메뉴 건너뛰기




Volumn 31, Issue 12, 2014, Pages 1-8

The prognostic value of preoperative NLR, d-NLR, PLR and LMR for predicting clinical outcome in surgical colorectal cancer patients

Author keywords

Colorectal cancer; Neutrophil to lymphocyte ratio; Nomogram

Indexed keywords

ADULT; ARTICLE; BLOOD CELL RATIO; CANCER PATIENT; CANCER PROGNOSIS; CANCER SPECIFIC SURVIVAL; CANCER SURGERY; COLORECTAL CANCER; DERIVED NEUTROPHIL TO LYMPHOCYTE RATIO; FEMALE; FOLLOW UP; HUMAN; LYMPHOCYTE TO MONOCYTE RATIO; MAJOR CLINICAL STUDY; MALE; MEASUREMENT ACCURACY; NEUTROPHIL LYMPHOCYTE RATIO; NOMOGRAM; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PLATELET LYMPHOCYTE RATIO; PREDICTION; PREOPERATIVE EVALUATION; RECURRENCE FREE SURVIVAL; RISK FACTOR; SURVIVAL RATE; AGED; BLOOD; BLOOD CELL COUNT; CLINICAL TRIAL; COLORECTAL NEOPLASMS; DISEASE FREE SURVIVAL; KAPLAN MEIER METHOD; LYMPHOCYTE COUNT; MIDDLE AGED; MORTALITY; PREDICTIVE VALUE; PREOPERATIVE PERIOD; PROPORTIONAL HAZARDS MODEL; THROMBOCYTE COUNT; TREATMENT OUTCOME;

EID: 84919882027     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-014-0305-0     Document Type: Article
Times cited : (268)

References (36)
  • 3
    • 43749111776 scopus 로고    scopus 로고
    • Prognostic and predictive factors in colorectal cancer
    • COI: 1:STN:280:DC%2BD1c3ns1Wjsg%3D%3D, PID: 18326017
    • Zlobec I, Lugli A. Prognostic and predictive factors in colorectal cancer. J Clin Pathol. 2008;61:561–9.
    • (2008) J Clin Pathol , vol.61 , pp. 561-569
    • Zlobec, I.1    Lugli, A.2
  • 4
    • 0037393449 scopus 로고    scopus 로고
    • Colorectal carcinoma: diagnostic, prognostic, and molecular features
    • PID: 12692203
    • Compton CC. Colorectal carcinoma: diagnostic, prognostic, and molecular features. Mod Pathol. 2003;16:376–88.
    • (2003) Mod Pathol , vol.16 , pp. 376-388
    • Compton, C.C.1
  • 5
    • 47949096781 scopus 로고    scopus 로고
    • Cancer-related inflammation
    • COI: 1:CAS:528:DC%2BD1cXovV2mtbg%3D, PID: 18650914
    • Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454:436–44.
    • (2008) Nature , vol.454 , pp. 436-444
    • Mantovani, A.1    Allavena, P.2    Sica, A.3    Balkwill, F.4
  • 6
    • 84888633713 scopus 로고    scopus 로고
    • Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms
    • COI: 1:CAS:528:DC%2BC3sXhs1Krt7fI, PID: 24154716
    • Elinav E, Nowarski R, Thaiss CA, Hu B, Jin C, Flavell RA. Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat Rev Cancer. 2013;13:759–71.
    • (2013) Nat Rev Cancer , vol.13 , pp. 759-771
    • Elinav, E.1    Nowarski, R.2    Thaiss, C.A.3    Hu, B.4    Jin, C.5    Flavell, R.A.6
  • 7
    • 3042599473 scopus 로고    scopus 로고
    • Inflammation and cancer IV Colorectal cancer in inflammatory bowel disease: the role of inflammation
    • COI: 1:CAS:528:DC%2BD2cXlvFOhu7s%3D, PID: 15194558
    • Itzkowitz SH, Yio X. Inflammation and cancer IV Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am J Physiol Gastrointest Liver Physiol. 2004;287:G7–17.
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287 , pp. G7-G17
    • Itzkowitz, S.H.1    Yio, X.2
  • 8
    • 78650389810 scopus 로고    scopus 로고
    • High blood neutrophil-to-lymphocyte ratio is an indicator of poor prognosis in malignant mesothelioma patients undergoing systemic therapy
    • COI: 1:CAS:528:DC%2BC3cXhsFamtLvN, PID: 20956618
    • Kao SC, Pavlakis N, Harvie R, Vardy JL, Boyer MJ, van Zandwijk N, et al. High blood neutrophil-to-lymphocyte ratio is an indicator of poor prognosis in malignant mesothelioma patients undergoing systemic therapy. Clin Cancer Res. 2010;16:5805–13.
    • (2010) Clin Cancer Res , vol.16 , pp. 5805-5813
    • Kao, S.C.1    Pavlakis, N.2    Harvie, R.3    Vardy, J.L.4    Boyer, M.J.5    van Zandwijk, N.6
  • 10
    • 84900010587 scopus 로고    scopus 로고
    • The lymphocyte/monocyte ratio predicts poor clinical outcome and improves the predictive accuracy in patients with soft tissue sarcomas
    • COI: 1:CAS:528:DC%2BC2cXmtVCqtg%3D%3D, PID: 24347236
    • Szkandera J, Gerger A, Liegl-Atzwanger B, Absenger G, Stotz M, Friesenbichler J, et al. The lymphocyte/monocyte ratio predicts poor clinical outcome and improves the predictive accuracy in patients with soft tissue sarcomas. Int J Cancer. 2014;135:362–70.
    • (2014) Int J Cancer , vol.135 , pp. 362-370
    • Szkandera, J.1    Gerger, A.2    Liegl-Atzwanger, B.3    Absenger, G.4    Stotz, M.5    Friesenbichler, J.6
  • 11
    • 84881116763 scopus 로고    scopus 로고
    • A derived neutrophil to lymphocyte ratio predicts clinical outcome in stage II and III colon cancer patients
    • COI: 1:CAS:528:DC%2BC3sXhtFOit73N, PID: 23820252
    • Absenger G, Szkandera J, Pichler M, Stotz M, Arminger F, Weissmueller M, et al. A derived neutrophil to lymphocyte ratio predicts clinical outcome in stage II and III colon cancer patients. Br J Cancer. 2013;109:395–400.
    • (2013) Br J Cancer , vol.109 , pp. 395-400
    • Absenger, G.1    Szkandera, J.2    Pichler, M.3    Stotz, M.4    Arminger, F.5    Weissmueller, M.6
  • 12
    • 84892910540 scopus 로고    scopus 로고
    • The preoperative lymphocyte to monocyte ratio predicts clinical outcome in patients with stage III colon cancer
    • COI: 1:STN:280:DC%2BC2c3nvFaisQ%3D%3D, PID: 24357796
    • Stotz M, Pichler M, Absenger G, Szkandera J, Arminger F, Schaberl-Moser R, et al. The preoperative lymphocyte to monocyte ratio predicts clinical outcome in patients with stage III colon cancer. Br J Cancer. 2014;110:435–40.
    • (2014) Br J Cancer , vol.110 , pp. 435-440
    • Stotz, M.1    Pichler, M.2    Absenger, G.3    Szkandera, J.4    Arminger, F.5    Schaberl-Moser, R.6
  • 13
    • 84891600524 scopus 로고    scopus 로고
    • Preoperative platelet-lymphocyte ratio is an independent prognostic factor for resectable colorectal cancer
    • Liu H, DU X, Sun P, Xiao C, Xu Y, Li R. Preoperative platelet-lymphocyte ratio is an independent prognostic factor for resectable colorectal cancer. J South Med Univ. 2013;33:70–3.
    • (2013) J South Med Univ , vol.33 , pp. 70-73
    • Liu, H.1    DU, X.2    Sun, P.3    Xiao, C.4    Xu, Y.5    Li, R.6
  • 14
    • 24344442821 scopus 로고    scopus 로고
    • Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer
    • COI: 1:STN:280:DC%2BD2MvlvFCjtA%3D%3D, PID: 16118772
    • Walsh SR, Cook EJ, Goulder F, Justin TA, Keeling NJ. Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer. J Surg Oncol. 2005;91:181–4.
    • (2005) J Surg Oncol , vol.91 , pp. 181-184
    • Walsh, S.R.1    Cook, E.J.2    Goulder, F.3    Justin, T.A.4    Keeling, N.J.5
  • 15
    • 84867009402 scopus 로고    scopus 로고
    • Can neutrophil-to-lymphocyte ratio predict the survival of colorectal cancer patients who have received curative surgery electively?
    • PID: 22460305
    • Chiang SF, Hung HY, Tang R, Changchien CR, Chen JS, You YT, et al. Can neutrophil-to-lymphocyte ratio predict the survival of colorectal cancer patients who have received curative surgery electively? Int J Colorectal Dis. 2012;27:1347–57.
    • (2012) Int J Colorectal Dis , vol.27 , pp. 1347-1357
    • Chiang, S.F.1    Hung, H.Y.2    Tang, R.3    Changchien, C.R.4    Chen, J.S.5    You, Y.T.6
  • 16
    • 0034732869 scopus 로고    scopus 로고
    • Principles and practical application of thereceiver-operating characteristic analysis for diagnostic tests
    • COI: 1:STN:280:DC%2BD3c3msVajsQ%3D%3D, PID: 10802332
    • Greiner M, Pfeiffer D, Smith RD. Principles and practical application of thereceiver-operating characteristic analysis for diagnostic tests. Prev Vet Med. 2000;45:23–41.
    • (2000) Prev Vet Med , vol.45 , pp. 23-41
    • Greiner, M.1    Pfeiffer, D.2    Smith, R.D.3
  • 17
    • 0023637126 scopus 로고
    • Kinetics and mechanisms of recombinant human interleukin 1 and tumor necrosisfactor-alpha- induced changes in circulating numbers of neutrophils and lymphocytes
    • COI: 1:CAS:528:DyaL1cXlsVWiuw%3D%3D, PID: 3316383
    • Ulich TR, del Castillo J, Keys M, Granger GA, Ni RX. Kinetics and mechanisms of recombinant human interleukin 1 and tumor necrosisfactor-alpha- induced changes in circulating numbers of neutrophils and lymphocytes. J Immunol. 1987;139:3406–15.
    • (1987) J Immunol , vol.139 , pp. 3406-3415
    • Ulich, T.R.1    del Castillo, J.2    Keys, M.3    Granger, G.A.4    Ni, R.X.5
  • 18
    • 0024498048 scopus 로고
    • In vivo hematologic effects of recombinant interleukin-6 on hematopoiesis and circulating numbers of RBCs and WBCs
    • COI: 1:CAS:528:DyaL1MXptlaltQ%3D%3D, PID: 2783370
    • Ulich TR, del Castillo J, Guo KZ. In vivo hematologic effects of recombinant interleukin-6 on hematopoiesis and circulating numbers of RBCs and WBCs. Blood. 1989;73:108–10.
    • (1989) Blood , vol.73 , pp. 108-110
    • Ulich, T.R.1    del Castillo, J.2    Guo, K.Z.3
  • 19
    • 67649304466 scopus 로고    scopus 로고
    • Pretreatment neutrophil count as an independent prognostic factor in advanced non-small-cell lung cancer: an analysis of Japan Multinational Trial Organisation LC00-03
    • PID: 19231158
    • Teramukai S, Kitano T, Kishida Y, Kawahara M, Kubota K, Komuta K, et al. Pretreatment neutrophil count as an independent prognostic factor in advanced non-small-cell lung cancer: an analysis of Japan Multinational Trial Organisation LC00-03. Eur J Cancer. 2009;45:1950–8.
    • (2009) Eur J Cancer , vol.45 , pp. 1950-1958
    • Teramukai, S.1    Kitano, T.2    Kishida, Y.3    Kawahara, M.4    Kubota, K.5    Komuta, K.6
  • 20
    • 0024358141 scopus 로고
    • The kinetics of human granulopoiesis following treatment with granulocyte colony-stimulating factor in vivo
    • COI: 1:CAS:528:DyaK3cXnsFSgsw%3D%3D, PID: 2480603
    • Lord BI, Bronchud MH, Owens S, Chang J, Howell A, Souza L, et al. The kinetics of human granulopoiesis following treatment with granulocyte colony-stimulating factor in vivo. Proc Natl Acad Sci USA. 1989;86:9499–503.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 9499-9503
    • Lord, B.I.1    Bronchud, M.H.2    Owens, S.3    Chang, J.4    Howell, A.5    Souza, L.6
  • 21
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • COI: 1:CAS:528:DC%2BD38XpsFygtb4%3D, PID: 12490959
    • Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420:860–7.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 22
    • 84871211511 scopus 로고    scopus 로고
    • Neutrophil to lymphocyte ratio (NLR) as an indicator of poor prognosis in stage IV non-small cell lung cancer
    • PID: 22855161
    • Cedrés S, Torrejon D, Martínez A, Martinez P, Navarro A, Zamora E, et al. Neutrophil to lymphocyte ratio (NLR) as an indicator of poor prognosis in stage IV non-small cell lung cancer. Clin Transl Oncol. 2012;14:864–9.
    • (2012) Clin Transl Oncol , vol.14 , pp. 864-869
    • Cedrés, S.1    Torrejon, D.2    Martínez, A.3    Martinez, P.4    Navarro, A.5    Zamora, E.6
  • 23
    • 84881115045 scopus 로고    scopus 로고
    • Increased neutrophil-lymphocyte ratio is a poor prognostic factor in patients with primary operable and inoperable pancreatic cancer
    • COI: 1:CAS:528:DC%2BC3sXhtFOit7rF, PID: 23799847
    • Stotz M, Gerger A, Eisner F, Szkandera J, Loibner H, Ress AL, et al. Increased neutrophil-lymphocyte ratio is a poor prognostic factor in patients with primary operable and inoperable pancreatic cancer. Br J Cancer. 2013;109:416–21.
    • (2013) Br J Cancer , vol.109 , pp. 416-421
    • Stotz, M.1    Gerger, A.2    Eisner, F.3    Szkandera, J.4    Loibner, H.5    Ress, A.L.6
  • 24
    • 84880570170 scopus 로고    scopus 로고
    • Preoperative neutrophil-to-lymphocyte ratio is a predictor of survival after hepatectomy for hepatocellular carcinoma: a retrospective analysis
    • PID: 23774313
    • Mano Y, Shirabe K, Yamashita Y, Harimoto N, Tsujita E, Takeishi K, et al. Preoperative neutrophil-to-lymphocyte ratio is a predictor of survival after hepatectomy for hepatocellular carcinoma: a retrospective analysis. Ann Surg. 2013;258:301–5.
    • (2013) Ann Surg , vol.258 , pp. 301-305
    • Mano, Y.1    Shirabe, K.2    Yamashita, Y.3    Harimoto, N.4    Tsujita, E.5    Takeishi, K.6
  • 25
    • 84897019987 scopus 로고    scopus 로고
    • Significance of preoperative neutrophil-to-lymphocyte ratio as a predictor of prognosis in patients with stage IV colorectal cancer
    • PID: 24393862
    • Shibutani M, Maeda K, Nagahara H, Noda E, Ohtani H, Sugano K, et al. Significance of preoperative neutrophil-to-lymphocyte ratio as a predictor of prognosis in patients with stage IV colorectal cancer. Gan To Kagaku Ryoho. 2013;40:1603–5.
    • (2013) Gan To Kagaku Ryoho , vol.40 , pp. 1603-1605
    • Shibutani, M.1    Maeda, K.2    Nagahara, H.3    Noda, E.4    Ohtani, H.5    Sugano, K.6
  • 26
    • 84883307604 scopus 로고    scopus 로고
    • A high preoperative neutrophil-to-lymphocyte ratio is associated with poor survival in patients with colorectal cancer
    • PID: 23898094
    • Shibutani M, Maeda K, Nagahara H, Noda E, Ohtani H, Nishiguchi Y, et al. A high preoperative neutrophil-to-lymphocyte ratio is associated with poor survival in patients with colorectal cancer. Anticancer Res. 2013;33:3291–4.
    • (2013) Anticancer Res , vol.33 , pp. 3291-3294
    • Shibutani, M.1    Maeda, K.2    Nagahara, H.3    Noda, E.4    Ohtani, H.5    Nishiguchi, Y.6
  • 27
    • 0025083101 scopus 로고
    • Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis
    • COI: 1:CAS:528:DyaK3cXls12ls7o%3D, PID: 2200535
    • Weitzman SA, Gordon LI. Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis. Blood. 1990;76:655–63.
    • (1990) Blood , vol.76 , pp. 655-663
    • Weitzman, S.A.1    Gordon, L.I.2
  • 28
    • 3343016654 scopus 로고    scopus 로고
    • Platelets and granulocytes, in particular the neutrophils, form important compartments for circulating vascular endothelial growth factor
    • COI: 1:CAS:528:DC%2BD2cXktlykt7g%3D, PID: 15166496
    • Kusumanto YH, Dam WA, Hospers GA, Meijer C, Mulder NH. Platelets and granulocytes, in particular the neutrophils, form important compartments for circulating vascular endothelial growth factor. Angiogenesis. 2003;6:283–7.
    • (2003) Angiogenesis , vol.6 , pp. 283-287
    • Kusumanto, Y.H.1    Dam, W.A.2    Hospers, G.A.3    Meijer, C.4    Mulder, N.H.5
  • 29
    • 0037531794 scopus 로고    scopus 로고
    • The angiogenic switch for vascular endothelial growth factor (VEGF)-A, VEGF-B, VEGF-C, and VEGF-D in the adenoma-carcinoma sequence during colorectal cancer progression
    • COI: 1:CAS:528:DC%2BD3sXlsFeisro%3D, PID: 12754739
    • Hanrahan V, Currie MJ, Gunningham SP, Morrin HR, Scott PA, Robinson BA, et al. The angiogenic switch for vascular endothelial growth factor (VEGF)-A, VEGF-B, VEGF-C, and VEGF-D in the adenoma-carcinoma sequence during colorectal cancer progression. J Pathol. 2003;200:183–94.
    • (2003) J Pathol , vol.200 , pp. 183-194
    • Hanrahan, V.1    Currie, M.J.2    Gunningham, S.P.3    Morrin, H.R.4    Scott, P.A.5    Robinson, B.A.6
  • 30
    • 84899500279 scopus 로고    scopus 로고
    • Parthenolide exerts inhibitory effects on angiogenesis through the down regulation of VEGF/VEGFRs in colorectal cancer
    • COI: 1:CAS:528:DC%2BC2cXht1egtbzI, PID: 24573421
    • Kim SL, Lee ST, Trang KT, Kim SH, Kim IH, Lee SO, et al. Parthenolide exerts inhibitory effects on angiogenesis through the down regulation of VEGF/VEGFRs in colorectal cancer. Int J Mol Med. 2014;33:1261–7.
    • (2014) Int J Mol Med , vol.33 , pp. 1261-1267
    • Kim, S.L.1    Lee, S.T.2    Trang, K.T.3    Kim, S.H.4    Kim, I.H.5    Lee, S.O.6
  • 31
    • 0033831517 scopus 로고    scopus 로고
    • Infections as a major preventable cause of human cancer
    • COI: 1:STN:280:DC%2BD3cvps1Cqtw%3D%3D, PID: 10971784
    • Kuper H, Adami HO, Trichopoulos D. Infections as a major preventable cause of human cancer. J Intern Med. 2000;248:171–83.
    • (2000) J Intern Med , vol.248 , pp. 171-183
    • Kuper, H.1    Adami, H.O.2    Trichopoulos, D.3
  • 32
    • 0028936341 scopus 로고
    • Age at establishment of Helicobacter pylori infection and gastric carcinoma, gastric ulcer, and duodenal ulcer risk
    • COI: 1:CAS:528:DyaK2MXjtlykt7c%3D, PID: 7834625
    • Blaser MJ, Chyou PH, Nomura A. Age at establishment of Helicobacter pylori infection and gastric carcinoma, gastric ulcer, and duodenal ulcer risk. Cancer Res. 1995;55:562–5.
    • (1995) Cancer Res , vol.55 , pp. 562-565
    • Blaser, M.J.1    Chyou, P.H.2    Nomura, A.3
  • 33
    • 0028057251 scopus 로고
    • Anti-colony-stimulating factor-1 antibody staining in primary breast adenocarcinomas correlates with marked inflammatory cell infiltrates and prognosis
    • COI: 1:STN:280:DyaK2c%2Fps1Ciug%3D%3D, PID: 8271294
    • Scholl SM, Pallud C, Beuvon F, Hacene K, Stanley ER, et al. Anti-colony-stimulating factor-1 antibody staining in primary breast adenocarcinomas correlates with marked inflammatory cell infiltrates and prognosis. J Natl Cancer Inst. 1994;86:120–6.
    • (1994) J Natl Cancer Inst , vol.86 , pp. 120-126
    • Scholl, S.M.1    Pallud, C.2    Beuvon, F.3    Hacene, K.4    Stanley, E.R.5
  • 34
    • 0036484856 scopus 로고    scopus 로고
    • Chronic inflammation and cancer
    • PID: 11866137
    • Shacter E, Weitzman SA. Chronic inflammation and cancer. Oncology. 2002;16:217–26.
    • (2002) Oncology , vol.16 , pp. 217-226
    • Shacter, E.1    Weitzman, S.A.2
  • 35
    • 0023099067 scopus 로고
    • Functional analysis of mononuclear cells infiltrating into tumors: lysis of autologous human tumor cells by cultured infiltrating lymphocytes
    • COI: 1:STN:280:DyaL2s%2Fnsl2msg%3D%3D, PID: 3491673
    • Rabinowich H, Cohen R, Bruderman I, Steiner Z, Klajman A. Functional analysis of mononuclear cells infiltrating into tumors: lysis of autologous human tumor cells by cultured infiltrating lymphocytes. Cancer Res. 1987;47:173–7.
    • (1987) Cancer Res , vol.47 , pp. 173-177
    • Rabinowich, H.1    Cohen, R.2    Bruderman, I.3    Steiner, Z.4    Klajman, A.5
  • 36
    • 0032941907 scopus 로고    scopus 로고
    • Changes in blood lymphocyte populations after multiple trauma: association with posttraumatic complications
    • COI: 1:STN:280:DyaK1M3ltlGkuw%3D%3D, PID: 10321662
    • Menges T, Engel J, Welters I, Wagner RM, Little S, Ruwoldt R, et al. Changes in blood lymphocyte populations after multiple trauma: association with posttraumatic complications. Crit Care Med. 1999;27:733–40.
    • (1999) Crit Care Med , vol.27 , pp. 733-740
    • Menges, T.1    Engel, J.2    Welters, I.3    Wagner, R.M.4    Little, S.5    Ruwoldt, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.