Genotypic susceptibility testing of Mycobacterium tuberculosis isolates for amikacin and kanamycin resistance by use of a rapid sloppy molecular beacon-based assay identifies more cases of low-level drug resistance than phenotypic Lowenstein-Jensen testing

Journal of Clinical Microbiology

Volumn 53, Issue 1, 2015, Pages 43-51

  Chakravorty, Soumitesh ^a   Lee, Jong Seok ^b   Cho, Eun Jin ^b   Roh, Sandy S ^a   Smith, Laura E ^a   Lee, Jiim ^b   Kim, Cheon Tae ^c   Via, Laura E ^d   Cho, Sang Nae ^b,e   Barry, Clifton E ^d   Alland, David ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b International Tuberculosis Research Center   (South Korea)

^c National Masan Tuberculosis Hospital   (South Korea)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^e Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; BACTERIAL DNA; KANAMYCIN; ANTIINFECTIVE AGENT;

5' UNTRANSLATED REGION; AMPLICON; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; EIS GENE; GENE MUTATION; GENE SEQUENCE; GENOTYPE; HUMAN; LOWENSTEIN JENSEN TESTING; MAJOR CLINICAL STUDY; MICROBIOLOGICAL EXAMINATION; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR BEACON; MULTIDRUG RESISTANT TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHENOTYPE; PROMOTER REGION; RRS GENE; SENSITIVITY AND SPECIFICITY; SLOPPY MOLECULAR BEACON; SOUTH KOREA; STANDARD; WILD TYPE; DNA SEQUENCE; DRUG EFFECTS; GENETICS; GENOTYPING TECHNIQUE; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MULTIDRUG RESISTANCE; MUTATION; PROCEDURES; REPRODUCIBILITY; STANDARDS; TUBERCULOSIS; TUBERCULOSIS, MULTIDRUG-RESISTANT;

MYCOBACTERIUM TUBERCULOSIS;

AMIKACIN; ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GENES, BACTERIAL; GENOTYPING TECHNIQUES; HUMANS; KANAMYCIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; MUTATION; MYCOBACTERIUM TUBERCULOSIS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SEQUENCE ANALYSIS, DNA; TUBERCULOSIS; TUBERCULOSIS, MULTIDRUG-RESISTANT;

EID: 84919468008     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.02059-14     Document Type: Article

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