Common variants in CYP2R1 and GC genes predict vitamin D concentrations in healthy Danish children

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Nissen, Janna ^a   Rasmussen, Lone Banke ^a   Ravn Haren, Gitte ^a   Wreford Andersen, Elisabeth ^a   Hansen, Bettina ^b   Andersen, Rikke ^a   Mejborn, Heddie ^a   Madsen, Katja Howarth ^a   Vogel, Ulla ^c  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c NATIONAL RESEARCH CENTRE FOR THE WORKING ENVIRONMENT   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

VITAMIN D;

ADOLESCENT; ADULT; ALLELE; ARTICLE; CAUCASIAN; CHILD; CONTROLLED STUDY; CYP24A1 GENE; CYP27B1 GENE; CYP2R1 GENE; DANISH; DENMARK; DHCR7 GENE; ENVIRONMENTAL FACTOR; ETHNIC GROUP; FEMALE; GC GENE; GENE; GENE LINKAGE DISEQUILIBRIUM; GENETIC EPIDEMIOLOGY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NADSYN1 GENE; SINGLE NUCLEOTIDE POLYMORPHISM; VDR GENE; VITAMIN BLOOD LEVEL; VITAMIN INTAKE; VITAMIN SUPPLEMENTATION;

ADOLESCENT; ADULT; ALLELES; CHILD; CHILD, PRESCHOOL; CHOLESTANETRIOL 26-MONOOXYGENASE; CROSS-SECTIONAL STUDIES; DENMARK; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC VARIATION; HAPLOTYPES; HEALTHY VOLUNTEERS; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; VITAMIN D; VITAMIN D-BINDING PROTEIN; YOUNG ADULT;

EID: 84896380840     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0089907     Document Type: Article

References (53)

1. Holick MF (2007) Vitamin D deficiency. N Engl J Med 357: 266-281. Available: http://www.ncbi.nlm.nih.gov/pubmed/17634462.
2. Lips P, van Schoor NM (2011) The effect of vitamin D on bone and osteoporosis. Best Pract Res Clin Endocrinol Metab 25: 585-591. Available: http://www.ncbi.nlm.nih.gov/pubmed/21872800. Accessed 16 July 2012.
3. Pilz S, Tomaschitz A, März W, Drechsler C, Ritz E, et al. (2011) Vitamin D, cardiovascular disease and mortality. Clin Endocrinol (Oxf) 75: 575-584. Available: http://www.ncbi.nlm.nih.gov/pubmed/21682758. Accessed 16 July 2012.
4. Saliba W, Barnett-Griness O, Rennert G (2012) The relationship between obesity and the increase in serum 25(OH)D levels in response to vitamin D supplementation. Osteoporos Int 25. Available: http://www.ncbi.nlm.nih.gov/ pubmed/22955311. Accessed 18 September 2012.
5. Sung CC, Liao MT, Lu KC, Wu CC (2012) Role of vitamin d in insulin resistance. J Biomed Biotechnol 2012: 634195. Available: http://www.ncbi.nlm. nih.gov/pubmed/22988423. Accessed 19 September 2012.
6. Brown SD, Calvert HH, Fitzpatrick AM (2012) Vitamin D and asthma: 137-145.
7. Weinstock-Guttman B, Mehta BK, Ramanathan M, Karmon Y, Henson LJ, et al. (2012) Vitamin D and multiple sclerosis. Neurologist 18: 179-183. Available: http://www.ncbi.nlm.nih.gov/pubmed/22735240. Accessed 18 September 2012.
8. Gandini S, Boniol M, Haukka J, Byrnes G, Cox B, et al. (2011) Meta-analysis of observational studies of serum 25-hydroxyvitamin D levels and colorectal, breast and prostate cancer and colorectal adenoma. Int J Cancer 128: 1414-1424. Available: http://www.ncbi.nlm.nih.gov/pubmed/20473927. Accessed 3 August 2011.
9. Durup D, Jørgensen HL, Christensen J, Schwarz P, Heegaard AM, et al. (2012) A Reverse J-Shaped Association of All-Cause Mortality with Serum 25-Hydroxyvitamin D in General Practice, the CopD Study. J Clin Endocrinol Metab 25: 1-9. Available: http://www.ncbi.nlm.nih.gov/pubmed/22573406. Accessed 16 May 2012.
10. Melamed ML, Michos ED, Post W, Astor B (2008) 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med 168: 1629-1637. Available: http://www.ncbi.nlm.nih.gov/pubmed/20185562.
11. Jones G, Strugnell S a, DeLuca HF (1998) Current understanding of the molecular actions of vitamin D. Physiol Rev 78: 1193-1231. Available: http://www.ncbi.nlm.nih.gov/pubmed/9790574.
12. Carter GD (2011) Accuracy of 25-hydroxyvitamin D assays: confronting the issues. Curr Drug Targets 12: 19-28. Available: http://www.ncbi.nlm.nih.gov/ pubmed/20795940.
13. Dastani Z, Li R, Richards B (2013) Genetic regulation of vitamin d levels. Calcif Tissue Int 92: 106-117. Available: http://www.ncbi.nlm.nih.gov/ pubmed/23114382. Accessed 4 February 2013.
14. Burgaz A, Akesson A, Oster A, Michaëlsson K, Wolk A (2007) Associations of diet, supplement use, and ultraviolet B radiation exposure with vitamin D status in Swedish women during winter. Am J Clin Nutr 86: 1399-1404. Available: http://www.ncbi.nlm.nih.gov/pubmed/17991652.
15. Shea MK, Benjamin EJ, Dupuis J, Massaro JM, Jacques PF, et al. (2009) Genetic and non-genetic correlates of vitamins K and D. Eur J Clin Nutr 63: 458-464. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid= 2681093&tool=pmcentrez&rendertype=abstract. Accessed 1 March 2012.
16. Arguelles LM, Langman CB, Ariza AJ, Ali FN, Dilley K, et al. (2009) Heritability and environmental factors affecting vitamin D status in rural Chinese adolescent twins. J Clin Endocrinol Metab 94: 3273-3281. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2741721&tool= pmcentrez&rendertype=abstract. Accessed 1 March 2012.
17. Engelman CD, Fingerlin TE, Langefeld CD, Hicks PJ, Rich SS, et al. (2008) Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans. J Clin Endocrinol Metab 93: 3381-3388. Available: http://www.pubmedcentral.nih.gov/ articlerender.fcgi?artid=2567851&tool=pmcentrez&rendertype=abstract. Accessed 1 March 2012.
18. Hunter D, De Lange M, Snieder H (2001) Genetic Contribution of Bone Metabolism, Calcium Excretion and Vitamin D and Parathyroid Hormone Regulation. 16: 371-378.
19. Karohl C, Su S, Kumari M, Tangpricha V, Veledar E, et al. (2010) Heritability and seasonal variability of vitamin D concentrations. 25: 1393-1398. doi:10.3945/ajcn.2010.30176.1.
20. Snellman G, Melhus H, Gedeborg R, Olofsson S, Wolk A, et al. (2009) Seasonal genetic influence on serum 25-hydroxyvitamin D levels: a twin study. PLoS One 4: e7747. Available: http://www.pubmedcentral.nih.gov/articlerender. fcgi?artid=2774516&tool=pmcentrez&rendertype=abstract. Accessed 13 September 2012.
21. Wjst M, Altmüller J, Faus-Kessler T, Braig C, Bahnweg M, et al. (2006) Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway. Respir Res 7: 60. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1508148&tool= pmcentrez&rendertype=abstract. Accessed 1 March 2012.
22. Signorello LB, Shi J, Cai Q, Zheng W, Williams SM, et al. (2011) Common variation in vitamin D pathway genes predicts circulating 25-hydroxyvitamin D Levels among African Americans. PLoS One 6: e28623. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3244405&tool= pmcentrez&rendertype=abstract. Accessed 1 March 2012.
23. McGrath JJ, Saha S, Burne TH, Eyles DW (2010) A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations. J Steroid Biochem Mol Biol 121: 471-477. Available: http://www.ncbi.nlm.nih.gov/pubmed/20363324. Accessed 29 February 2012.
24. Ahn J, Yu K, Stolzenberg-Solomon R, Simon KC, McCullough ML, et al. (2010) Genome-wide association study of circulating vitamin D levels. Hum Mol Genet 19: 2739-2745. Available: http://www.pubmedcentral.nih.gov/articlerender. fcgi?artid=2883344&tool=pmcentrez&rendertype=abstract. Accessed 17 June 2011.
25. Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, et al. (2010) Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Available: http://www.pubmedcentral.nih.gov/articlerender. fcgi?artid=3086761&tool=pmcentrez&rendertype=abstract. Accessed 1 March 2012.
26. Thuesen B, Husemoen L, Fenger M, Jakobsen J, Schwarz P, et al. (2012) Determinants of vitamin D status in a general population of Danish adults. Bone 50: 605-610. Available: http://www.ncbi.nlm.nih.gov/pubmed/22227435. Accessed 19 March 2012.
27. Hollis BW, Wagner CL, Drezner MK, Binkley NC (2007) Circulating vitamin D3 and 25-hydroxyvitamin D in humans: An important tool to define adequate nutritional vitamin D status. J Steroid Biochem Mol Biol 103: 631-634. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid= 1868557&tool=pmcentrez&rendertype=abstract. Accessed 4 December 2013.
28. Madsen KH, Rasmussen LB, Andersen R, Mølgaard C, Jakobsen J, et al. (2013) Randomized controlled trial of the effects of vitamin D - fortified milk and bread on serum 25-hydroxyvitamin D concentrations in families in Denmark during winter: the VitmaD study 1 - 3. Am J Clin Nutr: 1-9. doi:10.3945/ajcn.113.059469.
29. Miller S, Dykes D, Polesky H (1988) A simple salting out procedure for extracting DNA from human nucleated cells. NucleicAcids Res 16: 55404.
30. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 320: 1240-1243. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi? artid=27365&tool=pmcentrez&rendertype=abstract.
31. World Health Organization (2000) Obesity: preventing and managing the global epidemic. Report of a WHO consultation. WHO Heal Organ Tech Rep Ser 894: 1-253.
32. Ramos-lopez E, Brück P (2007) CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans. Diabetes Metab Res Rev 1: 631-636. doi:10.1002/dmrr.
33. Bu FX, Armas L, Lappe J, Zhou Y, Gao G, et al. (2010) Comprehensive association analysis of nine candidate genes with serum 25-hydroxy vitamin D levels among healthy Caucasian subjects. Hum Genet 128: 549-556. Available: http://www.ncbi.nlm.nih.gov/pubmed/20809279. Accessed 16 August 2011.
34. Lasky-Su J, Lange N, Brehm JM, Damask A, Soto-Quiros M, et al. (2012) Genome-wide association analysis of circulating vitamin D levels in children with asthma. Hum Genet 131: 1495-1505. Available: http://www.ncbi.nlm.nih.gov/ pubmed/22673963. Accessed 29 August 2012.
35. Zhang Z, He JW, Fu WZ, Zhang CQ, Zhang ZL (2013) An analysis of the association between the vitamin D pathway and serum 25-hydroxyvitamin D levels in a healthy Chinese population. J Bone Miner Res. Available: http://www.ncbi.nlm.nih.gov/pubmed/23505139. Accessed 25 March 2013.
36. Engelman CD, Meyers KJ, Iyengar SK, Liu Z, Karki CK, et al. (2013) Vitamin D Intake and Season Modify the Effects of the GC and CYP2R1 Genes on 25-hydroxyvitamin D concentrations. 25: 17-26. doi:10.3945/jn.112.169482.17.
37. Bikle D, Gee E, Halloran B, Kowalski M, Ryzen E, et al. (1986) Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein. J Clin Endocrinol Metab 63: 954-959. (Pubitemid 16004301)
38. Abbas S, Linseisen J, Slanger T, Kropp S, Mutschelknauss EJ, et al. (2008) The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status. Cancer Epidemiol Biomarkers Prev 17: 1339-1343. Available: http://www.ncbi.nlm.nih.gov/pubmed/18559548. Accessed 1 March 2012.
39. Fu L, Yun F, Oczak M, Wong BY, Vieth R, et al. (2009) Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation. Clin Biochem 42: 1174-1177. Available: http://www.ncbi.nlm.nih.gov/pubmed/19302999. Accessed 1 March 2012.
40. Fang Y, van Meurs JB, Arp P, van Leeuwen JP, Hofman A, et al. (2009) Vitamin D binding protein genotype and osteoporosis. Calcif Tissue Int 85: 85-93. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid= 2729412&tool=pmcentrez&rendertype=abstract. Accessed 1 March 2012.
41. Gozdzik A, Zhu J, Wong BY, Fu L, Cole DE, et al. (2011) Association of vitamin D binding protein (VDBP) polymorphisms and serum 25(OH)D concentrations in a sample of young Canadian adults of different ancestry. J Steroid Biochem Mol Biol 127:405-412. Available: http://www.ncbi.nlm.nih.gov/pubmed/21684333. Accessed 25 October 2011.
42. Sinotte M, Diorio C, Berube S, Pollak M, Brisson J (2009) Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women 1 - 3. Am J Clin Nutr 25: 634-640. doi:10.3945/ajcn.2008.26445.INTRODUCTION.
43. Lauridsen AL, Vestergaard P, Hermann AP, Brot C, Heickendorff L, et al. (2005) Plasma concentrations of 25-hydroxy-vitamin D and 1,25-dihydroxyvitamin D are related to the phenotype of Gc (vitamin D-binding protein): a cross-sectional study on 595 early postmenopausal women. Calcif Tissue Int 77:15-22. Available: http://www.ncbi.nlm.nih.gov/pubmed/15868280. Accessed 1 March 2012.
44. Kurylowicz A, Ramos-Lopez E, Bednarczuk T, Badenhoop K (2006) Vitamin D-binding protein (DBP) gene polymorphism is associated with Graves' disease and the vitamin D status in a Polish population study. Exp Clin Endocrinol Diabetes 114:329-335 Available: http://www.ncbi.nlm.nih.gov/pubmed/16868893. Accessed 1 March 2012.
45. Lu L, Sheng H, Li H, Gan W, Liu C, et al. (2012) Associations between common variants in GC and DHCR7/NADSYN1 and vitamin D concentration in Chinese Hans. Hum Genet 131:505-512 Available: http://www.ncbi.nlm.nih.gov/pubmed/ 21972121. Accessed 1 March 2012.
46. Arnaud J, Constans J (1993) Affinity differences for vitamin D metabolites associaated with the genetic isoforms of the human serum carrier protein (DBP). Hum Genet 92:183-188 Available: http://link.springer.com/article/ 10.1007/BF00219689. Accessed 25 July 2013.
47. Kawakami M, Blum C, Ramakrishnan R, Dell R, Goodman D (1981) Turnover of the plasma binding protein for vitamin D and its metabolites in normal human subjects. J Clin Endocrinol Metab: 1110-1116. (Pubitemid 13237540)
48. Kamboh MI, Ferrell RE (1986) Ethnic variation in vitamin D-binding protein (GC): a review of isoelectric focusing studies in human populations. Hum Genet 72: 281-293. Available: http://www.ncbi.nlm.nih.gov/pubmed/3516862.
49. Perna L (2013) Genetic Variatons in the Vitamin D Binding Protein and Season-Specific Levels of Vitamin D Among Older Aldults. Epidemiology 24: 104-109. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid= 3150431&tool=pmcentrez&rendertype=abstract. Accessed 5 June 2013.
50. Ahn J, Albanes D, Berndt SI, Peters U, Chatterjee N, et al. (2009) Vitamin Drelated genes, serum vitamin D concentrations and prostate cancer risk. Carcinogenesis 30: 769-776 Available: http://www.pubmedcentral.nih.gov/ articlerender.fcgi?artid=2675652&tool=pmcentrez&rendertype=abstract. Accessed March 2012.
51. Jorde R, Schirmer H, Wilsgaard T, Joakimsen RM, Mathiesen EB, et al. (2012) polymorphisms related to the serum 25-hydroxyvitamin d level and risk of myocardial infarction, diabetes, cancer and mortality. The tromsø study. PLoS One 7: e37295. Available: http://www.pubmedcentral.nih.gov/articlerender. fcgi?artid=3359337&tool=pmcentrez&rendertype=abstract. Accessed 7 June 2012.
52. Berry DJ, Vimaleswaran KS, Whittaker JC, Hingorani AD, Hyppönen E (2012) Evaluation of Genetic Markers as Instruments for Mendelian Randomization Studies on Vitamin D. PLoS One 7: e37465. Available: http://dx.plos.org/10.1371/ journal.pone.0037465. Accessed 21 May 2012.
53. National Board of Health (2010) Forebyggelse, diagnostik og behandling af D-vitaminmangel (Prevention, diagnostics and treatment of vitamin D defiency). Natl Board Heal. Available: http://sundhedsstyrelsen. dk/~/media/ FA2FC43A29D146918C9695BEC2716A33.ashx. Accessed 2014 February 1.