-
1
-
-
59849125142
-
SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity
-
Gangemi, R. M., Griffero, F., Marubbi, D., Perera, M., Capra, M. C., Malatesta, P., Ravetti, G. L., Zona, G. L., Daga, A., and Corte, G. (2009) SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity. Stem Cells 27, 40-48
-
(2009)
Stem Cells
, vol.27
, pp. 40-48
-
-
Gangemi, R.M.1
Griffero, F.2
Marubbi, D.3
Perera, M.4
Capra, M.C.5
Malatesta, P.6
Ravetti, G.L.7
Zona, G.L.8
Daga, A.9
Corte, G.10
-
2
-
-
34848866647
-
Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4
-
Todaro, M., Alea, M. P., Di Stefano, A. B., Cammareri, P., Vermeulen, L., Iovino, F., Tripodo, C., Russo, A., Gulotta, G., Medema, J. P., and Stassi, G. (2007) Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. Cell Stem Cell 1, 389-402
-
(2007)
Cell Stem Cell
, vol.1
, pp. 389-402
-
-
Todaro, M.1
Alea, M.P.2
Di Stefano, A.B.3
Cammareri, P.4
Vermeulen, L.5
Iovino, F.6
Tripodo, C.7
Russo, A.8
Gulotta, G.9
Medema, J.P.10
Stassi, G.11
-
3
-
-
79952370202
-
The cancer stem cell: Premises, promises and challenges
-
Clevers, H. (2011) The cancer stem cell: premises, promises and challenges. Nat. Med. 17, 313-319
-
(2011)
Nat. Med.
, vol.17
, pp. 313-319
-
-
Clevers, H.1
-
4
-
-
80755141289
-
Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients
-
de Sousa E Melo, F., Colak, S., Buikhuisen, J., Koster, J., Cameron, K., de Jong, J. H., Tuynman, J. B., Prasetyanti, P. R., Fessler, E., van den Bergh, S. P., Rodermond, H., Dekker, E., van der Loos, C. M., Pals, S. T., van de Vijver, M. J., Versteeg, R., Richel, D. J., Vermeulen, L., and Medema, J. P. (2011) Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients. Cell Stem Cell 9, 476-485
-
(2011)
Cell Stem Cell
, vol.9
, pp. 476-485
-
-
De Sousa, E.1
Melo, F.2
Colak, S.3
Buikhuisen, J.4
Koster, J.5
Cameron, K.6
De Jong, J.H.7
Tuynman, J.B.8
Prasetyanti, P.R.9
Fessler, E.10
Van Den Bergh, S.P.11
Rodermond, H.12
Dekker, E.13
Van Der Loos, C.M.14
Pals, S.T.15
Van De Vijver, M.J.16
Versteeg, R.17
Richel, D.J.18
Vermeulen, L.19
Medema, J.P.20
more..
-
5
-
-
33745052145
-
Achaetescute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia
-
Jubb, A. M., Chalasani, S., Frantz, G. D., Smits, R., Grabsch, H. I., Kavi, V., Maughan, N. J., Hillan, K. J., Quirke, P., and Koeppen, H. (2006) Achaetescute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia. Oncogene 25, 3445-3457
-
(2006)
Oncogene
, vol.25
, pp. 3445-3457
-
-
Jubb, A.M.1
Chalasani, S.2
Frantz, G.D.3
Smits, R.4
Grabsch, H.I.5
Kavi, V.6
Maughan, N.J.7
Hillan, K.J.8
Quirke, P.9
Koeppen, H.10
-
6
-
-
61349150537
-
Transcription factor achaete scute-like 2 controls intestinal stem cell fate
-
van der Flier, L. G., van Gijn, M. E., Hatzis, P., Kujala, P., Haegebarth, A., Stange, D. E., Begthel, H., van den Born, M., Guryev, V., Oving, I., van Es, J. H., Barker, N., Peters, P. J., van de Wetering, M., and Clevers, H. (2009) Transcription factor achaete scute-like 2 controls intestinal stem cell fate. Cell 136, 903-912
-
(2009)
Cell
, vol.136
, pp. 903-912
-
-
Van Der Flier, L.G.1
Van Gijn, M.E.2
Hatzis, P.3
Kujala, P.4
Haegebarth, A.5
Stange, D.E.6
Begthel, H.7
Van Den Born, M.8
Guryev, V.9
Oving, I.10
Van Es, J.H.11
Barker, N.12
Peters, P.J.13
Van De Wetering, M.14
Clevers, H.15
-
7
-
-
80053572391
-
Ascl2 and 11p15.5 amplification in colorectal cancer
-
Jubb, A. M., Hoeflich, K. P., Haverty, P. M., Wang, J., and Koeppen, H. (2011) Ascl2 and 11p15.5 amplification in colorectal cancer. Gut 60, 1606-1607
-
(2011)
Gut
, vol.60
, pp. 1606-1607
-
-
Jubb, A.M.1
Hoeflich, K.P.2
Haverty, P.M.3
Wang, J.4
Koeppen, H.5
-
8
-
-
77956107307
-
Expression of an ASCL2 related stem cell signature and IGF2 in colorectal cancer liver metastases with 11p15.5 gain
-
Stange, D. E., Engel, F., Longerich, T., Koo, B. K., Koch, M., Delhomme, N., Aigner, M., Toedt, G., Schirmacher, P., Lichter, P., Weitz, J., and Radlwimmer, B. (2010) Expression of an ASCL2 related stem cell signature and IGF2 in colorectal cancer liver metastases with 11p15.5 gain. Gut 59, 1236-1244
-
(2010)
Gut
, vol.59
, pp. 1236-1244
-
-
Stange, D.E.1
Engel, F.2
Longerich, T.3
Koo, B.K.4
Koch, M.5
Delhomme, N.6
Aigner, M.7
Toedt, G.8
Schirmacher, P.9
Lichter, P.10
Weitz, J.11
Radlwimmer, B.12
-
9
-
-
63049085576
-
MicroRNAs-The micro steering wheel of tumour metastases
-
Nicoloso, M. S., Spizzo, R., Shimizu, M., Rossi, S., and Calin, G. A. (2009) MicroRNAs-the micro steering wheel of tumour metastases. Nat. Rev. Cancer 9, 293-302
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 293-302
-
-
Nicoloso, M.S.1
Spizzo, R.2
Shimizu, M.3
Rossi, S.4
Calin, G.A.5
-
10
-
-
84870677094
-
Isocitrate dehydrogenase (IDH) mutations promote a reversible ZEB1/microRNA (miR)-200-dependent epithelial-mesenchymal transition (EMT)
-
Grassian, A. R., Lin, F., Barrett, R., Liu, Y., Jiang, W., Korpal, M., Astley, H., Gitterman, D., Henley, T., Howes, R., Levell, J., Korn, J. M., and Pagliarini, R. (2012) Isocitrate dehydrogenase (IDH) mutations promote a reversible ZEB1/microRNA (miR)-200-dependent epithelial-mesenchymal transition (EMT). J. Biol. Chem. 287, 42180-42194
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 42180-42194
-
-
Grassian, A.R.1
Lin, F.2
Barrett, R.3
Liu, Y.4
Jiang, W.5
Korpal, M.6
Astley, H.7
Gitterman, D.8
Henley, T.9
Howes, R.10
Levell, J.11
Korn, J.M.12
Pagliarini, R.13
-
11
-
-
78149234118
-
MiR-21 and miR-31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells
-
Cottonham, C. L., Kaneko, S., and Xu, L. (2010) miR-21 and miR-31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells. J. Biol. Chem. 285, 35293-35302
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 35293-35302
-
-
Cottonham, C.L.1
Kaneko, S.2
Xu, L.3
-
12
-
-
79961168650
-
MiR-155 promotes macroscopic tumor formation yet inhibits tumor dissemination from mammary fat pads to the lung by preventing EMT
-
Xiang, X., Zhuang, X., Ju, S., Zhang, S., Jiang, H., Mu, J., Zhang, L., Miller, D., Grizzle, W., and Zhang, H. G. (2011) miR-155 promotes macroscopic tumor formation yet inhibits tumor dissemination from mammary fat pads to the lung by preventing EMT. Oncogene 30, 3440-3453
-
(2011)
Oncogene
, vol.30
, pp. 3440-3453
-
-
Xiang, X.1
Zhuang, X.2
Ju, S.3
Zhang, S.4
Jiang, H.5
Mu, J.6
Zhang, L.7
Miller, D.8
Grizzle, W.9
Zhang, H.G.10
-
13
-
-
33244463813
-
Complex networks orchestrate epithelial-mesenchymal transitions
-
Thiery, J. P., and Sleeman, J. P. (2006) Complex networks orchestrate epithelial-mesenchymal transitions. Nat. Rev. Mol. Cell Biol. 7, 131-142
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 131-142
-
-
Thiery, J.P.1
Sleeman, J.P.2
-
14
-
-
79952283482
-
P53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs
-
Chang, C. J., Chao, C. H., Xia, W., Yang, J. Y., Xiong, Y., Li, C. W., Yu, W. H., Rehman, S. K., Hsu, J. L., Lee, H. H., Liu, M., Chen, C. T., Yu, D., and Hung, M. C. (2011) p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nat. Cell Biol. 13, 317-323
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 317-323
-
-
Chang, C.J.1
Chao, C.H.2
Xia, W.3
Yang, J.Y.4
Xiong, Y.5
Li, C.W.6
Yu, W.H.7
Rehman, S.K.8
Hsu, J.L.9
Lee, H.H.10
Liu, M.11
Chen, C.T.12
Yu, D.13
Hung, M.C.14
-
15
-
-
84881551103
-
MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis
-
Hur, K., Toiyama, Y., Takahashi, M., Balaguer, F., Nagasaka, T., Koike, J., Hemmi, H., Koi, M., Boland, C. R., and Goel, A. (2013) MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis. Gut 62, 1315-1326
-
(2013)
Gut
, vol.62
, pp. 1315-1326
-
-
Hur, K.1
Toiyama, Y.2
Takahashi, M.3
Balaguer, F.4
Nagasaka, T.5
Koike, J.6
Hemmi, H.7
Koi, M.8
Boland, C.R.9
Goel, A.10
-
16
-
-
84880285292
-
Estrogen receptor beta expression induces changes in the microRNA pool in human colon cancer cells
-
Edvardsson, K., Nguyen-Vu, T., Kalasekar, S. M., Pontén, F., Gustafsson, J. Å., and Williams, C. (2013) Estrogen receptor beta expression induces changes in the microRNA pool in human colon cancer cells. Carcinogenesis 34, 1431-1441
-
(2013)
Carcinogenesis
, vol.34
, pp. 1431-1441
-
-
Edvardsson, K.1
Nguyen-Vu, T.2
Kalasekar, S.M.3
Pontén, F.4
Gustafsson J.Å.5
Williams, C.6
-
17
-
-
84863163710
-
Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells
-
Zhu, R., Yang, Y., Tian, Y., Bai, J., Zhang, X., Li, X., Peng, Z., He, Y., Chen, L., Pan, Q., Fang, D., Chen, W., Qian, C., Bian, X., and Wang, R. (2012) Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells. PLoS One 7, e32170
-
(2012)
PLoS One
, vol.7
, pp. e32170
-
-
Zhu, R.1
Yang, Y.2
Tian, Y.3
Bai, J.4
Zhang, X.5
Li, X.6
Peng, Z.7
He, Y.8
Chen, L.9
Pan, Q.10
Fang, D.11
Chen, W.12
Qian, C.13
Bian, X.14
Wang, R.15
-
18
-
-
54049084380
-
A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelialmesenchymal transition
-
Bracken, C. P., Gregory, P. A., Kolesnikoff, N., Bert, A. G., Wang, J., Shannon, M. F., and Goodall, G. J. (2008) A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelialmesenchymal transition. Cancer Res. 68, 7846-7854
-
(2008)
Cancer Res.
, vol.68
, pp. 7846-7854
-
-
Bracken, C.P.1
Gregory, P.A.2
Kolesnikoff, N.3
Bert, A.G.4
Wang, J.5
Shannon, M.F.6
Goodall, G.J.7
-
19
-
-
84874341083
-
Enhanced membrane-tethered mucin 3 (MUC3) expression by a tetrameric branched peptide with a conserved TFLK motif inhibits bacteria adherence
-
Pan, Q., Tian, Y., Li, X., Ye, J., Liu, Y., Song, L., Yang, Y., Zhu, R., He, Y., Chen, L., Chen, W., Mao, X., Peng, Z., and Wang, R. (2013) Enhanced membrane-tethered mucin 3 (MUC3) expression by a tetrameric branched peptide with a conserved TFLK motif inhibits bacteria adherence. J. Biol. Chem. 288, 5407-5416
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 5407-5416
-
-
Pan, Q.1
Tian, Y.2
Li, X.3
Ye, J.4
Liu, Y.5
Song, L.6
Yang, Y.7
Zhu, R.8
He, Y.9
Chen, L.10
Chen, W.11
Mao, X.12
Peng, Z.13
Wang, R.14
-
20
-
-
0017064628
-
Human colonic adenocarcinoma cells. I. Establishment and description of a new line
-
Tom, B. H., Rutzky, L. P., Jakstys, M. M., Oyasu, R., Kaye, C. I., and Kahan, B. D. (1976) Human colonic adenocarcinoma cells. I. Establishment and description of a new line. In Vitro 12, 180-191
-
(1976)
Vitro
, vol.12
, pp. 180-191
-
-
Tom, B.H.1
Rutzky, L.P.2
Jakstys, M.M.3
Oyasu, R.4
Kaye, C.I.5
Kahan, B.D.6
-
21
-
-
0026539165
-
DNA binding and transcriptional regulatory activity of mammalian achaetescute homologous (MASH) proteins revealed by interaction with a mus-cle-specific enhancer
-
Johnson, J. E., Birren, S. J., Saito, T., and Anderson, D. J. (1992) DNA binding and transcriptional regulatory activity of mammalian achaetescute homologous (MASH) proteins revealed by interaction with a mus-cle-specific enhancer. Proc. Natl. Acad. Sci. U.S.A. 89, 3596-3600
-
(1992)
Proc. Natl. Acad. Sci. U.S.A.
, vol.89
, pp. 3596-3600
-
-
Johnson, J.E.1
Birren, S.J.2
Saito, T.3
Anderson, D.J.4
-
22
-
-
0027941535
-
Essential role of Mash-2 in extraembryonic development
-
Guillemot, F., Nagy, A., Auerbach, A., Rossant, J., and Joyner, A. L. (1994) Essential role of Mash-2 in extraembryonic development. Nature 371, 333-336
-
(1994)
Nature
, vol.371
, pp. 333-336
-
-
Guillemot, F.1
Nagy, A.2
Auerbach, A.3
Rossant, J.4
Joyner, A.L.5
-
23
-
-
84866058761
-
Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice
-
Reed, K. R., Tunster, S. J., Young, M., Carrico, A., John, R. M., and Clarke, A. R. (2012) Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice. Gut 61, 1435-1438
-
(2012)
Gut
, vol.61
, pp. 1435-1438
-
-
Reed, K.R.1
Tunster, S.J.2
Young, M.3
Carrico, A.4
John, R.M.5
Clarke, A.R.6
-
24
-
-
0347444723
-
MicroRNAs: Genomics, biogenesis, mechanism, and function
-
Bartel, D. P. (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297
-
(2004)
Cell
, vol.116
, pp. 281-297
-
-
Bartel, D.P.1
-
25
-
-
47249091921
-
The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2
-
Korpal, M., Lee, E. S., Hu, G., and Kang, Y. (2008) The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J. Biol. Chem. 283, 14910-14914
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 14910-14914
-
-
Korpal, M.1
Lee, E.S.2
Hu, G.3
Kang, Y.4
-
26
-
-
79955954699
-
An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
-
Gregory, P. A., Bracken, C. P., Smith, E., Bert, A. G., Wright, J. A., Roslan, S., Morris, M., Wyatt, L., Farshid, G., Lim, Y. Y., Lindeman, G. J., Shannon, M. F., Drew, P. A., Khew-Goodall, Y., and Goodall, G. J. (2011) An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Mol. Biol. Cell 22, 1686-1698
-
(2011)
Mol. Biol. Cell
, vol.22
, pp. 1686-1698
-
-
Gregory, P.A.1
Bracken, C.P.2
Smith, E.3
Bert, A.G.4
Wright, J.A.5
Roslan, S.6
Morris, M.7
Wyatt, L.8
Farshid, G.9
Lim, Y.Y.10
Lindeman, G.J.11
Shannon, M.F.12
Drew, P.A.13
Khew-Goodall, Y.14
Goodall, G.J.15
-
27
-
-
84871385387
-
ZEB/miR-200 feedback loop: At the crossroads of signal transduction in cancer
-
Hill, L., Browne, G., and Tulchinsky, E. (2013) ZEB/miR-200 feedback loop: at the crossroads of signal transduction in cancer. Int. J. Cancer 132, 745-754
-
(2013)
Int. J. Cancer
, vol.132
, pp. 745-754
-
-
Hill, L.1
Browne, G.2
Tulchinsky, E.3
-
28
-
-
79956143950
-
P53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
-
Kim, T., Veronese, A., Pichiorri, F., Lee, T. J., Jeon, Y. J., Volinia, S., Pineau, P., Marchio, A., Palatini, J., Suh, S. S., Alder, H., Liu, C. G., Dejean, A., and Croce, C. M. (2011) p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2. J. Exp. Med. 208, 875-883
-
(2011)
J. Exp. Med.
, vol.208
, pp. 875-883
-
-
Kim, T.1
Veronese, A.2
Pichiorri, F.3
Lee, T.J.4
Jeon, Y.J.5
Volinia, S.6
Pineau, P.7
Marchio, A.8
Palatini, J.9
Suh, S.S.10
Alder, H.11
Liu, C.G.12
Dejean, A.13
Croce, C.M.14
-
29
-
-
79952748822
-
DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism
-
Sureban, S. M., May, R., Lightfoot, S. A., Hoskins, A. B., Lerner, M., Brackett, D. J., Postier, R. G., Ramanujam, R., Mohammed, A., Rao, C. V., Wyche, J. H., Anant, S., and Houchen, C. W. (2011) DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism. Cancer Res. 71, 2328-2338
-
(2011)
Cancer Res.
, vol.71
, pp. 2328-2338
-
-
Sureban, S.M.1
May, R.2
Lightfoot, S.A.3
Hoskins, A.B.4
Lerner, M.5
Brackett, D.J.6
Postier, R.G.7
Ramanujam, R.8
Mohammed, A.9
Rao, C.V.10
Wyche, J.H.11
Anant, S.12
Houchen, C.W.13
-
30
-
-
84878768150
-
In situ validation of an intestinal stem cell signature in colorectal cancer
-
Ziskin, J. L., Dunlap, D., Yaylaoglu, M., Fodor, I. K., Forrest, W. F., Patel, R., Ge, N., Hutchins, G. G., Pine, J. K., Quirke, P., Koeppen, H., and Jubb, A. M. (2013) In situ validation of an intestinal stem cell signature in colorectal cancer. Gut 62, 1012-1023
-
(2013)
Gut
, vol.62
, pp. 1012-1023
-
-
Ziskin, J.L.1
Dunlap, D.2
Yaylaoglu, M.3
Fodor, I.K.4
Forrest, W.F.5
Patel, R.6
Ge, N.7
Hutchins, G.G.8
Pine, J.K.9
Quirke, P.10
Koeppen, H.11
Jubb, A.M.12
-
31
-
-
84862703901
-
Smad3 regulates E-cadherin via miRNA-200 pathway
-
Ahn, S. M., Cha, J. Y., Kim, J., Kim, D., Trang, H. T., Kim, Y. M., Cho, Y. H., Park, D., and Hong, S. (2012) Smad3 regulates E-cadherin via miRNA-200 pathway. Oncogene 31, 3051-3059
-
(2012)
Oncogene
, vol.31
, pp. 3051-3059
-
-
Ahn, S.M.1
Cha, J.Y.2
Kim, J.3
Kim, D.4
Trang, H.T.5
Kim, Y.M.6
Cho, Y.H.7
Park, D.8
Hong, S.9
-
32
-
-
84904265560
-
Significance of PELP1/HDAC2/miR-200 regulatory network in EMT and metastasis of breast cancer
-
Roy, S. S., Gonugunta, V. K., Bandyopadhyay, A., Rao, M. K., Goodall, G. J., Sun, L. Z., Tekmal, R. R., and Vadlamudi, R. K. (2014) Significance of PELP1/HDAC2/miR-200 regulatory network in EMT and metastasis of breast cancer. Oncogene 33, 3707-3716
-
(2014)
Oncogene
, vol.33
, pp. 3707-3716
-
-
Roy, S.S.1
Gonugunta, V.K.2
Bandyopadhyay, A.3
Rao, M.K.4
Goodall, G.J.5
Sun, L.Z.6
Tekmal, R.R.7
Vadlamudi, R.K.8
-
33
-
-
84891929773
-
WASF3 regulates miR-200 inactivation by ZEB1 through suppression of KISS1 leading to increased invasiveness in breast cancer cells
-
Teng, Y., Mei, Y., Hawthorn, L., and Cowell, J. K. (2014) WASF3 regulates miR-200 inactivation by ZEB1 through suppression of KISS1 leading to increased invasiveness in breast cancer cells. Oncogene 33, 203-211
-
(2014)
Oncogene
, vol.33
, pp. 203-211
-
-
Teng, Y.1
Mei, Y.2
Hawthorn, L.3
Cowell, J.K.4
|