Untying the gordian knot: What we do and don't know about gender-specific medicine - Keynote address for the 2014 academic emergency medicine consensus conference

Academic Emergency Medicine

Volumn 21, Issue 12, 2014, Pages 1320-1324

  Legato, Marianne ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SEX HORMONE;

CONFERENCE PAPER; CONSENSUS; EMERGENCY MEDICINE; EMERGENCY WARD; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; FEMALE; GENDER IDENTITY; GENE EXPRESSION; HUMAN; METHODOLOGY; NONHUMAN; PHENOTYPE; PHYSICIAN ATTITUDE; RESEARCH; SCIENTIST; SEX DIFFERENCE; SOCIAL CLASS; SOCIAL WELFARE; SRY GENE; Y CHROMOSOME; CONSENSUS DEVELOPMENT; MALE; MEDICAL RESEARCH; ORGANIZATION AND MANAGEMENT; SEXUAL DEVELOPMENT; WOMEN'S HEALTH;

BIOMEDICAL RESEARCH; CONSENSUS DEVELOPMENT CONFERENCES AS TOPIC; EMERGENCY MEDICINE; FEMALE; GENDER IDENTITY; HUMANS; MALE; SEX CHARACTERISTICS; SEX FACTORS; WOMEN'S HEALTH;

EID: 84919919356     PISSN: 10696563     EISSN: 15532712     Source Type: Journal    
DOI: 10.1111/acem.12533     Document Type: Conference Paper

References (36)

1. Legato MJ,. Beyond women's health. The new discipline of gender-specific medicine. Med Clin N Am 2003; 87: 917-37.
2. Nathan DG,. Clinical research: perceptions, reality, and proposed solutions. National Institutes of Health Director's Panel on Clinical Research. JAMA 1998; 280: 1427-31.
3. National Institutes of Health. NIH Revitalization Act of 1993, Public Law 103-43 (FTNT). Available at: http://orwh.od.nih.gov/about/pdf/NIH-Revitalization-Act-1993.pdf. Accessed Sep 26, 2014.
4. Beery AK, Zucker I,. Sex bias in neuroscience and biomedical research. Neurosci Biobehav Rev 2011; 35: 565-72.
5. Mogil JS,. Chanda ML The case for the inclusion of female subjects in basic science studies of pain. Pain 2005; 117: 1-5.
6. Hsiao LL, Dangond F, Yoshida T, et al. A compendium of gene expression in normal human tissues. Physiol Genomics 2001; 7: 97-104.
7. Yang X, Schadt EE, Wang S, et al. Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res 2006; 16: 995-1004.
8. Isensee J, Noppinger PR,. Sexually dimorphic gene expression in mammalian somatic tissue. Gend Med 2007;Suppl B(4): 575-595.
9. Gabory A, Attig L, Junien C,. Sexual dimorphism in environmental epigenetic programming. Mol Cell Endocrinol 2009; 304: 8-18.
10. Rinn JL, Snyder M,. Sexual dimorphism in mammalian gene expression. Trends Genetics 2005; 21: 298-305.
11. Marts SA, Keitt S,. Forward: a historical overview of advocacy for research in sex-based biology. In:, Bittar E, (editor). Principles of Sex-based Differences in Physiology. Adv Mol Cell Biol 2004;34:v-xiii.
12. Xu X, Coats KL, Yang CF, et al. Modular genetic control of sexually dimorphic behaviors. Cell 2012; 148: 596-607.
13. Macilwain C,. World leaders heap praise on human genome landmark. Nature 2000; 405: 983-4.
14. Oertelt-Prigione S, Parol R, Krohn K, Preissner R, Regitz-Zagrosek V,. Analysis of sex and gender-specific research reveals a common increase in publications and marked differences between disciplines [correspondence]. BMC Med 2010; 8: 70.
15. Sinclair AH, Berta P, Palmer MS, et al. A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Nature 1990; 346: 240-4.
16. Hacker A, Capel B, Goodfellow P, Lovell-Badger R,. Expression of Sry, the mouse sex determining gene. Development 1995; 121: 1603-14.
17. Uhlenhaut NH, Jakob S, Anglag K, Eisenberger T,. Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. Cell 2009; 139: 1130-42.
18. Matson CK, Murphy MW, Sarver AL, Gristwold MD, Bardwell VJ, Zarkower D,. DMRT1 prevents female reprogramming in the postnatal mammalian testis. Nature 2011; 476: 101-4.
19. Veitia RA,. FOX2 versus SOX9: A lifelong "battle of the sexes". Bioessays 2010; 32: 375-80.
20. Cardwell JR, Liley NR,. Hormonal control of sex and color change in the stoplight parrotfish, Sparisoma viride. Gen Compare Endocrinol 1991; 81: 7-20.
21. Blackless M, Charuvastra A, Derryck A, Fausto-Sterling A, LaUzzanne K, Lee E,. How sexually dimorphic are we? Review and synthesis. Am J Hum Biol 2000; 12: 151-66.
22. Ritchie R, Reynard J, Lewis T,. Intersex and the Olympic games. J R Soc Med 2008; 101: 395-9.
23. Houk LP, Ahmed S, Hughes I,. Consensus statement on management of intersex disorders. International Consensus Conference on Intersex. Pediatrics 2006; 118: e488-500.
24. Karkazis K, Jordan-Young R, Davis G, Camporesi S,. Out of bounds? A critique of the new policies on hyperandrogenism in elite female athletes. Am J Bioethics 21012; 12: 3-16.
25. Dickinson B, Genel M, Robinowitz C, Turner P, Woods G,. Gender verification of female Olympic athletes. Med Sci Sports Exerc 2002; 34: 1539-42.
26. Wizeman TM, Pardue M, (editors). Exploring the Biological Contributions to Human Health. Does Sex Matter? Committee on Understanding the Biology of Sex and Gender Differences. Board on Health Sciences Policy. Institute of Medicine. Washington, DC: National Academies Press, 2001, p 17.
27. Dunn GA, Morgan CP, Bale T,. Sex-specificity in transgenerational epigenetic programming. Hormones Behav 2011; 59: 290-5.
28. Roth TL, Sweatt JD,. Epigenetic marking of the BDNF gene by early-life adverse experiences. Hormones Behav 2011; 59: 315-20.
29. Bock J, Rether K, Groger N, Xie L, Braun K,. Perinatal programming of emotional brain circuits: an integrative view from systems to molecules. Front Neurosci 2014; 8: e11.
30. Baker LM, Williams LM, Korganonkar MS, Cohen RA, Heaps JM, Paul RH,. Impact of early vs. late childhood early life stress on brain morphometrics. Brain Imag Behav 2013; 7: 196-203.
31. Curley JP, Mashoodh R, Champagne FA,. Epigenetics and the origins of paternal effects. Hormones Behav 2011; 59: 306-14.
32. Franklin TB, Russig H, Weiss IC, et al. Epigenetic transmission of the impact of early stress across generations. Biol Psychiatry 2010; 68: 408-15.
33. Hertzman C, Boyce T,. How experience gets under the skin to create gradients in developmental health. Annu Rev Public Health 2010; 31: 329-47.
34. Romeo RD,. Pubertal maturation and programming of hypothalamic-pituitary-adrenal reactivity. Front Neuroendocrinol 2010; 31: 232-40.
35. Burger C, Lepoez MC, Baker HV, Mandel RJ, Muzyczka N,. Genome-wide analysis of aging and learning-related genes in the hippocampal dentate gyrus. Neurobiol Learn Memory 2008; 89: 379-96.
36. Fausto-Sterling A,. The bare bones of sex: part 1- sex and gender. J Women Culture Soc 2005; 30: 1491-527.