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Volumn 217, Issue 13, 2014, Pages 2348-2357

Could thermal sensitivity of mitochondria determine species distribution in a changing climate?

Author keywords

Cardiac mitochondria; Fish; Heart failure; Oxidative phosphorylation; Thermal limits

Indexed keywords

LABRIDAE; NOTOLABRUS CELIDOTUS; NOTOLABRUS FUCICOLA; THALASSOMA LUNARE;

EID: 84919898989     PISSN: 00220949     EISSN: 14779145     Source Type: Journal    
DOI: 10.1242/jeb.098798     Document Type: Article
Times cited : (84)

References (53)
  • 2
    • 79961174954 scopus 로고    scopus 로고
    • Metab: An R package for high-throughput analysis of metabolomics data generated by GC-MS
    • Aggio, R., Villas-Bôas, S. G. and Ruggiero, K. (2011). Metab: an R package for high-throughput analysis of metabolomics data generated by GC-MS. Bioinformatics 27, 2316-2318.
    • (2011) Bioinformatics , vol.27 , pp. 2316-2318
    • Aggio, R.1    Villas-Bôas, S.G.2    Ruggiero, K.3
  • 4
    • 0034914567 scopus 로고    scopus 로고
    • The impact of the thermal sensitivity of cytochrome c oxidase on the respiration rate of Arctic charr red muscle mitochondria
    • Blier, P. U. and Lemieux, H. (2001). The impact of the thermal sensitivity of cytochrome c oxidase on the respiration rate of Arctic charr red muscle mitochondria. J. Comp. Physiol. B 171, 247-253.
    • (2001) J. Comp. Physiol. B , vol.171 , pp. 247-253
    • Blier, P.U.1    Lemieux, H.2
  • 5
    • 80053116396 scopus 로고    scopus 로고
    • Detecting range shifts among Australian fishes in response to climate change
    • Booth, D. J., Bond, N. and Macreadie, P. (2011). Detecting range shifts among Australian fishes in response to climate change. Mar. Freshw. Res. 62, 1027-1042.
    • (2011) Mar. Freshw. Res. , vol.62 , pp. 1027-1042
    • Booth, D.J.1    Bond, N.2    Macreadie, P.3
  • 6
    • 79953180902 scopus 로고    scopus 로고
    • Assessing mitochondrial dysfunction in cells
    • Brand, M. D. and Nicholls, D. G. (2011). Assessing mitochondrial dysfunction in cells. Biochem. J. 435, 297-312.
    • (2011) Biochem. J. , vol.435 , pp. 297-312
    • Brand, M.D.1    Nicholls, D.G.2
  • 7
    • 0025017256 scopus 로고
    • Temperature acclimation in respiratory and cytochrome c oxidase activity in common carp (Cyprinus carpio)
    • Cai, Y. J. and Adelman, I. R. (1990). Temperature acclimation in respiratory and cytochrome c oxidase activity in common carp (Cyprinus carpio). Comp. Biochem. Physiol. 95A, 139-144.
    • (1990) Comp. Biochem. Physiol. , vol.95 A , pp. 139-144
    • Cai, Y.J.1    Adelman, I.R.2
  • 8
    • 84881183114 scopus 로고    scopus 로고
    • Aerobic scope measurements of fishes in an era of climate change: Respirometry, relevance and recommendations
    • Clark, T. D., Sandblom, E. and Jutfelt, F. (2013). Aerobic scope measurements of fishes in an era of climate change: respirometry, relevance and recommendations. J. Exp. Biol. 216, 2771-2782.
    • (2013) J. Exp. Biol. , vol.216 , pp. 2771-2782
    • Clark, T.D.1    Sandblom, E.2    Jutfelt, F.3
  • 9
    • 67649646730 scopus 로고    scopus 로고
    • Dating the evolutionary origins of wrasse lineages (Labridae) and the rise of trophic novelty on coral reefs
    • Cowman, P. F., Bellwood, D. R. and van Herwerden, L. (2009). Dating the evolutionary origins of wrasse lineages (Labridae) and the rise of trophic novelty on coral reefs. Mol. Phylogenet. Evol. 52, 621-631.
    • (2009) Mol. Phylogenet. Evol. , vol.52 , pp. 621-631
    • Cowman, P.F.1    Bellwood, D.R.2    Van Herwerden, L.3
  • 10
    • 0027143369 scopus 로고
    • Effects of temperature on mitochondria from abalone (Genus Haliotis)-adaptive plasticity and its limits
    • Dahlhoff, E. and Somero, G. N. (1993). Effects of temperature on mitochondria from abalone (Genus Haliotis)-adaptive plasticity and its limits. J. Exp. Biol. 185, 151-168.
    • (1993) J. Exp. Biol. , vol.185 , pp. 151-168
    • Dahlhoff, E.1    Somero, G.N.2
  • 11
    • 0035715208 scopus 로고    scopus 로고
    • Feeding ecology of the banded wrasse Notolabrus fucicola (Labridae) in southern New Zealand: Prey items, seasonal differences, and ontogenetic variation
    • Denny, C. M. and Schiel, D. R. (2001). Feeding ecology of the banded wrasse Notolabrus fucicola (Labridae) in southern New Zealand: prey items, seasonal differences, and ontogenetic variation. N. Z. J. Mar. Freshwater Res. 35, 925-933.
    • (2001) N. Z. J. Mar. Freshwater Res. , vol.35 , pp. 925-933
    • Denny, C.M.1    Schiel, D.R.2
  • 12
    • 0036768937 scopus 로고    scopus 로고
    • Reproductive biology and population structure of the banded wrasse, Notolabrus fucicola (Labridae) around Kaikoura, New Zealand
    • Denny, C. M. and Schiel, D. R. (2002). Reproductive biology and population structure of the banded wrasse, Notolabrus fucicola (Labridae) around Kaikoura, New Zealand. N. Z. J. Mar. Freshwater Res. 36, 555-563.
    • (2002) N. Z. J. Mar. Freshwater Res. , vol.36 , pp. 555-563
    • Denny, C.M.1    Schiel, D.R.2
  • 13
    • 71449092609 scopus 로고    scopus 로고
    • Fish cardiorespiratory physiology in an era of climate change
    • Farrell, A. P., Eliason, E. J., Sandblom, E. and Clark, T. D. (2009). Fish cardiorespiratory physiology in an era of climate change. Can. J. Zool. 87, 835-851.
    • (2009) Can. J. Zool. , vol.87 , pp. 835-851
    • Farrell, A.P.1    Eliason, E.J.2    Sandblom, E.3    Clark, T.D.4
  • 14
    • 0001107072 scopus 로고
    • The effects of temperature acclimation on organ/tissue mass and cytochrome c oxidase activity in juvenile cod (Gadus morhua)
    • Foster, A. R., Hall, S. J. and Houlihan, D. F. (1993). The effects of temperature acclimation on organ/tissue mass and cytochrome c oxidase activity in juvenile cod (Gadus morhua). J. Fish Biol. 42, 947-957.
    • (1993) J. Fish Biol. , vol.42 , pp. 947-957
    • Foster, A.R.1    Hall, S.J.2    Houlihan, D.F.3
  • 18
    • 84858712270 scopus 로고    scopus 로고
    • Thermal acclimation is not necessary to maintain a wide thermal breadth of aerobic scope in the common killifish (Fundulus heteroclitus)
    • Healy, T. M. and Schulte, P. M. (2012). Thermal acclimation is not necessary to maintain a wide thermal breadth of aerobic scope in the common killifish (Fundulus heteroclitus). Physiol. Biochem. Zool. 85, 107-119.
    • (2012) Physiol. Biochem. Zool. , vol.85 , pp. 107-119
    • Healy, T.M.1    Schulte, P.M.2
  • 19
    • 0038208002 scopus 로고    scopus 로고
    • Key metabolic enzymes and muscle structure in triplefin fishes (Tripterygiidae): A phylogenetic comparison
    • Hickey, A. J. and Clements, K. D. (2003). Key metabolic enzymes and muscle structure in triplefin fishes (Tripterygiidae): a phylogenetic comparison. J. Comp. Physiol. B 173, 113-123.
    • (2003) J. Comp. Physiol. B , vol.173 , pp. 113-123
    • Hickey, A.J.1    Clements, K.D.2
  • 20
    • 77956771710 scopus 로고    scopus 로고
    • Temperature sensitivity of cardiac mitochondria in intertidal and subtidal triplefin fishes
    • Hilton, Z., Clements, K. D. and Hickey, A. J. (2010). Temperature sensitivity of cardiac mitochondria in intertidal and subtidal triplefin fishes. J. Comp. Physiol. B 180, 979-990.
    • (2010) J. Comp. Physiol. B , vol.180 , pp. 979-990
    • Hilton, Z.1    Clements, K.D.2    Hickey, A.J.3
  • 21
    • 0020625988 scopus 로고
    • Metabolic meaning of elevated levels of oxidative enzymes in high altitude adapted animals: An interpretive hypothesis
    • Hochachka, P. W., Stanley, C., Merkt, J. and Sumar-Kalinowski, J. (1983). Metabolic meaning of elevated levels of oxidative enzymes in high altitude adapted animals: an interpretive hypothesis. Respir. Physiol. 52, 303-313.
    • (1983) Respir. Physiol. , vol.52 , pp. 303-313
    • Hochachka, P.W.1    Stanley, C.2    Merkt, J.3    Sumar-Kalinowski, J.4
  • 22
    • 84878382914 scopus 로고    scopus 로고
    • Do mitochondria limit hot fish hearts? Understanding the role of mitochondrial function with heat stress in Notolabrus celidotus
    • Iftikar, F. I. and Hickey, A. J. R. (2013). Do mitochondria limit hot fish hearts? Understanding the role of mitochondrial function with heat stress in Notolabrus celidotus. PLoS ONE 8, e64120.
    • (2013) PLoS ONE , vol.8 , pp. e64120
    • Iftikar, F.I.1    Hickey, A.J.R.2
  • 23
    • 77957926268 scopus 로고    scopus 로고
    • Thermal limits of portunid crab heart mitochondria: Could more thermo-stable mitochondria advantage invasive species?
    • Iftikar, F. I., MacDonald, J. and Hickey, A. J. R. (2010). Thermal limits of portunid crab heart mitochondria: could more thermo-stable mitochondria advantage invasive species? J. Exp. Mar. Biol. Ecol. 395, 232-239.
    • (2010) J. Exp. Mar. Biol. Ecol. , vol.395 , pp. 232-239
    • Iftikar, F.I.1    Macdonald, J.2    Hickey, A.J.R.3
  • 25
    • 37049017172 scopus 로고    scopus 로고
    • Does membrane fatty acid composition modulate mitochondrial functions and their thermal sensitivities?
    • Lemieux, H., Blier, P. U. and Tardif, J. C. (2008). Does membrane fatty acid composition modulate mitochondrial functions and their thermal sensitivities? Comp. Biochem. Physiol. 149A, 20-29.
    • (2008) Comp. Biochem. Physiol. , vol.149 A , pp. 20-29
    • Lemieux, H.1    Blier, P.U.2    Tardif, J.C.3
  • 27
    • 0008292915 scopus 로고
    • A comparison of fuel preferences of mitochondria from vertebrates and invertebrates
    • Moyes, C., Suarez, R., Hochachka, P. and Ballantyne, J. (1990). A comparison of fuel preferences of mitochondria from vertebrates and invertebrates. Can. J. Zool. 68, 1337-1349.
    • (1990) Can. J. Zool. , vol.68 , pp. 1337-1349
    • Moyes, C.1    Suarez, R.2    Hochachka, P.3    Ballantyne, J.4
  • 28
    • 0022761823 scopus 로고
    • Maximum catalytic activity of some key enzymes in provision of physiologically useful information about metabolic fluxes
    • Newsholme, E. A. and Crabtree, B. (1986). Maximum catalytic activity of some key enzymes in provision of physiologically useful information about metabolic fluxes. J. Exp. Zool. 239, 159-167.
    • (1986) J. Exp. Zool. , vol.239 , pp. 159-167
    • Newsholme, E.A.1    Crabtree, B.2
  • 29
    • 0042780617 scopus 로고
    • Thermal resistance of mitochondrial respiration: Hydrophobic interactions of membrane proteins may limit thermal resistance
    • O'Brien, J., Dahlhoff, E. and Somero, G. N. (1991). Thermal resistance of mitochondrial respiration: hydrophobic interactions of membrane proteins may limit thermal resistance. Physiol. Zool. 64, 1509-1526.
    • (1991) Physiol. Zool. , vol.64 , pp. 1509-1526
    • O'Brien, J.1    Dahlhoff, E.2    Somero, G.N.3
  • 30
    • 0036018452 scopus 로고    scopus 로고
    • Climate variations and the physiological basis of temperature dependent biogeography: Systemic to molecular hierarchy of thermal tolerance in animals
    • Pörtner, H. O. (2002). Climate variations and the physiological basis of temperature dependent biogeography: systemic to molecular hierarchy of thermal tolerance in animals. Comp. Biochem. Physiol. 132A, 739-761.
    • (2002) Comp. Biochem. Physiol. , vol.132 A , pp. 739-761
    • Pörtner, H.O.1
  • 31
    • 55349117799 scopus 로고    scopus 로고
    • Ecology. Physiology and climate change
    • Pörtner, H. O. and Farrell, A. P. (2008). Ecology. Physiology and climate change. Science 322, 690-692.
    • (2008) Science , vol.322 , pp. 690-692
    • Pörtner, H.O.1    Farrell, A.P.2
  • 32
    • 33846695363 scopus 로고    scopus 로고
    • Climate change affects marine fishes through the oxygen limitation of thermal tolerance
    • Pörtner, H. O. and Knust, R. (2007). Climate change affects marine fishes through the oxygen limitation of thermal tolerance. Science 315, 95-97.
    • (2007) Science , vol.315 , pp. 95-97
    • Pörtner, H.O.1    Knust, R.2
  • 33
    • 78449285752 scopus 로고    scopus 로고
    • Climate change effects on fishes and fisheries: Towards a cause-and-effect understanding
    • Pörtner, H. O. and Peck, M. A. (2010). Climate change effects on fishes and fisheries: towards a cause-and-effect understanding. J. Fish Biol. 77, 1745-1779.
    • (2010) J. Fish Biol. , vol.77 , pp. 1745-1779
    • Pörtner, H.O.1    Peck, M.A.2
  • 34
    • 0001505995 scopus 로고    scopus 로고
    • Levels of metabolic cold adaptation: Tradeoffs in eurythermal and stenothermal ectotherms
    • (ed. W. Davison and C. H. Williams) Christchurch, New Zealand: Caxton Press
    • Pörtner, H.-O., Van Dijk, P., Hardewig, I. and Sommer, A. (2000). Levels of metabolic cold adaptation: tradeoffs in eurythermal and stenothermal ectotherms. In Antarctic Ecosystems: Models for Wider Ecological Understanding (ed. W. Davison and C. H. Williams), pp. 109-122. Christchurch, New Zealand: Caxton Press.
    • (2000) Antarctic Ecosystems: Models for Wider Ecological Understanding , pp. 109-122
    • Pörtner, H.-O.1    Van Dijk, P.2    Hardewig, I.3    Sommer, A.4
  • 36
    • 0023804571 scopus 로고
    • Mitochondrial malic enzyme from crustacean and fish muscle
    • Skorkowski, E. F. (1988). Mitochondrial malic enzyme from crustacean and fish muscle. Comp. Biochem. Physiol. 90B, 19-24.
    • (1988) Comp. Biochem. Physiol. , vol.90 B , pp. 19-24
    • Skorkowski, E.F.1
  • 37
    • 0021306060 scopus 로고
    • Evidence for the role of malic enzyme in the rapid oxidation of malate by cod heart mitochondria
    • Skorkowski, E. F., Aleksandrowicz, Z., Scisłowski, P. W. and Swierczynski, J. (1984). Evidence for the role of malic enzyme in the rapid oxidation of malate by cod heart mitochondria. Comp. Biochem. Physiol. 77B, 379-384.
    • (1984) Comp. Biochem. Physiol. , vol.77 B , pp. 379-384
    • Skorkowski, E.F.1    Aleksandrowicz, Z.2    Scisłowski, P.W.3    Swierczynski, J.4
  • 38
    • 0021905021 scopus 로고
    • Malic enzymes of salmon trout heart mitochondria: Separation and some physicochemical properties of NAD-preferring and NADP-specific enzymes
    • Skorkowski, E. F., Biegniewska, A., Aleksandrowicz, Z. and Swierczynski, J. (1985). Malic enzymes of salmon trout heart mitochondria: separation and some physicochemical properties of NAD-preferring and NADP-specific enzymes. Comp. Biochem. Physiol. 80B, 901-907.
    • (1985) Comp. Biochem. Physiol. , vol.80 B , pp. 901-907
    • Skorkowski, E.F.1    Biegniewska, A.2    Aleksandrowicz, Z.3    Swierczynski, J.4
  • 39
    • 77649199218 scopus 로고    scopus 로고
    • The physiology of climate change: How potentials for acclimatization and genetic adaptation will determine 'winners' and 'losers'
    • Somero, G. N. (2010). The physiology of climate change: how potentials for acclimatization and genetic adaptation will determine 'winners' and 'losers'. J. Exp. Biol. 213, 912-920.
    • (2010) J. Exp. Biol. , vol.213 , pp. 912-920
    • Somero, G.N.1
  • 40
    • 79960005539 scopus 로고    scopus 로고
    • Comparative physiology: A "crystal ball" for predicting consequences of global change
    • Somero, G. N. (2011). Comparative physiology: a "crystal ball" for predicting consequences of global change. J. Physiol. Reg. I 301, R1-R14.
    • (2011) J. Physiol. Reg. i , vol.301 , pp. R1-R14
    • Somero, G.N.1
  • 41
    • 0001934417 scopus 로고    scopus 로고
    • Cold adaptation and stenothermy in Antarctic notothenioid fishes: What has been gained and what has been lost?
    • (ed. G. di Prisco, E. Pisano and A. Clarke) Milan: Springer
    • Somero, G., Fields, P., Hofmann, G., Weinstein, R. and Kawall, H. (1998). Cold adaptation and stenothermy in Antarctic notothenioid fishes: What has been gained and what has been lost? In Fishes of Antarctica (ed. G. di Prisco, E. Pisano and A. Clarke), pp. 97-109. Milan: Springer.
    • (1998) Fishes of Antarctica , pp. 97-109
    • Somero, G.1    Fields, P.2    Hofmann, G.3    Weinstein, R.4    Kawall, H.5
  • 42
    • 77957010982 scopus 로고
    • [1] Citrate Synthase: [EC 4.1.3.7. Citrate Oxaloacetate-lyase (CoA-acetylating)]
    • (ed. M. L. John Waltham, MA: Academic Press
    • Srere, P. A. (1969). [1] Citrate synthase: [EC 4.1.3.7. Citrate oxaloacetate-lyase (CoA-acetylating)]. In Methods in Enzymology, Vol. 13 (ed. M. L. John, pp. 3-11. Waltham, MA: Academic Press.
    • (1969) Methods in Enzymology , vol.13 , pp. 3-11
    • Srere, P.A.1
  • 43
    • 31644443263 scopus 로고    scopus 로고
    • Preserved coupling of oxidative phosphorylation but decreased mitochondrial respiratory capacity in IL-1β-treated human peritoneal mesothelial cells
    • Stadlmann, S., Renner, K., Pollheimer, J., Moser, P. L., Zeimet, A. G., Offner, F. A. and Gnaiger, E. (2006). Preserved coupling of oxidative phosphorylation but decreased mitochondrial respiratory capacity in IL-1β-treated human peritoneal mesothelial cells. Cell Biochem. Biophys. 44, 179-186.
    • (2006) Cell Biochem. Biophys. , vol.44 , pp. 179-186
    • Stadlmann, S.1    Renner, K.2    Pollheimer, J.3    Moser, P.L.4    Zeimet, A.G.5    Offner, F.A.6    Gnaiger, E.7
  • 44
    • 0029823855 scopus 로고    scopus 로고
    • Adaptation to temperature stress and aerial exposure in congeneric species of intertidal porcelain crabs (genus Petrolisthes): Correlation of physiology, biochemistry and morphology with vertical distribution
    • Stillman, J. and Somero, G. (1996). Adaptation to temperature stress and aerial exposure in congeneric species of intertidal porcelain crabs (genus Petrolisthes): correlation of physiology, biochemistry and morphology with vertical distribution. J. Exp. Biol. 199, 1845-1855.
    • (1996) J. Exp. Biol. , vol.199 , pp. 1845-1855
    • Stillman, J.1    Somero, G.2
  • 45
    • 0034130468 scopus 로고    scopus 로고
    • A comparative analysis of the upper thermal tolerance limits of eastern Pacific porcelain crabs, genus Petrolisthes: Influences of latitude, vertical zonation, acclimation, and phylogeny
    • Stillman, J. H. and Somero, G. N. (2000). A comparative analysis of the upper thermal tolerance limits of eastern Pacific porcelain crabs, genus Petrolisthes: influences of latitude, vertical zonation, acclimation, and phylogeny. Physiol. Biochem. Zool. 73, 200-208.
    • (2000) Physiol. Biochem. Zool. , vol.73 , pp. 200-208
    • Stillman, J.H.1    Somero, G.N.2
  • 46
    • 79955760830 scopus 로고    scopus 로고
    • Global analysis of thermal tolerance and latitude in ectotherms
    • Sunday, J. M., Bates, A. E. and Dulvy, N. K. (2011). Global analysis of thermal tolerance and latitude in ectotherms. Proc. R. Soc. B 278, 1823-1830.
    • (2011) Proc. R. Soc. B , vol.278 , pp. 1823-1830
    • Sunday, J.M.1    Bates, A.E.2    Dulvy, N.K.3
  • 47
    • 84865703914 scopus 로고    scopus 로고
    • Thermal tolerance and the global redistribution of animals
    • Sunday, J. M., Bates, A. E. and Dulvy, N. K. (2012). Thermal tolerance and the global redistribution of animals. Nat. Clim. Change 2, 686-690.
    • (2012) Nat. Clim. Change , vol.2 , pp. 686-690
    • Sunday, J.M.1    Bates, A.E.2    Dulvy, N.K.3
  • 48
    • 0000615166 scopus 로고
    • Studies on the physiological variation between tropical and temperate zone fiddler crabs of the Genus UCA i
    • Vernberg, F. J. and Tashian, R. E. (1959). Studies on the physiological variation between tropical and temperate zone fiddler crabs of the Genus UCA I. Thermal death limits. Ecology 40, 589-593.
    • (1959) Thermal Death Limits. Ecology , vol.40 , pp. 589-593
    • Vernberg, F.J.1    Tashian, R.E.2
  • 49
    • 0141534473 scopus 로고    scopus 로고
    • Simultaneous analysis of amino and nonamino organic acids as methyl chloroformate derivatives using gas chromatography-mass spectrometry
    • Villas-Bôas, S. G., Delicado, D. G., Åkesson, M. and Nielsen, J. (2003). Simultaneous analysis of amino and nonamino organic acids as methyl chloroformate derivatives using gas chromatography-mass spectrometry. Anal. Biochem. 322, 134-138.
    • (2003) Anal. Biochem. , vol.322 , pp. 134-138
    • Villas-Bôas, S.G.1    Delicado, D.G.2    Åkesson, M.3    Nielsen, J.4
  • 50
    • 33846695365 scopus 로고    scopus 로고
    • Ecology. The heartbreak of adapting to global warming
    • Wang, T. and Overgaard, J. (2007). Ecology. The heartbreak of adapting to global warming. Science 315, 49-50.
    • (2007) Science , vol.315 , pp. 49-50
    • Wang, T.1    Overgaard, J.2
  • 51
    • 0031942199 scopus 로고    scopus 로고
    • Effects of temperature on mitochondrial function in the Antarctic fish Trematomus bernacchii
    • Weinstein, R. B. and Somero, G. N. (1998). Effects of temperature on mitochondrial function in the Antarctic fish Trematomus bernacchii. J. Comp. Physiol. B 168, 190-196.
    • (1998) J. Comp. Physiol. B , vol.168 , pp. 190-196
    • Weinstein, R.B.1    Somero, G.N.2
  • 53
    • 84920430250 scopus 로고    scopus 로고
    • Response of heart mitochondria to hyperthermia: Activation at the febrile temperature versus loss of the inner membrane barrier at higher temperatures
    • Žukiene, R., Nauciene, Z., Ciapaite, J. and Milda-iene, V. (2007). Response of heart mitochondria to hyperthermia: activation at the febrile temperature versus loss of the inner membrane barrier at higher temperatures. Biologija 53, 34-39.
    • (2007) Biologija , vol.53 , pp. 34-39
    • Žukiene, R.1    Nauciene, Z.2    Ciapaite, J.3    Milda-Iene, V.4


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