Oligosaccharide composition of breast milk influences survival of uninfected children born to HIV-infected mothers in Lusaka, Zambia

Journal of Nutrition

Volumn 145, Issue 1, 2015, Pages 66-72

  Kuhn, Louise ^a   Kim, Hae Young ^a   Hsiao, Lauren ^b   Nissan, Caroline ^b   Kankasa, Chipepo ^c   Mwiya, Mwiya ^c   Thea, Donald M ^d   Aldrovandi, Grace M ^e   Bode, Lars ^b  

^a Department of Epidemiology   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY TEACHING HOSPITAL   (Zambia)

^d BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Breastfeeding; Child survival; HIV exposed uninfected; Human milk oligosaccharides; Mother to child HIV transmission

Indexed keywords

2' FUCOSYLLACTOSE; 3 FUCOSYLLACTOSE; LACTO N FUCOPENTAOSE; OLIGOSACCHARIDE; UNCLASSIFIED DRUG; 2'-FUCOSYLLACTOSE; 3'-FUCOSYLLACTOSE; IMMUNOLOGIC FACTOR; LACTO-N-FUCOPENTAOSE I; LACTO-N-FUCOPENTAOSE II; PREBIOTIC AGENT; TRISACCHARIDE;

ADULT; ARTICLE; BREAST FEEDING; BREAST MILK; CHILD; CHILDHOOD MORTALITY; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; FOOD COMPOSITION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; SURVIVAL TIME; SURVIVOR; WEANING; ZAMBIA; ANIMAL; CHEMISTRY; HIV INFECTIONS; INFANT; INFANT MORTALITY; MILK; MORTALITY; NEWBORN; PREGNANCY; PREGNANCY COMPLICATION; TRANSMISSION; VERTICAL TRANSMISSION;

ADULT; ANIMALS; BREAST FEEDING; COHORT STUDIES; FEMALE; HIV INFECTIONS; HUMANS; IMMUNOLOGIC FACTORS; INFANT; INFANT MORTALITY; INFANT, NEWBORN; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; MALE; MILK; MILK, HUMAN; OLIGOSACCHARIDES; PREBIOTICS; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; TRISACCHARIDES; ZAMBIA;

EID: 84919772203     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.114.199794     Document Type: Article

References (30)

1. Kourtis AP, Lee FK, Abrams EJ, Jamieson DJ, Bulterys M. Mother-tochild transmission of HIV-1: timing and implications for prevention. Lancet Infect Dis 2006;6:726-32.
2. Fox MP, Brooks D, Kuhn L, Aldrovandi G, Sinkala M, Kankasa C, Mwiya M, Horsburgh R, Thea DM. Reduced mortality associated with breast-feeding-acquired HIV infection and breast-feeding among HIVinfected children in Zambia. J Acquir Immune Defic Syndr 2008;48:90-6.
3. Becquet R, Marston M, Dabis F, Moulton LH, Gray G, Coovadia HM, Essex M, Ekouevi DK, Jackson D, Coutsoudis A, et al. Children who acquire HIV infection perinatally are at higher risk of early death than those acquiring infection through breastmilk: a meta-analysis. PLoS ONE 2012;7:e28510.
4. Marinda E, Humphrey JH, Iliff PJ, Mutasa K, Nathoo KJ, Piwoz EG, Moulton LH, Salama P, Ward BJ. Child mortality according to maternal and infant HIV status in Zimbabwe. Pediatr Infect Dis J 2007;26:519-26.
5. Filteau S. The HIV-exposed, uninfected African child. Trop Med Int Health 2009;14:276-87.
6. Kuhn L, Kasonde P, Sinkala M, Kankasa C, Semrau K, Scott N, Tsai WY, Vermund SH, Aldrovandi GM, Thea DM. Does severity of HIV disease in HIV-infected mothers affect mortality and morbidity among their uninfected infants? Clin Infect Dis 2005;41:1654-61.
7. Newell ML, Coovadia H, Cortina-Borja M, Rollins N, Gaillard P, Dabis F. Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis. Lancet 2004;364:1236-43.
8. Kuhn L, Sinkala M, Semrau K, Kankasa C, Kasonde P, Mwiya M, Hu CC, Tsai WY, Thea DM, Aldrovandi GM. Elevations in mortality associated with weaning persist into the second year of life among uninfected children born to HIV-infected mothers. Clin Infect Dis 2010;50:437-44.
9. Coutsoudis A, Coovadia HM, Wilfert CM. HIV, infant feeding and more perils for poor people: new WHO guidelines encourage review of formula milk policies. Bull World Health Organ 2008;86:210-4.
10. Bode L. Human milk oligosaccharides: every baby needs a sugar mama. Glycobiology 2012;22:1147-62.
11. Bode L, Kuhn L, Kim HY, Hsiao L, Nissan C, Sinkala M, Kankasa C, Mwiya M, Thea DM, Aldrovandi GM. Human milk oligosaccharide concentration and risk of postnatal transmission of HIV through breastfeeding. Am J Clin Nutr 2012;96:831-9.
12. Kuhn L, Aldrovandi GM, Sinkala M, Kankasa C, Semrau K, Mwiya M, Kasonde P, Scott N, Vwalika C, Walter J, et al. Effects of early, abrupt weaning on HIV-free survival of children in Zambia. N Engl J Med 2008;359:130-41.
13. Jantscher-Krenn E, Zherebtsov M, Nissan C, Goth K, Guner YS, Naidu N, Choudhury B, Grishin AV, Ford HR, Bode L. The human milk oligosaccharide disialyllacto-N-tetraose prevents necrotising enterocolitis in neonatal rats. Gut 2012;61:1417-25.
14. Jantscher-Krenn E, Lauwaet T, Bliss LA, Reed SL, Gillin FD, Bode L. Human milk oligosaccharides reduce Entamoeba histolytica attachment and cytotoxicity in vitro. Br J Nutr 2012;108:1839-46.
15. Kunz C. Historical aspects of human milk oligosaccharides. Adv Nutr 2012;3(Suppl):430S-9S.
16. Zivkovic AM, German JB, Lebrilla CB, Mills DA. Human milk glycobiome and its impact on the infant gastrointestinal microbiota. Proc Natl Acad Sci USA 2011;108(Suppl 1):4653-8.
17. Newburg DS. Glycobiology of human milk. Biochemistry (Mosc) 2013;78:771-85.
18. Morrow AL, Ruiz-Palacios GM, Altaye M, Jiang X, Guerrero ML, Meinzen-Derr JK, Farkas T, Chaturvedi P, Pickering LK, Newburg DS. Human milk oligosaccharides are associated with protection against diarrhea in breast-fed infants. J Pediatr 2004;145:297-303.
19. Newburg DS, Ruiz-Palacios GM, Altaye M, Chaturvedi P, Meinzen-Derr J, Guerrero Mde L, Morrow AL. Innate protection conferred by fucosylated oligosaccharides of human milk against diarrhea in breastfed infants. Glycobiology 2004;14:253-63.
20. Magne F, Hachelaf W, Suau A, Boudraa G, Mangin I, Touhami M, Bouziane-Nedjadi K, Pochart P. A longitudinal study of infant faecal microbiota during weaning. FEMS Microbiol Ecol 2006;58:563-71.
21. Bode L, Kunz C, Muhly-Reinholz M, Mayer K, Seeger W, Rudloff S. Inhibition of monocyte, lymphocyte, and neutrophil adhesion to endothelial cells by human milk oligosaccharides. Thromb Haemost 2004;92:1402-10.
22. Bode L, Rudloff S, Kunz C, Strobel S, Klein N. Human milk oligosaccharides reduce platelet-neutrophil complex formation leading to a decrease in neutrophil beta 2 integrin expression. J Leukoc Biol 2004;76:820-6.
23. Tozzi AE, Pezzotti P, Greco D. Does breast-feeding delay progression to AIDS in HIV-infected children? AIDS 1990;4:1293-4.
24. Taha TE, Kumwenda NI, Hoover DR, Kafulafula G, Fiscus SA, Nkhoma C, Chen S, Broadhead RL. The impact of breastfeeding on the health of HIV-positive mothers and their children in sub-Saharan Africa. Bull World Health Organ 2006;84:546-54.
25. Smilowitz JT, O'Sullivan A, Barile D, German JB, Lonnerdal B, Slupsky CM. The human milk metabolome reveals diverse oligosaccharide profiles. J Nutr 2013;143:1709-18.
26. De Leoz ML, Gaerlan SC, Strum JS, Dimapasoc LM, Mirmiran M, Tancredi DJ, Smilowitz JT, Kalanetra KM, Mills DA, German JB, et al. Lacto-N-tetraose, fucosylation, and secretor status are highly variable in human milk oligosaccharides from women delivering preterm. J Proteome Res 2012;11:4662-72.
27. Kuhn L, Thea DM, Aldrovandi GM. Bystander effects: children who escape infection but not harm. J Acquir Immune Defic Syndr 2007;46:517-8.
28. Abrams EJ, Myer L. Can we achieve an AIDS-free generation? Perspectives on the global campaign to eliminate new pediatric HIV infections. J Acquir Immune Defic Syndr 2013;63(Suppl 2): S208-12.
29. Arslanoglu S, Moro GE, Schmitt J, Tandoi L, Rizzardi S, Boehm G. Early dietary intervention with a mixture of prebiotic oligosaccharides reduces the incidence of allergic manifestations and infections during the first two years of life. J Nutr 2008;138:1091-5.
30. Deshpande GC, Rao SC, Keil AD, Patole SK. Evidence-based guidelines for use of probiotics in preterm neonates. BMC Med 2011;9:92.