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Volumn 21, Issue 3, 2010, Pages 297-300

Synthesis and CDK2 kinase inhibitory activity of 7/7′-azaindirubin derivatives

Author keywords

7 Azaindirubin; 7 Azaindirubin; CDK2 cyclinA; Inhibition; Synthesis

Indexed keywords

EID: 74649083263 PISSN: 10018417 EISSN: None Source Type: Journal
DOI: 10.1016/j.cclet.2009.11.029 Document Type: Article

Times cited : (4)

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- The data of selected compounds: 1d. 136-138 °C; ESI-MS m/z: 320.2 [M+H, 1H NMR (300 MHz, CDCl3, δ 0.97 (t, 3H, J, 7.32 Hz, CH3, 1.38-1.43 (m, 2H, CH2, 1.65-1.74 (m, 2H, CH2, 3.83 (t, 2H, J, 7.29 Hz, N-CH2, 6.89 (d, 1H, J, 7.78 Hz, 7-H, 6.99 (dd, 1H, J, 5.05, 7.49 Hz, 5′-H, 7.12 (t, 1H, J, 7.72 Hz, 5-H, 7.34 (t, 1H, J, 7.72 Hz, 6-H, 8.01 (dd, 1H, J, 0.90, 7.49 Hz, 6′-H, 8.44 (d, 1H, J, 3.62 Hz, 4-H, 8.91 (dd, 1H, J, 0.90, 7.80 Hz, 4′-H, 10.87 (s, 1H, N′-H, Anal. Calcd. for C19H17N3O2 (319.3, C 71.46, H 5.37, N 13.16; Found: C 71.05, H 5.37, N 13.25. 1f. mp: 275-276 °C; ESI-MS m/z: 321.2 [M+H, 1H NMR (300 MHz, DMSO-d6, δ 1.49 (d, 6H, J, 7.05 Hz, 2CH3, 4.70-4.76 (m, 1H, N-CH, 7.02-7.12 (m, 2H, Ar-H, 7.22-7.29 (m, 2H, Ar-H, 8.29-8.31 (m, 1H, Ar-H, 8.47 d, 1
- 2 (353.3) (%): C 74.78, H 4.28, N 11.89; Found: C 74.62, H 4.14, N 11.68.

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