Ectopic lymphoid structures in primary cutaneous melanoma

Pathology and Oncology Research

Volumn 20, Issue 4, 2014, Pages 981-985

  Ladányi, Andrea ^a   Sebestyén, Tímea ^b   Mohos, Anita ^c   Liszkay, Gabriella ^a   Somlai, Beáta ^c   Tóth, Erika ^a   Tímár, József ^c  

^a NATIONAL INSTITUTE OF ONCOLOGY   (Hungary)

^b Saint John's City Council Hospital   (Hungary)

^c SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

B cells; Ectopic lymphoid structures; Follicular dendritic cells; High endothelial venules; Primary melanoma; T cells

Indexed keywords

CD20 ANTIGEN; CD45RO ANTIGEN; COMPLEMENT COMPONENT C3D RECEPTOR; PENICILLIN BINDING PROTEIN 2A;

ADULT; ANTIGEN EXPRESSION; ARTICLE; B CELL FOLLICLE; B LYMPHOCYTE; CANCER PROGNOSIS; CELL AGGREGATION; CUTANEOUS MELANOMA; DENDRITIC CELL; DISEASE ASSOCIATION; ECTOPIC LYMPHOID STRUCTURE; ECTOPIC TISSUE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MALE; MEMORY T LYMPHOCYTE; METASTASIS; PREVALENCE; PRIMARY TUMOR; VENULE; CANCER STAGING; LYMPH NODE METASTASIS; LYMPHOID TISSUE; MELANOMA; MIDDLE AGED; MORTALITY; PATHOLOGY; PROGNOSIS; SECONDARY; SKIN TUMOR; SURVIVAL RATE;

B-LYMPHOCYTES; FEMALE; HUMANS; LYMPHATIC METASTASIS; LYMPHOID TISSUE; MALE; MELANOMA; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; SKIN NEOPLASMS; SURVIVAL RATE;

EID: 84919921807     PISSN: 12194956     EISSN: 15322807     Source Type: Journal    
DOI: 10.1007/s12253-014-9784-8     Document Type: Article

References (23)

1. Bell D, Chomarat P, Broyles D, Netto G, Moumneh Harb G, Lebecque S, Valladeau J, Davoust J, Palucka KA, Banchereau J (1999) In breast carcinoma tissue, immature dendritic cells reside within the tumor, whereas mature dendritic cells are located in peritumoral areas. J Exp Med 10:1417–1425
2. Bombardieri M, Barone F, Humby F, Kelly S, McGurk M, Morgan P, Challacombe S, De Vita S, Valesini G, Spencer J, Pitzalis C (2007) Activation-induced cytidine deaminase expression in follicular dendritic cell networks and interfollicular large B cells supports functionality of ectopic lymphoid neogenesis in autoimmune sialoadenitis and MALT lymphoma in Sjögren’s syndrome. J Immunol 179:4929–4938
3. Cipponi A, Mercier M, Seremet T, Baurain JF, Théate I, van den Oord J, Stas M, Boon T, Coulie PG, van Baren N (2012) Neogenesis of lymphoid structures and antibody responses occur in human melanoma metastases. Cancer Res 72:3997–4007
4. Coppola D, Nebozhyn M, Khalil F, Dai H, Yeatman T, Loboda A, Mulé JJ (2011) Unique ectopic lymph node-like structures present in human primary colorectal carcinoma are identified by immune gene array profiling. Am J Pathol 179:37–45
5. Coronella-Wood JA, Hersh EM (2003) Naturally occurring B-cell responses to breast cancer. Cancer Immunol Immunother 52:715–738
6. de Chaisemartin L, Goc J, Damotte D, Validire P, Magdeleinat P, Alifano M, Cremer I, Fridman WH, Sautès-Fridman C, Dieu-Nosjean MC (2011) Characterization of chemokines and adhesion molecules associated with T cell presence in tertiary lymphoid structures in human lung cancer. Cancer Res 71:6391–6399
7. Dieu-Nosjean MC, Antoine M, Danel C, Heudes D, Wislez M, Poulot V, Rabbe N, Laurans L, Tartour E, de Chaisemartin L, Lebecque S, Fridman WH, Cadranel J (2008) Long-term survival for patients with non–small-cell lung cancer with intratumoral lymphoid structures. J Clin Oncol 26:4410–4417
8. Iwamoto M, Shinohara H, Miyamoto A, Okuzawa M, Mabuchi H, Nohara T, Gon G, Toyoda M, Tanigawa N (2003) Prognostic value of tumor-infiltrating dendritic cells expressing CD83 in human breast carcinomas. Int J Cancer 104:92–97
9. Jensen TO, Schmidt H, Møller HJ, Donskov F, Høyer M, Sjoegren P, Christensen IJ, Steiniche T (2012) Intratumoral neutrophils and plasmacytoid dendritic cells indicate poor prognosis and are associated with pSTAT3 expression in AJCC stage I/II melanoma. Cancer 118:2476–2485
10. Kirk CJ, Hartigan-O’Connor D, Mulé JJ (2001) The dynamics of the T-cell antitumor response: Chemokine-secreting dendritic cells can prime tumor-reactive T cells extranodally. Cancer Res 61:8794–8802
11. Ladányi A, Kiss J, Mohos A, Somlai B, Liszkay G, Gilde K, Fejős Z, Gaudi I, Dobos J, Tímár J (2011) Prognostic impact of B-cell density in cutaneous melanoma. Cancer Immunol Immunother 60:1729–1738
12. + mature dendritic cells in combination with activated T lymphocytes infiltrating primary cutaneous melanoma is a strong independent prognostic factor. Cancer Immunol Immunother 56:1459–1469
13. Martinet L, Le Guellec S, Filleron T, Lamant L, Meyer N, Rochaix P, Garrido I, Girard JP (2012) High endothelial venules (HEVs) in human melanoma lesions. Major gateways for tumor-infiltrating lymphocytes. OncoImmunology 1:829–839
14. Messina JL, Fenstermacher DA, Eschrich S, Qu X, Berglund AE, Lloyd MC, Schell MJ, Sondak VK, Weber JS, Mulé JJ (2012) 12-chemokine gene signature identifies lymph node-like structures in melanoma: Potential for patient selection for immunotherapy? Sci Rep 2:765
15. Miyagawa S, Soeda J, Takagi S, Miwa S, Ichikawa E, Noike T (2004) Prognostic significance of mature dendritic cells and factors associated with their accumulation in metastatic liver tumors from colorectal cancer. Hum Pathol 35:1392–1396
16. Moldenhauer G, Popov SW, Wotschke B, Brüderlein S, Riedl P, Fissolo N, Schirmbeck R, Ritz O, Möller P, Leithäuser F (2006) AID expression identifies interfollicular large B cells as putative precursors of mature B-cell malignancies. Blood 107:2470–2473
17. Nzula S, Going JJ, Stott DI (2003) Antigen-driven clonal proliferation, somatic hypermutation, and selection of B lymphocytes infiltrating human ductal breast carcinomas. Cancer Res 63:3275–3280
18. O’Brien PM, Tsirimonaki E, Coomber DW, Millan DW, Davis JA, Campo MS (2001) Immunoglobulin genes expressed by B-lymphocytes infiltrating cervical carcinoma show evidence of antigen-driven selection. Cancer Immunol Immunother 50:523–532
19. +/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci U S A 102:18538–18543
20. Suzuki A, Masuda A, Nagata H, Kameoka S, Kikawada Y, Yamakawa M, Kasajima T (2002) Mature dendritic cells make clusters with T cells in the invasive margin of colorectal carcinoma. J Pathol 196:37–43
21. Thompson ED, Enriquez HL, Fu YX, Engelhard VH (2010) Tumor masses support naïve T cell infiltration, activation, and differentiation into effectors. J Exp Med 207:1791–1804
22. Tsukayama S, Omura K, Yoshida K, Tanaka Y, Watanabe G (2005) Prognostic value of CD83-positive mature dendritic cells and their relation to vascular endothelial growth factor in advanced human gastric cancer. Oncol Rep 14:369–375
23. van Baren N, Baurain JF, Coulie PG (2013) Lymphoid neogenesis in melanoma. What does it tell us? OncoImmunology 2:e22505