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Volumn 29, Issue S4, 2014, Pages 112-123

Angiogenesis in gastric mucosa: An important component of gastric erosion and ulcer healing and its impairment in aging

Author keywords

Aging gastric mucosa; Angiogenesis; Growth factors; Healing; Injury; Serum response factor

Indexed keywords

ACETYLSALICYLIC ACID; ALCOHOL; CALCITONIN GENE RELATED PEPTIDE; CORTICOSTEROID; CYCLOOXYGENASE 2; EARLY GROWTH RESPONSE FACTOR 1; GHRELIN; KARYOPHERIN; MELATONIN; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROSTAGLANDIN; SERUM RESPONSE FACTOR; SURVIVIN; VASCULOTROPIN; EGR1 PROTEIN, HUMAN; PTEN PROTEIN, HUMAN; PTGS2 PROTEIN, HUMAN; VASCULOTROPIN A;

EID: 84919449427     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/jgh.12734     Document Type: Article
Times cited : (70)

References (64)
  • 1
    • 0001991144 scopus 로고
    • Gastric ulceration
    • In: Cotran RS, Kumar V, Robbins SL, eds., 5th edn. Philadelphia, MA: Saunders
    • Cotran RS, Kumar V, Robbins SL. Gastric ulceration. In: Cotran RS, Kumar V, Robbins SL, eds. Robins Pathologic Basis of Disease, 5th edn. Philadelphia, MA: Saunders, 1994; 773-777.
    • (1994) Robins Pathologic Basis of Disease , pp. 773-777
    • Cotran, R.S.1    Kumar, V.2    Robbins, S.L.3
  • 2
    • 0000485644 scopus 로고
    • Role of angiogenesis in healing of experimental gastric ulcer
    • In: Halter F, Gamer A, Tytgat GNJ, eds. . Dordrecht; Boston, MA; London: Kluwer Acad. Publ
    • Tarnawski A, Hollander D, Stachura J, Gergely H, Krause WJ, Sarfeh IJ. Role of angiogenesis in healing of experimental gastric ulcer. In: Halter F, Gamer A, Tytgat GNJ, eds. Mechanisms of Peptic Ulcer Healing. Dordrecht; Boston, MA; London: Kluwer Acad. Publ, 1991; 165-171.
    • (1991) Mechanisms of Peptic Ulcer Healing , pp. 165-171
    • Tarnawski, A.1    Hollander, D.2    Stachura, J.3    Gergely, H.4    Krause, W.J.5    Sarfeh, I.J.6
  • 3
    • 25644437787 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of gastrointestinal ulcer healing
    • Tarnawski AS. Cellular and molecular mechanisms of gastrointestinal ulcer healing. Dig. Dis. Sci. 2005; 50 (Suppl. 1): S24-S33.
    • (2005) Dig. Dis. Sci. , vol.50 , pp. S24-S33
    • Tarnawski, A.S.1
  • 5
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau W. Mechanisms of angiogenesis. Nature 1997; 386: 671-673.
    • (1997) Nature , vol.386 , pp. 671-673
    • Risau, W.1
  • 6
    • 0030448814 scopus 로고    scopus 로고
    • Blood vessel formation: its molecular basis?
    • Folkman J, D'Amore PA. Blood vessel formation: its molecular basis? Cell 1996; 87: 1153-1155.
    • (1996) Cell , vol.87 , pp. 1153-1155
    • Folkman, J.1    D'Amore, P.A.2
  • 7
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature 2005; 438: 967-974.
    • (2005) Nature , vol.438 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 8
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P. Angiogenesis in health and disease. Nat. Med. 2003; 9: 653-660.
    • (2003) Nat. Med. , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 9
    • 0026070033 scopus 로고
    • Duodenal ulcer. Discovery of a new mechanism and development of angiogenic therapy that accelerates healing
    • Folkman J, Szabo S, Stovroff M, McNeil P, Li W, Shing Y. Duodenal ulcer. Discovery of a new mechanism and development of angiogenic therapy that accelerates healing. Ann. Surg. 1991; 214: 414-427.
    • (1991) Ann. Surg. , vol.214 , pp. 414-427
    • Folkman, J.1    Szabo, S.2    Stovroff, M.3    McNeil, P.4    Li, W.5    Shing, Y.6
  • 10
    • 0031729982 scopus 로고    scopus 로고
    • Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis
    • Goede V, Schmidt T, Kimmina S, Kozian D, Augustin HG. Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis. Lab. Invest. 1998; 78: 1385-1394.
    • (1998) Lab. Invest. , vol.78 , pp. 1385-1394
    • Goede, V.1    Schmidt, T.2    Kimmina, S.3    Kozian, D.4    Augustin, H.G.5
  • 11
    • 0020630407 scopus 로고
    • Capillary endothelial cell cultures: phenotypic modulation by matrix components
    • Madri JA, Williams SK. Capillary endothelial cell cultures: phenotypic modulation by matrix components. J. Cell Biol. 1983; 97: 153-165.
    • (1983) J. Cell Biol. , vol.97 , pp. 153-165
    • Madri, J.A.1    Williams, S.K.2
  • 12
    • 0032750920 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing
    • Jones MK, Wang H, Peskar BM etal. Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. Nat. Med. 1999; 5: 1418-1423.
    • (1999) Nat. Med. , vol.5 , pp. 1418-1423
    • Jones, M.K.1    Wang, H.2    Peskar, B.M.3
  • 14
    • 16644395747 scopus 로고    scopus 로고
    • The role of VEGF in the regulation of physiological and pathological angiogenesis
    • Ferrara N. The role of VEGF in the regulation of physiological and pathological angiogenesis. EXS 2005; 94: 209-231.
    • (2005) EXS , vol.94 , pp. 209-231
    • Ferrara, N.1
  • 15
    • 4143136640 scopus 로고    scopus 로고
    • VEGF basic science and clinical progress
    • Ferrara N. VEGF basic science and clinical progress. Endocr. Rev. 2004; 25: 581-611.
    • (2004) Endocr. Rev. , vol.25 , pp. 581-611
    • Ferrara, N.1
  • 16
    • 0033000342 scopus 로고    scopus 로고
    • Activation of VEGF and RAS genes in gastric mucosa during angiogenic response to ethanol injury
    • Jones MK, Itani RM, Wang H etal. Activation of VEGF and RAS genes in gastric mucosa during angiogenic response to ethanol injury. Am. J. Physiol. 1999; 276: G1345-1355.
    • (1999) Am. J. Physiol. , vol.276 , pp. G1345-G1355
    • Jones, M.K.1    Itani, R.M.2    Wang, H.3
  • 17
    • 0035049240 scopus 로고    scopus 로고
    • Endogenous angiogenesis inhibitors and their therapeutic implications
    • Cao Y. Endogenous angiogenesis inhibitors and their therapeutic implications. Int. J. Biochem. Cell Biol. 2001; 33: 357-369.
    • (2001) Int. J. Biochem. Cell Biol. , vol.33 , pp. 357-369
    • Cao, Y.1
  • 19
    • 0034672644 scopus 로고    scopus 로고
    • Generation and degradation of human endostatin proteins by various proteinases
    • Ferreras M, Felbor U, Lenhard T, Olsen BR, Delaisse J. Generation and degradation of human endostatin proteins by various proteinases. FEBS Lett. 2000; 486: 247-251.
    • (2000) FEBS Lett. , vol.486 , pp. 247-251
    • Ferreras, M.1    Felbor, U.2    Lenhard, T.3    Olsen, B.R.4    Delaisse, J.5
  • 20
    • 77953988924 scopus 로고    scopus 로고
    • Targeting the tumour vasculature: insights from physiological angiogenesis
    • Chung AS, Lee J, Ferrara N. Targeting the tumour vasculature: insights from physiological angiogenesis. Nat. Rev. Cancer 2010; 10: 505-514.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 505-514
    • Chung, A.S.1    Lee, J.2    Ferrara, N.3
  • 21
    • 0038376002 scopus 로고    scopus 로고
    • Molecular regulation of vessel maturation
    • Jain RK. Molecular regulation of vessel maturation. Nat. Med. 2003; 9: 685-693.
    • (2003) Nat. Med. , vol.9 , pp. 685-693
    • Jain, R.K.1
  • 22
    • 79951791126 scopus 로고    scopus 로고
    • Endothelial progenitor cells: novel biomarker and promising cell therapy for cardiovascular disease
    • Sen S, McDonald SP, Coates PT, Bonder CS. Endothelial progenitor cells: novel biomarker and promising cell therapy for cardiovascular disease. Clin. Sci. (Lond) 2011; 120: 263-283.
    • (2011) Clin. Sci. (Lond) , vol.120 , pp. 263-283
    • Sen, S.1    McDonald, S.P.2    Coates, P.T.3    Bonder, C.S.4
  • 23
    • 0031019745 scopus 로고    scopus 로고
    • Isolation of putative progenitor endothelial cells for angiogenesis
    • Asahara T, Murohara T, Sullivan A etal. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997; 275: 964-967.
    • (1997) Science , vol.275 , pp. 964-967
    • Asahara, T.1    Murohara, T.2    Sullivan, A.3
  • 24
    • 0032528555 scopus 로고    scopus 로고
    • Evidence for circulating bone marrow-derived endothelial cells
    • Shi Q, Rafii S, Wu MH, Wijelath ES etal. Evidence for circulating bone marrow-derived endothelial cells. Blood 1998; 92: 362-367.
    • (1998) Blood , vol.92 , pp. 362-367
    • Shi, Q.1    Rafii, S.2    Wu, M.H.3    Wijelath, E.S.4
  • 25
    • 0034721785 scopus 로고    scopus 로고
    • Endothelial cells of hematopoietic origin make a significant contribution to adult blood vessel formation
    • Crosby JR, Kaminski WE, Schatteman G etal. Endothelial cells of hematopoietic origin make a significant contribution to adult blood vessel formation. Circ. Res. 2000; 87: 728-730.
    • (2000) Circ. Res. , vol.87 , pp. 728-730
    • Crosby, J.R.1    Kaminski, W.E.2    Schatteman, G.3
  • 26
    • 0037155051 scopus 로고    scopus 로고
    • Bone marrow-derived endothelial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouse
    • Zhang ZG, Zhang L, Jiang Q, Chopp M. Bone marrow-derived endothelial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouse. Circ. Res. 2002; 90: 284-288.
    • (2002) Circ. Res. , vol.90 , pp. 284-288
    • Zhang, Z.G.1    Zhang, L.2    Jiang, Q.3    Chopp, M.4
  • 27
  • 28
    • 0345688062 scopus 로고    scopus 로고
    • Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells
    • Urbich C, Heeschen C, Aicher A, Dernbach E, Zeiher AM, Dimmeler S. Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells. Circulation 2003; 108: 2511-2516.
    • (2003) Circulation , vol.108 , pp. 2511-2516
    • Urbich, C.1    Heeschen, C.2    Aicher, A.3    Dernbach, E.4    Zeiher, A.M.5    Dimmeler, S.6
  • 29
    • 4143052506 scopus 로고    scopus 로고
    • Endothelial progenitor cells: characterization and role in vascular biology
    • Urbich C, Dimmeler S. Endothelial progenitor cells: characterization and role in vascular biology. Circ. Res. 2004; 95: 343-353.
    • (2004) Circ. Res. , vol.95 , pp. 343-353
    • Urbich, C.1    Dimmeler, S.2
  • 30
    • 78651362828 scopus 로고    scopus 로고
    • Stromal cell-derived factor-1 (SDF-1): homing factor for engineered regenerative medicine
    • Lau TT, Wang DA. Stromal cell-derived factor-1 (SDF-1): homing factor for engineered regenerative medicine. Expert Opin. Biol. Ther. 2011; 11: 189-197.
    • (2011) Expert Opin. Biol. Ther. , vol.11 , pp. 189-197
    • Lau, T.T.1    Wang, D.A.2
  • 31
    • 0035992268 scopus 로고    scopus 로고
    • The synergy between stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF): molecular basis and clinical relevance
    • Duarte RF, Frank DA. The synergy between stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF): molecular basis and clinical relevance. Leuk. Lymphoma 2002; 43: 1179-1187.
    • (2002) Leuk. Lymphoma , vol.43 , pp. 1179-1187
    • Duarte, R.F.1    Frank, D.A.2
  • 32
    • 35349031088 scopus 로고    scopus 로고
    • Cyclooxygenase-2/prostaglandin E2 accelerates the healing of gastric ulcers via EP4 receptors
    • Hatazawa R, Tanaka A, Tanigami M etal. Cyclooxygenase-2/prostaglandin E2 accelerates the healing of gastric ulcers via EP4 receptors. Am. J. Physiol. Gastrointest. Liver Physiol. 2007; 293: G788-797.
    • (2007) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.293 , pp. G788-G797
    • Hatazawa, R.1    Tanaka, A.2    Tanigami, M.3
  • 33
    • 0026070033 scopus 로고
    • Duodenal ulcer. Discovery of a new mechanism and development of angiogenic therapy that accelerates healing
    • discussion 426-27.
    • Folkman J, Szabo S, Stovroff M, McNeil P, Li W, Shing Y. Duodenal ulcer. Discovery of a new mechanism and development of angiogenic therapy that accelerates healing. Ann. Surg. 1991; 214: 414-425. discussion 426-27.
    • (1991) Ann. Surg. , vol.214 , pp. 414-425
    • Folkman, J.1    Szabo, S.2    Stovroff, M.3    McNeil, P.4    Li, W.5    Shing, Y.6
  • 34
    • 0028270417 scopus 로고
    • Accelerated healing of duodenal ulcers by oral administration of a mutein of basic fibroblast growth factor in rats
    • Szabo S, Folkman J, Vattay P, Morales RE, Pinkus GS, Kato K. Accelerated healing of duodenal ulcers by oral administration of a mutein of basic fibroblast growth factor in rats. Gastroenterology 1994; 106: 1106-1111.
    • (1994) Gastroenterology , vol.106 , pp. 1106-1111
    • Szabo, S.1    Folkman, J.2    Vattay, P.3    Morales, R.E.4    Pinkus, G.S.5    Kato, K.6
  • 35
    • 0034767707 scopus 로고    scopus 로고
    • Gene therapy for gastric ulcers. With single local injection of VEGF naked DNA encoding VEGF and angiopoietin-1
    • Jones MK, Kawanaka H, Baatar D etal. Gene therapy for gastric ulcers. With single local injection of VEGF naked DNA encoding VEGF and angiopoietin-1. Gastroenterology 2001; 121: 1040-1047.
    • (2001) Gastroenterology , vol.121 , pp. 1040-1047
    • Jones, M.K.1    Kawanaka, H.2    Baatar, D.3
  • 36
    • 0029159846 scopus 로고
    • Angiogenesis in gastric ulcers: impaired in patients taking non-steroidal anti-inflammatory drugs
    • Hudson N, Balsitis M, Everitt S, Hawkey CJ. Angiogenesis in gastric ulcers: impaired in patients taking non-steroidal anti-inflammatory drugs. Gut 1995; 37: 191-194.
    • (1995) Gut , vol.37 , pp. 191-194
    • Hudson, N.1    Balsitis, M.2    Everitt, S.3    Hawkey, C.J.4
  • 37
    • 0036481770 scopus 로고    scopus 로고
    • von Hippel Lindau tumor suppressor and HIF-1alpha: new targets of NSAIDs inhibition of hypoxia-induced angiogenesis
    • Jones MK, Szabó IL, Kawanaka H, Husain SS, Tarnawski AS. von Hippel Lindau tumor suppressor and HIF-1alpha: new targets of NSAIDs inhibition of hypoxia-induced angiogenesis. FASEB J. 2002; 16: 264-266.
    • (2002) FASEB J. , vol.16 , pp. 264-266
    • Jones, M.K.1    Szabó, I.L.2    Kawanaka, H.3    Husain, S.S.4    Tarnawski, A.S.5
  • 38
    • 0021971851 scopus 로고
    • Prostaglandin protection of the gastric mucosa against alcohol injury-a dynamic time-related process. Role of the mucosal proliferative zone
    • Tarnawski A, Hollander D, Stachura J, Krause WJ, Gergely H. Prostaglandin protection of the gastric mucosa against alcohol injury-a dynamic time-related process. Role of the mucosal proliferative zone. Gastroenterology 1985; 88 (1 Pt 2): 334-352.
    • (1985) Gastroenterology , vol.88 , Issue.1 , pp. 334-352
    • Tarnawski, A.1    Hollander, D.2    Stachura, J.3    Krause, W.J.4    Gergely, H.5
  • 39
    • 0022404189 scopus 로고
    • Ultrastructural changes in the gastric mucosal microvessels after ethanol
    • Tarnawski A, Hollander D, Stachura J. Ultrastructural changes in the gastric mucosal microvessels after ethanol. Gastroenterol. Clin. Biol. 1985; 9 (12 Pt 2): 93-97.
    • (1985) Gastroenterol. Clin. Biol. , vol.9 , Issue.12 , pp. 93-97
    • Tarnawski, A.1    Hollander, D.2    Stachura, J.3
  • 41
    • 79958202727 scopus 로고    scopus 로고
    • Gastric mucosal injury activates bFGF gene expression and triggers preferential translation of high molecular weight bFGF isoforms through CUG-initiated, non-canonical codons
    • Florkiewicz RZC, Ahluwalia A, Sandor Z, Szabo S, Tarnawski AS. Gastric mucosal injury activates bFGF gene expression and triggers preferential translation of high molecular weight bFGF isoforms through CUG-initiated, non-canonical codons. Biochem. Biophys. Res. Commun. 2011; 409: 494-499.
    • (2011) Biochem. Biophys. Res. Commun. , vol.409 , pp. 494-499
    • Florkiewicz, R.Z.C.1    Ahluwalia, A.2    Sandor, Z.3    Szabo, S.4    Tarnawski, A.S.5
  • 42
    • 9444243244 scopus 로고    scopus 로고
    • Serum response factor is a critical requirement for VEGF signaling in endothelial cells and VEGF-induced angiogenesis: insight into the mechanisms
    • Chai J, Baatar D, Tarnawski AS. Serum response factor is a critical requirement for VEGF signaling in endothelial cells and VEGF-induced angiogenesis: insight into the mechanisms. FASEB J. 2004; 18: 1264-1266.
    • (2004) FASEB J. , vol.18 , pp. 1264-1266
    • Chai, J.1    Baatar, D.2    Tarnawski, A.S.3
  • 43
    • 34247135913 scopus 로고    scopus 로고
    • Classical nuclear localization signals: definition, function, and interaction with importin alpha
    • Lange A, Mills RE, Lange CJ, Stewart M, Devine SE, Corbett AH. Classical nuclear localization signals: definition, function, and interaction with importin alpha. J. Biol. Chem. 2007; 282: 5101-5105.
    • (2007) J. Biol. Chem. , vol.282 , pp. 5101-5105
    • Lange, A.1    Mills, R.E.2    Lange, C.J.3    Stewart, M.4    Devine, S.E.5    Corbett, A.H.6
  • 44
    • 39149098464 scopus 로고    scopus 로고
    • Nuclear translocation of hypoxia-inducible factors (HIFs): involvement of the classical importin alpha/beta pathway
    • Depping R, Steinhoff A, Schindler SG etal. Nuclear translocation of hypoxia-inducible factors (HIFs): involvement of the classical importin alpha/beta pathway. Biochim. Biophys. Acta 2008; 1783: 394-404.
    • (2008) Biochim. Biophys. Acta , vol.1783 , pp. 394-404
    • Depping, R.1    Steinhoff, A.2    Schindler, S.G.3
  • 45
    • 84894076913 scopus 로고    scopus 로고
    • Key role of endothelial importin α in VEGF expression and gastric angiogenesis: novel insight into aging gastropathy
    • Ahluwalia A, Jones MK, Tarnawski AS. Key role of endothelial importin α in VEGF expression and gastric angiogenesis: novel insight into aging gastropathy. Am. J. Physiol. Gastrointest. Liver Physiol. 2014; 306: G338-345.
    • (2014) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.306 , pp. G338-G345
    • Ahluwalia, A.1    Jones, M.K.2    Tarnawski, A.S.3
  • 46
    • 84897110974 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor 1 signaling facilitates gastric ulcer healing and angiogenesis through the upregulation of epidermal growth factor expression on VEGFR1(+)CXCR4 (+) cells recruited from bone marrow
    • Sato T, Amano H, Ito Y etal. Vascular endothelial growth factor receptor 1 signaling facilitates gastric ulcer healing and angiogenesis through the upregulation of epidermal growth factor expression on VEGFR1(+)CXCR4 (+) cells recruited from bone marrow. J. Gastroenterol. 2014; 49: 455-469.
    • (2014) J. Gastroenterol. , vol.49 , pp. 455-469
    • Sato, T.1    Amano, H.2    Ito, Y.3
  • 47
    • 84884819495 scopus 로고    scopus 로고
    • D, aspirin delays gastric ulcer healing with reduced accumulation of CXCR4(+)VEGFR1(+) cells to the ulcer granulation tissues
    • Sato T, Amano H, Ito Y etal. D, aspirin delays gastric ulcer healing with reduced accumulation of CXCR4(+)VEGFR1(+) cells to the ulcer granulation tissues. Biomed. Pharmacother. 2013; 67: 607-613.
    • (2013) Biomed. Pharmacother. , vol.67 , pp. 607-613
    • Sato, T.1    Amano, H.2    Ito, Y.3
  • 48
    • 84919443361 scopus 로고    scopus 로고
    • New insight into gastric ulcer healing: direct evidence that bone marrow derived endothelial progenitor cells form in granulation tissue new hybrid blood vessels jointly with local endothelial cells
    • Tarnawski AS, Ahluwalia A, Jones MK, Sandor Z, Szabo S. New insight into gastric ulcer healing: direct evidence that bone marrow derived endothelial progenitor cells form in granulation tissue new hybrid blood vessels jointly with local endothelial cells. Gastroenterology 2012; 5: S142-146.
    • (2012) Gastroenterology , vol.5 , pp. S142-S146
    • Tarnawski, A.S.1    Ahluwalia, A.2    Jones, M.K.3    Sandor, Z.4    Szabo, S.5
  • 49
    • 78649412513 scopus 로고    scopus 로고
    • Prostaglandin EP receptors involved in modulating gastrointestinal mucosal integrity
    • Takeuchi K, Kato S, Amagase K. Prostaglandin EP receptors involved in modulating gastrointestinal mucosal integrity. J. Pharmacol. Sci. 2010; 114: 248-261.
    • (2010) J. Pharmacol. Sci. , vol.114 , pp. 248-261
    • Takeuchi, K.1    Kato, S.2    Amagase, K.3
  • 50
    • 35349022651 scopus 로고    scopus 로고
    • Prostaglandin E2 stimulates VEGF expression in primary rat gastric fibroblasts through EP4 receptors
    • Hatazawa R, Tanigami M, Izumi N, Kamei K, Tanaka A, Takeuchi K. Prostaglandin E2 stimulates VEGF expression in primary rat gastric fibroblasts through EP4 receptors. Inflammopharmacology 2007; 15: 214-217.
    • (2007) Inflammopharmacology , vol.15 , pp. 214-217
    • Hatazawa, R.1    Tanigami, M.2    Izumi, N.3    Kamei, K.4    Tanaka, A.5    Takeuchi, K.6
  • 52
    • 77955159826 scopus 로고    scopus 로고
    • Melatonin promotes angiogenesis during protection and healing of indomethacin-induced gastric ulcer: role of matrix metaloproteinase-2
    • Ganguly K, Sharma AV, Reiter RJ, Swarnakar S. Melatonin promotes angiogenesis during protection and healing of indomethacin-induced gastric ulcer: role of matrix metaloproteinase-2. J. Pineal Res. 2010; 49: 130-140.
    • (2010) J. Pineal Res. , vol.49 , pp. 130-140
    • Ganguly, K.1    Sharma, A.V.2    Reiter, R.J.3    Swarnakar, S.4
  • 54
  • 55
    • 37349026909 scopus 로고    scopus 로고
    • Roles of calcitonin gene-related peptide in maintenance of gastric mucosal integrity and in enhancement of ulcer healing and angiogenesis
    • Ohno T, Hattori Y, Komine R etal. Roles of calcitonin gene-related peptide in maintenance of gastric mucosal integrity and in enhancement of ulcer healing and angiogenesis. Gastroenterology 2008; 134: 215-225.
    • (2008) Gastroenterology , vol.134 , pp. 215-225
    • Ohno, T.1    Hattori, Y.2    Komine, R.3
  • 56
    • 0024364730 scopus 로고
    • Effects of prednisolone and human epidermal growth factor on angiogenesis in granulation tissue of gastric ulcer induced by acetic acid
    • Hase S, Nakazawa S, Tsukamoto Y, Segawa K. Effects of prednisolone and human epidermal growth factor on angiogenesis in granulation tissue of gastric ulcer induced by acetic acid. Digestion 1989; 42: 135-142.
    • (1989) Digestion , vol.42 , pp. 135-142
    • Hase, S.1    Nakazawa, S.2    Tsukamoto, Y.3    Segawa, K.4
  • 57
    • 33845762963 scopus 로고    scopus 로고
    • Ghrelin stimulates angiogenesis in human microvascular endothelial cells: implications beyond GH release
    • Li A, Cheng G, Zhu GH, Tarnawski AS. Ghrelin stimulates angiogenesis in human microvascular endothelial cells: implications beyond GH release. Biochem. Biophys. Res. Commun. 2007; 353: 238-243.
    • (2007) Biochem. Biophys. Res. Commun. , vol.353 , pp. 238-243
    • Li, A.1    Cheng, G.2    Zhu, G.H.3    Tarnawski, A.S.4
  • 58
    • 0035834295 scopus 로고    scopus 로고
    • Activation of hypoxia inducible factor-1alpha in gastric mucosa in response to ethanol injury: a trigger for angiogenesis?
    • Szabo IL, Kawanaka H, Jones MK etal. Activation of hypoxia inducible factor-1alpha in gastric mucosa in response to ethanol injury: a trigger for angiogenesis? Life Sci. 2001; 69: 3035-3044.
    • (2001) Life Sci. , vol.69 , pp. 3035-3044
    • Szabo, I.L.1    Kawanaka, H.2    Jones, M.K.3
  • 59
    • 0028097713 scopus 로고
    • Distorted microangioarchitecture and impaired angiogenesis in gastric mucosa of portal hypertensive rats
    • Ichikawa Y, Tarnawski A, Sarfeh IJ, Ishikawa T, Shimada H. Distorted microangioarchitecture and impaired angiogenesis in gastric mucosa of portal hypertensive rats. Gastroenterology 1994; 106: 702-708.
    • (1994) Gastroenterology , vol.106 , pp. 702-708
    • Ichikawa, Y.1    Tarnawski, A.2    Sarfeh, I.J.3    Ishikawa, T.4    Shimada, H.5
  • 60
    • 0035289776 scopus 로고    scopus 로고
    • Portal hypertensive gastric mucosa has reduced activation of MAP kinase (ERK2) in response to alcohol injury: a key to impaired healing?
    • Kawanaka H, Tomikawa M, Jones MK etal. Portal hypertensive gastric mucosa has reduced activation of MAP kinase (ERK2) in response to alcohol injury: a key to impaired healing? FASEB J. 2001; 15: 574-576.
    • (2001) FASEB J. , vol.15 , pp. 574-576
    • Kawanaka, H.1    Tomikawa, M.2    Jones, M.K.3
  • 61
    • 0642272496 scopus 로고    scopus 로고
    • Abnormal PTEN expression in portal hypertensive gastric mucosa: a key to impaired PI 3-kinase/Akt activation and delayed injury healing?
    • Tsugawa K, Jones MK, Akahoshi T etal. Abnormal PTEN expression in portal hypertensive gastric mucosa: a key to impaired PI 3-kinase/Akt activation and delayed injury healing? FASEB J. 2003; 17: 2316-2318.
    • (2003) FASEB J. , vol.17 , pp. 2316-2318
    • Tsugawa, K.1    Jones, M.K.2    Akahoshi, T.3
  • 62
    • 0036151948 scopus 로고    scopus 로고
    • Activation of eNOS in rat portal hypertensive gastric mucosa is mediated by TNF-α via the PI 3-kinase-Akt signaling pathway
    • Kawanaka H, Jones MK, Szabo IL etal. Activation of eNOS in rat portal hypertensive gastric mucosa is mediated by TNF-α via the PI 3-kinase-Akt signaling pathway. Hepatology 2002; 35: 393-402.
    • (2002) Hepatology , vol.35 , pp. 393-402
    • Kawanaka, H.1    Jones, M.K.2    Szabo, I.L.3
  • 63
    • 0028820549 scopus 로고
    • Role of gastric blood flow in impaired defense and repair of aged rat stomachs
    • Grønbech JE, Lacy ER. Role of gastric blood flow in impaired defense and repair of aged rat stomachs. Am. J. Physiol. 1995; 269 (5 Pt 1): G737-744.
    • (1995) Am. J. Physiol. , vol.269 , Issue.5 , pp. G737-G744
    • Grønbech, J.E.1    Lacy, E.R.2
  • 64
    • 78149491656 scopus 로고    scopus 로고
    • Effect of aging on gastric mucosal defense mechanisms: ROS, apoptosis, angiogenesis, and sensory neurons
    • Kang JM, Kim N, Kim JH etal. Effect of aging on gastric mucosal defense mechanisms: ROS, apoptosis, angiogenesis, and sensory neurons. Am. J. Physiol. Gastrointest. Liver Physiol. 2010; 299: G1147-1153.
    • (2010) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.299 , pp. G1147-G1153
    • Kang, J.M.1    Kim, N.2    Kim, J.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.