Epigenetic modification of MiR-429 promotes liver tumour-initiating cell properties by targeting Rb binding protein 4

Gut

Volumn 64, Issue 1, 2015, Pages 156-167

  Li, Liang ^a,b   Tang, Jing ^a,b   Zhang, Baohua ^a   Yang, Wen ^a,b   LiuGao, Miyang ^a,b   Wang, Ruoyu ^a   Tan, Yexiong ^a,b   Fan, Jianling ^a,c   Chang, Yanxin ^a   Fu, Jing ^a,b   Jiang, Feng ^a   Chen, Caiyang ^a   Yang, Yingcheng ^a,b   Gu, Jin ^d   Wu, Dingming ^d   Guo, Linna ^a,b   Cao, Dan ^a,b   Li, Hengyu ^a   Cao, Guangwen ^a   Wu, Mengchao ^a   Zhang, Michael Q ^d   Chen, Lei ^a,b   Wang, Hongyang ^a,b,e   more..

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b National Scientific Centre for Liver Cancer   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

^d TSINGHUA UNIVERSITY   (China)

^e SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTAGOMIR; BINDING PROTEIN; CISPLATIN; EPITHELIAL CELL ADHESION MOLECULE; MICRORNA; MICRORNA 200A; MICRORNA 200B; MICRORNA 429; NUCLEAR PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; PHOSPHOPROTEIN; RB BINDING PROTEIN 4; RB1 PROTEIN; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG; MIRN429 MICRORNA, HUMAN; RETINOBLASTOMA PROTEIN;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER PROGNOSIS; CARCINOGENICITY; CELL ISOLATION; CELL PROLIFERATION; CELL RENEWAL; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DRUG RESISTANCE; EPIGENETICS; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIVER CELL; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PROTEIN PROTEIN INTERACTION; TUMOR CELL; TUMOR INITIATING CELL; UPREGULATION; CANCER STEM CELL; GENETIC EPIGENESIS; GENETICS; LIVER TUMOR; PATHOLOGY; PHYSIOLOGY; PROGNOSIS; TUMOR CELL CULTURE;

CARCINOMA, HEPATOCELLULAR; EPIGENESIS, GENETIC; HUMANS; LIVER NEOPLASMS; MICRORNAS; NEOPLASTIC STEM CELLS; PROGNOSIS; RETINOBLASTOMA PROTEIN; TUMOR CELLS, CULTURED;

EID: 84919733857     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2013-305715     Document Type: Article

References (41)

1. Lapidot T, Sirard C, Vormoor J, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994; 367: 645-8.
2. O'Brien CA, Pollett A, Gallinger S, et al. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007; 445: 106-10.
3. Al-Hajj M. Cancer stem cells and oncology therapeutics. Curr Opin Oncol 2007; 19: 61-4.
4. Collins AT, Berry PA, Hyde C, et al. Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res 2005; 65: 10946-51.
5. Hermann PC, Huber SL, Herrler T, et al. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 2007; 1: 313-23.
6. Al-Hajj M, Becker MW, Wicha M, et al. Therapeutic implications of cancer stem cells. Curr Opin Genet Dev 2004; 14: 43-7.
7. Jordan CT Targeting the most critical cells: approaching leukemia therapy as a problem in stem cell biology. Nat Clin Pract Oncol 2005; 2: 224-5.
8. Ma S, Chan KW, Hu L, et al. Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology 2007; 132: 2542-56.
9. Yang ZF, Ho DW, Ng MN, et al. Significance of CD90+ cancer stem cells in human liver cancer. Cancer Cell 2008; 13: 153-66.
10. Yamashita T, Ji J, Budhu A, et al. EPCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology 2009; 136: 1012-24.
11. Lee TK, Castilho A, Cheung VC, et al. CD24(+) liver tumor-initiating cells drive self-renewal and tumor initiation through STAT3-mediated NANOG regulation. Cell Stem Cell 2011; 9: 50-63.
12. DeSano JT, Xu L. MicroRNA regulation of cancer stem cells and therapeutic implications. AAPS J 2009; 11: 682-92.
13. Esquela-Kerscher A, Slack FJ. Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer 2006; 6: 259-69.
14. Wienholds E, Kloosterman WP, Miska E, et al. MicroRNA expression in zebrafish embryonic development. Science 2005; 309: 310-11.
15. Sun T, Wang C, Xing J, et al. miR-429 modulates the expression of c-myc in human gastric carcinoma cells. Eur J Cancer 2011; 47: 2552-9.
16. Bockmeyer CL, Christgen M, Müller M, et al. MicroRNA profiles of healthy basal and luminal mammary epithelial cells are distinct and reflected in different breast cancer subtypes. Breast Cancer Res Treat 2011; 130: 735-45.
17. Chen J, Wang L, Matyunina LV, et al. Over-expression of miR-429 induces mesenchymal-to-epithelial transition (MET) in metastatic ovarian cancer cells. Gynecol Oncol 2011; 121: 200-5.
18. Hu X, Macdonald DM, Huettner PC, et al. A miR-200 microRNA cluster as prognostic marker in advanced ovarian cancer. Gynecol Oncol 2009; 114: 457-64.
19. Li J, Du L, Yang Y, et al. MiR-429 is an independent prognostic factor in colorectal cancer and exerts its anti-apoptotic function by targeting SOX2. Cancer Lett 2013; 329: 84-90.
20. Xie P, Xu F, Cheng W, et al. Infiltration related miRNAs in bladder urothelial carcinoma. J Huazhong Univ Sci Technolog Med Sci 2012; 32: 576-80.
21. Snowdon J, Zhang X, Childs T, et al. The microRNA-200 family is upregulated in endometrial carcinoma. PLoS ONE 2011; 6:e22828.
22. Mees ST, Mardin WA, Wendel C, et al. EP300 - a miRNA-regulated metastasis suppressor gene in ductal adenocarcinomas of the pancreas. Int J Cancer 2010; 126: 114-24.
23. Nissan X, Denis JA, Saidani M, et al. miR-203 modulates epithelial differentiation of human embryonic stem cells towards epidermal stratification. Dev Biol 2011; 356: 506-15.
24. Jung DE, Wen J, Oh T, et al. Differentially expressed microRNAs in pancreatic cancer stem cells. Pancreas 2011; 40: 1180-7.
25. Jordan CT, Guzman ML, Noble M. Cancer stem cells. N Engl J Med 2006; 355: 1253-61.
26. Haraguchi N, Ishii H, Mimori K, et al. CD13 is a therapeutic target in human liver cancer stem cells. J Clin Invest 2010; 120: 3326-39.
27. Qian YW, Wang YC, Hollingsworth RE Jr, et al. A retinoblastoma-binding protein related to a negative regulator of Ras in yeast. Nature 1993; 364: 648-52.
28. O'Connor MD, Wederell E, Robertson G, et al. Retinoblastoma-binding proteins 4 and 9 are important for human pluripotent stem cell maintenance. Exp Hematol 2011; 39: 866-79.e1.
29. Bonuccelli L, Rossi L, Lena A, et al. An RbAp48-like gene regulates adult stem cells in planarians. J Cell Sci 2010; 123(Pt 5): 690-8.
30. Nicolas E, Morales V, Magnaghi-Jaulin L, et al. RbAp48 belongs to the histone deacetylase complex that associates with the retinoblastoma protein. J Biol Chem 2000; 275: 9797-804.
31. Nicolas E, Ait-Si-Ali S, Trouche D. The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein. Nucleic Acids Res 2001; 29: 3131-6.
32. Yeo Hock Chuan, Beh Thian Thian, Quek Jovina Jia Ling, et al. Integrated transcriptome and binding sites analysis implicates E2F in the regulation of self-renewal in human pluripotent stem cells. PLoS ONE 2011; 6:e27231.
33. Chen Xi, Xu Han, Yuan Ping, et al. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 2008; 133: 1106-17.
34. Nichols J, Zevnik B, Anastassiadis K, et al. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor OCT4. Cell 1998; 95: 379-91.
35. Wang XQ, Ongkeko WM, Chen L, et al. Octamer 4 (OCT4) mediates chemotherapeutic drug resistance in liver cancer cells through a potential OCT4-AKT-ATP-binding cassette G2 pathway. Hepatology 2010; 52: 528-39.
36. Knouf EC, Garg K, Arroyo JD, et al. An integrative genomic approach identifies p73 and p63 as activators of miR-200 microRNA family transcription. Nucleic Acids Res 2012; 40: 499-510.
37. Li A, Omura N, Hong S-M, et al. Epigenetic silencing of transcription factor SIP1 in pancreatic cancer cells is associated with elevated expression and blood plasma levels of miRNAs miR-200a, b. Cancer Res 2010; 70: 5226-37.
38. Baskerville S, Bartel DP. Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA 2005; 11: 241-7.
39. Skog J, Würdinger T, van Rijn S, et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 2008; 10: 1470-6.
40. Zhang Y, Liu D, Chen X, et al. Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell 2010; 39: 133-44.
41. Wang G, Guo X, Hong W, et al. Critical regulation of miR-200/ZEB2 pathway in OCT4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation. Proc Natl Acad Sci 2013; 110: 2858-63.