Evaluation of the effects of preconditioning regimens on hepatic veno-occlusive disease in mice after hematopoietic stem cell transplantation

Experimental and Molecular Pathology

Volumn 98, Issue 1, 2015, Pages 73-78

  Qiao, Jianlin ^a,b   Fu, Jinyu ^a,b   Fang, Ting ^a,b   Huang, Yujin ^a,b   Mi, Hongling ^a,b   Yang, Na ^a,b   Chen, Chao ^a,b   Xu, Kailin ^a,b   Zeng, Lingyu ^a,b  

^a XUZHOU MEDICAL UNIVERSITY   (China)

^b Key Laboratory of Bone Marrow Stem Cell   (China)

Author keywords

Busulfan; Cyclophosphamide; Hematopoietic stem cell transplantation; Hepatic veno occlusive disease; Total body irradiation

Indexed keywords

BUSULFAN; CYCLOPHOSPHAMIDE; FAT DROPLET; ANTINEOPLASTIC AGENT; FIBRIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOSUPPRESSIVE TREATMENT; INCIDENCE; LIVER DYSFUNCTION; LIVER FUNCTION; LIVER SINUSOID; LIVER VENOOCCLUSIVE DISEASE; MALE; MITOCHONDRION SWELLING; MOUSE; NONHUMAN; PATHOGENESIS; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; WHOLE BODY RADIATION; ADVERSE EFFECTS; ALLOTRANSPLANTATION; ANIMAL; APOPTOSIS; BAGG ALBINO MOUSE; C57BL MOUSE; CELL CULTURE; CELL PROLIFERATION; CYTOLOGY; DRUG EFFECTS; ENZYME IMMUNOASSAY; EVALUATION STUDY; HEPATIC VENO-OCCLUSIVE DISEASE; HUMAN; LIVER; METABOLISM; PATHOLOGY; RADIATION RESPONSE; RETICULOCYTE; THROMBOCYTE; VASCULAR ENDOTHELIUM;

MUS;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BLOOD PLATELETS; BUSULFAN; CELL PROLIFERATION; CELLS, CULTURED; CYCLOPHOSPHAMIDE; ENDOTHELIUM, VASCULAR; FEMALE; FIBRIN; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEPATIC VENO-OCCLUSIVE DISEASE; HUMANS; IMMUNOENZYME TECHNIQUES; INCIDENCE; LIVER; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MITOCHONDRIAL SWELLING; PLATELET ACTIVATION; RETICULOCYTES; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS; WHOLE-BODY IRRADIATION;

EID: 84920074290     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2014.12.008     Document Type: Article

References (27)

1. Al-Hashmi S., et al. Busulphan-cyclophosphamide cause endothelial injury, remodeling of resistance arteries and enhanced expression of endothelial nitric oxide synthase. PLoS ONE 2012, 7(1):e30897.
2. Baglin T.P. Veno-occlusive disease of the liver complicating bone marrow transplantation. Bone Marrow Transplant. 1994, 13(1):1-4.
3. Barton-Burke M., et al. Graft-versus-host disease: a complex long-term side effect of hematopoietic stem cell transplant. Oncology (Williston Park) 2008, 22(11 Suppl. Nurse Ed):31-45.
4. Bearman S.I. The syndrome of hepatic veno-occlusive disease after marrow transplantation. Blood 1995, 85(11):3005-3020.
5. Carreras E., et al. Incidence and outcome of hepatic veno-occlusive disease after blood or marrow transplantation: a prospective cohort study of the European Group for Blood and Marrow Transplantation. European Group for Blood and Marrow Transplantation Chronic Leukemia Working Party. Blood 1998, 92(10):3599-3604.
6. Carreras E., et al. The incidence of veno-occlusive disease following allogeneic hematopoietic stem cell transplantation has diminished and the outcome improved over the last decade. Biol. Blood Marrow Transplant. 2011, 17(11):1713-1720.
7. Cheuk D.K. Hepatic veno-occlusive disease after hematopoietic stem cell transplantation: prophylaxis and treatment controversies. World J. Transplant. 2012, 2(2):27-34.
8. Copelan E.A. Hematopoietic stem-cell transplantation. N. Engl. J. Med. 2006, 354(17):1813-1826.
9. Coppell J.A., et al. Veno-occlusive disease: cytokines, genetics, and haemostasis. Blood Rev. 2003, 17(2):63-70.
10. Coppell J.A., et al. Hepatic veno-occlusive disease following stem cell transplantation: incidence, clinical course, and outcome. Biol. Blood Marrow Transplant. 2010, 16(2):157-168.
11. el Mouelhi M., Kauffman F.C. Sublobular distribution of transferases and hydrolases associated with glucuronide, sulfate and glutathione conjugation in human liver. Hepatology 1986, 6(3):450-456.
12. Giralt S. Stem cell transplantation for multiple myeloma: current and future status. Hematol. Am. Soc. Hematol. Educ. Program. 2011, 2011:191-196.
13. Guglielmelli T., et al. Update on the use of defibrotide. Expert. Opin. Biol. Ther. 2012, 12(3):353-361.
14. Kumar S., et al. Hepatic veno-occlusive disease (sinusoidal obstruction syndrome) after hematopoietic stem cell transplantation. Mayo Clin. Proc. 2003, 78(5):589-598.
15. McDonald G.B., et al. Cyclophosphamide metabolism, liver toxicity, and mortality following hematopoietic stem cell transplantation. Blood 2003, 101(5):2043-2048.
16. Richardson P., Guinan E. The pathology, diagnosis, and treatment of hepatic veno-occlusive disease: current status and novel approaches. Br. J. Haematol. 1999, 107(3):485-493.
17. Richardson P.G., et al. Safety and efficacy of defibrotide for the treatment of severe hepatic veno-occlusive disease. Ther. Adv. Hematol. 2012, 3(4):253-265.
18. Richardson P.G., et al. Hepatic veno-occlusive disease after hematopoietic stem cell transplantation: novel insights to pathogenesis, current status of treatment, and future directions. Biol. Blood Marrow Transplant. 2013, 19(1 Suppl.):S88-S90.
19. Rozman C., et al. Risk factors for hepatic veno-occlusive disease following HLA-identical sibling bone marrow transplants for leukemia. Bone Marrow Transplant. 1996, 17(1):75-80.
20. Sadeghi B., et al. The effect of administration order of BU and CY on engraftment and toxicity in HSCT mouse model. Bone Marrow Transplant. 2008, 41(10):895-904.
21. Schuler U., et al. Busulfan pharmacokinetics in bone marrow transplant patients: is drug monitoring warranted?. Bone Marrow Transplant. 1994, 14(5):759-765.
22. Shulman H.M., et al. Hepatic veno-occlusive disease after bone marrow transplantation. Immunohistochemical identification of the material within occluded central venules. Am. J. Pathol. 1987, 127(3):549-558.
23. Shulman H.M., et al. Veno-occlusive disease of the liver after marrow transplantation: histological correlates of clinical signs and symptoms. Hepatology 1994, 19(5):1171-1181.
24. Wadleigh M., et al. Hepatic veno-occlusive disease: pathogenesis, diagnosis and treatment. Curr. Opin. Hematol. 2003, 10(6):451-462.
25. Wayne A.S., et al. Hematopoietic stem cell transplantation for leukemia. Pediatr. Clin. N. Am. 2010, 57(1):1-25.
26. Zeng L., et al. Infusion of endothelial progenitor cells accelerates hematopoietic and immune reconstitution, and ameliorates the graft-versus-host disease after hematopoietic stem cell transplantation. Cell Biochem. Biophys. 2012, 64(3):213-222.
27. Zeng L., et al. A murine model of hepatic veno-occlusive disease induced by allogeneic hematopoietic stem cell transplantation. Cell Biochem. Biophys. 2013, 67(3):939-948.