Altered microRNA expression in inflamed and non-inflamed terminal ileal mucosa of adult patients with active Crohn's disease

Journal of Gastroenterology and Hepatology (Australia)

Volumn 30, Issue 1, 2015, Pages 109-116

  Guo, Zhen ^a   Wu, Rong ^a   Gong, Jianfeng ^a   Zhu, Weiming ^a   Li, Yi ^a   Wang, Zhiming ^a   Li, Ning ^a   Li, Jieshou ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

Crohn's disease; MiRNAs expression; Terminal ileal mucosa

Indexed keywords

LET 7A 2 3P; LET 7B 5P; MICRORNA; MICRORNA 124 3P; MICRORNA 192 5P; MICRORNA 199B 5P; MICRORNA 21 5P; MICRORNA 31 5P; MICRORNA 361 3P; MICRORNA 495 5P; MICRORNA 564; MICRORNA 630; UNCLASSIFIED DRUG; TRANSCRIPTOME;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; DOWN REGULATION; ENTERITIS; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; ILEUM MUCOSA; MALE; MICROARRAY ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; UPREGULATION; GENETICS; ILEUM; INTESTINE MUCOSA; METABOLISM; MIDDLE AGED; YOUNG ADULT;

ADULT; CROHN DISEASE; FEMALE; GENE EXPRESSION; HUMANS; ILEUM; INTESTINAL MUCOSA; MALE; MICRORNAS; MIDDLE AGED; TRANSCRIPTOME; YOUNG ADULT;

EID: 84919668045     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/jgh.12644     Document Type: Article

References (26)

1. Khor B, Gardet A, Xavier RJ. Genetics and pathogenesis of inflammatory bowel disease. Nature 2011; 474: 307-317.
2. Budarf ML, Labbe C, David G, Rioux JD. GWA studies: rewriting the story of IBD. Trends Genet. 2009; 25: 137-146.
3. Carthew RW. Gene regulation by microRNAs. Curr. Opin. Genet. Dev. 2006; 16: 203-208.
4. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116: 281-297.
5. Garzon R, Calin GA, Croce CM. MicroRNAs in Cancer. Annu. Rev. Med. 2009; 60: 167-179.
6. Lu LF, Liston A. MicroRNA in the immune system, microRNA as an immune system. Immunology 2009; 127: 291-298.
7. Ye D, Guo S, Al-Sadi R, Ma TY. MicroRNA regulation of intestinal epithelial tight junction permeability. Gastroenterology 2011; 141: 1323-1333.
8. Xue X, Feng T, Yao S etal. Microbiota downregulates dendritic cell expression of miR-10a, which targets IL-12/IL-23p40. J. Immunol. 2011; 187: 5879-5886.
9. Huang Z, Shi T, Zhou Q etal. miR-141 Regulates colonic leukocytic trafficking by targeting CXCL12beta during murine colitis and human Crohn's disease. Gut 2013; Sep 2; doi: 10.1136/gutjnl-2012-304213.
10. Du C, Liu C, Kang J etal. MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat. Immunol. 2009; 10: 1252-1259.
11. Pekow JR, Kwon JH. MicroRNAs in inflammatory bowel disease. Inflamm. Bowel Dis. 2012; 18: 187-193.
12. Paraskevi A, Theodoropoulos G, Papaconstantinou I, Mantzaris G, Nikiteas N, Gazouli M. Circulating MicroRNA in inflammatory bowel disease. J. Crohns Colitis 2012; 6: 900-904.
13. Wu F, Zhang S, Dassopoulos T etal. Identification of microRNAs associated with ileal and colonic Crohn's disease. Inflamm. Bowel Dis. 2010; 16: 1729-1738.
14. Fasseu M, Treton X, Guichard C etal. Identification of restricted subsets of mature microRNA abnormally expressed in inactive colonic mucosa of patients with inflammatory bowel disease. PloS ONE 2010; 5: e13160.
15. Wu F, Guo NJ, Tian H etal. Peripheral blood microRNAs distinguish active ulcerative colitis and Crohn's disease. Inflamm. Bowel Dis. 2011; 17: 241-250.
16. Satsangi J, Silverberg MS, Vermeire S, Colombel JF. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut 2006; 55: 749-753.
17. Dalal SR, Kwon JH. The role of microRNA in inflammatory bowel disease. Gastroenterol. Hepatol. 2010; 6: 714-722.
18. Zahm AM, Thayu M, Hand NJ, Horner A, Leonard MB, Friedman JR. Circulating microRNA is a biomarker of pediatric Crohn disease. J. Pediatr. Gastroenterol. Nutr. 2011; 53: 26-33.
19. Archanioti P, Gazouli M, Theodoropoulos G, Vaiopoulou A, Nikiteas N. Micro-RNAs as regulators and possible diagnostic bio-markers in inflammatory bowel disease. J. Crohns Colitis 2011; 5: 520-524.
20. Kroh EM, Parkin RK, Mitchell PS, Tewari M. Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR). Methods 2010; 50: 298-301.
21. Wu F, Zikusoka M, Trindade A etal. MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha. Gastroenterology 2008; 135: 1624-35 e24.
22. Teng GG, Wang WH, Dai Y, Wang SJ, Chu YX, Li J. Let-7b is involved in the inflammation and immune responses associated with Helicobacter pylori infection by targeting Toll-like receptor 4. PloS ONE 2013; 8: e56709.
23. Li D, Jia H, Zhang H etal. TLR4 signaling induces the release of microparticles by tumor cells that regulate inflammatory cytokine IL-6 of macrophages via microRNA let-7b. Oncoimmunology 2012; 1: 687-693.
24. Koukos G, Polytarchou C, Kaplan JL etal. MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis. Gastroenterology 2013; 145: 842-52 e2.
25. Allez M, Tieng V, Nakazawa A etal. CD4+NKG2D+ T cells in Crohn's disease mediate inflammatory and cytotoxic responses through MICA interactions. Gastroenterology 2007; 132: 2346-2358.
26. Costello CM, Mah N, Hasler R etal. Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays. PLoS Med. 2005; 2: e199.