A phase Ia study to assess the safety and immunogenicity of new malaria vaccine candidates ChAd63 CS administered alone and with MVA CS

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  De Barra, Eoghan ^a   Hodgson, Susanne H ^b   Ewer, Katie J ^b   Bliss, Carly M ^b   Hennigan, Kerrie ^a   Collins, Ann ^a   Berrie, Eleanor ^b   Lawrie, Alison M ^b   Gilbert, Sarah C ^b   Nicosia, Alfredo ^c,d   McConkey, Samuel J ^a   Hill, Adrian V S ^b  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c Jenner Institute University of Oxford ^*  (Italy)

^d CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CHIMPANZEE ADENOVIRUS 63 CIRCUMSPOROZOITE PROTEIN VACCINE; CIRCUMSPOROZOITE PROTEIN; GAMMA INTERFERON; IMMUNOGLOBULIN G; MALARIA VACCINE; MODIFIED VACCINIA VIRUS ANKARA CIRCUMSPOROZOITE PROTEIN VACCINE; UNCLASSIFIED DRUG; CIRCUMSPOROZOITE PROTEIN, PROTOZOAN; MVA VACCINE; PROTOZOAL PROTEIN; VIRUS VACCINE;

ADULT; ANTIBODY BLOOD LEVEL; ARTHRALGIA; ARTICLE; CELLULAR IMMUNITY; CONCENTRATION RESPONSE; DESCRIPTIVE RESEARCH; DRUG DOSE ESCALATION; DRUG SAFETY; ERYTHEMA; FATIGUE; FEMALE; FEVER; HEADACHE; HLA TYPING; HUMAN; HUMAN EXPERIMENT; IMMUNE RESPONSE; IMMUNOFLUORESCENCE; IMMUNOGENICITY; IMMUNOGLOBULIN BLOOD LEVEL; INJECTION SITE REACTION; MALAISE; MALARIA FALCIPARUM; MALE; MYALGIA; NAUSEA; NORMAL HUMAN; OBSERVATIONAL STUDY; PAIN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHASE 1 CLINICAL TRIAL; PLASMODIUM FALCIPARUM; PRURITUS; SKIN DISEASE; SKIN SCALING; SKIN WARMTH; SWELLING; VACCINATION; VIRUS PARTICLE; VOMITING; ADOLESCENT; BLOOD; CLINICAL TRIAL; GENETICS; IMMUNOLOGY; MIDDLE AGED; SIMIAN VIRUS;

CHIMPANZEE ADENOVIRUS; PLASMODIUM FALCIPARUM; VACCINIA VIRUS ANKARA;

ADENOVIRUSES, SIMIAN; ADOLESCENT; ADULT; FEMALE; HUMANS; IMMUNOGLOBULIN G; MALARIA VACCINES; MIDDLE AGED; PROTOZOAN PROTEINS; VIRAL VACCINES;

EID: 84919487863     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0115161     Document Type: Article

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