Peptide inhibitors of human HMG-CoA reductase as potential hypocholesterolemia agents

Biochemical and Biophysical Research Communications

Volumn 456, Issue 1, 2015, Pages 104-109

  Lin, Shih Hung ^a   Chang, Ding Kwo ^b   Chou, Mei Ju ^b   Huang, Kao Jean ^a   Shiuan, David ^a  

^a NATIONAL DONG HWA UNIVERSITY   (Taiwan)

^b INSTITUTE OF CHEMISTRY   (Taiwan)

Author keywords

HMG CoA reductase; Molecule docking; Phage display

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYPOCHOLESTEROLEMIC AGENT; TETRAPEPTIDE; ENZYME INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PEPTIDE LIBRARY; PROTEIN BINDING; RECOMBINANT PROTEIN;

ARTICLE; CLONING; DNA SEQUENCE; DRUG BINDING SITE; DRUG SCREENING; ENZYMATIC ASSAY; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; IC50; MOLECULAR DOCKING; NONHUMAN; NUCLEOTIDE SEQUENCE; PEPTIDE SYNTHESIS; PHAGE DISPLAY; CHEMISTRY; DOSE RESPONSE; DRUG DESIGN; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; METABOLISM; MOLECULAR CLONING; PEPTIDE LIBRARY; PROTEIN CONFORMATION;

ANTICHOLESTEREMIC AGENTS; CLONING, MOLECULAR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERCHOLESTEROLEMIA; INHIBITORY CONCENTRATION 50; MOLECULAR DOCKING SIMULATION; PEPTIDE LIBRARY; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

EID: 84919597018     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.11.042     Document Type: Article

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