The modulatory effect of ellagic acid and rosmarinic acid on ultraviolet-B-induced cytokine/chemokine gene expression in skin keratinocyte (HaCaT) cells

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Lembo, Serena ^a   Balato, Anna ^a   Di Caprio, Roberta ^a   Cirillo, Teresa ^a   Giannini, Valentina ^b   Gasparri, Franco ^b   Monfrecola, Giuseppe ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b Rotta Research Laboratorium   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ELLAGIC ACID; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; ROSMARINIC ACID; TUMOR NECROSIS FACTOR ALPHA; CHEMOKINE; CINNAMIC ACID DERIVATIVE; CYTOKINE; DEPSIDE;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMORTALIZED CELL LINE; IN VITRO STUDY; IRRADIATION; KERATINOCYTE; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; ULTRAVIOLET B RADIATION; BIOSYNTHESIS; CELL LINE; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; RADIATION RESPONSE; SKIN; ULTRAVIOLET RADIATION;

CELL LINE; CHEMOKINES; CINNAMATES; CYTOKINES; DEPSIDES; ELLAGIC ACID; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KERATINOCYTES; SKIN; ULTRAVIOLET RAYS;

EID: 84919816816     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/346793     Document Type: Article

References (25)

1. M. M. Bashir, M. R. Sharma, and V. P. Werth, "UVB and proinflammatory cytokines synergistically activate TNF-α production in keratinocytes through enhanced gene transcription, " Journal of Investigative Dermatology, vol. 129, no. 4, pp. 994-1001, 2009.
2. Y. C. Hseu, C. W. Chou, K. J. Senthil Kumar et al., "Ellagic acid protects human keratinocyte (HaCaT) cells against UVAinduced oxidative stress and apoptosis through the upregulation of the HO-1 and Nrf-2 antioxidant genes, " Food and Chemical Toxicology, vol. 50, no. 5, pp. 1245-1255, 2012.
3. J. Y. Bae, J. S. Choi, S. W. Kang, Y. J. Lee, J. Park, and Y. H. Kang, "Dietary compound ellagic acid alleviates skin wrinkle and inflammation induced by UVB irradiation, " Experimental Dermatology, vol. 19, no. 8, pp. e182-e190, 2010.
4. F. Jimenez, T. F. Mitts, K. Liu, Y. Wang, and A. Hinek, "Ellagic newly synthesized elastic fibers from premature enzymatic degradation in dermal fibroblast cultures, " Journal of Investigative Dermatology, vol. 126, no. 6, pp. 1272-1280, 2006.
5. M. Petersen and M. S. J. Simmonds, "Rosmarinic acid, " Phytochemistry, vol. 62, no. 2, pp. 121-125, 2003.
6. J. Vostalova, A. Zdarilova, and A. Svobodova, "Prunella vulgaris extract and rosmarinic acid preventUVBinducedDNAdamage and oxidative stress in HaCaT keratinocytes, " Archives of Dermatological Research, vol. 302, no. 3, pp. 171-181, 2010.
7. M. Sanchez-Campillo, J. A. Gabaldon, and J. Castillo, "Rosmarinic acid, a photo-protective agent against UV and other ionizing radiations, " Food and Chemical Toxicology, vol. 47, no. 2, pp. 386-392, 2009.
8. M. Kang, S. Yun, and J. Won, "Rosmarinic acid inhibits Ca2+-dependent pathways of T-cell antigen receptor-mediated signaling by inhibiting the PLC-γ1 and Itk activity, " Blood, vol. 101, no. 9, pp. 3534-3542, 2003.
9. G. Monfrecola, F. Gaudiello, T. Cirillo, G. Fabbrocini, A. Balato, and S. Lembo, "Nicotinamide downregulates gene expression of interleukin-6, interleukin-10, monocyte chemoattractant protein-1, and tumour necrosis factor-α gene expression in HaCaT keratinocytes after ultraviolet B irradiation, " Clinical and Experimental Dermatology, vol. 38, no. 2, pp. 185-188, 2013.
10. K. J. Livak and T. D. Schmittgen, "Analysis of relative gene expression data using real-time quantitative PCR and the 2-δδCT method, " Methods, vol. 25, no. 4, pp. 402-408, 2001.
11. J. Lee, E. Jung, J. Koh, Y. S. Kim, and D. Park, "Effect of rosmarinic acid on atopic dermatitis, " The Journal of Dermatology, vol. 35, no. 12, pp. 768-771, 2008.
12. J. Lee, E. Jung, Y. Kim et al., "Rosmarinic acid as a downstream inhibitor of IKK-β in TNF-α-induced upregulation of CCL11 and CCR3, " British Journal of Pharmacology, vol. 148, no. 3, pp. 366-375, 2006.
13. J. S. Kang, H. N. Kim, D. J. Jung et al., "Regulation of UVB-induced IL-8 and MCP-1 production in skin keratinocytes by increasing vitamin C uptake via the redistribution of SVCT-1 from the cytosol to the membrane, " Journal of Investigative Dermatology, vol. 127, no. 3, pp. 698-706, 2007.
14. T. S. Kupper, A. O. Chua, P. Flood, J. McGuire, and U. Gubler, "Interleukin 1 gene expression in cultured human keratinocytes is augmented by ultraviolet irradiation, " Journal of Clinical Investigation, vol. 80, no. 2, pp. 430-436, 1987.
15. J. B. Mumm, J. Emmerich, X. Zhang et al., "IL-10 elicits IFNγ-dependent tumor immune surveillance, " Cancer Cell, vol. 20, no. 6, pp. 781-796, 2011.
16. M. J. H. Girard-Madoux, J. M. Kel, B. Reizis, and B. E. Clausen, "IL-10 controls dendritic cell-induced T-cell reactivation in the skin to limit contact hypersensitivity, " Journal of Allergy and Clinical Immunology, vol. 129, no. 1, pp. 143. e10-150. e10, 2012.
17. S. H. Oh, C. O. Park, W. H. Wu et al., "Corticotropin-releasing hormone downregulates IL-10 production by adaptive forkhead box protein 3-negative regulatory T cells in patients with atopic dermatitis, " Journal of Allergy andClinical Immunology, vol. 129, no. 1, pp. 151. e1-159. e1, 2012.
18. N. A. El-Shitany, E. A. El-Bastawissy, and K. El-Desoky, "Ellagic acid protects against carrageenan-induced acute inflammation through inhibition of nuclear factor kappa B, inducible cyclooxygenase and proinflammatory cytokines and enhancement of interleukin-10 via an antioxidant mechanism, " International Immunopharmacology, vol. 19, no. 2, pp. 129-299, 2014.
19. Y. Chang, W. F. Chen, K. H. Lin et al., "Novel bioactivity of ellagic acid in inhibiting human platelet activation, " Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 595128, 9 pages, 2013.
20. H. K. Kim, J. J. Lee, J. S. Lee, Y. Park, and T. R. Yoon, "Rosmarinic acid down-regulates the LPS-induced production of monocyte chemoattractant protein-1 (MCP-1) andmacrophage inflammatory protein-1α (MIP-1α) via the MAPK pathway in bone-marrow derived dendritic cells, " Molecules and Cells, vol. 26, no. 6, pp. 583-589, 2008.
21. C. M. Hedrich and J. H. Bream, "Cell type-specific regulation of IL-10 expression in inflammation and disease, " Immunologic Research, vol. 47, no. 1-3, pp. 185-206, 2010.
22. P. A. Ward and A. B. Lentsch, "Endogenous regulation of the acute inflammatory response, "Molecular and Cellular Biochemistry, vol. 234-235, pp. 225-228, 2002.
23. S. Umesalma and G. Sudhandiran, "Differential inhibitory effects of the polyphenol ellagic acid on inflammatory mediators NF-κB, iNOS, COX-2, TNF-α, and IL-6 in 1, 2-dimethylhydrazine-induced rat colon carcinogenesis, " Basic and Clinical Pharmacology and Toxicology, vol. 107, no. 2, pp. 650-655, 2010.
24. F. Driessler, K. Venstrom, R. Sabat, K. Asadullah, and A. J. Schottelius, "Molecular mechanisms of interleukin-10-mediated inhibition of NF-κB activity: a role for p50, " Clinical and Experimental Immunology, vol. 135, no. 1, pp. 64-73, 2004.
25. M. Seifert, B. H. Gruenberg, R. Sabat et al., "Keratinocyte unresponsiveness towards interleukin-10: lack of specific binding due to deficient IL-10 receptor 1 expression, " Experimental Dermatology, vol. 12, no. 2, pp. 137-144, 2003.