Common variants in CYP2R1 and GC genes are both determinants of serum 25-hydroxyvitamin D concentrations after UVB irradiation and after consumption of vitamin D3-fortified bread and milk during winter in Denmark

American Journal of Clinical Nutrition

Volumn 101, Issue 1, 2015, Pages 218-227

  Nissen, Janna ^a   Vogel, Ulla ^b   Ravn Haren, Gitte ^a   Andersen, Elisabeth W ^a   Madsen, Katja H ^a   Nexo, Bjorn A ^c   Andersen, Rikke ^a   Mejborn, Heddie ^a   Bjerrum, Poul J ^d   Rasmussen, Lone B ^a   Wulf, Hans Christian ^e  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b NATIONAL RESEARCH CENTRE FOR THE WORKING ENVIRONMENT   (Denmark)

^c AARHUS UNIVERSITY   (Denmark)

^d HOLBÆK HOSPITAL   (Denmark)

^e Mental Health Center Glostrup   (Denmark)

Author keywords

25 hydroxyvitamin D; Genetic polymorphism; SNPs; UVB radiation; Vitamin D status; Vitamin D supplements

Indexed keywords

25 HYDROXYLASE; 25 HYDROXYVITAMIN D; COLECALCIFEROL; OXYGENASE; UNCLASSIFIED DRUG; VITAMIN D BINDING PROTEIN; 25 HYDROXYERGOCALCIFEROL; CALCIFEDIOL; CHOLESTANETRIOL 26 MONOOXYGENASE; CYP2R1 PROTEIN, HUMAN;

ADULT; ALLELE; ARTICLE; BREAD; CONTROLLED STUDY; DENMARK; DOUBLE BLIND PROCEDURE; ERYTHEMA; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HETEROZYGOTE; HUMAN; MILK; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; SINGLE NUCLEOTIDE POLYMORPHISM; SYNTHESIS; ULTRAVIOLET B RADIATION; VITAMIN SUPPLEMENTATION; WINTER; ADOLESCENT; ANIMAL; BLOOD; CHILD; CONTROLLED CLINICAL TRIAL; DIET SUPPLEMENTATION; GENETICS; MALE; METABOLISM; MIDDLE AGED; PHOTOTHERAPY; RADIATION RESPONSE; SEASON; SKIN; VITAMIN D DEFICIENCY; WHOLE BODY RADIATION; YOUNG ADULT;

25-HYDROXYVITAMIN D 2; ADOLESCENT; ADULT; ANIMALS; BREAD; CALCIFEDIOL; CHILD; CHOLECALCIFEROL; CHOLESTANETRIOL 26-MONOOXYGENASE; DENMARK; DOUBLE-BLIND METHOD; FOOD, FORTIFIED; GENETIC ASSOCIATION STUDIES; HUMANS; MALE; MIDDLE AGED; MILK; POLYMORPHISM, SINGLE NUCLEOTIDE; SEASONS; SKIN; ULTRAVIOLET THERAPY; VITAMIN D DEFICIENCY; VITAMIN D-BINDING PROTEIN; WHOLE-BODY IRRADIATION; YOUNG ADULT;

EID: 84919686113     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.114.092148     Document Type: Article

References (31)

1. Holick MF, Chen T. Vitamin D deficiency : a worldwide problem with health consequences. Am J Clin Nutr 2008;87:1080S-6S.
2. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Glenville J, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab 2011;96:53-8.
3. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011;96: 1911-30.
4. Thuesen B, Husemoen L, Fenger M, Jakobsen J, Schwarz P, Toft U, Ovesen L, Jørgensen T, Linneberg A. Determinants of vitamin D status in a general population of Danish adults. Bone 2012;50: 605-10.
5. Berry D, Hyppönen E. Determinants of vitamin D status: focus on genetic variations. Curr Opin Nephrol Hypertens 2011;20:331-6.
6. Kühn T, Kaaks R, Teucher B, Hirche F, Dierkes J,Weikert C, Katzke V, Boeing H, Stangl GI, Buijsse B. Dietary, lifestyle, and genetic determinants of vitamin D status: a cross-sectional analysis from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study. Eur J Nutr 2014;53:731-41.
7. Ahn J, Yu K, Stolzenberg-Solomon R, Simon KC, McCullough ML, Gallicchio L, Jacobs EJ, Ascherio A, Helzlsouer K, Jacobs KB, et al. Genome-wide association study of circulating vitamin D levels. Hum Mol Genet 2010;19:2739-45.
8. Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Berry D, Kiel DP, Streeten EA, Ohlsson C, Koller DL, et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 2010;376:180-8.
9. Nissen J, Rasmussen LB, Ravn-Haren G, Andersen EW, Hansen B, Andersen R, Mejborn H, Madsen KH, Vogel U. Common variants in CYP2R1 and GC genes predict vitamin D concentrations in healthy Danish children and adults. PLoS One 2014;9:e89907.
10. Madsen KH, Rasmussen LB, Andersen R, Molgaard C, Jakobsen J, Bjerrum PJ, Andersen EW, Mejborn H, Tetens I. Randomized controlled trial of the effects of vitamin D-fortified milk and bread on serum 25-hydroxyvitamin D concentrations in families in Denmark during winter: the VitmaD study. Am J Clin Nutr 2013;98: 374-82.
11. Madsen KH, Rasmussen LB, Mejborn H, Andersen EW, Molgaard C, Nissen J, Tetens I, Andersen R. Vitamin D status and its determinants in children and adults among families in late summer in Denmark. Br J Nutr 2014;112:776-84
12. Nissen J, Vogel U, Ravn-Haren G, Andersen EW, Nexo BA, Andersen R, Mejborn H, Madsen KH, Rasmussen LB. Real-life use of vitamin D3-fortified bread and milk during a winter season: the effects of CYP2R1 and GC genes on 25-hydroxyvitamin D concentrations in Danish families, the VitmaD study. Genes Nutr. 2014;9:413.
13. Wulf HC. Method and apparatus for determining an individual's ability to stand exposure of UV. United States patent 14:822, 598:1-32. 1986.
14. Na R, Stender IM, Henriksen M, Wulf HC. Autofluorescence of human skin is age-related after correction for skin pigmentation and redness. J Invest Dermatol 2001;116:536-40.
15. Kongshoj B, Thorleifsson A, Wulf HC. Pheomelanin and eumelanin in human skin determined by high-performance liquid chromatography and its relation to in vivo reflectance measurements. Photodermatol Photoimmunol Photomed 2006;22:141-7.
16. Fitzpatrick TB. The validity and practicality of sun-reactive skin types I through VI. Arch Dermatol 1988;124:869-71.
17. Lock-Andersen J, Wulf H, Mortensen N. Erythemally weighted radiometric dose and standard erythema dose (SED). Proceedings 12th International Congress on Photobiology, Vienna, Austria; 1996. p. 315-7.
18. Diffey BL, Jansén CT, Urbach F, Wulf HC. The standard erythema dose: a new photobiological concept. Photodermatol Photoimmunol Photomed 1997;13:64-6.
19. Miller SA, Dykes D, Polesky H. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16:1215.
20. World Health Organization. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. WHO Heal Organ Tech Rep Ser 2000;894:i-12, 1-253.
21. Nimitphong H, Saetung S, Chanprasertyotin S, Chailurkit L-O, Ongphiphadhanakul B. Changes in circulating 25-hydroxyvitamin D according to vitamin D binding protein genotypes after vitamin D3 or D2supplementation. Nutr J 2013;12:39.
22. Engelman CD, Meyers KJ, Iyengar SK, Liu Z, Karki CK, Igo RP, Truitt B, Robinson J, Sarto GE, Wallace R, et al. Vitamin D intake and season modify the effects of the GC and CYP2R1 genes on 25-hydroxyvitamin D concentrations. J Nutr 2013;143:17-26.
23. Ramos-Lopez E, Brück P, Jansen T, Herwig J, Badenhoop K. CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans. Diabetes Metab Res Rev 2007;23:631-6.
24. Speeckaert M, Huang G, Delanghe JR, Taes YEC. Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism. Clin Chim Acta 2006;372:33-42.
25. Malik S, Fu L, Juras DJ, Karmali M, Wong BYL, Gozdzik A, Cole DEC. Common variants of the vitamin D binding protein gene and adverse health outcomes. Crit Rev Clin Lab Sci 2013;50:1-22.
26. Abbas S, Linseisen J, Slanger T, Kropp S, Mutschelknauss EJ, Flesch-Janys D, Chang-Claude J. The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status. Cancer Epidemiol Biomarkers Prev 2008;17:1339-43.
27. Sayegh L, Fuleihan GE-H, Nassar AH. Vitamin D in endometriosis: a causative or confounding factor? Metabolism 2014;63: 32-41.
28. Li F, Jiang L, Willis-Owen SA, Zhang Y, Gao J. Vitamin D binding protein variants associate with asthma susceptibility in the Chinese Han population. BMC Med Genet 2011;12:103.
29. Pekkinen M, Saarnio E, Viljakainen HT, Kokkonen E, Jakobsen J, Cashman K, Mäkitie O, Lamberg-Allardt C. Vitamin D binding protein genotype is associated with serum 25-hydroxyvitamin D and PTH concentrations, as well as bone health in children and adolescents in Finland. PLoS ONE 2014;9:e87292.
30. Powe CE, Evans MK, Wenger J, Zonderman AB, Berg AH, Nalls M, Tamez H, Zhang D, Bhan I, Karumanchi SA, et al. Vitamin D-binding protein and vitamin D status of black Americans and white Americans. N Engl J Med 2013;369:1991-2000.
31. Johnsen MS, Grimnes G, Figenschau Y, Torjesen PA, Almas B, Jorde R. Serum free and bio-available 25-hydroxyvitamin D correlate better with bone density than serum total 25-hydroxyvitamin D. Scand J Clin Lab Invest 2014;74:177-83.