Small-molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 14, 2008, Pages 5632-5637

  Hayashi, Ken Ichiro ^a   Tan, Xu ^b   Zheng, Ning ^b   Hatate, Tatsuya ^a   Kimura, Yoshio ^a   Kepinski, Stefan ^c   Nozaki, Hiroshi ^a  

^a OKAYAMA UNIVERSITY OF SCIENCE   (Japan)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Chemical biology; Plant hormones; SCF; TIR1; Ubiquitin ligase

Indexed keywords

AUXIN; AUXIN AGONIST; AUXIN ANTAGONIST; F BOX PROTEIN; F BOX PROTEIN TIR1; HORMONE RECEPTOR BLOCKING AGENT; HORMONE RECEPTOR STIMULATING AGENT; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CELL FUNCTION; DRUG DESIGN; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SYNTHESIS; EUKARYOTE; MOLECULAR DYNAMICS; MOLECULAR PROBE; MOLECULAR RECOGNITION; MOSS; PHYSCOMITRELLA; PHYTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UBIQUITINATION; X RAY CRYSTALLOGRAPHY;

ARABIDOPSIS PROTEINS; BRYOPSIDA; CRYSTALLOGRAPHY, X-RAY; F-BOX PROTEINS; INDOLEACETIC ACIDS; PROTEIN BINDING; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; UBIQUITINATION;

ARABIDOPSIS; BRYOPHYTA; EUKARYOTA; PHYSCOMITRELLA PATENS;

EID: 44449108005     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0711146105     Document Type: Article

References (29)

1. Woodward AW, Bartel B (2005) Auxin: regulation, action, and interaction. Ann Bot (London) 95:707-735.
2. Dharmasiri N, Dharmasiri S, Estelle M (2005) The F-box protein TIR1 is an auxin receptor. Nature 435:441-445.
3. Kepinski S, Leyser O (2005) The Arabidopsis F-box protein TIR1 is an auxin receptor. Nature 435:446-451.
4. Dharmasiri N, et al. (2005) Plant development is regulated by a family of auxin receptor F box proteins. Dev Cell 9:109-119.
5. Kepinski S (2007) The anatomy of auxin perception. BioEssays 29:953-956.
6. Gagne JM, Downes BP, Shiu SH, Durski AM, Vierstra RD (2002) The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis. Proc Natl Acad Sci USA 99:11519-11524.
7. Dharmasiri N, Dharmasiri S, Jones AM, Estelle M (2003) Auxin action in a cell-free system. Curr Biol 13:1418-1422.
8. Tan X, et al. (2007) Mechanism of auxin perception by the TIR1 ubiquitin ligase. Nature 446:640-645.
9. Hayashi K, et al. (2003) Yokonolide B, a novel inhibitor of auxin action, blocks degradation of AUX/IAA factors. J Biol Chem 278:23797-23806.
10. Yamazoe A, Hayashi K, Kepinski S, Leyser O, Nozaki H (2005) Characterization of terfestatin A, a new specific inhibitor for auxin signaling. Plant Physiol 139:779-789.
11. Oono Y, et al. (2003) p-Chlorophenoxyisobutyric acid impairs auxin response in Arabidopsis root. Plant Physiol 133:1135-1147.
12. Biswas KK, et al. (2007) Genetic Characterization of Mutants Resistant to the Antiauxin p-chlorophenoxyisobutyric Acid (PCIB) Reveals that AAR3, a Gene Encoding DCN1-Like Protein, regulates responses to the synthetic auxin 2,4-dichlorophenoxyacetic acid in Arabidopsis roots. Plant Physiol 145:773-785.
13. Ulmasov T, Murfett J, Hagen G, Guilfoyle TJ (1997) Aux/IAA proteins repress expression of reporter genes containing natural and highly active synthetic auxin response elements. Plant Cell 9:1963-1971.
14. TIR1 complex. Proc Natl Acad Sci USA 101:12381-12386.
15. Gray WM, Kepinski S, Rouse D, Leyser O, Estelle M (2001) Auxin regulates SCF(TIR1)-dependent degradation of AUX/IAA proteins. Nature 414:271-276.
16. Rashotte AM, Brady SR, Reed RC, Ante SJ, Muday GK (2000) Basipetal auxin transport is required for gravitropism in roots of Arabidopsis. Plant Physiol 122:481-490.
17. Zhao Y, et al. (2001) A role for flavin monooxygenase-like enzymes in auxin biosynthesis. Science 291:306-309.
18. Collett CE, Harberd NP, Leyser O (2000) Hormonal interactions in the control of Arabidopsis hypocotyl elongation. Plant Physiol 124:553-562.
19. Liscum E, Reed JW (2002) Genetics of Aux/IAA and ARF action in plant growth and development. Plant Mol Biol 49:387-400.
20. Morris GM, et al. (1988) Automated docking using a Lamarckian genetic algorithm and empirical binding free energy function. J Comput Chem 19:1639-1662.
21. Woo EJ, et al. (2002) Crystal structure of auxin-binding protein 1 in complex with auxin. EMBO J 21:2877-2885.
22. Cove D (2005) The moss Physcomitrella patens. Annu Rev Genet 39:339-358.
23. Decker EL, Frank W, Sarnighausen E, Reski R (2006) Moss systems biology en route: phytohormones in Physcomitrella development. Plant Biol 8:397-405.
24. Yasumura Y, Crumpton-Taylor M, Fuentes S, Harberd NP (2007) Step-by-step acquisition of the gibberellin-DELLA growth-regulatory mechanism during land-plant evolution. Curr Biol 17:1225-1230.
25. Thines B, et al. (2007) JAZ repressor proteins are targets of the SCF(COI1) complex during jasmonate signalling. Nature 448:661-665.
26. Tanaka K, Suzuki T, Hattori N, Mizuno Y (2004) Ubiquitin, proteasome and parkin. Biochim Biophys Acta 1695:235-247.
27. Strohmaier H, et al. (2001) Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature 413:316-322.
28. Nishiyama T, Hiwatashi Y, Sakakibara I, Kato M, Hasebe M (2000) Tagged mutagenesis and gene-trap in the moss, Physcomitrella patens by shuttle mutagenesis. DNA Res 7:9-17.
29. Sanner MF (1999) Python: A programming language for software integration and development. J Mol Graphics Mod 17:57-61.