Phage display - Mediated discovery of novel tyrosinase-targeting tetrapeptide inhibitors reveals the significance of N-terminal preference of cysteine residues and their functional sulfur atom

Molecular Pharmacology

Volumn 87, Issue 2, 2015, Pages 218-230

  Lee, Yu Ching ^a   Hsiao, Nai Wan ^c   Tseng, Tien Sheng ^c,d   Chen, Wang Chuan ^e,f   Lin, Hui Hsiung ^c,d   Leu, Sy Jye ^b   Yang, Ei Wen ^g   Tsai, Keng Chang ^d  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL CHANGHUA UNIVERSITY OF EDUCATION   (Taiwan)

^d NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^e I SHOU UNIVERSITY   (Taiwan)

^f E DA HOSPITAL   (Taiwan)

^g University of California Riverside   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARBUTIN; CYSTEINE; CYSTEINYLARGINYLVALYLISOLEUCINE; ENZYME INHIBITOR; FUNCTIONAL GROUP; FUNGAL ENZYME; KOJIC ACID; MONOPHENOL MONOOXYGENASE; SULFUR; TETRAPEPTIDE; TYROSINASE INHIBITOR; UNCLASSIFIED DRUG; OLIGOPEPTIDE; PEPTIDE LIBRARY; PROTEIN BINDING;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG DEVELOPMENT; DRUG POTENCY; DRUG SCREENING; DRUG TARGETING; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; IC50; MOLECULAR DOCKING; MOLECULAR MODEL; MUSHROOM; NONHUMAN; PEPTIDE LIBRARY; PHAGE DISPLAY; STRUCTURE ACTIVITY RELATION; AGARICALES; ANTAGONISTS AND INHIBITORS; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

AGARICALES; BASE SEQUENCE; CYSTEINE; ENZYME INHIBITORS; MOLECULAR SEQUENCE DATA; MONOPHENOL MONOOXYGENASE; OLIGOPEPTIDES; PEPTIDE LIBRARY; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SULFUR;

EID: 84919724824     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.114.094185     Document Type: Article

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