A promising CpG adjuvant-loaded nanoparticle-based vaccine for treatment of dust mite allergies

Immunotherapy

Volumn 6, Issue 11, 2014, Pages 1161-1163

  Salem, Aliasger K ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

allergy; asthma; biodegradable; CpG; Der p2; house dust mite allergens; nanoparticles; PLGA

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; HOUSE DUST ALLERGEN; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; NANOPARTICLE; ARTHROPOD PROTEIN; DERMATOPHAGOIDES PTERONYSSINUS ANTIGEN P 2; OLIGONUCLEOTIDE;

ANTIBODY RESPONSE; ASTHMA; B LYMPHOCYTE; DENDRITIC CELL; HOUSE DUST ALLERGY; HUMAN; IMMUNE RESPONSE; MOLECULE; REVIEW; SUBCUTANEOUS IMMUNOTHERAPY; SUBLINGUAL IMMUNOTHERAPY; TH2 CELL; VACCINATION; ACTIVE IMMUNIZATION; ADJUVANT CHEMOTHERAPY; ADULT; ANIMAL; CHEMISTRY; CHILD; CPG ISLAND; DRUG DELIVERY SYSTEM; GENETICS; HYPERSENSITIVITY; IMMUNOLOGY; MOUSE; PARTICLE SIZE; PYROGLYPHIDAE; TH1 CELL; TH1 TH2 BALANCE;

ADULT; ANIMALS; ANTIGENS, DERMATOPHAGOIDES; ARTHROPOD PROTEINS; CHEMOTHERAPY, ADJUVANT; CHILD; CPG ISLANDS; DRUG DELIVERY SYSTEMS; HUMANS; HYPERSENSITIVITY; IMMUNOTHERAPY, ACTIVE; MICE; NANOPARTICLES; OLIGONUCLEOTIDES; PARTICLE SIZE; PYROGLYPHIDAE; TH1 CELLS; TH1-TH2 BALANCE; TH2 CELLS;

EID: 84919821728     PISSN: 1750743X     EISSN: 17507448     Source Type: Journal    
DOI: 10.2217/imt.14.97     Document Type: Review

References (20)

1. Joshi VB, Adamcakova-Dodd A, Jing X, et al. Development of a Poly (lactic-co-glycolic acid) Particle Vaccine to Protect Against House Dust Mite Induced Allergy. AAPS J. doi:10.1208/s12248-014-9624-5 (2014)(Epub ahead of print
2. Arbes SJ Jr, Cohn RD, Yin M, et al. House dust mite allergen in US beds: Results from the First National Survey of Lead and Allergens in Housing. J. Allergy Clin. Immunol. 111(2), 408-414 (2003
3. Lambrecht BN, Hammad H. The airway epithelium in asthma. Nat. Med. 18(5), 684-692 (2012
4. Johnson JR, Wiley RE, Fattouh R, et al. Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodeling. Am. J. Resp. Crit. Care 169(3), 378-385 (2004
5. Mazzarella G, Bianco A, Catena E, De Palma R, Abbate GF. Th1/Th2 lymphocyte polarization in asthma. Allergy 55, 6-9 (2000
6. Kidon MI, Chiang WC, Liew WK, et al. Mite component-specific IgE repertoire and phenotypes of allergic disease in childhood: The tropical perspective. Pediatr. Allergy Immunol. 22(2), 202-210 (2011
7. Trombone APF, Tobias KRC, Ferriani VPL, et al. Use of a chimeric ELISA to investigate immunoglobulin E antibody responses to Der p 1 and Der p 2 in mite-Allergic patients with asthma, wheezing and/or rhinitis. Clin. Exp. Allergy 32(9), 1323-1328 (2002
8. Tan LK, Huang CH, Kuo IC, Liew LM, Chua KY. Intramuscular immunization with DNA construct containing Der p 2 and signal peptide sequences primed strong IgE production. Vaccine 24(29-30), 5762-5771 (2006
9. Fonseca DE, Kline JN. Use of CpG oligonucleotides in treatment of asthma and allergic disease. Adv. Drug Deliver. Rev. 61(3), 256-262 (2009
10. Geary SM, Lemke CD, Lubaroff DM, Salem AK. Tumor immunotherapy using adenovirus vaccines in combination with intratumoral doses of CpG ODN. Cancer Immunol. Immunother. 60(9), 1309-1317 (2011
11. Krishnamachari Y, Salem AK. Innovative strategies for co-delivering antigens and CpG oligonucleotides. Adv. Drug Deliver. Rev 61(3), 205-217 (2009
12. Mo JH, Park SW, Rhee CS, et al. Suppression of allergic response by CpG motif oligodeoxynucleotide-house-dust mite conjugate in animal model of allergic rhinitis. Am. J. Rhinol. 20(2), 212-218 (2006
13. Simons FE, Shikishima Y, Van Nest G, Eiden JJ, Hayglass KT. Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA. J. Allergy Clin. Immunol. 113(6), 1144-1151 (2004
14. Zhang XQ, Dahle CE, Baman NK, Rich N, Weiner GJ, Salem AK. Potent antigen-specific immune responses stimulated by codelivery of CpG ODN and antigens in Degradable microparticles. J. Immunother. 30(5), 469-478 (2007
15. Joshi VB, Geary SM, Salem AK. Biodegradable particles as vaccine delivery systems: Size matters. AAPS J. 15(1), 85-94 (2013
16. Zhang XQ, Dahle CE, Weiner GJ, Salem AK. A comparative study of the antigen-specific immune response induced by co-delivery of CpG ODN and antigen using fusion molecules or biodegradable microparticles. J. Pharm. Sci. 96(12), 3283-3292 (2007
17. Zhang XQ, Intra J, Salem AK. Conjugation of polyamidoamine dendrimers on biodegradable microparticles for nonviral gene delivery. Bioconjug. Chem. 18(6), 2068-2076 (2007
18. Joshi VB, Geary SM, Carrillo-Conde BR, Narasimhan B, Salem AK. Characterizing the antitumor response in mice treated with antigen-loaded polyanhydride microparticles. Acta biomater. 9(3), 5583-5589 (2013
19. Lemke CD, Geary SM, Joshi VB, Salem AK. Antigen-coated poly alpha-hydroxy acid based microparticles for heterologous prime-boost adenovirus based vaccinations. Biomaterials 34(10), 2524-2529 (2013
20. Goforth R, Salem AK, Zhu X, et al. Immune stimulatory antigen loaded particles combined with depletion of regulatory T-cells induce potent tumor specific immunity in a mouse model of melanoma. Cancer Immunol. Immunother. 58(4), 517-530 (2009