Topical vitamin D analogue calcipotriol reduces skin fibrosis in experimental scleroderma

Archives of Dermatological Research

Volumn 306, Issue 8, 2014, Pages 757-761

  Usategui, Alicia ^a   Criado, Gabriel ^a   Del Rey, Manuel J ^a   Faré, Regina ^a   Pablos, José L ^a  

^a Instituto de Investigación Hospital 12 de Octubre ^*  (Spain)

Author keywords

IL 13; Systemic sclerosis; TSLP; Vitamin D

Indexed keywords

BLEOMYCIN; CALCIPOTRIOL; COLLAGEN; CYTOKINE; GAMMA INTERFERON; HYDROXYPROLINE; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 4; MESSENGER RNA; THYMIC STROMAL LYMPHOPOIETIN; CALCITRIOL; DERMATOLOGICAL AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DRUG EFFICACY; FEMALE; GENE EXPRESSION; MOUSE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCLERODERMA; SKIN FIBROSIS; SKINFOLD THICKNESS; STAINING; TH2 CELL; ANALOGS AND DERIVATIVES; ANIMAL; C3H MOUSE; DISEASE MODEL; DRUG EFFECTS; FIBROSIS; GENETICS; HUMAN; METABOLISM; PATHOLOGY; SCLERODERMA, SYSTEMIC; SKIN; TOPICAL DRUG ADMINISTRATION; UPREGULATION;

ADMINISTRATION, TOPICAL; ANIMALS; BLEOMYCIN; CALCITRIOL; COLLAGEN; CYTOKINES; DERMATOLOGIC AGENTS; DISEASE MODELS, ANIMAL; FEMALE; FIBROSIS; HUMANS; HYDROXYPROLINE; INTERLEUKIN-13; MICE; MICE, INBRED C3H; SCLERODERMA, SYSTEMIC; SKIN; UP-REGULATION;

EID: 84919475137     PISSN: 03403696     EISSN: 1432069X     Source Type: Journal    
DOI: 10.1007/s00403-014-1466-6     Document Type: Article

References (21)

1. Bossini-Castillo L, Broen JC, Simeon CP, Beretta L, Vonk MC, Ortego-Centeno N, Espinosa G, Carreira P, Camps MT, Navarrete N, González-Escribano MF et al (2011) A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort. Ann Rheum Dis 70:638–641
2. Bossini-Castillo L, Martin JE, Broen J, Gorlova O, Simeón CP, Beretta L, Vonk MC, Callejas JL, Castellví I, Carreira P, García-Hernández FJ et al (2012) A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations. Hum Mol Genet 21:926–933
3. Christmann BR, Mathes A, Affandi AJ, Padilla C, Nazari B, Bujor AM, Stifano G, Lafyatis R (2013) Thymic stromal lymphopoietin is up-regulated in the skin of patients with systemic sclerosis and induces profibrotic genes and intracellular signaling that overlap with those induced by interleukin-13 and transforming growth factor β. Arthritis Rheum 65:1335–1346
4. Elst EF, Van Suijlekom-Smit LW, Oranje AP (1999) Treatment of linear scleroderma with oral 1,25-dihydroxyvitamin d3 (calcitriol) in seven children. Pediatr Dermatol 16:53–58
5. Hegyi Z, Zwicker S, Bureik D, Peric M, Koglin S, Batycka-Baran A, Prinz JC, Ruzicka T, Schauber J, Wolf R (2012) Vitamin D analog calcipotriol suppresses the Th17 cytokine-induced proinflammatory S100 “alarmins” psoriasin (S100A7) and koebnerisin (S100A15) in psoriasis. J Invest Dermatol 132:1416–1424
6. Hulshof MM, Bouwes Bavinck JN, Bergman W, Masclee AA, Heickendorff L, Breedveld FC, Dijkmans BA (2000) Double-blind, placebo-controlled study of oral calcitriol for the treatment of localized and systemic scleroderma. J Am Acad Dermatol 43:1017–1023
7. Humbert PG, Dupond JL, Rochefort A, Vasselet R, Lucas A, Laurent R, Agache P (1990) Localized scleroderma-response to 1,25-dihydroxyvitamin D3. Clin Exp Dermatol 15:396–398
8. Li M, Hener P, Zhang Z, Kato S, Metxger D, Chambon P (2006) Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc Natl Acad Sci USA 103:11736–11741
9. Li M, Hener P, Zhang Z, Ganti KP, Metzger D, Chambon P (2009) Induction of thymic stromal lymphopoietin expression in keratinocytes is necessary for generating an atopic dermatitis upon application of the active vitamin D3 analogue MC903 on mouse skin. J Invest Dermatol 129:498–502
10. Li Y, Spataro BC, Yang J, Dai C, Liu Y (2005) 1,25-dihydroxyvitamin D inhibits renal interstitial myofibroblast activation by inducing hepatocyte growth factor expression. Kidney Int 68:1500–1510
11. Meneghin A, Hogaboam CM (2007) Infectious disease, the innate immune response, and fibrosis. J Clin Invest 117:530–538
12. Ramirez AM, Wongtrakool C, Welch T, Steinmeyer A, Zugel U, Roman J (2010) Vitamin D inhibition of pro-fibrotic effects of transforming growth factor beta1 in lung fibroblasts and epithelial cells. J Steroid Biochem Mol Biol 118:42–50
13. Sato-Deguchi E, Imafuku S, Chou B, Ishii K, Hiromatsu K, Nakayama J (2012) Topical vitamin D3 analogues induce thymic stromal lymphopoietin and cathelicidin in psoriatic skin lesions. Br J Dermatol 167:77–84
14. Slominski A, Janjetovic Z, Tuckey RC, Nguyen MN, Bhattacharya KG, Wang J, Li W, Jiao Y, Gu W, Brown M, Postlethwaite AE (2013) 20S-hydroxyvitamin D3, noncalcemic product of CYP11A1 action on vitamin D3, exhibits potent antifibrogenic activity in vivo. J Clin Endocrinol Metab 98:E298–E303
15. Uchida M, Shima M, Chikazu D, Fujieda A, Obara K, Suzuki H, Nagai Y, Yamato H, Kawaguchi H (2001) Transcriptional induction of matrix metalloproteinase-13 (collagenase-3) by 1alpha,25-dihydroxyvitamin D3 in mouse osteoblastic MC3T3-E1 cells. J Bone Miner Res 16:221–230
16. Usategui A, Criado G, Izquierdo E, Del Rey MJ, Carreira PE, Ortiz P, Leonard WJ, Pablos JL (2013) A profibrotic role for thymic stromal lymphopoietin in systemic sclerosis. Ann Rheum Dis 72:2018–2023
17. Vacca A, Cormier C, Mathie A, Kahan A, Allanore Y (2011) Vitamin D levels and potential impact in systemic sclerosis. Clin Exp Rheumatol 29:1024–1031
18. Wynn TA (2011) Integrating mechanisms of pulmonary fibrosis. J Exp Med 208:1339–1350
19. Yamamoto T, Nishioka K (2005) Cellular and molecular mechanisms of bleomycin-induced murine scleroderma: current update and future perspective. Exp Dermatol 14:81–95
20. Zerr P, Vollath S, Palumbo-Zerr K, Tomcik M,Huang J,Distler A, Beyer C, Dees C, Gela K, Distler O, Schett G, Distler JH (2014) Vitamin D receptor regulates TGF-β signalling in systemic sclerosis. Ann Rheum Dis [Epub ahead of print]. doi:10.1136/annrheumdis-2013-204378
21. Zhang GY, Cheng T, Luan Q, Liao T, Nie CL, Zheng X, Xie XG, Gao WY (2011) Vitamin D: a novel therapeutic approach for keloid, an in vitro analysis. Br J Dermatol 164:729–737