Disturbance in Z-disk mechanosensitive proteins induced by a persistent mutant myopalladin causes familial restrictive cardiomyopathy

Journal of the American College of Cardiology

Volumn 64, Issue 25, 2014, Pages 2765-2776

  Huby, Anne Cecile ^a   Mendsaikhan, Uzmee ^a   Takagi, Ken ^b   Martherus, Ruben ^a   Wansapura, Janaka ^a   Gong, Nan ^a   Osinska, Hanna ^a   James, Jeanne F ^a   Kramer, Kristen ^a   Saito, Kazuyoshi ^a   Robbins, Jeffrey ^a   Khuchua, Zaza ^a   Towbin, Jeffrey A ^a   Purevjav, Enkhsaikhan ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

CARP ANKRD1; ERK1 2; fibrosis; remodeling

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; CARDIAC ANKYRIN REPEAT PROTEIN; DESMIN; LIM PROTEIN; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYOPALLADIN; MYOSIN HEAVY CHAIN; OSTEOPONTIN; PROTEIN KINASE B; SMAD2 PROTEIN; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; MUSCLE PROTEIN; MYPN PROTEIN, HUMAN; STOP CODON;

ANIMAL EXPERIMENT; ARTICLE; CARDIOVASCULAR MAGNETIC RESONANCE; CELL NUCLEUS; CONTROLLED STUDY; DIASTOLIC DYSFUNCTION; DOWN REGULATION; ELECTROCARDIOGRAPHY; ENZYME PHOSPHORYLATION; FAMILIAL DISEASE; FAMILIAL RESTRICTIVE CARDIOMYOPATHY; FIBROSING ALVEOLITIS; FIBROSIS; GENE; GENE EXPRESSION; GENE MUTATION; HEART FAILURE; HETEROZYGOTE; HISTOLOGY; HOMOZYGOTE; HUMAN; HUMAN CELL; MOUSE; MYPN GENE; NONHUMAN; PATHOGENESIS; PROTEIN LOCALIZATION; RESTRICTIVE CARDIOMYOPATHY; SYSTOLIC BLOOD PRESSURE; UPREGULATION; VASCULAR FIBROSIS; ANIMAL; DIASTOLIC HEART FAILURE; DISEASE MODEL; ECHOENCEPHALOGRAPHY; GENE TARGETING; GENETICS; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; STOP CODON;

ANIMALS; CARDIOMYOPATHY, RESTRICTIVE; CODON, NONSENSE; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ECHOENCEPHALOGRAPHY; ELECTROCARDIOGRAPHY; GENE KNOCK-IN TECHNIQUES; HEART FAILURE, DIASTOLIC; HETEROZYGOTE; HOMOZYGOTE; HUMANS; MAGNETIC RESONANCE IMAGING; MICE; MUSCLE PROTEINS; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84919608962     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2014.09.071     Document Type: Article

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