UVB and proinflammatory cytokines synergistically activate TNF-α production in keratinocytes through enhanced gene transcription

Journal of Investigative Dermatology

Volumn 129, Issue 4, 2009, Pages 994-1001

  Bashir, Muhammad M ^a,b   Sharma, Meena R ^a,b   Werth, Victoria P ^a,b  

^a Philadelphia VA Medical Center   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2B INTERFERON; INTERLEUKIN 1ALPHA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; KERATINOCYTE; NEWBORN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SKIN FIBROBLAST; ULTRAVIOLET B RADIATION; UPREGULATION;

CELLS, CULTURED; GENE EXPRESSION REGULATION; HUMANS; INTERFERON-ALPHA; INTERLEUKIN-1ALPHA; KERATINOCYTES; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA; ULTRAVIOLET RAYS;

EID: 63149123561     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2008.332     Document Type: Article

References (52)

1. Ansel J, Perry P, Brown J, Damm D, Phan T, Hart C et al. (1990) Cytokine modulation of keratinocyte cytokines. J Invest Dermatol 94:101S-7S
2. Ashkenazi A, Dixit VM (1998) Death receptors: signaling and modulation. Science 281:1305-8
3. Banno T, Gazel A, Blumenberg M (2004) Effects of tumor necrosis factor-α (TNF α) in epidermal keratinocytes revealed using global transcriptional profiling. J Biol Chem 279:32633-42
4. Bazzoni F, Kruys V, Shakhov A, Jongeneel CV, Beutler B (1994) Analysis of tumor necrosis factor promoter responses to ultraviolet light. J Clin Invest 93:56-62
5. Brink N, Szamel M, Young AR, Wittern KP, Bergemann J (2000) Comparative quantification of IL-1beta, IL-10, IL-10r, TNFα and IL-7 mRNA levels in UV-irradiated human skin in vivo. Inflamm Res 49:290-6
6. Briscoe DM, Cotran RS, Pober JS (1992) Effects of tumor necrosis factor, lipopolysaccharide, and IL-4 on the expression of vascular cell adhesion molecule-1 in vivo. Correlation with CD3+ T cell infiltration. J Immunol 149:2954-60
7. Clingen PH, Berneburg M, Petit-Frere C, Woollons A, Lowe JE, Arlett CF et al. (2001) Contrasting effects of an ultraviolet B and an ultraviolet A tanning lamp on interleukin-6, tumour necrosis factor-α and intercellular adhesion molecule-1 expression. Br J Dermatol 145:54-62
8. Collart MA, Baeuerle P, Vassalli P (1990) Regulation of tumor necrosis factor α transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B. Mol Cell Biol 10:1498-506
9. Devary Y, Rosette C, DiDonato JA, Karin M (1993) NF-kappa B activation by ultraviolet light not dependent on a nuclear signal. Science 261:1442-5
10. Fujisawa H, Wang B, Kondo S, Shivji GM, Sauder DN (1997) Costimulation with ultraviolet B and interleukin-1 α dramatically increase tumor necrosis factor-α production in human dermal fibroblasts. J Interferon Cytokine Res 17:307-13
11. Han J, Huez G, Beutler B (1991) Interactive effects of the tumor necrosis factor promoter and 3′-untranslated regions. J Immunol 146:1843-8
12. Hel Z, Di Marco S, Radzioch D (1998) Characterization of the RNA binding proteins forming complexes with a novel putative regulatory region in the 3′-UTR of TNF-α mRNA. Nucleic Acids Res 26:2803-12
13. Higuchi M, Aggarwal BB (1994) TNF induces internalization of the p60 receptor and shedding of the p80 receptor. J Immunol 152:3550-8
14. Huizinga TW, Brinkman BM, Verweij CL (1996) Regulation of tumor necrosis factor-α production: basic aspects and pharmacological modulation. J Rheumatol 23:416-8
15. Jacob CO, Tashman NB (1993) Disruption in the AU motif of the mouse TNF-α 3′ UTR correlates with reduced TNF production by macrophages in vitro. Nucleic Acids Res 21:2761-6
16. Jongeneel CV (1994) Regulation of the TNF α gene. Prog Clin Biol Res 388:367-81
17. Kameda K, Sato K (1994) Regulation of IL-1 α expression in human keratinocytes: transcriptional activation of the IL-1 α gene by TNF-α, LPS, and IL-1 α. Lymphokine Cytokine Res 13:29-35
18. Kim YU, Rus HG, Fisher SN, Pitha PM, Shin ML (1996) Binding of a protein to an AU-rich domain of tumour necrosis factor α mRNA as a 35 kDa complex and its regulation in primary rat astrocytes. Biochem J 316(Pt 2):455-60
19. Kinkhabwala M, Sehajpal P, Skolnik E, Smith D, Sharma VK, Vlassara H et al. (1990) A novel addition to the T cell repertory. Cell surface expression of tumor necrosis factor/cachectin by activated normal human T cells. J Exp Med 171:941-6
20. Kirnbauer R, Kock A, Neuner P, Forster E, Krutmann J, Urbanski A et al. (1991) Regulation of epidermal cell interleukin-6 production by UV light and corticosteroids. J Invest Dermatol 96:484-9
21. Kock A, Schwarz T, Kirnbauer R, Urbanski A, Perry P, Ansel JC et al. (1990) Human keratinocytes are a source for tumor necrosis factor α: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light. J Exp Med 172:1609-14
22. Kondo S, Kooshesh F, Sauder DN (1997) Penetration of keratinocyte-derived cytokines into basement membrane. J Cell Physiol 171:190-5
23. Kondo S, Sauder DN (1995) Keratinocyte-derived cytokines and UVB-induced immunosuppression. J Dermatol 22:888-93
24. Kondo S, Sauder DN, Kono T, Galley KA, McKenzie RC (1994) Differential modulation of interleukin-1 α (IL-1 α) and interleukin-1 beta (IL-1 beta) in human epidermal keratinocytes by UVB. Exp Dermatol 3:29-39
25. Kontoyiannis D, Pasparakis M, Pizarro TT, Cominelli F, Kollias G (1999) Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 10:387-98
26. Kulbe H, Thompson R, Wilson JL, Robinson S, Hagemann T, Fatah R et al. (2007) The inflammatory cytokine tumor necrosis factor-α generates an autocrine tumor-promoting network in epithelial ovarian cancer cells. Cancer Res 67:585-92
27. Lee SW, Morhenn VB, Ilnicka M, Eugui EM, Allison AC (1991) Autocrine stimulation of interleukin-1 α and transforming growth factor α production in human keratinocytes and its antagonism by glucocorticoids. J Invest Dermatol 97:106-10
28. Leverkus M, Yaar M, Eller MS, Tang EH, Gilchrest BA (1998) Posttranscriptional regulation of UV induced TNF-α expression. J Invest Dermatol 110:353-7
29. Li L, Chaikof EL (2002) Quantitative nuclear run-off transcription assay. Biotechniques 33:1016-7
30. Lieberman AP, Pitha PM, Shin ML (1990) Protein kinase regulates tumor necrosis factor mRNA stability in virus-stimulated astrocytes. J Exp Med 172:989-92
31. Lisby S, Faurschou A, Gniadecki R (2007) The autocrine TNFα signalling loop in keratinocytes requires atypical PKC species and NF-kappaB activation but is independent of cholesterol-enriched membrane microdomains. Biochem Pharmacol 73:526-33
32. Lisby S, Hauser C (2002) Transcriptional regulation of tumor necrosis factor-α in keratinocytes mediated by interleukin-1beta and tumor necrosis factor-α. Exp Dermatol 11:592-8
33. Matsuura K, Otsuka F, Fujisawa H (1998) Effects of interferons on tumour necrosis factor α production from human keratinocytes. Cytokine 10:500-5
34. Piecyk M, Wax S, Beck AR, Kedersha N, Gupta M, Maritim B et al. (2000) TIA-1 is a translational silencer that selectively regulates the expression of TNF-α. EMBO J 19:4154-63
35. Rijken F, Kiekens RC, van den Worm E, Lee PL, van Weelden H, Bruijnzeel PL (2006) Pathophysiology of photoaging of human skin: focus on neutrophils. Photochem Photobiol Sci 5:184-9
36. Robertshaw HJ, Brennan FM (2005) Release of tumour necrosis factor α (TNFα) by TNFα cleaving enzyme (TACE) in response to septic stimuli in vitro. Br J Anaesth 94:222-8
37. Shakhov AN, Collart MA, Vassalli P, Nedospasov SA, Jongeneel CV (1990) Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor α gene in primary macrophages. J Exp Med 171:35-47
38. Simon MM, Aragane Y, Schwarz A, Luger TA, Schwarz T (1994) UVB light induces nuclear factor kappa B (NF kappa B) activity independently from chromosomal DNA damage in cell-free cytosolic extracts. J Invest Dermatol 102:422-7
39. Skiba B, Neill B, Piva TJ (2005) Gene expression profiles of TNF-α, TACE, furin, IL-1beta and matrilysin in UVA- and UVB-irradiated HaCat cells. Photodermatol Photoimmunol Photomed 21:173-82
40. Skov L, Hansen H, Allen M, Villadsen L, Norval M, Barker JN et al. (1998) Contrasting effects of ultraviolet A1 and ultraviolet B exposure on the induction of tumour necrosis factor-α in human skin. Br J Dermatol 138:216-20
41. Spriggs DR, Deutsch S, Kufe DW (1992) Genomic structure, induction, and production of TNF-α. Immunol Ser 56:3-34
42. Strickland I, Rhodes LE, Flanagan BF, Friedmann PS (1997) TNF-α and IL-8 are upregulated in the epidermis of normal human skin after UVB exposure: correlation with neutrophil accumulation and E-selectin expression. J Invest Dermatol 108:763-8
43. Takashima A, Bergstresser PR (1996) Impact of UVB radiation on the epidermal cytokine network. Photochem Photobiol 63:397-400
44. Tseng YH, Schuler LA (1998) Transcriptional regulation of interleukin-1beta gene by interleukin-1beta itself is mediated in part by Oct-1 in thymic stromal cells. J Biol Chem 273:12633-41
45. Ullrich SE (1995) The role of epidermal cytokines in the generation of cutaneous immune reactions and ultraviolet radiation-induced immune suppression. Photochem Photobiol 62:389-401
46. van Hogerlinden M, Rozell BL, Toftgard R, Sundberg JP (2004) Characterization of the progressive skin disease and inflammatory cell infiltrate in mice with inhibited NF-kappaB signaling. J Invest Dermatol 123:101-8
47. Warner SJ, Auger KR, Libby P (1987) Human interleukin 1 induces interleukin 1 gene expression in human vascular smooth muscle cells. J Exp Med 165:1316-31
48. Werth VP, Zhang W (1999) Wavelength-specific synergy between ultraviolet radiation and interleukin-1 a in the regulation of matrix-related genes: mechanistic role for tumor necrosis factor-α. J Invest Dermatol 113:196-201
49. Wu S, Boyer CM, Whitaker RS, Berchuck A, Wiener JR, Weinberg JB et al. (1993) Tumor necrosis factor α as an autocrine and paracrine growth factor for ovarian cancer: monokine induction of tumor cell proliferation and tumor necrosis factor α expression. Cancer Res 53:1939-44
50. Yarosh D, Both D, Kibitel J, Anderson C, Elmets C, Brash D et al. (2000) Regulation of TNFα production and release in human and mouse keratinocytes and mouse skin after UV-B irradiation. Photodermatol Photoimmunol Photomed 16:263-70
51. Yi X, Tesmer VM, Savre-Train I, Shay JW, Wright WE (1999) Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels. Mol Cell Biol 19:3989-97
52. Zhuang L, Wang B, Shinder GA, Shivji GM, Mak TW, Sauder DN (1999) TNF receptor p55 plays a pivotal role in murine keratinocyte apoptosis induced by ultraviolet B irradiation. J Immunol 162:1440-7