Synthesis, in vitro and in vivo antitumor activity of symmetrical bis-Schiff base derivatives of isatin

European Journal of Medicinal Chemistry

Volumn 74, Issue , 2014, Pages 742-750

  Liang, Chengyuan ^a   Xia, Juan ^b   Lei, Dong ^a   Li, Xiang ^b   Yao, Qizheng ^a   Gao, Jing ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b JIANGSU UNIVERSITY   (China)

Author keywords

Antitumor; Apoptosis; Cytotoxicity; Isatin; Mitosis interference; Schiff base

Indexed keywords

3,3' (HYDRAZINE 1,2 DIYLIDENE)BIS(1 BENZYL 5 FLUOROINDOLIN 2 ONE); 3,3' (HYDRAZINE 1,2 DIYLIDENE)BIS(1 BENZYL 5 METHYLINDOLIN 2 ONE); 3,3' (HYDRAZINE 1,2 DIYLIDENE)BIS(1 BENZYLINDOLIN 2 ONE); 3,3' (HYDRAZINE 1,2 DIYLIDENE)BIS(1 ETHYL 5 FLUOROINDOLIN 2 ONE); 3,3' (HYDRAZINE 1,2 DIYLIDENE)BIS(1 ETHYL 5 METHYLINDOLIN 2 ONE); 3,3' (HYDRAZINE 1,2 DIYLIDENE)BIS(1 ETHYLINDOLIN 2 ONE); 3,3' (HYDRAZINE 1,2 DIYLIDENE)BIS(1 ISOPROPYL 5 METHYLINDOLIN 2 ONE); 3,3' (HYDRAZINE 1,2 DIYLIDENE)BIS(1 ISOPROPYLINDOLIN 2 ONE); 3,3' (HYDRAZINE 1,2 DIYLIDENE)BIS(5 BROMOINDOLIN 2 ONE); 3,3' (HYDRAZINE 1,2 DIYLIDENE)BIS(5 CHLOROINDOLIN 2 ONE); 3,3' (HYDRAZINE 1,2 DIYLIDENE)BIS(5 FLUORO 1 ISOPROPYLINDOLIN 2 ONE); 3,3' (HYDRAZINE 1,2 DIYLIDENE)BIS(5 FLUOROINDOLIN 2 ONE); 3,3' (HYDRAZINE 1,2 DIYLIDENE)BIS(5 METHOXYINDOLIN 2 ONE); 3,3' (HYDRAZINE 1,2 DIYLIDENE)BIS(5 METHYLINDOLIN 2 ONE); 3,3' (HYDRAZINE 1,2 DIYLIDENE)BIS(6 CHLOROINDOLIN 2 ONE); 3,3' (HYDRAZINE 1,2 DIYLIDENE)BIS(6 FLUOROINDOLIN 2 ONE); 3,3' (HYDRAZINE 1,2 DIYLIDENE)BIS(7 FLUOROINDOLIN 2 ONE); 3,3' (HYDRAZINE 1,2 DIYLIDENE)DIINDOLIN 2 ONE; ANTINEOPLASTIC AGENT; CYCLIN B1; FLUOROURACIL; ISATIN DERIVATIVE; SCHIFF BASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CYCLE; CELL DEATH; CELL PROLIFERATION; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG EFFICACY; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MITOSIS; MTT ASSAY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; TUMOR GROWTH;

ANTITUMOR; APOPTOSIS; CYTOTOXICITY; ISATIN; MITOSIS INTERFERENCE; SCHIFF BASE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HUMANS; ISATIN; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICE; NEOPLASMS; SCHIFF BASES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84919602295     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.04.040     Document Type: Article

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