G-quadruplex structures formed by expanded hexanucleotide repeat RNA and DNA from the neurodegenerative disease-linked C9orf72 gene efficiently sequester and activate heme

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Grigg, Jason C ^a   Shumayrikh, Nisreen ^a   Sen, Dipankar ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; GUANINE QUADRUPLEX; HEME; OLIGOMER; OXIDOREDUCTASE; PEROXIDASE; POTASSIUM ION; C9ORF72 PROTEIN, HUMAN; DNA; PROTEIN; REPETITIVE DNA; RNA;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BINDING AFFINITY; BINDING SITE; BRAIN NERVE CELL; C9ORF72 GENE; CIRCULAR DICHROISM; COMPLEX FORMATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DNA STRUCTURE; ENZYME ACTIVITY; EXPANDED HEXANUCLEOTIDE REPEAT RNA; FRONTOTEMPORAL DEMENTIA; GENE; GENETIC ASSOCIATION; MOLECULAR DYNAMICS; NUCLEIC ACID PROBE; OXIDATIVE STRESS; PROTEIN DNA BINDING; RNA FOLDING; RNA STRUCTURE; STRUCTURE ACTIVITY RELATION; CHEMISTRY; GENETICS; HUMAN; METABOLISM; OXIDATION REDUCTION REACTION;

DNA; DNA REPEAT EXPANSION; G-QUADRUPLEXES; HEME; HUMANS; NEURODEGENERATIVE DISEASES; OXIDATION-REDUCTION; PEROXIDASE; PROTEINS; RNA;

EID: 84919454028     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0106449     Document Type: Article

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