Unraveling plant hormone signaling through the use of small molecules

Frontiers in Plant Science

Volumn 5, Issue JUL, 2014, Pages

  Rigal, Adeline ^a   Ma, Qian ^a   Robert, Stéphanie ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

Agonists and antagonists; Hormone signaling; Labeled molecule; Phytohormones; Structure activity relationship

Indexed keywords

EID: 84919452119     PISSN: None     EISSN: 1664462X     Source Type: Journal    
DOI: 10.3389/fpls.2014.00373     Document Type: Review

References (170)

1. Abel, S., Nguyen, M. D., and Theologis, A. (1995). The PS-IAA4/5-like family of early auxin-inducible mRNAs inArabidopsis thaliana. J. Mol. Biol. 251, 533-549. doi: 10. 1006/jmbi. 1995. 0454.
2. Akiyama, K., Ogasawara, S., Ito, S., and Hayashi, H. (2010). Structural requirements of strigolactones for hyphal branching in AM Fungi. Plant Cell Physiol. 51, 1104-1117. doi: 10. 1093/Pcp/Pcq058.
3. Allan, A. C., Fricker, M. D., Ward, J. L., Beale, M. H., and Trewavas, A. J. (1994). Two transduction pathways mediate rapid effects of abscisic acid in Commelina guard cells. Plant Cell 6, 1319-1328. doi: 10. 1105/tpc. 6. 9. 1319.
4. Allan, A. C., Ward, J. L., Beale, M. H., and Trewavas, A. J. (1998). Caged plant growth regulators. Methods Enzymol. 291, 474-483.
5. Arata, Y., Nagasawa-Iida, A., Uneme, H., Nakajima, H., Kakimoto, T., and Sato, R. (2010). The phenylquinazoline compound S-4893 is a non-competitive cytokinin antagonist that targets Arabidopsis cytokinin receptor CRE1 and promotes root growth in Arabidopsis and rice. Plant Cell Physiol. 51, 2047-2059. doi: 10. 1093/pcp/pcq163.
6. Back, T. G., Janzen, L., Pharis, R. P., and Yan, Z. (2002). Synthesis and bioactivity of C-2 and C-3 methyl ether derivatives of brassinolide. Phytochemistry 59, 627-634. doi: 10. 1016/S0031-9422(02)00019-5.
7. Back, T. G., and Pharis, R. P. (2003). Structure-cctivity studies of brassinosteroids and the search for novel analogues and mimetics with improved bioactivity. J. Plant Growth Regul. 22, 350-361. doi: 10. 1007/s00344-003-0057-0.
8. Bajguz, A. (2011). "Brassinosteroids-occurence and chemical structures in plants", in Brassinosteroids: A Class of Plant Hormone, eds S. Hayat and A. Ahmad (Dordrecht: Springer), 1-27.
9. Bajguz, A., and Piotrowska, A. (2009). Conjugates of auxin and cytokinin. Phytochemistry 70, 957-969. doi: 10. 1016/j. phytochem. 2009. 05. 006.
10. Bajguz, A., and Tretyn, A. (2003). The chemical characteristic and distribution of brassinosteroids in plants. Phytochemistry 62, 1027-1046. doi: 10. 1016/S0031-9422(02)00656-8.
11. Bargmann, B. O. R., and Estelle, M. (2014). Auxin perception: in the IAA of the beholder. Physiol. Plant 151, 52-61. doi: 10. 1111/ppl. 12135.
12. Baron, D. L., Luo, W., Janzen, L., Pharis, R. P., and Back, T. G. (1998). Structure-activity studies of brassinolide B-ring analogues. Phytochemistry 49, 1849-1858. doi: 10. 1016/S0031-9422(98)00367-7.
13. Benson, C. L., Kepka, M., Wunschel, C., Rajagopalan, N., Nelson, K. M., Christmann, A., et al. (2014). Abscisic acid analogs as chemical probes for dissection of abscisic acid responses in Arabidopsis thaliana. Phytochemistry. doi: 10. 1016/j. phytochem. 2014. 03. 017. [Epub ahead of print].
14. Besserer, A., Puech-Pages, V., Kiefer, P., Gomez-Roldan, V., Jauneau, A., Roy, S., et al. (2006). Strigolactones stimulate arbuscular mycorrhizal fungi by activating mitochondria. PLoS Biol. 4: e226. doi: 10. 1371/journal. pbio. 0040226.
15. Bhattacharya, C., Bonfante, P., Deagostino, A., Kapulnik, Y., Larini, P., Occhiato, E. G., et al. (2009). A new class of conjugated strigolactone analogues with fluorescent properties: synthesis and biological activity. Org. Biomol. Chem. 7, 3413-3420. doi: 10. 1039/b907026e.
16. Boyer, F. D., De Saint Germain, A., Pillot, J. P., Pouvreau, J. B., Chen, V. X., Ramos, S., et al. (2012). Structure-activity relationship studies of strigolactone-related molecules for branching inhibition in garden pea: molecule design for shoot branching. Plant Physiol. 159, 1524-1544. doi: 10. 1104/pp. 112. 195826.
17. Boyer, F. D., De Saint Germain, A., Pouvreau, J. B., Clave, G., Pillot, J. P., Roux, A., et al. (2014). New strigolactone analogs as plant hormones with low activities in the rhizosphere. Mol. Plant 7, 675-690. doi: 10. 1093/mp/sst163.
18. Calderón-Villalobos, L. I. A., Lee, S., De Oliveira, C., Ivetac, A., Brandt, W., Armitage, L., et al. (2012). A combinatorial TIR1/AFB-Aux/IAA co-receptor system for differential sensing of auxin. Nat. Chem. Biol. 8, 477-485. doi: 10. 1038/nchembio. 926.
19. Cao, M., Liu, X., Zhang, Y., Xue, X., Zhou, X. E., Melcher, K., et al. (2013). An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants. Cell Res. 23, 1043-1054. doi: 10. 1038/cr. 2013. 95.
20. Chen, N. H., Reith, M. E., and Quick, M. W. (2004). Synaptic uptake and beyond: the sodium-and chloride-dependent neurotransmitter transporter family SLC6. Pflugers Arch. 447, 519-531. doi: 10. 1007/s00424-003-1064-5.
21. Chen, V. X., Boyer, F. D., Rameau, C., Pillot, J. P., Vors, J. P., and Beau, J. M. (2013). New synthesis of A-ring aromatic strigolactone analogues and their evaluation as plant hormones in pea (Pisum sativum). Chemistry 19, 4849-4857. doi: 10. 1002/chem. 201203585.
22. Chorell, E., Pinkner, J. S., Bengtsson, C., Edvinsson, S., Cusumano, C. K., Rosenbaum, E., et al. (2012). Design and synthesis of fluorescent pilicides and curlicides: bioactive tools to study bacterial virulence mechanisms. Chemistry 18, 4522-4532. doi: 10. 1002/chem. 201103936.
23. Cohen, M., Prandi, C., Occhiato, E. G., Tabasso, S., Wininger, S., Resnick, N., et al. (2013). Structure-function relations of strigolactone analogs: activity as plant hormones and plant interactions. Mol. Plant 6, 141-152. doi: 10. 1093/mp/sss134.
24. Cutler, S. R., Rodriguez, P. L., Finkelstein, R. R., and Abrams, S. R. (2010). Abscisic acid: emergence of a core signaling network. Annu. Rev. Plant Biol. 61, 651-679. doi: 10. 1146/annurev-arplant-042809-112122.
25. De Rybel, B., Audenaert, D., Beeckman, T., and Kepinski, S. (2009a). The past, present, and future of chemical biology in auxin research. ACS Chem. Biol. 4, 987-998. doi: 10. 1021/cb9001624.
26. De Rybel, B., Audenaert, D., Vert, G., Rozhon, W., Mayerhofer, J., Peelman, F., et al. (2009b). Chemical inhibition of a subset of Arabidopsis thaliana GSK3-like kinases activates brassinosteroid signaling. Chem. Biol. 16, 594-604. doi: 10. 1016/j. chembiol. 2009. 04. 008.
27. De-Saint Germain, A., Bonhomme, S., Boyer, F. D., and Rameau, C. (2013). Novel insights into strigolactone distribution and signalling. Curr. Opin. Plant Biol. 16, 583-589. doi: 10. 1016/j. pbi. 2013. 06. 007.
28. Dharmasiri, N., Dharmasiri, S., and Estelle, M. (2005a). The F-box protein TIR1 is an auxin receptor. Nature 435, 441-445. doi: 10. 1038/nature03543.
29. Dharmasiri, N., Dharmasiri, S., Weijers, D., Lechner, E., Yamada, M., Hobbie, L., et al. (2005b). Plant development is regulated by a family of auxin receptor F box proteins. Dev. Cell 9, 109-119. doi: 10. 1016/j. devcel. 2005. 05. 014.
30. Dos Santos Maraschin, F., Memelink, J., and Offringa, R. (2009). Auxin-induced, SCFTIR1-mediated poly-ubiquitination marks AUX/IAA proteins for degradation. Plant J. 59, 100-109. doi: 10. 1111/j. 1365-313X. 2009. 03854. x.
31. Ellis-Davies, G. C. R. (2007). Caged compounds: photorelease technology for control of cellular chemistry and physiology. Nat. Methods 4, 619-628. doi: 10. 1038/Nmeth1072.
32. Eriksen, J., Rasmussen, S. G., Rasmussen, T. N., Vaegter, C. B., Cha, J. H., Zou, M. F., et al. (2009). Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs. J. Neurosci. 29, 6794-6808. doi: 10. 1523/JNEUROSCI. 4177-08. 2009.
33. Estelle, M., and Somerville, C. (1987). Auxin-resistant mutants of Arabidopsis thaliana with an altered morphology. Mol. Genet. Gnomics 206, 200-206. doi: 10. 1007/BF00333575.
34. Fu, Z. Q., Yan, S., Saleh, A., Wang, W., Ruble, J., Oka, N., et al. (2012). NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants. Nature 486, 228-232. doi: 10. 1038/nature11162.
35. Fujii, H., Verslues, P. E., and Zhu, J.-K. (2007). Identification of two protein kinases required for abscisic acid regulation of seed germination, root growth, and gene expression in Arabidopsis. Plant Cell 19, 485-494. doi: 10. 1105/tpc. 106. 048538.
36. Fujii, H., and Zhu, J. K. (2009). Arabidopsis mutant deficient in 3 abscisic acid-activated protein kinases reveals critical roles in growth, reproduction, and stress. Proc. Natl. Acad. Sci. U. S. A. 106, 8380-8385. doi: 10. 1073/pnas. 0903144106.
37. Fujioka, S. (1999). "Natural occurrence of brassinosteroids in the plant kingdom", in Brassinosteroids: Steroidal Plant Hormones, eds A. Sakurai, T. Yokota, and S. D. Clouse (Tokyo: Springer-Verlag), 21-45.
38. Fukui, K., Ito, S., and Asami, T. (2013). Selective mimics of strigolactone actions and their potential use for controlling damage caused by root parasitic weeds. Mol. Plant 6, 88-99. doi: 10. 1093/mp/sss138.
39. Fukui, K., Ito, S., Ueno, K., Yamaguchi, S., Kyozuka, J., and Asami, T. (2011). New branching inhibitors and their potential as strigolactone mimics in rice. Bioorg. Med. Chem. Lett. 21, 4905-4908. doi: 10. 1016/j. bmcl. 2011. 06. 019.
40. Furihata, T., Maruyama, K., Fujita, Y., Umezawa, T., Yoshida, R., Shinozaki, K., et al. (2006). Abscisic acid-dependent multisite phosphorylation regulates the activity of a transcription activator AREB1. Proc. Natl. Acad. Sci. U. S. A. 103, 1988-1993. doi: 10. 1073/pnas. 0505667103.
41. Gendron, J. M., Haque, A., Gendron, N., Chang, T., Asami, T., and Wang, Z. Y. (2008). Chemical genetic dissection of brassinosteroid-ethylene interaction. Mol. Plant 1, 368-379. doi: 10. 1093/mp/ssn005.
42. Gether, U., Andersen, P. H., Larsson, O. M., and Schousboe, A. (2006). Neurotransmitter transporters: molecular function of important drug targets. Trends Pharmacol. Sci. 27, 375-383. doi: 10. 1016/j. tips. 2006. 05. 003.
43. Gleason, C., Foley, R. C., and Singh, K. B. (2011). Mutant analysis in Arabidopsis provides insight into the molecular mode of action of the auxinic herbicide dicamba. PLoS ONE 6: e17245. doi: 10. 1371/journal. pone. 0017245.
44. Gómez-Cadenas, A., Verhey, S. D., Holappa, L. D., Shen, Q., Ho, T. H. D., and Walker-Simmons, M. K. (1999). An abscisic acid-induced protein kinase, PKABA1, mediates abscisic acid-suppressed gene expression in barley aleurone layers. Proc. Natl. Acad. Sci. U. S. A. 96, 1767-1772. doi: 10. 1073/pnas. 96. 4. 1767.
45. Gray, W. M., Kepinski, S., Rouse, D., Leyser, O., and Estelle, M. (2001). Auxin regulates SCFTIR1-dependent degradation of AUX/IAA proteins. Nature 414, 271-276. doi: 10. 1038/35104500.
46. Greenham, K., Santner, A., Castillejo, C., Mooney, S., Sairanen, I., Ljung, K., et al. (2011). The AFB4 auxin receptor is a negative regulator of auxin signaling in seedlings. Curr. Biol. 21, 520-525. doi: 10. 1016/j. cub. 2011. 02. 029.
47. Grove, M. D., Spencer, G. F., Rohwedder, W. K., Mandava, N., Worley, J. F., Warthen, J. D., et al. (1979). Brassinolide, a plant growth-promoting steroid isolated from Brassica-Napus pollen. Nature 281, 216-217. doi: 10. 1038/281216a0.
48. Hamiaux, C., Drummond, R. S. M., Janssen, B. J., Ledger, S. E., Cooney, J. M., Newcomb, R. D., et al. (2012). DAD2 is an alpha/beta hydrolase likely to be involved in the perception of the plant branching hormone, strigolactone. Curr. Biol. 22, 2032-2036. doi: 10. 1016/j. cub. 2012. 08. 007.
49. Hasdenteufel, F., Luyasu, S., Hougardy, N., Fisher, M., Boisbrun, M., Mertes, P. M., et al. (2012). Structure-activity relationships and drug allergy. Curr. Clin. Pharmacol. 7, 15-27. doi: 10. 2174/15748841279921881.
50. Hayashi, K. I., Kusaka, N., Ando, K., Mitsui, T., Aoyama, T., and Nozaki, H. (2012a). Design and synthesis of photolabile caged cytokinin. Bioorg. Med. Chem. Lett. 22, 5663-5667. doi: 10. 1016/j. bmcl. 2012. 06. 090.
51. Hayashi, K. I., Neve, J., Hirose, M., Kuboki, A., Shimada, Y., Kepinski, S., et al. (2012b). Rational design of an auxin antagonist of the SCFTIR1 auxin receptor complex. ACS Chem. Biol. 7, 590-598. doi: 10. 1021/cb200404c.
52. Hayashi, K. I., and Overvoorde, P. (2013). "Use of chemical biology to understand auxin metabolism, signaling, and polar transport", in Plant Chemical Biology, eds D. Audenaert and P. Overvoorde (Hoboken, NJ: John Wiley & Sons, Inc), 93-127.
53. Hayashi, K. I., Tan, X., Zheng, N., Hatate, T., Kimura, Y., Kepinski, S., et al. (2008a). Small-molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling. Proc. Natl. Acad. Sci. U. S. A. 105, 5632-5637. doi: 10. 1073/pnas. 0711146105.
54. Hayashi, K. I., Yamazoe, A., Ishibashi, Y., Kusaka, N., Oono, Y., and Nozaki, H. (2008b). Active core structure of terfestatin A, a new specific inhibitor of auxin signaling. Bioorg. Med. Chem. 16, 5331-5344. doi: 10. 1016/j. bmc. 2008. 02. 085.
55. Hecht, S. M., Bock, R. M., Schmitz, R. Y., Skoog, F., and Leonard, N. J. (1971). Cytokinins-development of a potent antagonist. Proc. Natl. Acad. Sci. U. S. A. 68, 2608-2610. doi: 10. 1073/pnas. 68. 10. 2608.
56. Hothorn, M., Belkhadir, Y., Dreux, M., Dabi, T., Noel, J. P., Wilson, I. A., et al. (2011). Structural basis of steroid hormone perception by the receptor kinase BRI1. Nature 474, 467-471. doi: 10. 1038/nature10153.
57. Irani, N. G., Di Rubbo, S., Mylle, E., Van Den Begin, J., Schneider-Pizon, J., Hnilikova, J., et al. (2012). Fluorescent castasterone reveals BRI1 signaling from the plasma membrane. Nat. Chem. Biol. 8, 583-589. doi: 10. 1038/Nchembio. 958.
58. Iwamura, H., Ito, T., Kumazawa, Z., and Ogawa, Y. (1974). Anticytokinin activity of 4-furfurylamino-7-(beta-D-ribofuranosyl)pyrrolo(2, 3)pyrimidine. Biochem. Biophys. Res. Commun. 57, 412-416. doi: 10. 1016/0006-291X(74)90946-2.
59. Iwamura, H., Ito, T., Kumazawa, Z., and Ogawa, Y. (1975). Synthesis and anticytokinin activity of 4-substituted-7-(beta-D-ribofuranosyl)-pyrrolo[2, 3-D]pyrimidines. Phytochemistry 14, 2317-2321. doi: 10. 1016/0031-9422(75)80336-0.
60. Janssen, B. J., and Snowden, K. C. (2012). Strigolactone and karrikin signal perception: receptors, enzymes, or both? Front. Plant Sci. 3: 296. doi: 10. 3389/fpls. 2012. 00296.
61. Johnson, A. W., Gowada, G., Hassanali, A., Knox, J., Monaco, S., Razavi, Z., et al. (1981). The preparation of synthetic analogues of strigol. J. Chem. Soc. Perkin Trans. 1, 1734-1743. doi: 10. 1039/P19810001734.
62. Johnson, A. W., Rosebery, G., and Parker, C. (1976). Novel-approach to Striga and Orobanche control using synthetic germination stimulants. Weed Res. 16, 223-227. doi: 10. 1111/j. 1365-3180. 1976. tb00406. x.
63. Jones, A. M., and Venis, M. A. (1989). Photoaffinity labeling of indole-3-acetic acid-binding proteins in maize. Proc. Natl. Acad. Sci. U. S. A. 86, 6153-6156. doi: 10. 1073/pnas. 86. 16. 6153.
64. Kagiyama, M., Hirano, Y., Mori, T., Kim, S. Y., Kyozuka, J., Seto, Y., et al. (2013). Structures of D14 and D14L in the strigolactone and karrikin signaling pathways. Genes Cells 18, 147-160. doi: 10. 1111/Gtc. 12025.
65. Kepinski, S., and Leyser, O. (2005). The Arabidopsis F-box protein TIR1 is an auxin receptor. Nature 435, 446-451. doi: 10. 1038/nature03542.
66. Kim, T. H., Hauser, F., Ha, T., Xue, S., Böhmer, M., Nishimura, N., et al. (2011). Chemical genetics reveals negative regulation of abscisic acid signaling by a plant immune response pathway. Curr. Biol. 21, 990-997. doi: 10. 1016/j. cub. 2011. 04. 045.
67. Kim, W. H., Lee, J., Jung, D. W., and Williams, D. R. (2012). Visualizing sweetness: increasingly diverse applications for fluorescent-tagged glucose bioprobes and their recent structural modifications. Sensors (Basel) 12, 5005-5027. doi: 10. 3390/s120405005.
68. Kinoshita, T., Cano-Delgado, A. C., Seto, H., Hiranuma, S., Fujioka, S., Yoshida, S., et al. (2005). Binding of brassinosteroids to the extracellular domain of plant receptor kinase BRI1. Nature 433, 167-171. doi: 10. 1038/Nature03227.
69. Kitahata, N., and Asami, T. (2011). Chemical biology of abscisic acid. J. Plant Res. 124, 549-557. doi: 10. 1007/s10265-011-0415-0.
70. Kobayashi, Y., Murata, M., Minami, H., Yamamoto, S., Kagaya, Y., Hobo, T., et al. (2005). Abscisic acid-activated SNRK2 protein kinases function in the gene-regulation pathway of ABA signal transduction by phosphorylating ABA response element-binding factors. Plant J. 44, 939-949. doi: 10. 1111/j. 1365-313X. 2005. 02583. x.
71. Kondo, Y., Tadokoro, E., Matsuura, M., Iwasaki, K., Sugimoto, Y., Miyake, H., et al. (2007). Synthesis and seed germination stimulating activity of some imino analogs of strigolactones. Biosci. Biotechnol. Biochem. 71, 2781-2786. doi: 10. 1271/bbb. 70398.
72. Krivosheev, D. M., Kolyachkina, S. V., Mikhailov, S. N., Tararov, V. I., Vanyushin, B. F., and Romanov, G. A. (2012). N(6)-(benzyloxymethyl)adenosine is a novel anticytokinin, an antagonist of cytokinin receptor CRE1/AHK4 of Arabidopsis. Dokl. Biochem. Biophys. 444, 178-181. doi: 10. 1134/S1607672912030155.
73. Kusaka, N., Maisch, J., Nick, P., Hayashi, K., and Nozaki, H. (2009). Manipulation of intracellular auxin in a single cell by light with esterase-resistant caged auxins. Chembiochem 10, 2195-2202. doi: 10. 1002/cbic. 200900289.
74. Lawton, K. A., Friedrich, L., Hunt, M., Weymann, K., Delaney, T., Kessmann, H., et al. (1996). Benzothiadiazole induces disease resistance in Arabidopsis by activation of the systemic acquired resistance signal transduction pathway. Plant J. 10, 71-82. doi: 10. 1046/j. 1365-313X. 1996. 10010071. x.
75. Leonhardt, N., Kwak, J. M., Robert, N., Waner, D., Leonhardt, G., and Schroeder, J. I. (2004). Microarray expression analyses of Arabidopsis guard cells and isolation of a recessive abscisic acid hypersensitive protein phosphatase 2C mutant. Plant Cell 16, 596-615. doi: 10. 1105/tpc. 019000.
76. Liebisch, H. W., Benes, J., and Benes, I. (1988). Comparative investigations on the metabolic-fate of a GA3 amino-acid conjugate with those of glucosides and derivatives of GA3. Biol. Plant. 30, 120-123. doi: 10. 1007/Bf02878480.
77. Lomin, S. N., Krivosheev, D. M., Steklov, M. Y., Osolodkin, D. I., and Romanov, G. A. (2012). Receptor properties and features of cytokinin signaling. Acta Naturae 4, 31-45.
78. Löbler, M., and Klämbt, D. (1985). Auxin-binding protein from coleoptile membranes of corn (Zea mays L.). I. Purification by immunological methods and characterization. J. Biol. Chem. 260, 9848-9853.
79. Ma, Q., and Robert, S. (2014). Auxin biology revealed by small molecules. Physiol. Plant 151, 25-42. doi: 10. 1111/ppl. 12128.
80. Mandava, N. B. (1988). Plant growth-promoting brassinosteroids. Annu. Rev. Plant Physiol. Plant. Mol. Biol. 39, 23-52. doi: 10. 1146/annurev. arplant. 39. 1. 23.
81. Mangnus, E. M., Vanvliet, L. A., Vandenput, D. L., and Zwanenburg, B. (1992). Structural modifications of strigol analogs. Influence of the B and C rings on the bioactivity of the germination stimulant GR24. J. Agric. Food Chem. 40, 1222-1229. doi: 10. 1021/Jf00019a030.
82. Mangnus, E. M., and Zwanenburg, B. (1992). Tentative molecular mechanism for germination stimulation of Striga and Orobanche seeds by strigol and its synthetic analogs. J. Agric. Food Chem. 40, 1066-1070. doi: 10. 1021/Jf00018a032.
83. Mashiguchi, K., Sasaki, E., Shimada, Y., Nagae, M., Ueno, K., Nakano, T., et al. (2009). Feedback-regulation of strigolactone biosynthetic genes and strigolactone-regulated genes in Arabidopsis. Biosci. Biotechnol. Biochem. 73, 2460-2465. doi: 10. 1271/bbb. 90443.
84. Melcher, K., Ng, L.-M., Zhou, X. E., Soon, F.-F., Xu, Y., Suino-Powell, K. M., et al. (2009). A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors. Nature 462, 602-608. doi: 10. 1038/nature08613.
85. Melcher, K., Xu, Y., Ng, L.-M., Zhou, X. E., Soon, F.-F., Chinnusamy, V., et al. (2010). Identification and mechanism of ABA receptor antagonism. Nat. Struct. Mol. Biol. 17, 1102-1108. doi: 10. 1038/nsmb. 1887.
86. Merlot, S., Gosti, F., Guerrier, D., Vavasseur, A., and Giraudat, J. (2001). The ABI1 and ABI2 protein phosphatases 2C act in a negative feedback regulatory loop of the abscisic acid signalling pathway. Plant J. 25, 295-303. doi: 10. 1046/j. 1365-313x. 2001. 00965. x.
87. Miyakawa, T., Fujita, Y., Yamaguchi-Shinozaki, K., and Tanokura, M. (2013). Structure and function of abscisic acid receptors. Trends Plant Sci. 18, 259-266. doi: 10. 1016/j. tplants. 2012. 11. 002.
88. Miyazono, K.-I., Miyakawa, T., Sawano, Y., Kubota, K., Kang, H.-J., Asano, A., et al. (2009). Structural basis of abscisic acid signalling. Nature 462, 609-614. doi: 10. 1038/nature08583.
89. Mok, D. W., and Mok, M. C. (2001). Cytokinin metabolism and action. Annu. Rev. Plant Physiol. Plant Mol. Biol. 52, 89-118. doi: 10. 1146/annurev. arplant. 52. 1. 89.
90. Muscolo, A., Sidari, M., Francioso, O., Tugnoli, V., and Nardi, S. (2007). The auxin-like activity of humic substances is related to membrane interactions in carrot cell cultures. J. Chem. Ecol. 33, 115-129. doi: 10. 1007/s10886-006-9206-9.
91. Mustilli, A.-C., Merlot, S., Vavasseur, A., Fenzi, F., and Giraudat, J. (2002). Arabidopsis OST1 protein kinase mediates the regulation of stomatal aperture by abscisic acid and acts upstream of reactive oxygen species production. Plant Cell 14, 3089-3099. doi: 10. 1105/tpc. 007906.
92. Muto, T., and Todoroki, Y. (2013). Brassinolide-2, 3-acetonide: a brassinolide-induced rice lamina joint inclination antagonist. Bioorg. Med. Chem. 21, 4413-4419. doi: 10. 1016/j. bmc. 2013. 04. 048.
93. Nakashima, K., Fujita, Y., Kanamori, N., Katagiri, T., Umezawa, T., Kidokoro, S., et al. (2009). Three Arabidopsis SnRK2 protein kinases, SRK2D/SnRK2. 2, SRK2E/SnRK2. 6/OST1 and SRK2I/SnRK2. 3, involved in ABA signaling are essential for the control of seed development and dormancy. Plant Cell Physiol. 50, 1345-1363. doi: 10. 1093/pcp/pcp083.
94. Nefkens, G. H. L., Thuring, J. W. J. F., Beenakkers, M. F. M., and Zwanenburg, B. (1997). Synthesis of a phthaloylglycine-derived strigol analogue and its germination stimulatory activity toward seeds of the parasitic weeds Striga hermonthica and Orobanche crenata. J. Agric. Food Chem. 45, 2273-2277. doi: 10. 1021/Jf9604504.
95. Nelson, D. C., Flematti, G. R., Ghisalberti, E. L., Dixon, K. W., and Smith, S. M. (2012). Regulation of seed germination and seedling growth by chemical signals from burning vegetation. Annu. Rev. Plant Biol. 63, 107-130. doi: 10. 1146/annurev-arplant-042811-105545.
96. Nelson, D. C., Scaffidi, A., Dun, E. A., Waters, M. T., Flematti, G. R., Dixon, K. W., et al. (2011). F-box protein MAX2 has dual roles in karrikin and strigolactone signaling in Arabidopsis thaliana. Proc. Natl. Acad. Sci. U. S. A. 108, 8897-8902. doi: 10. 1073/pnas. 1100987108.
97. Nishimura, N., Hitomi, K., Arvai, A. S., Rambo, R. P., Hitomi, C., Cutler, S. R., et al. (2009). Structural mechanism of abscisic acid binding and signaling by dimeric PYR1. Science 326, 1373-1379. doi: 10. 1126/science. 1181829.
98. Nishimura, N., Yoshida, T., Kitahata, N., Asami, T., Shinozaki, K., and Hirayama, T. (2007). ABA-Hypersensitive Germination1 encodes a protein phosphatase 2C, an essential component of abscisic acid signaling in Arabidopsis seed. Plant J. 50, 935-949. doi: 10. 1111/j. 1365-313X. 2007. 03107. x.
99. Nisler, J., Zatloukal, M., Popa, I., Dolezal, K., Strnad, M., and Spichal, L. (2010). Cytokinin receptor antagonists derived from 6-benzylaminopurine. Phytochemistry 71, 823-830. doi: 10. 1016/j. phytochem. 2010. 01. 018.
100. Noutoshi, Y., Jikumaru, Y., Kamiya, Y., and Shirasu, K. (2012). ImprimatinC1, a novel plant immune-priming compound, functions as a partial agonist of salicylic acid. Sci. Rep. 2: 705. doi: 10. 1038/srep00705.
101. Okamoto, M., Peterson, F. C., Defries, A., Park, S.-Y., Endo, A., Nambara, E., et al. (2013). Activation of dimeric ABA receptors elicits guard cell closure, ABA-regulated gene expression, and drought tolerance. Proc. Natl. Acad. Sci. U. S. A. 110, 12132-12137. doi: 10. 1073/pnas. 1305919110.
102. Pajerowska-Mukhtar, K. M., Emerine, D. K., and Mukhtar, M. S. (2013). Tell me more: roles of NPRs in plant immunity. Trends Plant Sci. 18, 402-411. doi: 10. 1016/j. tplants. 2013. 04. 004.
103. Park, S. Y., Fung, P., Nishimura, N., Jensen, D. R., Fujii, H., Zhao, Y., et al. (2009). Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins. Science 324, 1068-1071. doi: 10. 1126/science. 1173041.
104. Prandi, C., Occhiato, E. G., Tabasso, S., Bonfante, P., Novero, M., Scarpi, D., et al. (2011). New potent fluorescent analogues of strigolactones: synthesis and biological activity in parasitic weed germination and fungal branching. European J. Org. Chem. 2011, 3781-3793. doi: 10. 1002/ejoc. 201100616.
105. Prandi, C., Rosso, H., Lace, B., Occhiato, E. G., Oppedisano, A., Tabasso, S., et al. (2013). Strigolactone analogs as molecular probes in chasing the (SLs) receptor/s: design and synthesis of fluorescent labeled molecules. Mol. Plant6, 113-127. doi: 10. 1093/mp/sss133.
106. Pulici, M., Asami, T., Robertson, M., Seto, H., and Yoshida, S. (1996). Amylase induction activity of fluorescein labeled gibberellin in barley aleurone protoplasts. Bioorg. Med. Chem. Lett. 6, 2549-2552. doi: 10. 1016/0960-894x(96)00462-3.
107. Ramirez, J. A., Brosa, C., and Galagovsky, L. R. (2005). Synthesis and bioactivity of C-29 brassinosteroid analogues with different functional groups at C-6. Phytochemistry 66, 581-587. doi: 10. 1016/j. phytochem. 2004. 12. 029.
108. Rasmussen, A., Heugebaert, T., Matthys, C., Van Deun, R., Boyer, F. D., Goormachtig, S., et al. (2013). A fluorescent alternative to the synthetic strigolactone GR24. Mol. Plant 6, 100-112. doi: 10. 1093/mp/sss110.
109. Reizelman, A., Wigchert, S. C. M., Del-Bianco, C., and Zwanenburg, B. (2003). Synthesis and bioactivity of labelled germination stimulants for the isolation and identification of the strigolactone receptor. Org. Biomol. Chem. 1, 950-959. doi: 10. 1039/B210678g.
110. Rinne, P. L. H., Kaikuranta, P. M., and Van Der Schoot, C. (2001). The shoot apical meristem restores its symplasmic organization during chilling-induced release from dormancy. Plant J. 26, 249-264. doi: 10. 1046/j. 1365-313X. 2001. 01022. x.
111. Rivas-San Vicente, M., and Plasencia, J. (2011). Salicylic acid beyond defence: its role in plant growth and development. J. Exp. Bot. 62, 3321-3338. doi: 10. 1093/jxb/err031.
112. Robert, S., Kleine-Vehn, J., Barbez, E., Sauer, M., Paciorek, T., Baster, P., et al. (2010). ABP1 mediates auxin inhibition of clathrin-dependent endocytosis in Arabidopsis. Cell 143, 111-121. doi: 10. 1016/j. cell. 2010. 09. 027.
113. Rubio, V., Bustos, R., Irigoyen, M. L., Cardona-Lopez, X., Rojas-Triana, M., and Paz-Ares, J. (2009). Plant hormones and nutrient signaling. Plant Mol. Biol. 69, 361-373. doi: 10. 1007/s11103-008-9380-y.
114. Saez, A., Apostolova, N., Gonzalez-Guzman, M., Gonzalez-Garcia, M. P., Nicolas, C., Lorenzo, O., et al. (2004). Gain-of-function and loss-of-function phenotypes of the protein phosphatase 2C HAB1 reveal its role as a negative regulator of abscisic acid signalling. Plant J. 37, 354-369. doi: 10. 1046/j. 1365-313X. 2003. 01966. x.
115. Sakakibara, H. (2006). Cytokinins: activity, biosynthesis, and translocation. Annu. Rev. Plant Biol. 57, 431-449. doi: 10. 1146/annurev. arplant. 57. 032905. 105231.
116. Santiago, J., Dupeux, F., Round, A., Antoni, R., Park, S.-Y., Jamin, M., et al. (2009). The abscisic acid receptor PYR1 in complex with abscisic acid. Nature 462, 665-668. doi: 10. 1038/nature08591.
117. Santiago, J., Henzler, C., and Hothorn, M. (2013). Molecular mechanism for plant steroid receptor activation by somatic embryogenesis co-receptor kinases. Science 341, 889-892. doi: 10. 1126/science. 1242468.
118. Sauer, M., and Kleine-Vehn, J. (2011). AUXIN BINDING PROTEIN1: the outsider. Plant Cell 23, 2033-2043. doi: 10. 1105/tpc. 111. 087064.
119. Scherer, G. F. E. (2011). AUXIN-BINDING-PROTEIN1, the second auxin receptor: what is the significance of a two-receptor concept in plant signal transduction? J. Exp. Bot. 62, 3339-3357. doi: 10. 1093/jxb/err033.
120. Seto, H., Fujioka, S., Koshino, H., Suenaga, T., Yoshida, S., Watanabe, T., et al. (1999). 2, 3, 5-Tri-epi-brassinolide: preparation and biological activity in rice lamina inclination test. Phytochemistry 52, 815-818. doi: 10. 1016/S0031-9422(99)00335-0.
121. Seto, Y., Kameoka, H., Yamaguchi, S., and Kyozuka, J. (2012). Recent advances in strigolactone research: chemical and biological aspects. Plant Cell Physiol. 53, 1843-1853. doi: 10. 1093/pcp/pcs142.
122. Shani, E., Weinstain, R., Zhang, Y., Castillejo, C., Kaiserli, E., Chory, J., et al. (2013). Gibberellins accumulate in the elongating endodermal cells of Arabidopsis root. Proc. Natl. Acad. Sci. U. S. A. 110, 4834-4839. doi: 10. 1073/pnas. 1300436110.
123. She, J., Han, Z., Kim, T. W., Wang, J., Cheng, W., Chang, J., et al. (2011). Structural insight into brassinosteroid perception by BRI1. Nature 474, 472-476. doi: 10. 1038/nature10178.
124. Simon, S., Kubeš, M., Baster, P., Robert, S., Dobrev, P. I., Friml, J., et al. (2013). Defining the selectivity of processes along the auxin response chain: a study using auxin analogues. New Phytol. 200, 1034-1048. doi: 10. 1111/nph. 12437.
125. Simon, S., and Petrášek, J. (2011). Why plants need more than one type of auxin. Plant Sci. 180, 454-460. doi: 10. 1016/j. plantsci. 2010. 12. 007.
126. Skoog, F., Schmitz, R. Y., Bock, R. M., and Hecht, S. M. (1973). Cytokinin antagonists-synthesis and physiological effects of 7-substituted 3-methylpyrazolo[4, 3-D]pyrimidines. Phytochemistry 12, 25-37. doi: 10. 1016/S0031-9422(00)84620-8.
127. Skoog, F., Schmitz, R. Y., Hecht, S. M., and Frye, R. B. (1975). Anticytokinin activity of substituted pyrrolo[2, 3-d]pyrimidines. Proc. Natl. Acad. Sci. U. S. A. 72, 3508-3512. doi: 10. 1073/pnas. 72. 9. 3508.
128. Sokolowska, K., Kizinska, J., Szewczuk, Z., and Banasiak, A. (2014). Auxin conjugated to fluorescent dyes-a tool for the analysis of auxin transport pathways. Plant Biol. doi: 10. 1111/plb. 12144. [Epub ahead of print].
129. Sṕichal, L., Krystof, V., Paprskarova, M., Lenobel, R., Styskala, J., Binarova, P., et al. (2007). Classical anticytokinins do not interact with cytokinin receptors but inhibit cyclin-dependent kinases. J. Biol. Chem. 282, 14356-14363. doi: 10. 1074/jbc. M609750200.
130. Sṕichal, L., Werner, T., Popa, I., Riefler, M., Schmulling, T., and Strnad, M. (2009). The purine derivative PI-55 blocks cytokinin action via receptor inhibition. FEBS J. 276, 244-253. doi: 10. 1111/j. 1742-4658. 2008. 06777. x.
131. Spoel, S. H., Mou, Z., Tada, Y., Spivey, N. W., Genschik, P., and Dong, X. (2009). Proteasome-mediated turnover of the transcription coactivator NPR1 plays dual roles in regulating plant immunity. Cell 137, 860-872. doi: 10. 1016/j. cell. 2009. 03. 038.
132. Szemenyei, H., Hannon, M., and Long, J. A. (2008). TOPLESS mediates auxin-dependent transcriptional repression during Arabidopsis embryogenesis. Science 319, 1384-1386. doi: 10. 1126/science. 1151461.
133. Takeuchi, J., Okamoto, M., Akiyama, T., Muto, T., Yajima, S., Sue, M., et al. (2014). Designed abscisic acid analogs as antagonists of PYL-PP2C receptor interactions. Nat. Chem. Biol. 10, 477-482. doi: 10. 1038/nchembio. 1524.
134. Tan, X., Calderon-Villalobos, L. I. A., Sharon, M., Zheng, C., Robinson, C. V., Estelle, M., et al. (2007). Mechanism of auxin perception by the TIR1 ubiquitin ligase. Nature 446, 640-645. doi: 10. 1038/nature05731.
135. Torres, G. E., and Amara, S. G. (2007). Glutamate and monoamine transporters: new visions of form and function. Curr. Opin. Neurobiol. 17, 304-312. doi: 10. 1016/j. conb. 2007. 05. 002.
136. Toth, R., and Van Der Hoorn, R. A. (2010). Emerging principles in plant chemical genetics. Trends Plant Sci. 15, 81-88. doi: 10. 1016/j. tplants. 2009. 11. 005.
137. Tromas, A., Paque, S., Stierlé, V., Quettier, A.-L., Muller, P., Lechner, E., et al. (2013). Auxin-Binding Protein 1 is a negative regulator of the SCFTIR1/AFB pathway. Nat. Commun. 4: 2496. doi: 10. 1038/ncomms3496.
138. Uknes, S., Mauch-Mani, B., Moyer, M., Potter, S., Williams, S., Dincher, S., et al. (1992). Acquired resistance in Arabidopsis. Plant Cell 4, 645-656. doi: 10. 1105/tpc. 4. 6. 645.
139. Ulmasov, T., Murfett, J., Hagen, G., and Guilfoyle, T. J. (1997). Aux/IAA proteins repress expression of reporter genes containing natural and highly active synthetic auxin response elements. Plant Cell 9, 1963-1971. doi: 10. 1105/tpc. 9. 11. 1963.
140. Umehara, M., Hanada, A., Yoshida, S., Akiyama, K., Arite, T., Takeda-Kamiya, N., et al. (2008). Inhibition of shoot branching by new terpenoid plant hormones. Nature 455, 195-200. doi: 10. 1038/nature07272.
141. Vanneste, S., and Friml, J. (2009). Auxin: a trigger for change in plant development. Cell 136, 1005-1016. doi: 10. 1016/j. cell. 2009. 03. 001.
142. Vlot, A. C., Dempsey, D. M. A., and Klessig, D. F. (2009). Salicylic acid, a multifaceted hormone to combat disease. Annu. Rev. Phytopathol. 47, 177-206. doi: 10. 1146/annurev. phyto. 050908. 135202.
143. Walsh, T. A., Neal, R., Merlo, A. O., Honma, M., Hicks, G. R., Wolff, K., et al. (2006). Mutations in an auxin receptor homolog AFB5 and in SGT1b confer resistance to synthetic picolinate auxins and not to 2, 4-dichlorophenoxyacetic acid or indole-3-acetic acid in Arabidopsis. Plant Physiol. 142, 542-552. doi: 10. 1104/pp. 106. 085969.
144. Wang, Z. Y., Bai, M. Y., Oh, E., and Zhu, J. Y. (2012). Brassinosteroid signaling network and regulation of photomorphogenesis. Annu. Rev. Genet. 46, 701-724. doi: 10. 1146/annurev-genet-102209-163450.
145. Ward, J. L., and Beale, M. H. (1995). Caged plant hormones. Phytochemistry 38, 811-816. doi: 10. 1016/0031-9422(94)00662-D.
146. Waters, M. T., Scaffidi, A., Flematti, G. R., and Smith, S. M. (2012). Karrikins force a rethink of strigolactone mode of action. Plant Signal. Behav. 7, 969-972. doi: 10. 4161/psb. 20977.
147. Waters, M. T., Scaffidi, A., Sun, Y. K., Flematti, G. R., and Smith, S. M. (2014). The karrikin response system of Arabidopsis. Plant J. doi: 10. 1111/tpj. 12430. [Epub ahead of print].
148. Weijers, D., Benkova, E., Jäger, K. E., Schlereth, A., Hamann, T., Kientz, M., et al. (2005). Developmental specificity of auxin response by pairs of ARF and Aux/IAA transcriptional regulators. EMBO J. 24, 1874-1885. doi: 10. 1038/sj. emboj. 7600659.
149. Weiner, J. J., Peterson, F. C., Volkman, B. F., and Cutler, S. R. (2010). Structural and functional insights into core ABA signaling. Curr. Opin. Plant Biol. 13, 495-502. doi: 10. 1016/j. pbi. 2010. 09. 007.
150. Werner, T., Motyka, V., Laucou, V., Smets, R., Van Onckelen, H., and Schmulling, T. (2003). Cytokinin-deficient transgenic Arabidopsis plants show multiple developmental alterations indicating opposite functions of cytokinins in the regulation of shoot and root meristem activity. Plant Cell 15, 2532-2550. doi: 10. 1105/Tpc. 014928.
151. Werner, T., Motyka, V., Strnad, M., and Schmulling, T. (2001). Regulation of plant growth by cytokinin. Proc. Natl. Acad. Sci. U. S. A. 98, 10487-10492. doi: 10. 1073/pnas. 171304098.
152. Wilen, R. W., Hays, D. B., Mandel, R. M., Abrams, S. R., and Moloney, M. M. (1993). Competitive inhibition of abscisic acid-regulated gene expression by stereoisomeric acetylenic analogs of abscisic acid. Plant Physiol. 101, 469-476. doi: 10. 1104/pp. 101. 2. 469.
153. Woo, E. J., Marshall, J., Bauly, J., Chen, J. G., Venis, M., Napier, R. M., et al. (2002). Crystal structure of auxin-binding protein 1 in complex with auxin. EMBO J. 21, 2877-2885. doi: 10. 1093/emboj/cdf291.
154. Woodward, A. W., and Bartel, B. (2005). Auxin: regulation, action, and interaction. Ann. Bot. 95, 707-735. doi: 10. 1093/aob/mci083.
155. Wu, Y., Zhang, D., Chu, J. Y., Boyle, P., Wang, Y., Brindle, I. D., et al. (2012). The Arabidopsis NPR1 protein is a receptor for the plant defense hormone salicylic acid. Cell Rep. 1, 639-647. doi: 10. 1016/j. celrep. 2012. 05. 008.
156. Xie, X., Yoneyama, K., and Yoneyama, K. (2010). The strigolactone story. Annu. Rev. Phytopathol. 48, 93-117. doi: 10. 1146/annurev-phyto-073009-114453.
157. Xu, T., Dai, N., Chen, J., Nagawa, S., Cao, M., Li, H., et al. (2014). Cell surface ABP1-TMK auxin-sensing complex activates ROP GTPase signaling. Science 343, 1025-1028. doi: 10. 1126/science. 1245125.
158. Xu, T., Wen, M., Nagawa, S., Fu, Y., Chen, J.-G., Wu, M.-J., et al. (2010). Cell surface-and rho GTPase-based auxin signaling controls cellular interdigitation in Arabidopsis. Cell 143, 99-110. doi: 10. 1016/j. cell. 2010. 09. 003.
159. Yamazoe, A., Hayashi, K., Kepinski, S., Leyser, O., and Nozaki, H. (2005). Characterization of terfestatin A, a new specific inhibitor for auxin signaling. Plant Physiol. 139, 779-789. doi: 10. 1104/pp. 105. 068924.
160. Yamazoe, A., Hayashi, K., Kuboki, A., Ohira, S., and Nozaki, H. (2004). The isolation, structural determination, and total synthesis of terfestatin A, a novel auxin signaling inhibitor from Streptomyces sp. Tetrahedron Lett. 45, 8359-8362. doi: 10. 1016/j. tetlet. 2004. 09. 055.
161. Yang, C. J., Zhang, C., Lu, Y. N., Jin, J. Q., and Wang, X. L. (2011). The mechanisms of brassinosteroids action: from signal transduction to plant development. Mol. Plant 4, 588-600. doi: 10. 1093/mp/ssr020.
162. Yin, P., Fan, H., Hao, Q., Yuan, X., Wu, D., Pang, Y., et al. (2009). Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat. Struct. Mol. Biol. 16, 1230-1236. doi: 10. 1038/nsmb. 1730.
163. Yokota, T., Arima, M., and Takahashi, N. (1982). Castasterone, a new phytosterol with plant-hormone potency, from chestnut insect gall. Tetrahedron Lett. 23, 1275-1278. doi: 10. 1016/S0040-4039(00)87081-1.
164. Yoshida, T., Nishimura, N., Kitahata, N., Kuromori, T., Ito, T., Asami, T., et al. (2006). ABA-Hypersensitive Germination3 encodes a protein phosphatase 2C (AtPP2CA) that strongly regulates abscisic acid signaling during germination among Arabidopsis protein phosphatase 2Cs. Plant Physiol. 140, 115-126. doi: 10. 1104/pp. 105. 070128.
165. Zhao, Y., Chow, T. F., Puckrin, R. S., Alfred, S. E., Korir, A. K., Larive, C. K., et al. (2007). Chemical genetic interrogation of natural variation uncovers a molecule that is glycoactivated. Nat. Chem. Biol. 3, 716-721. doi: 10. 1038/nchembio. 2007. 32.
166. Zhao, L. H., Zhou, X. E., Wu, Z. S., Yi, W., Xu, Y., Li, S. L., et al. (2013). Crystal structures of two phytohormone signal-transducing alpha/beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14. Cell Res. 23, 436-439. doi: 10. 1038/Cr. 2013. 19.
167. Zullo, M. A. T., and Adam, G. (2002). Brassinosteroid phytohormones: structure, bioactivity and applications. Braz. J. Plant Physiol. 14, 143-181. doi: 10. 1590/S1677-04202002000300001.
168. Zwanenburg, B., Mangnus, E. M., and Thuring, J. W. J. F. (1994). "Strigol analogues: design, synthesis and biological activity", in Proceedings of the Third International Workshop on Orobanche and Related Striga Research, eds A. H. Pieterse, J. A. C. Verkleij, and S. J. ter Borg (Amsterdam: Royal Tropical Institute), 187-197.
169. Zwanenburg, B., Mwakaboko, A. S., Reizelman, A., Anilkumar, G., and Sethumadhavan, D. (2009). Structure and function of natural and synthetic signalling molecules in parasitic weed germination. Pest. Manag. Sci. 65, 478-491. doi: 10. 1002/Ps. 1706.
170. Zwanenburg, B., and Pospíšil, T. (2013). Structure and activity of strigolactones: new plant hormones with a rich future. Mol. Plant 6, 38-62. doi: 10. 1093/Mp/Sss141.