Nanotopology potentiates growth hormone signalling and osteogenesis of mesenchymal stem cells

Growth Hormone and IGF Research

Volumn 24, Issue 6, 2014, Pages 245-250

  Wang, Jessie R ^a   Ahmed, S Faisal ^a   Gadegaard, Nikolaj ^a   Meek, R M Dominic ^c   Dalby, Matthew J ^b   Yarwood, Stephen J ^b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c SOUTHERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

Growth hormone; Nanotopology; Osteogenesis; Stem cells

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; POLYCAPROLACTONE; RECOMBINANT GROWTH HORMONE; ALKALINE PHOSPHATASE; HUMAN GROWTH HORMONE; MESSENGER RNA; POLYESTER;

ADULT; ARTICLE; BONE DEVELOPMENT; BONE GROWTH; CELL DIFFERENTIATION; CELL STIMULATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; NANOTOPOLOGY; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SURFACE PROPERTY; CELL CULTURE; CHEMISTRY; CYTOLOGY; ENZYME IMMUNOASSAY; GENETICS; MESENCHYMAL STROMA CELL; METABOLISM; NANOTECHNOLOGY; OSTEOBLAST; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ALKALINE PHOSPHATASE; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELLS, CULTURED; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMAN GROWTH HORMONE; HUMANS; IMMUNOENZYME TECHNIQUES; MESENCHYMAL STROMAL CELLS; NANOTECHNOLOGY; OSTEOBLASTS; OSTEOGENESIS; POLYESTERS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84919490254     PISSN: 10966374     EISSN: 15322238     Source Type: Journal    
DOI: 10.1016/j.ghir.2014.10.003     Document Type: Article

References (18)

1. Biggs M.J., Richards R.G., Dalby M.J. Nanotopographical modification: a regulator of cellular function through focal adhesions. Nanomedicine 2010, 6:619-633.
2. Blumbach K., Niehoff A., Belgardt B.F., Ehlen H.W., Schmitz M., Hallinger R., Schulz J.N., Bruning J.C., Krieg T., Schubert M., Gullberg D., Eckes B. Dwarfism in mice lacking collagen-binding integrins alpha2beta1 and alpha11beta1 is caused by severely diminished IGF-1 levels. J. Biol. Chem. 2012, 287:6431-6440.
3. Cool S.M., Grunert M., Jackson R., Li H., Nurcombe V., Waters M.J. Role of growth hormone receptor signaling in osteogenesis from murine bone marrow progenitor cells. Biochem. Biophys. Res. Commun. 2005, 338:1048-1058.
4. Dalby M.J., Gadegaard N., Tare R., Andar A., Riehle M.O., Herzyk P., Wilkinson C.D., Oreffo R.O. The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder. Nat. Mater. 2007, 6:997-1003.
5. Jaiswal R.K., Jaiswal N., Bruder S.P., Mbalaviele G., Marshak D.R., Pittenger M.F. Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase. J. Biol. Chem. 2000, 275:9645-9652.
6. Laron Z., Klinger B. Laron syndrome: clinical features, molecular pathology and treatment. Horm. Res. 1994, 42:198-202.
7. Li H., Bartold P.M., Young W.G., Xiao Y., Waters M.J. Growth hormone induces bone morphogenetic proteins and bone-related proteins in the developing rat periodontium. J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res. 2001, 16:1068-1076.
8. Lincoln D.T., Sinowatz F., Gabius S., Gabius H.J., Temmim L., Baker H., Mathew T.C., Waters M.J. Subpopulations of stromal cells from long-term human bone marrow cultures: ontogeny of progenitor cells and expression of growth hormone receptors. Anat. Histol. Embryol. 1997, 26:11-28.
9. McMurray R.J., Gadegaard N., Tsimbouri P.M., Burgess K.V., McNamara L.E., Tare R., Murawski K., Kingham E., Oreffo R.O., Dalby M.J. Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency. Nat. Mater. 2011, 10:637-644.
10. Meinhardt U., Eble A., Besson A., Strasburger C.J., Sraer J.D., Mullis P.E. Regulation of growth-hormone-receptor gene expression by growth hormone and pegvisomant in human mesangial cells. Kidney Int. 2003, 64:421-430.
11. Menagh P.J., Turner R.T., Jump D.B., Wong C.P., Lowry M.B., Yakar S., Rosen C.J., Iwaniec U.T. Growth hormone regulates the balance between bone formation and bone marrow adiposity. J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res. 2010, 25:757-768.
12. Mirmalek-Sani S.H., Tare R.S., Morgan S.M., Roach H.I., Wilson D.I., Hanley N.A., Oreffo R.O. Characterization and multipotentiality of human fetal femur-derived cells: implications for skeletal tissue regeneration. Stem Cells 2006, 24:1042-1053.
13. Muller P., Langenbach A., Kaminski A., Rychly J. Modulating the actin cytoskeleton affects mechanically induced signal transduction and differentiation in mesenchymal stem cells. PLoS ONE 2013, 8:e71283.
14. Oreffo R.O., Cooper C., Mason C., Clements M. Mesenchymal stem cells: lineage, plasticity, and skeletal therapeutic potential. Stem Cell Rev. 2005, 1:169-178.
15. Schwartzbauer G., Menon R.K. Regulation of growth hormone receptor gene expression. Mol. Genet. Metab. 1998, 63:243-253.
16. Sims N.A., Clement-Lacroix P., Da Ponte F., Bouali Y., Binart N., Moriggl R., Goffin V., Coschigano K., Gaillard-Kelly M., Kopchick J., Baron R., Kelly P.A. Bone homeostasis in growth hormone receptor-null mice is restored by IGF-I but independent of Stat5. J. Clin. Invest. 2000, 106:1095-1103.
17. Wuster C., Abs R., Bengtsson B.A., Bennmarker H., Feldt-Rasmussen U., Hernberg-Stahl E., Monson J.P., Westberg B., Wilton P. The influence of growth hormone deficiency, growth hormone replacement therapy, and other aspects of hypopituitarism on fracture rate and bone mineral density. J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res. 2001, 16:398-405.
18. Yarwood S.J., Woodgett J.R. Extracellular matrix composition determines the transcriptional response to epidermal growth factor receptor activation. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:4472-4477.