Understanding the availability, prevalence of use, desired effects, acute toxicity and dependence potential of the novel opioid MT-45

Clinical Toxicology

Volumn 53, Issue 1, 2015, Pages 54-59

  Siddiqi, Sindhu ^a   Verney, Charlotte ^a   Dargan, Paul ^a,b,c   Wood, David M ^a,b,c  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

MT 45; Novel psychoactive substance; Recreational drugs; Toxicity

Indexed keywords

1 CYCLOHEXYL 4 (1,2 DIPHENYLETHYL)PIPERAZINE; NALOXONE; OPIATE; UNCLASSIFIED DRUG; (+/-)-1-CYCLOHEXYL-4-(1,2-DIPHENYLETHYL)PIPERAZINE; NARCOTIC ANALGESIC AGENT; PIPERAZINE DERIVATIVE;

ACUTE TOXICITY; AERATION; ANXIETY DISORDER; ARTICLE; CAUSE OF DEATH; DEHYDRATION; DISORIENTATION; DIZZINESS; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG COST; DRUG EFFECT; DRUG HALF LIFE; DRUG USE; HUMAN; INSOMNIA; INTERNET; MEDICAL LITERATURE; MUSCLE DISEASE; NAUSEA; OPIATE ADDICTION; PREVALENCE; RESPIRATION DEPRESSION; RESTLESSNESS; SWEAT GLAND DISEASE; VOMITING; DOSE RESPONSE; FACTUAL DATABASE; SUBSTANCE-RELATED DISORDERS; TOXICITY;

ANALGESICS, OPIOID; DATABASES, FACTUAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; PIPERAZINES; PREVALENCE; SUBSTANCE-RELATED DISORDERS;

EID: 84920101173     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.3109/15563650.2014.983239     Document Type: Article

References (33)

1. United Nations Office on Drugs and Crime (UNODC). The challenge of new psychoactive substances. Available from: http://www.unodc. org/documents/scientifi c/NPS-2013-SMART.pdf (Last accessed 14th October 2014
2. European Monitoring Centre for Drugs and Drug Addiction. 2014 European Drug Report: Trends and developments. Available from: www.emcdda.europa.eu/attachements.cfm/att-228272-EN- TDAT14001ENN.pdf (Last accessed 14th October 2014
3. European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) and Europol. EMCDDA-Europol Joint Report on Anew psychoactive substance: AH-7921. Available from: www.emcdda.europa.eu/publications/joint-report/AH-7921 (Last accessed 17th September 2014
4. European Monitoring Centre for Drugs and Drug Addiction. R eport on the risk assessment of 3,4-dichloro-N-{[1-(dimethylamino)cyclohexyl] methyl}benzamide (AH-7921) in the framework of the Council Decision on new psychoactive substances. Available from: http://www.emcdda.europa.eu/publications/risk-assessment/AH-7921 (Last accessed 14th October 2014
5. European Patent Office. 1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives and their salts and the preparation thereof. US Patent 3,957,788. Issued 18th May 1976. Available from: http://worldwide. espacenet.com/publicationDetails/biblio;jsessionid- D7CD40ECCEEFC5D97B47A2A07311908C. espacenet-levelx-prod-3?. FT- D & date- 19760518 & DB- & locale- en-EP & CC- US & NR- 3957788A & KC- A & ND- 1 (Last accessed 14th October 2014
6. Natsuka K, Nakamura H, Uno H, Umemoto S. Studies on 1-substituted 4-(1,2-diphenylethyl) piperazine derivatives and their analgesic activities. J Med Chem 1975;18:1240-1244
7. N atsuka K, N akamura H, N ishikawa Y, N egoro T, U no H, N ishimura H. Synthesis and structure-activity relationships of 1-substituted 4- (1,2-diphenylethyl) piperazine derivatives having narcotic agonist and antagonist activity. J Med Chem 1987;30:1779-1787
8. Fujimura H, Tsurumi K, Nozaki M, Hori M, Imai E. Analgesic activity and opiate receptor binding of 1-cyclohexyl-4-(1,2- Diphenylethyl) Piperazine. Jpn J Pharmacol 1978;28:505-506
9. Nakamura H, Shimizu M. Comparative study of 1-cyclohexyl-4-(1,2- diphenylethyl)-piperazine (MT-45) and its enantiomorphs on analgesic and other pharmacological activities in experimental animals. Arch Int Pharmacodyn Th é r 1976;221:105-121
10. N ozaki M, N iwa M, I mai E, H ori M, F ujimura H. ( 1,2-Diphenylethyl) piperazines as potent opiate-like analgesics: the unusual relationships between stereoselectivity and affi nity to opioid recepto r. Life Sci 1983;33:431-434
11. Matsuno K, Senda T, Kobayashi T, Murai M, Mita S. Reduction of 4-cyclohexyl-1-[(1R)-1,2-diphenylethyl]-piperazine-induced memory impairment of passive avoidance performance by 1 receptor agonists in mice. Methods Find Exp Clin Pharmacol 1988;20:575-580
12. European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). Action on new drugs. Available from: www.emcdda.europa. eu/activities/action-on-new-drugs (Last accessed 14th October 2014
13. Wood DM, Dargan PI. Novel psychoactive substances: how to understand the toxicity (harm) associated with the use of these substances. Ther Drug Monit 2012;34:363-367
14. Wood DM, Dargan PI. Understanding how data triangulation identifi es acute toxicity of novel psychoactive drugs. J Med Toxicol 2012 ; 8:300-303
15. Wood DM, D argan PI. Use and acute toxicity associated with the novel psychoactive substances diphenolprolinol (D2PM) and desoxypipradrol (2-DPMP). Clin Toxicol (Phila) 2012;50:727-732
16. Wood DM, Davies S, Puchnaewicz M, Button J, Archer R, Ovaska H, et al. Recreational use of Mephedrone (4-methylmethcathinone, 4-MMC) with associated sympathomimetic toxicity. J Med Toxicol 2010;6:327-330
17. Bersani FS, Corazza O, Albano G, Valeriani G, Santacroce R, Bolzan Mariotti Posocco F, et al. 25C-NBOMe: preliminary data on pharmacology, psychoactive effects, and toxicity of Anew potent and dangerous hallucinogenic drug. Biomed Res Int 2014:734749
18. Corazza O, Schifano F, Simonato P, Fergus S, Assi S, Stair J, et al. Phenomenon of new drugs on the Internet: The case of ketamine derivative methoxetamine. Hum Psychopharmacol 2012;27 : 145-149
19. Corkery JM, Elliott S, Schifano F, Corazza O, Ghodse AH. 2-DPMP (desoxypipradrol, 2-benzhydrylpiperidine, 2-phenylmethylpiperidine) and D2PM (diphenyl-2-pyrrolidin-2-yl-methanol, diphenylprolinol): a preliminary review. Prog Neuropsychopharmacol Biol Psychiatry 2012;39:253-258
20. Corkery JM, Elliott S, Schifano F, Corazza O, Ghodse AH. MDAI (5,6-methylenedioxy-2-aminoindane; 6,7-dihydro-5H-cyclopenta[f] [1,3]benzodioxol-6-amine;sparkle mindy) toxicity: a brief overview and update. Hum Psychopharmacol 2013;28:345-355
21. European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). Briefi ng paper: Online sales of new psychoactive substances/ legal highs :summary of results from the 2011 multilingual snapshots:Available from: www.emcdda.europa.eu/attachements.cfm/att.143801-EN- SnapshotSummary.pdf (Last accessed 17th September 2014
22. H illebrand J, O lszewski D, S edefov R. L egal highs on the Internet. Subst Use Misuse 2010;45:330-340
23. Bluelight forum. Available from: http://www.bluelight.org/vb/threads/640564-MT-45-(1-cyclohexyl-4-(1-2-diphenylethyl)piperazine) (Last accessed 17th September 2014
24. Shroomery forum. Available from: http://www.shroomery.org/forums/showfl at.php/Number/18265612. (Last accessed 21st May 2014
25. UK Chemical Research forum. Available from: h ttp://www.ukchemicalresearch. org/Thread-MT-45?page- 6 (Last accessed 21st May 2014
26. Helander A, B ä ckberg M, Beck O. MT-45, Anew psychoactive substance associated with hearing loss and unconsciousness. Clin Toxicol (Phila) 2014;52:901-904
27. US Immigration and Custom Enforcement. HSI seizes websites selling potentially deadly illegal narcotics. Available from: m.ice.gov/news/releases/1404/140411buffalo.htm?f- m (Last accessed 14th October 2014
28. EMCDDA-Europol Joint Report on Anew psychoactive substance: 1-cyclohexyl-4-(1,2-diphenylethyl)piperazine ( MT-45). Available from: www.emcdda.europa.eu/attachements.cfm/att-230615-EN- TDAS14007ENN.pdf (Last accessed 14th October 2014
29. Measham F, Moore K, Newcombe R, Welch Z. Tweaking, bombing, dabbing and stockpiling: the emergence of mephedrone and the perversity of prohibition. Drugs Alcohol Today 2010;10:14-21
30. Wood DM, D argan PI. Using Internet snapshot surveys to enhance our understanding of the availability of the novel psychoactive substance alpha-methyltryptamine (AMT). Subst Use Misuse 2013;49:7-12
31. Vermette-Marcotte A-E, Dargan PI, Archer J RH, Gosselin S, Wood DM. An Internet snapshot study to compare the international availability of the novel psychoactive substance methiopropamine. Clin Toxicol (Phila) 2014;52:678-681
32. N izar H, D argan PI, Wood DM. Using internet snapshot surveys to enhance our understanding of the availability of the novel psychoactive substance 4-methylaminorex and 4,4 -dimethylaminorex. J Med Toxicol 2014;Epub ahead of print 29 Aug 2014 [DOI: 10.1007/s13181-014-0425-0
33. D argan PI, S edefov R, G allegos A, Wood DM. The pharmacology and toxicology of the synthetic cathinone Mephedrone (4-methylmethcathinone). Drug Test Anal 2011;3:454-463