Ophiopogonin D attenuates doxorubicin-induced autophagic cell death by relieving mitochondrial damage in vitro and in vivo

Journal of Pharmacology and Experimental Therapeutics

Volumn 352, Issue 1, 2015, Pages 166-174

  Zhang, Ying Yu ^a,b   Meng, Chen ^a   Zhang, Xin Mu ^c   Yuan, Cai Hua ^a   Wen, Ming Da ^a   Chen, Zhong ^a   Dong, Da Chuan ^a   Gao, Yan Hong ^a   Liu, Chang ^a   Zhang, Zhao ^a  

^a NANJING NORMAL UNIVERSITY   (China)

^b Changchun Medical College   (China)

^c JILIN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLADENINE; CARDIOVASCULAR AGENT; DOXORUBICIN; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN LIGHT CHAIN 3 I; MICROTUBULE ASSOCIATED PROTEIN LIGHT CHAIN 3 II; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; OPHIOPOGONIN D; PLANT GLYCOSIDE; PROTEIN P62; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; MITOGEN ACTIVATED PROTEIN KINASE; SAPONIN; SPIROSTAN DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; AUTOPHAGY; CELL PROTECTION; DRUG CYTOTOXICITY; DRUG STRUCTURE; HEART DISEASE; HEART MUSCLE CELL; HEART PROTECTION; IN VITRO STUDY; IN VIVO STUDY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; RAT; ANIMAL; CYTOLOGY; DOWN REGULATION; DRUG EFFECTS; ENZYME ACTIVATION; METABOLISM; MITOCHONDRION;

ANIMALS; AUTOPHAGY; CYTOPROTECTION; DOWN-REGULATION; DOXORUBICIN; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; MYOCYTES, CARDIAC; RATS; REACTIVE OXYGEN SPECIES; SAPONINS; SPIROSTANS;

EID: 84919761011     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.114.219261     Document Type: Article

References (34)

1. Chen K, Xu X, Kobayashi S, Timm D, Jepperson T, and Liang Q (2011) Caloric restriction mimetic 2-deoxyglucose antagonizes doxorubicin-induced cardiomyocyte death by multiple mechanisms. J Biol Chem 286:21993-22006.
2. Chen M, Yang ZW, Zhu JT, Xiao ZY, and Xiao R (1990) [Anti-arrhythmic effects and electrophysiological properties of Ophiopogon total saponins]. Zhongguo Yao Li Xue Bao 11:161-165.
3. Chen X, Tang J, Xie W, Wang J, Jin J, Ren J, Jin L, and Lu J (2013) Protective effect of the polysaccharide from Ophiopogon japonicus on streptozotocin-induced diabetic rats. Carbohydr Polym 94:378-385.
4. Cortés-Funes H and Coronado C (2007) Role of anthracyclines in the era of targeted therapy. Cardiovasc Toxicol 7:56-60.
5. Davies KJ and Doroshow JH (1986) Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase. J Biol Chem 261:3060-3067.
6. Guo RM, Xu WM, Lin JC, Mo LQ, Hua XX, Chen PX, Wu K, Zheng DD, and Feng JQ (2013) Activation of the p38 MAPK/NF-kB pathway contributes to doxorubicininduced inflammation and cytotoxicity in H9c2 cardiac cells. Mol Med Rep 8: 603-608.
7. Huang J, Lam GY, and Brumell JH (2011) Autophagy signaling through reactive oxygen species. Antioxid Redox Signal 14:2215-2231.
8. Ichikawa H, Wang X, and Konishi T (2003) Role of component herbs in antioxidant activity of shengmai san-a traditional Chinese medicine formula preventing cerebral oxidative damage in rat. Am J Chin Med 31:509-521.
9. Kanamori H, Takemura G, Goto K, Maruyama R, Tsujimoto A, Ogino A, Takeyama T, Kawaguchi T, Watanabe T, and Fujiwara T, et al. (2011) The role of autophagy emerging in postinfarction cardiac remodelling. Cardiovasc Res 91:330-339.
10. Kobayashi S, Volden P, Timm D, Mao K, Xu X, and Liang Q (2010) Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death. J Biol Chem 285:793-804.
11. Kou J, Tian Y, Tang Y, Yan J, and Yu B (2006) Antithrombotic activities of aqueous extract from Radix Ophiopogon japonicus and its two constituents. Biol Pharm Bull 29:1267-1270.
12. Lebrecht D and Walker UA (2007) Role of mtDNA lesions in anthracycline cardiotoxicity. Cardiovasc Toxicol 7:108-113.
13. Li S, Wang W, Niu T, Wang H, Li B, Shao L, Lai Y, Li H, Janicki JS, and Wang XL, et al. (2014) Nrf2 deficiency exaggerates doxorubicin-induced cardiotoxicity and cardiac dysfunction. Oxid Med Cell Longev 2014:748524.
14. Liu J, Mao W, Ding B, and Liang CS (2008) ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes. Am J Physiol Heart Circ Physiol 295:H1956-H1965.
15. Lou H, Danelisen I, and Singal PK (2005) Involvement of mitogen-activated protein kinases in adriamycin-induced cardiomyopathy. Am J Physiol Heart Circ Physiol 288:H1925-H1930.
16. Lu L, Wu W, Yan J, Li X, Yu H, and Yu X (2009) Adriamycin-induced autophagic cardiomyocyte death plays a pathogenic role in a rat model of heart failure. Int J Cardiol 134:82-90.
17. Matsui Y, Kyoi S, Takagi H, Hsu CP, Hariharan N, Ago T, Vatner SF, and Sadoshima J (2008) Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion. Autophagy 4:409-415.
18. Minotti G, Menna P, Salvatorelli E, Cairo G, and Gianni L (2004) Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 56:185-229.
19. Nakai A, Yamaguchi O, Takeda T, Higuchi Y, Hikoso S, Taniike M, Omiya S, Mizote I, Matsumura Y, and Asahi M, et al. (2007) The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med 13:619-624.
20. Neilan TG, Blake SL, Ichinose F, Raher MJ, Buys ES, Jassal DS, Furutani E, Perez-Sanz TM, Graveline A, and Janssens SP, et al. (2007) Disruption of nitric oxide synthase 3 protects against the cardiac injury, dysfunction, and mortality induced by doxorubicin. Circulation 116:506-514.
21. Nishida K, Kyoi S, Yamaguchi O, Sadoshima J, and Otsu K (2009) The role of autophagy in the heart. Cell Death Differ 16:31-38.
22. Qian J, Jiang F, Wang B, Yu Y, Zhang X, Yin Z, and Liu C (2010) Ophiopogonin D prevents H2O2-induced injury in primary human umbilical vein endothelial cells. J Ethnopharmacol 128:438-445.
23. Scott JM, Khakoo A, Mackey JR, Haykowsky MJ, Douglas PS, and Jones LW (2011) Modulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: current evidence and underlying mechanisms. Circulation 124:642-650.
24. Silber JH and Barber G (1995) Doxorubicin-induced cardiotoxicity. N Engl J Med 333:1359-1360.
25. Spallarossa P, Altieri P, Garibaldi S, Ghigliotti G, Barisione C, Manca V, Fabbi P, Ballestrero A, Brunelli C, and Barsotti A (2006) Matrix metalloproteinase-2 and -9 are induced differently by doxorubicin in H9c2 cells: The role of MAP kinases and NAD(P)H oxidase. Cardiovasc Res 69:736-745.
26. Stěrba M, Popelová O, Vávrová A, Jirkovský E, Kovaříková P, Geršl V, and Simunek T (2013) Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection. Antioxid Redox Signal 18:899-929.
27. Takemura G and Fujiwara H (2007) Doxorubicin-induced cardiomyopathy from the cardiotoxic mechanisms to management. Prog Cardiovasc Dis 49:330-352.
28. Tokarska-Schlattner M, Zaugg M, Zuppinger C, Wallimann T, and Schlattner U (2006) New insights into doxorubicin-induced cardiotoxicity: the critical role of cellular energetics. J Mol Cell Cardiol 41:389-405.
29. Vásquez-Vivar J, Martasek P, Hogg N, Masters BS, Pritchard KA, Jr, and Kalyanaraman B (1997) Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin. Biochemistry 36:11293-11297.
30. Wallace KB (2007) Adriamycin-induced interference with cardiac mitochondrial calcium homeostasis. Cardiovasc Toxicol 7:101-107.
31. Wang XY, Yang CT, Zheng DD, Mo LQ, Lan AP, Yang ZL, Hu F, Chen PX, Liao XX, and Feng JQ (2012) Hydrogen sulfide protects H9c2 cells against doxorubicin-induced cardiotoxicity through inhibition of endoplasmic reticulum stress. Mol Cell Biochem 363:419-426.
32. Xu X, Chen K, Kobayashi S, Timm D, and Liang Q (2012) Resveratrol attenuates doxorubicin-induced cardiomyocyte death via inhibition of p70 S6 kinase 1-mediated autophagy. J Pharmacol Exp Ther 341:183-195.
33. Yuan H, Perry CN, Huang C, Iwai-Kanai E, Carreira RS, Glembotski CC, and Gottlieb RA (2009) LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection. Am J Physiol Heart Circ Physiol 296:H470-H479.
34. Zhang YW, Shi J, Li YJ, and Wei L (2009) Cardiomyocyte death in doxorubicininduced cardiotoxicity. Arch Immunol Ther Exp (Warsz) 57:435-445.