflon-Guibout V, Nordmann P, Nicolas-Chanoine MH (2004) Genetic and biochemical characterization of the chromosomal class A β-lactamases of Raoultella (formerly Klebsiella) planticola and Raoultella ornithinolytica. Antimicrob Agents Chemother 48: 305-312.