Design and synthesis of novel quinazoline derivatives and their evaluation as PI3Ks inhibitors

Chemical and Pharmaceutical Bulletin

Volumn 62, Issue 12, 2014, Pages 1166-1172

  El Said, Omar Maged ^a   Hamed, Mostafa Mohamed ^a,b   Laufer, Stefan ^c   Abadi, Ashraf Hassan ^a  

^a German University in Cairo   (Egypt)

^b SAARLAND UNIVERSITY   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Aminoquinazoline; Inhibitor; Kinase; Phosphoinositide

Indexed keywords

(4 ACETAMIDOQUINAZOLIN 6 YL) 2 CHLOROISONICOTINAMIDE; (4 ACETAMIDOQUINAZOLIN 6 YL) 3 CHLOROBENZAMIDE; (4 ACETAMIDOQUINAZOLIN 6 YL) 4 CHLOROBENZAMIDE; (4 ACETAMIDOQUINAZOLIN 6 YL) 4 FLUOROBENZAMIDE; (4 ACETAMIDOQUINAZOLIN 6 YL) 4 METHYLBENZAMIDE; (4 ACETAMIDOQUINAZOLIN 6 YL) 4 NITROBENZAMIDE; (4 ACETAMIDOQUINAZOLIN 6 YL) 4 TERT BUTYLBENZAMIDE; (4 ACETAMIDOQUINAZOLIN 6 YL) FURAN 2 CARBOXAMIDE; (4 ACETAMIDOQUINAZOLIN 6 YL)BENZAMIDE; (4 ACETAMIDOQUINAZOLIN 6 YL)CYCLOPENTANECARBOXAMIDE; (4 ACETAMIDOQUINAZOLIN 6 YL)NICOTINAMIDE; (4 ACETAMIDOQUINAZOLIN 6 YL)THIOPHENE 2 CARBOXAMIDE; (4 OXO 3,4 DIHYDROQUINAZOLIN 6 YL)BENZAMIDE; 1 (4 ACETAMIDOQUINAZOLIN 6 YL) 3 BENZOYLUREA; 1 (4 ACETAMIDOQUINAZOLIN 6 YL) 3 PHENYLTHIOUREA; 1 (4 ACETAMIDOQUINAZOLIN 6 YL) 3 PHENYLUREA; ACETIC ACID DERIVATIVE; BENZAMIDE; N (4 AMINOQUINAZOLIN 6 YL) 4 CHLOROBENZAMIDE; N (4 AMINOQUINAZOLIN 6 YL)BENZAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE BETA; PHOSPHATIDYLINOSITOL 3 KINASE C2ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE C2BETA; PHOSPHATIDYLINOSITOL 3 KINASE C2GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE DELTA; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG; PROTEIN KINASE INHIBITOR;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; PROTON NUCLEAR MAGNETIC RESONANCE; ANTAGONISTS AND INHIBITORS; ENZYME ACTIVE SITE; SYNTHESIS;

CATALYTIC DOMAIN; DRUG DESIGN; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE INHIBITORS; QUINAZOLINES;

EID: 84920084016     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.c14-00560     Document Type: Article

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