메뉴 건너뛰기




Volumn 29, Issue 10, 2011, Pages 1948-1958

A phase I trial of preventive HIV vaccination with heterologous poxviral-vectors containing matching HIV-1 inserts in healthy HIV-uninfected subjects

(20)  Keefer, Michael C a   Frey, Sharon E b   Elizaga, Marnie c   Metch, Barbara c   De Rosa, Stephen C c   Barroso, Paulo F d   Tomaras, Georgia e   Cardinali, Massimo f   Goepfert, Paul g   Kalichman, Artur h   Philippon, Valérie i,j   McElrath, M Juliana c   Jin, Xia a   Ferrari, Guido e   Defawe, Olivier D c   Mazzara, Gail P i   Montefiori, David e   Pensiero, Michael f   Panicali, Dennis L i   Corey, Lawrence c  


Author keywords

MVA and Fowlpox vectors; Phase I clinical trial; Preventive HIV vaccine

Indexed keywords

GAMMA INTERFERON; HUMAN IMMUNODEFICIENCY VIRUS VACCINE;

EID: 79951721121     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2010.12.104     Document Type: Article
Times cited : (46)

References (52)
  • 2
    • 44049108744 scopus 로고    scopus 로고
    • Toward an AIDS vaccine
    • Walker B.D., Burton D.R. Toward an AIDS vaccine. Science 2008, 320:760-764.
    • (2008) Science , vol.320 , pp. 760-764
    • Walker, B.D.1    Burton, D.R.2
  • 3
    • 70849093010 scopus 로고    scopus 로고
    • Moving forward in HIV vaccine development
    • Letvin N.L. Moving forward in HIV vaccine development. Science 2009, 326:1196-1198.
    • (2009) Science , vol.326 , pp. 1196-1198
    • Letvin, N.L.1
  • 4
    • 0028337166 scopus 로고
    • Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
    • Koup R.A., Safrit J.T., Cao Y., Andrews C.A., McLeod G., Borkowsky W., et al. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol 1994, 68:4650-4655.
    • (1994) J Virol , vol.68 , pp. 4650-4655
    • Koup, R.A.1    Safrit, J.T.2    Cao, Y.3    Andrews, C.A.4    McLeod, G.5    Borkowsky, W.6
  • 5
    • 0028041344 scopus 로고
    • Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection
    • Borrow P., Lewicki H., Hahn B.H., Shaw G.M., Oldstone M.B. Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J Virol 1994, 68:6103-6110.
    • (1994) J Virol , vol.68 , pp. 6103-6110
    • Borrow, P.1    Lewicki, H.2    Hahn, B.H.3    Shaw, G.M.4    Oldstone, M.B.5
  • 6
    • 7144227284 scopus 로고    scopus 로고
    • Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
    • Ogg G.S., Jin X., Bonhoeffer S., Dunbar P.R., Nowak M.A., Monard S., et al. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. Science 1998, 279:2103-2106.
    • (1998) Science , vol.279 , pp. 2103-2106
    • Ogg, G.S.1    Jin, X.2    Bonhoeffer, S.3    Dunbar, P.R.4    Nowak, M.A.5    Monard, S.6
  • 7
    • 0036171258 scopus 로고    scopus 로고
    • Magnitude of functional CD8+ T-cell responses to the gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasma
    • Edwards B.H., Bansal A., Sabbaj S., Bakari J., Mulligan M.J., Goepfert P.A. Magnitude of functional CD8+ T-cell responses to the gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasma. J Virol 2002, 76:2298-2305.
    • (2002) J Virol , vol.76 , pp. 2298-2305
    • Edwards, B.H.1    Bansal, A.2    Sabbaj, S.3    Bakari, J.4    Mulligan, M.J.5    Goepfert, P.A.6
  • 8
    • 0028944192 scopus 로고
    • HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women
    • Rowland-Jones S., Sutton J., Ariyoshi K., Dong T., Gotch F., McAdam S., et al. HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women. Nat Med 1995, 1:59-64.
    • (1995) Nat Med , vol.1 , pp. 59-64
    • Rowland-Jones, S.1    Sutton, J.2    Ariyoshi, K.3    Dong, T.4    Gotch, F.5    McAdam, S.6
  • 9
    • 0027478866 scopus 로고
    • HIV-specific cytotoxic T-cell activity in an HIV-exposed but uninfected infant
    • Rowland-Jones S.L., Nixon D.F., Gotch F., McMichael A., Kroll J.S., Hallam N., et al. HIV-specific cytotoxic T-cell activity in an HIV-exposed but uninfected infant. Lancet 1993, 341:860-861.
    • (1993) Lancet , vol.341 , pp. 860-861
    • Rowland-Jones, S.L.1    Nixon, D.F.2    Gotch, F.3    McMichael, A.4    Kroll, J.S.5    Hallam, N.6
  • 10
    • 77956663126 scopus 로고    scopus 로고
    • HIV vaccine could use a little help
    • Wang J., Jin X. HIV vaccine could use a little help. Human Vaccines 2010, 6:1-6.
    • (2010) Human Vaccines , vol.6 , pp. 1-6
    • Wang, J.1    Jin, X.2
  • 11
    • 53349160053 scopus 로고    scopus 로고
    • Challenges in the development of an HIV-1 vaccine
    • Barouch D.H. Challenges in the development of an HIV-1 vaccine. Nature 2008, 455:613-619.
    • (2008) Nature , vol.455 , pp. 613-619
    • Barouch, D.H.1
  • 12
    • 44949100369 scopus 로고    scopus 로고
    • Nonhuman primate models and the failure of the Merck HIV-1 vaccine in humans
    • Watkins D.I., Burton D.R., Kallas E.G., Moore J.P., Koff W.C. Nonhuman primate models and the failure of the Merck HIV-1 vaccine in humans. Nat Med 2008, 14:617-621.
    • (2008) Nat Med , vol.14 , pp. 617-621
    • Watkins, D.I.1    Burton, D.R.2    Kallas, E.G.3    Moore, J.P.4    Koff, W.C.5
  • 14
    • 77949264937 scopus 로고    scopus 로고
    • Mosaic vaccines elicit CD8(+) T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys
    • Santra S., Liao H.X., Zhang R., Muldoon M., Watson S., Fischer W., et al. Mosaic vaccines elicit CD8(+) T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys. Nat Med 2010, 16:324-328.
    • (2010) Nat Med , vol.16 , pp. 324-328
    • Santra, S.1    Liao, H.X.2    Zhang, R.3    Muldoon, M.4    Watson, S.5    Fischer, W.6
  • 15
    • 77949263061 scopus 로고    scopus 로고
    • Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys
    • Barouch D.H., O'Brien K.L., Simmons N.L., King S.L., Abbink P., Maxfield L.F., et al. Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys. Nat Med 2010, 16:319-323.
    • (2010) Nat Med , vol.16 , pp. 319-323
    • Barouch, D.H.1    O'Brien, K.L.2    Simmons, N.L.3    King, S.L.4    Abbink, P.5    Maxfield, L.F.6
  • 16
    • 56649097350 scopus 로고    scopus 로고
    • Safety and immunogenicity of recombinant poxvirus HIV-1 vaccines in young adults on highly active antiretroviral therapy
    • Greenough T.C., Cunningham C.K., Muresan P., McManus M., Persaud D., Fenton T., et al. Safety and immunogenicity of recombinant poxvirus HIV-1 vaccines in young adults on highly active antiretroviral therapy. Vaccine 2008, 26:6883-6893.
    • (2008) Vaccine , vol.26 , pp. 6883-6893
    • Greenough, T.C.1    Cunningham, C.K.2    Muresan, P.3    McManus, M.4    Persaud, D.5    Fenton, T.6
  • 17
    • 0031000023 scopus 로고    scopus 로고
    • Early HIV-1 envelope-specific cytotoxic T lymphocyte responses in vertically infected infants
    • Pikora C.A., Sullivan J.L., Panicali D., Luzuriaga K. Early HIV-1 envelope-specific cytotoxic T lymphocyte responses in vertically infected infants. J Exp Med 1997, 185:1153-1161.
    • (1997) J Exp Med , vol.185 , pp. 1153-1161
    • Pikora, C.A.1    Sullivan, J.L.2    Panicali, D.3    Luzuriaga, K.4
  • 18
    • 0025223467 scopus 로고
    • Structural analysis of wild-type and mutant human immunodeficiency virus type 1 tat proteins
    • Rice A.P., Carlotti F. Structural analysis of wild-type and mutant human immunodeficiency virus type 1 tat proteins. J Virol 1990, 64:6018-6026.
    • (1990) J Virol , vol.64 , pp. 6018-6026
    • Rice, A.P.1    Carlotti, F.2
  • 19
    • 0025766815 scopus 로고
    • Mutational definition of the human immunodeficiency virus type 1 rev activation domain
    • Malim M.H., McCarn D.F., Tiley L.S., Cullen B.R. Mutational definition of the human immunodeficiency virus type 1 rev activation domain. J Virol 1991, 65:4248-4254.
    • (1991) J Virol , vol.65 , pp. 4248-4254
    • Malim, M.H.1    McCarn, D.F.2    Tiley, L.S.3    Cullen, B.R.4
  • 20
    • 0032525137 scopus 로고    scopus 로고
    • The SH3 domain-binding surface and an acidic motif in HIV-1 nef regulate trafficking of class I MHC complexes
    • Greenberg M.E., Iafrate A.J., Skowronski J. The SH3 domain-binding surface and an acidic motif in HIV-1 nef regulate trafficking of class I MHC complexes. EMBO J 1998, 17:2777-2789.
    • (1998) EMBO J , vol.17 , pp. 2777-2789
    • Greenberg, M.E.1    Iafrate, A.J.2    Skowronski, J.3
  • 21
    • 0025731752 scopus 로고
    • Mutational analysis of two conserved sequence motifs in HIV-1 reverse transcriptase
    • Lowe D.M., Parmar V., Kemp S.D., Larder B.A. Mutational analysis of two conserved sequence motifs in HIV-1 reverse transcriptase. FEBS Lett 1991, 282:231-234.
    • (1991) FEBS Lett , vol.282 , pp. 231-234
    • Lowe, D.M.1    Parmar, V.2    Kemp, S.D.3    Larder, B.A.4
  • 22
    • 0037471207 scopus 로고    scopus 로고
    • Cardiac adverse events following smallpox vaccination-United States, 2003
    • Centers for Disease Control and Prevention.
    • Centers for Disease Control and Prevention. Cardiac adverse events following smallpox vaccination-United States, 2003. MMWR Morb Mort Wkly Rep 2003;52:248-50.
    • (2003) MMWR Morb. Mort. Wkly. Rep. , vol.52 , pp. 248-50
  • 24
    • 77949895922 scopus 로고    scopus 로고
    • Overall survival analysis of a phase II randomized controlled trial of a poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer
    • Kantoff P.W., Schuetz T.J., Blumenstein B.A., Glode L.M., Bilhartz D.L., Wyand M., et al. Overall survival analysis of a phase II randomized controlled trial of a poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer. J Clin Oncol 2010, 28:1099-1105.
    • (2010) J Clin Oncol , vol.28 , pp. 1099-1105
    • Kantoff, P.W.1    Schuetz, T.J.2    Blumenstein, B.A.3    Glode, L.M.4    Bilhartz, D.L.5    Wyand, M.6
  • 26
    • 84873061248 scopus 로고    scopus 로고
    • Division of AIDS table for grading the severity of adult and pediatric adverse events, version 1.0, December 2004; clarification August 2009
    • DAIDS Regulatory Compliance Center Web site.
    • Division of AIDS table for grading the severity of adult and pediatric adverse events, version 1.0, December 2004; clarification August 2009. DAIDS Regulatory Compliance Center Web site. http://rcc.tech-res.com/Document/safetyandpharmacovigilance/DAIDS_AE_GradingTable_Clarification_August2009_Final.doc.%20Accessed%2011%20March%202010.
  • 27
    • 34147176167 scopus 로고    scopus 로고
    • Defining blood processing parameters for optimal detection of cryopreserved antigen-specific responses for HIV vaccine trials
    • Bull M., Lee D., Stucky J.A., Chiu Y.L., Rubin A., Horton H., et al. Defining blood processing parameters for optimal detection of cryopreserved antigen-specific responses for HIV vaccine trials. J Immunol Methods 2007, 322:57-69.
    • (2007) J Immunol Methods , vol.322 , pp. 57-69
    • Bull, M.1    Lee, D.2    Stucky, J.A.3    Chiu, Y.L.4    Rubin, A.5    Horton, H.6
  • 28
    • 34248149301 scopus 로고    scopus 로고
    • Optimization and validation of an 8-color intracellular cytokine staining (ICS) assay to quantify antigen-specific T-cells induced by vaccination
    • Horton H., Thomas E.P., Stucky J.A., Frank I., Moodie Z., Huang Y., et al. Optimization and validation of an 8-color intracellular cytokine staining (ICS) assay to quantify antigen-specific T-cells induced by vaccination. J Immunol Methods 2007, 323:39-54.
    • (2007) J Immunol Methods , vol.323 , pp. 39-54
    • Horton, H.1    Thomas, E.P.2    Stucky, J.A.3    Frank, I.4    Moodie, Z.5    Huang, Y.6
  • 29
    • 56649114351 scopus 로고    scopus 로고
    • HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis
    • McElrath M.J., DeRosa S.C., Moodie Z., Dubey S., Kierstead L., Janes H., et al. HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis. Lancet 2008, 372:1894-1905.
    • (2008) Lancet , vol.372 , pp. 1894-1905
    • McElrath, M.J.1    DeRosa, S.C.2    Moodie, Z.3    Dubey, S.4    Kierstead, L.5    Janes, H.6
  • 30
    • 33846057692 scopus 로고    scopus 로고
    • Peptide selection for human immunodeficiency virus type 1 CTL-based vaccine evaluation
    • Li F., Malhotra U., Gilbert P.B., Hawkins N.R., Duerr A.C., McElrath J.M., et al. Peptide selection for human immunodeficiency virus type 1 CTL-based vaccine evaluation. Vaccine 2006, 24:6893-6904.
    • (2006) Vaccine , vol.24 , pp. 6893-6904
    • Li, F.1    Malhotra, U.2    Gilbert, P.B.3    Hawkins, N.R.4    Duerr, A.C.5    McElrath, J.M.6
  • 31
    • 33847121696 scopus 로고    scopus 로고
    • Phase 2 study of an HIV-1 canarypox vaccine (vCP1452) alone and in combination with rgp120: negative results fail to trigger a phase 3 correlates trial
    • Russell N.D., Graham B.S., Keefer M.C., McElrath M.J., Self S.G., Weinhold K.J., et al. Phase 2 study of an HIV-1 canarypox vaccine (vCP1452) alone and in combination with rgp120: negative results fail to trigger a phase 3 correlates trial. J Acquir Immune Defic Syndr 2007, 44:203-212.
    • (2007) J Acquir Immune Defic Syndr , vol.44 , pp. 203-212
    • Russell, N.D.1    Graham, B.S.2    Keefer, M.C.3    McElrath, M.J.4    Self, S.G.5    Weinhold, K.J.6
  • 33
    • 33845207796 scopus 로고    scopus 로고
    • Durable HIV-1 antibody and T-cell responses elicited by an adjuvanted multi-protein recombinant vaccine in uninfected human volunteers
    • Goepfert P.A., Tomaras G., Horton H., Montefiori D., Ferrari G., Deers M., et al. Durable HIV-1 antibody and T-cell responses elicited by an adjuvanted multi-protein recombinant vaccine in uninfected human volunteers. Vaccine 2007, 25:510-518.
    • (2007) Vaccine , vol.25 , pp. 510-518
    • Goepfert, P.A.1    Tomaras, G.2    Horton, H.3    Montefiori, D.4    Ferrari, G.5    Deers, M.6
  • 34
    • 43249120426 scopus 로고    scopus 로고
    • Recent advances in the characterization of HIV-1 neutralization assays for standard evaluation of the antibody response to infection and vaccination
    • Polonis V.R., Brown B.K., Rosa-Borges A., Zolla-Pazner S., Dimitrov D.S., Zhang M.-Y., et al. Recent advances in the characterization of HIV-1 neutralization assays for standard evaluation of the antibody response to infection and vaccination. Virology 2008, 375:315-320.
    • (2008) Virology , vol.375 , pp. 315-320
    • Polonis, V.R.1    Brown, B.K.2    Rosa-Borges, A.3    Zolla-Pazner, S.4    Dimitrov, D.S.5    Zhang, M.-Y.6
  • 35
    • 23244467373 scopus 로고    scopus 로고
    • Recommendations for the design and use of standard virus panels to assess neutralizing antibody responses elicited by candidate human immunodeficiency virus type 1 vaccines
    • Mascola J.R., D'Souza P., Gilbert P., Hahn B.H., Haigwood N.L., Morris L., et al. Recommendations for the design and use of standard virus panels to assess neutralizing antibody responses elicited by candidate human immunodeficiency virus type 1 vaccines. J Virol 2005, 79:10103-10107.
    • (2005) J Virol , vol.79 , pp. 10103-10107
    • Mascola, J.R.1    D'Souza, P.2    Gilbert, P.3    Hahn, B.H.4    Haigwood, N.L.5    Morris, L.6
  • 36
    • 0032377357 scopus 로고    scopus 로고
    • Approximate is better than " exact" for interval estimation of binomial proportions
    • Agresti A., Coull B.A. Approximate is better than " exact" for interval estimation of binomial proportions. The American Statistician 1998, 52:119-126.
    • (1998) The American Statistician , vol.52 , pp. 119-126
    • Agresti, A.1    Coull, B.A.2
  • 37
    • 77649173768 scopus 로고
    • Longitudinal data analysis using generalized linear models
    • Liang K.Y., Zeger S.L. Longitudinal data analysis using generalized linear models. Biometrika 1986, 73:13-22.
    • (1986) Biometrika , vol.73 , pp. 13-22
    • Liang, K.Y.1    Zeger, S.L.2
  • 38
    • 44749088148 scopus 로고    scopus 로고
    • EV02: A phase I trial to compare the safety and immunogenicity of HIV DNA-C prime-NYVAC-C boost to NYVAC-C alone
    • McCormack S., Stohr W., Barber T., Bart P.-A., Harari A., Moog C., et al. EV02: A phase I trial to compare the safety and immunogenicity of HIV DNA-C prime-NYVAC-C boost to NYVAC-C alone. Vaccine 2008, 26:3162-3174.
    • (2008) Vaccine , vol.26 , pp. 3162-3174
    • McCormack, S.1    Stohr, W.2    Barber, T.3    Bart, P.-A.4    Harari, A.5    Moog, C.6
  • 39
    • 33646449925 scopus 로고    scopus 로고
    • Expansion and diversification of virus-specific T cells following immunization of human immunodeficiency virus type 1 (HIV-1)-infected individuals with a recombinant modified vaccinia virus Ankara/HIV-1 Gag vaccine
    • Dorrell L., Yang H., Ondondo B., Dong T., di Gleria K., Suttill A., et al. Expansion and diversification of virus-specific T cells following immunization of human immunodeficiency virus type 1 (HIV-1)-infected individuals with a recombinant modified vaccinia virus Ankara/HIV-1 Gag vaccine. J Virol 2006, 80:4705-4716.
    • (2006) J Virol , vol.80 , pp. 4705-4716
    • Dorrell, L.1    Yang, H.2    Ondondo, B.3    Dong, T.4    di Gleria, K.5    Suttill, A.6
  • 40
    • 38749132973 scopus 로고    scopus 로고
    • An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses
    • Harari A., Bart P.-A., Stohr W., Tapia G., Garcia M., Medjitna-Rais E., et al. An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses. J Exp Med 2008, 205:63-77.
    • (2008) J Exp Med , vol.205 , pp. 63-77
    • Harari, A.1    Bart, P.-A.2    Stohr, W.3    Tapia, G.4    Garcia, M.5    Medjitna-Rais, E.6
  • 41
    • 43049181912 scopus 로고    scopus 로고
    • Safety and immunogenicity of recombinant low-dosage HIV-1 A vaccine candidates vectored by plasmid pTHr DNA or modified vaccinia virus Ankara (MVA) in humans in East Africa
    • Jaoko W., Nakwagala F.N., Anzala O., Manyonyi G.O., Birungi J., Nanvubya A., et al. Safety and immunogenicity of recombinant low-dosage HIV-1 A vaccine candidates vectored by plasmid pTHr DNA or modified vaccinia virus Ankara (MVA) in humans in East Africa. Vaccine 2008, 26:2788-2795.
    • (2008) Vaccine , vol.26 , pp. 2788-2795
    • Jaoko, W.1    Nakwagala, F.N.2    Anzala, O.3    Manyonyi, G.O.4    Birungi, J.5    Nanvubya, A.6
  • 42
    • 71949091412 scopus 로고    scopus 로고
    • A phase 1 study to evaluate the safety and immunogenicity of a recombinant HIV type-1 subtype C modified vaccinia Ankara virus vaccine candidate in Indian volunteers
    • Ramanathan V.D., Kumar M., Mahalingam J., Sathyamoorthy P., Narayanan P.R., Solomon S., et al. A phase 1 study to evaluate the safety and immunogenicity of a recombinant HIV type-1 subtype C modified vaccinia Ankara virus vaccine candidate in Indian volunteers. AIDS Res Hum Retroviruses 2009, 25:1107-1116.
    • (2009) AIDS Res Hum Retroviruses , vol.25 , pp. 1107-1116
    • Ramanathan, V.D.1    Kumar, M.2    Mahalingam, J.3    Sathyamoorthy, P.4    Narayanan, P.R.5    Solomon, S.6
  • 43
    • 77749321171 scopus 로고    scopus 로고
    • Phase 1 safety and immunogenicity evaluation of ADMVA, a multigenic, modified vaccinia Ankara-HIV-1 B'/C candidate vaccine
    • Vasan S., Schlesinger S.J., Chen Z., Hurley A., Lombardo A., Than S., et al. Phase 1 safety and immunogenicity evaluation of ADMVA, a multigenic, modified vaccinia Ankara-HIV-1 B'/C candidate vaccine. PLoS ONE 2010, 5:e8816.
    • (2010) PLoS ONE , vol.5
    • Vasan, S.1    Schlesinger, S.J.2    Chen, Z.3    Hurley, A.4    Lombardo, A.5    Than, S.6
  • 44
    • 76749126266 scopus 로고    scopus 로고
    • MVA-85A A novel candidate booster vaccine for the prevention of tuberculosis in children and adults
    • Nicol M.P., Grobler L.A., MVA-85A a novel candidate booster vaccine for the prevention of tuberculosis in children and adults. Curr Opin Mol Ther 2010, 12:24-34.
    • (2010) Curr Opin Mol Ther , vol.12 , pp. 24-34
    • Nicol, M.P.1    Grobler, L.A.2
  • 45
    • 10844264174 scopus 로고    scopus 로고
    • Differential immunogenicity of various heterologous prime-boost vaccine regimens using DNA and viral vectors in healthy volunteers
    • Vuola J.M., Keating S., Webster D.P., Berthoud T., Dunachie S., Gilbert S.C., et al. Differential immunogenicity of various heterologous prime-boost vaccine regimens using DNA and viral vectors in healthy volunteers. J Immunol 2005, 174:449-455.
    • (2005) J Immunol , vol.174 , pp. 449-455
    • Vuola, J.M.1    Keating, S.2    Webster, D.P.3    Berthoud, T.4    Dunachie, S.5    Gilbert, S.C.6
  • 46
    • 33646826522 scopus 로고    scopus 로고
    • Immunogenicity of the candidate malaria vaccines FP9 and modified vaccinia Ankara encoding the pre-erythrocytic antigen ME-TRAP in 1-6 year old children in a malaria endemic area
    • Bejon P., Mwacharo J., Kai O.K., Todryk S., Keating S., Land T., et al. Immunogenicity of the candidate malaria vaccines FP9 and modified vaccinia Ankara encoding the pre-erythrocytic antigen ME-TRAP in 1-6 year old children in a malaria endemic area. Vaccine 2006, 24:4709-4715.
    • (2006) Vaccine , vol.24 , pp. 4709-4715
    • Bejon, P.1    Mwacharo, J.2    Kai, O.K.3    Todryk, S.4    Keating, S.5    Land, T.6
  • 47
    • 33747414435 scopus 로고    scopus 로고
    • Alternating vector immunizations encoding pre-erythrocytic malaria antigens enhance memory responses in a malaria endemic area
    • Bejon P., Kai O.K., Mwacharo J., Keating S., Lang T., Gilbert S.C., et al. Alternating vector immunizations encoding pre-erythrocytic malaria antigens enhance memory responses in a malaria endemic area. Eur J Immunol 2006, 36:2264-2272.
    • (2006) Eur J Immunol , vol.36 , pp. 2264-2272
    • Bejon, P.1    Kai, O.K.2    Mwacharo, J.3    Keating, S.4    Lang, T.5    Gilbert, S.C.6
  • 48
    • 34250327922 scopus 로고    scopus 로고
    • Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8+ responses
    • Precopio M.L., Betts M.R., Parrino J., Price D.A., Gostick E., Ambrozak D.R., et al. Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8+ responses. J Exp Med 2007, 204:1405-1416.
    • (2007) J Exp Med , vol.204 , pp. 1405-1416
    • Precopio, M.L.1    Betts, M.R.2    Parrino, J.3    Price, D.A.4    Gostick, E.5    Ambrozak, D.R.6
  • 49
    • 34547763195 scopus 로고    scopus 로고
    • Heterologous prime/boost immunization of rhesus monkeys by using diverse poxvirus vectors
    • Santra S., Sun Y., Parvani J.G., Philippon V., Wyand M.S., Manson K., et al. Heterologous prime/boost immunization of rhesus monkeys by using diverse poxvirus vectors. J Virol 2007, 81:8563-8570.
    • (2007) J Virol , vol.81 , pp. 8563-8570
    • Santra, S.1    Sun, Y.2    Parvani, J.G.3    Philippon, V.4    Wyand, M.S.5    Manson, K.6
  • 50
    • 56649105122 scopus 로고    scopus 로고
    • Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial
    • Buchbinder S.P., Mehrotra D.V., Duerr A., Fitzgerald D.W., Mogg R., Li D., et al. Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet 2008, 372:1881-1893.
    • (2008) Lancet , vol.372 , pp. 1881-1893
    • Buchbinder, S.P.1    Mehrotra, D.V.2    Duerr, A.3    Fitzgerald, D.W.4    Mogg, R.5    Li, D.6
  • 51
    • 34548810955 scopus 로고    scopus 로고
    • IL-2 regulated expansion of CD4+ T-cell populations by affecting cell death: insights from modeling CFSE data
    • Ganusov V.V., Milutinovic D., DeBoer R.J. IL-2 regulated expansion of CD4+ T-cell populations by affecting cell death: insights from modeling CFSE data. J Immunol 2007, 179:950-957.
    • (2007) J Immunol , vol.179 , pp. 950-957
    • Ganusov, V.V.1    Milutinovic, D.2    DeBoer, R.J.3
  • 52
    • 0037651066 scopus 로고    scopus 로고
    • Stochastic model of T-cell proliferation: a calculus revealing IL-2 regulation of precursor frequencies, cell cycle time and survival
    • Deenick E.K., Gett A.V., Hodgkin P.D. Stochastic model of T-cell proliferation: a calculus revealing IL-2 regulation of precursor frequencies, cell cycle time and survival. J Immunol 2003, 170:4963-4972.
    • (2003) J Immunol , vol.170 , pp. 4963-4972
    • Deenick, E.K.1    Gett, A.V.2    Hodgkin, P.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.