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Volumn 306, Issue 4, 2014, Pages

Key role of endothelial importin-α in VEGF expression and gastric angiogenesis: Novel insight into aging gastropathy

Author keywords

Aging; Angiogenesis; Gastric endothelial cells; Hypoxia; Hypoxia inducible factor 1 ; Importin ; VEGF

Indexed keywords

AGING; ANGIOGENESIS; GASTRIC ENDOTHELIAL CELLS; HYPOXIA; HYPOXIA-INDUCIBLE FACTOR-1Α; IMPORTIN-Α; VEGF;

EID: 84894076913     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00382.2013     Document Type: Article
Times cited : (22)

References (40)
  • 1
    • 1542357569 scopus 로고    scopus 로고
    • Sexual dimorphism of rat liver gene expression: Regulatory role of growth hormone revealed by deoxyribonucleic Acid microarray analysis
    • Ahluwalia A, Clodfelter KH, Waxman DJ. Sexual dimorphism of rat liver gene expression: regulatory role of growth hormone revealed by deoxyribonucleic Acid microarray analysis. Mol Endocrinol 18: 747-760, 2004.
    • (2004) Mol Endocrinol , vol.18 , pp. 747-760
    • Ahluwalia, A.1    Clodfelter, K.H.2    Waxman, D.J.3
  • 3
    • 2942616971 scopus 로고    scopus 로고
    • Serum response factor promotes re-epithelialization and muscular structure restoration during gastric ulcer healing
    • Chai J, Baatar D, Tarnawski A. Serum response factor promotes re-epithelialization and muscular structure restoration during gastric ulcer healing. Gastroenterology 126: 1809-1818, 2004.
    • (2004) Gastroenterology , vol.126 , pp. 1809-1818
    • Chai, J.1    Baatar, D.2    Tarnawski, A.3
  • 4
    • 9444243244 scopus 로고    scopus 로고
    • Serum response factor is a critical requirement for VEGF signaling in endothelial cells and VEGF-induced angiogenesis
    • Chai J, Jones MK, Tarnawski AS. Serum response factor is a critical requirement for VEGF signaling in endothelial cells and VEGF-induced angiogenesis. FASEB J 18: 1264-1266, 2004.
    • (2004) FASEB J , vol.18 , pp. 1264-1266
    • Chai, J.1    Jones, M.K.2    Tarnawski, A.S.3
  • 5
    • 85047689953 scopus 로고
    • 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMPactivated protein kinase in intact cells?
    • Corton JM, Gillespie JG, Hawley SA, Hardie DG. 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMPactivated protein kinase in intact cells? Eur J Biochem 229: 558-565, 1995.
    • (1995) Eur J Biochem , vol.229 , pp. 558-565
    • Corton, J.M.1    Gillespie, J.G.2    Hawley, S.A.3    Hardie, D.G.4
  • 6
    • 0026517111 scopus 로고
    • Effect of aging on gastric and duodenal mucosal prostaglandin concentrations in humans
    • Cryer B, Redfern JS, Goldschmiedt M, Lee E, Feldman M. Effect of aging on gastric and duodenal mucosal prostaglandin concentrations in humans. Gastroenterology 102: 1118-1123, 1992.
    • (1992) Gastroenterology , vol.102 , pp. 1118-1123
    • Cryer, B.1    Redfern, J.S.2    Goldschmiedt, M.3    Lee, E.4    Feldman, M.5
  • 8
    • 0031749197 scopus 로고    scopus 로고
    • Effects of age on gastric alkaline and nonparietal fluid secretion in humans
    • Feldman M, Cryer B. Effects of age on gastric alkaline and nonparietal fluid secretion in humans. Gerontology 44: 222-227, 1998.
    • (1998) Gerontology , vol.44 , pp. 222-227
    • Feldman, M.1    Cryer, B.2
  • 9
    • 16644395747 scopus 로고    scopus 로고
    • The role of VEGF in the regulation of physiological and pathological angiogenesis
    • Ferrara N. The role of VEGF in the regulation of physiological and pathological angiogenesis. EXS 209-231, 2005.
    • (2005) EXS , pp. 209-231
    • Ferrara, N.1
  • 10
    • 66349093990 scopus 로고    scopus 로고
    • Vascular endothelial growth factor
    • Ferrara N. Vascular endothelial growth factor. Arterioscler Thromb Vasc Biol 29: 789-791, 2009.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 789-791
    • Ferrara, N.1
  • 11
    • 72249119811 scopus 로고    scopus 로고
    • VEGF-A: A critical regulator of blood vessel growth
    • Ferrara N. VEGF-A: a critical regulator of blood vessel growth. Eur Cytokine Netw 20: 158-163, 2009.
    • (2009) Eur Cytokine Netw , vol.20 , pp. 158-163
    • Ferrara, N.1
  • 13
    • 7044239406 scopus 로고    scopus 로고
    • Aging, the gastrointestinal tract, and risk of acid-related disease
    • Greenwald DA. Aging, the gastrointestinal tract, and risk of acid-related disease. Am J Med 117, Suppl 5A: 8S-13S, 2004.
    • (2004) Am J Med , vol.117 , Issue.SUPPL. 5A
    • Greenwald, D.A.1
  • 14
    • 0028820549 scopus 로고
    • Role of gastric blood flow in impaired defense and repair of aged rat stomachs
    • Gronbech JE, Lacy ER. Role of gastric blood flow in impaired defense and repair of aged rat stomachs. Am J Physiol Gastrointest Liver Physiol 269: G737-G744, 1995.
    • (1995) Am J Physiol Gastrointest Liver Physiol , vol.269
    • Gronbech, J.E.1    Lacy, E.R.2
  • 15
    • 0034864294 scopus 로고    scopus 로고
    • Cyclooxygenase 2-implications on maintenance of gastric mucosal integrity and ulcer healing: Controversial issues and perspectives
    • Halter F, Tarnawski AS, Schmassmann A, Peskar BM. Cyclooxygenase 2-implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives. Gut 49: 443-453, 2001.
    • (2001) Gut , vol.49 , pp. 443-453
    • Halter, F.1    Tarnawski, A.S.2    Schmassmann, A.3    Peskar, B.M.4
  • 16
    • 50049091255 scopus 로고    scopus 로고
    • AMPK: A key regulator of energy balance in the single cell and the whole organism. Int J Obes (Lond) 32
    • Hardie DG. AMPK: a key regulator of energy balance in the single cell and the whole organism. Int J Obes (Lond) 32, Suppl 4: S7-S12, 2008.
    • (2008) Suppl , vol.4
    • Hardie, D.G.1
  • 18
    • 0037204743 scopus 로고    scopus 로고
    • Influence of aging on gastric ulcer healing activities of cimetidine and omeprazole
    • Ishihara M, Ito M. Influence of aging on gastric ulcer healing activities of cimetidine and omeprazole. Eur J Pharmacol 444: 209-215, 2002.
    • (2002) Eur J Pharmacol , vol.444 , pp. 209-215
    • Ishihara, M.1    Ito, M.2
  • 19
    • 0036481770 scopus 로고    scopus 로고
    • Von Hippel Lindau tumor suppressor and HIF-1α: New targets of NSAIDs inhibition of hypoxia-induced angiogenesis
    • Jones MK, Szabo IL, Kawanaka H, Husain SS, Tarnawski AS. von Hippel Lindau tumor suppressor and HIF-1α: new targets of NSAIDs inhibition of hypoxia-induced angiogenesis. FASEB J 16: 264-266, 2002.
    • (2002) FASEB J , vol.16 , pp. 264-266
    • Jones, M.K.1    Szabo, I.L.2    Kawanaka, H.3    Husain, S.S.4    Tarnawski, A.S.5
  • 20
    • 0032750920 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing
    • Jones MK, Wang H, Peskar BM, Levin E, Itani RM, Sarfeh IJ, Tarnawski AS. Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. Nat Med 5: 1418-1423, 1999.
    • (1999) Nat Med , vol.5 , pp. 1418-1423
    • Jones, M.K.1    Wang, H.2    Peskar, B.M.3    Levin, E.4    Itani, R.M.5    Sarfeh, I.J.6    Tarnawski, A.S.7
  • 21
    • 0034569910 scopus 로고    scopus 로고
    • Isolation and characterization of rat gastric microvascular endothelial cells as a model for studying gastric angiogenesis in vitro
    • Jones MK, Wang H, Tomikawa M, Szabo IL, Kawanaka H, Sarfeh IJ, Tarnawski AS. Isolation and characterization of rat gastric microvascular endothelial cells as a model for studying gastric angiogenesis in vitro. J Physiol Pharmacol 51: 813-820, 2000.
    • (2000) J Physiol Pharmacol , vol.51 , pp. 813-820
    • Jones, M.K.1    Wang, H.2    Tomikawa, M.3    Szabo, I.L.4    Kawanaka, H.5    Sarfeh, I.J.6    Tarnawski, A.S.7
  • 23
    • 34247135913 scopus 로고    scopus 로고
    • Classical nuclear localization signals: Definition, function, and interaction with importin alpha
    • Lange A, Mills RE, Lange CJ, Stewart M, Devine SE, Corbett AH. Classical nuclear localization signals: definition, function, and interaction with importin alpha. J Biol Chem 282: 5101-5105, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 5101-5105
    • Lange, A.1    Mills, R.E.2    Lange, C.J.3    Stewart, M.4    Devine, S.E.5    Corbett, A.H.6
  • 24
    • 0028046268 scopus 로고
    • Age-related reductions in gastric mucosal prostaglandin levels increase susceptibility to aspirin-induced injury in rats
    • Lee M, Feldman M. Age-related reductions in gastric mucosal prostaglandin levels increase susceptibility to aspirin-induced injury in rats. Gastroenterology 107: 1746-1750, 1994.
    • (1994) Gastroenterology , vol.107 , pp. 1746-1750
    • Lee, M.1    Feldman, M.2
  • 25
    • 0030823412 scopus 로고    scopus 로고
    • The aging stomach: Implications for NSAID gastropathy
    • Lee M, Feldman M. The aging stomach: implications for NSAID gastropathy. Gut 41: 425-426, 1997.
    • (1997) Gut , vol.41 , pp. 425-426
    • Lee, M.1    Feldman, M.2
  • 26
    • 0031779227 scopus 로고    scopus 로고
    • Age-related changes in gastric mucosal repair and proliferative activities in rats exposed acutely to aspirin
    • Lee M, Hardman WE, Cameron I. Age-related changes in gastric mucosal repair and proliferative activities in rats exposed acutely to aspirin. Gerontology 44: 198-203, 1998.
    • (1998) Gerontology , vol.44 , pp. 198-203
    • Lee, M.1    Hardman, W.E.2    Cameron, I.3
  • 27
    • 0029039195 scopus 로고
    • Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia
    • Levy AP, Levy NS, Wegner S, Goldberg MA. Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J Biol Chem 270: 13333-13340, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 13333-13340
    • Levy, A.P.1    Levy, N.S.2    Wegner, S.3    Goldberg, M.A.4
  • 29
    • 0024402674 scopus 로고
    • Biochemical changes in the gastric mucosa after injury in young and aged rats
    • Majumdar AP, Moshier JA, Arlow FL, Luk GD. Biochemical changes in the gastric mucosa after injury in young and aged rats. Biochim Biophys Acta 992: 35-40, 1989.
    • (1989) Biochim Biophys Acta , vol.992 , pp. 35-40
    • Majumdar, A.P.1    Moshier, J.A.2    Arlow, F.L.3    Luk, G.D.4
  • 30
    • 0029917792 scopus 로고    scopus 로고
    • Increased susceptibility of rat gastric mucosa to ulcerogenic stimulation with aging. Role of capsaicinsensitive sensory neurons
    • Miyake H, Inaba N, Kato S, Takeuchi K. Increased susceptibility of rat gastric mucosa to ulcerogenic stimulation with aging. Role of capsaicinsensitive sensory neurons. Dig Dis Sci 41: 339-345, 1996.
    • (1996) Dig Dis Sci , vol.41 , pp. 339-345
    • Miyake, H.1    Inaba, N.2    Kato, S.3    Takeuchi, K.4
  • 32
    • 10644271521 scopus 로고    scopus 로고
    • Aging and upper gastrointestinal disorders
    • Pilotto A. Aging and upper gastrointestinal disorders. Best Pract Res Clin Gastroenterol 18, Suppl: 73-81, 2004.
    • (2004) Best Pract Res Clin Gastroenterol , vol.18 , Issue.SUPPL. , pp. 73-81
    • Pilotto, A.1
  • 36
    • 0029008658 scopus 로고
    • Changes in gastric function and healing of chronic gastric ulcers in aged rats
    • Tsukimi Y, Okabe S. Changes in gastric function and healing of chronic gastric ulcers in aged rats. Jpn J Pharmacol 68: 103-110, 1995.
    • (1995) Jpn J Pharmacol , vol.68 , pp. 103-110
    • Tsukimi, Y.1    Okabe, S.2
  • 37
    • 0025057148 scopus 로고
    • Healing of acetic acid-induced gastric ulcer and gastric mucosal PGI2 level in rats
    • Uchida M, Kawano O, Misaki N, Saitoh K, Irino O. Healing of acetic acid-induced gastric ulcer and gastric mucosal PGI2 level in rats. Dig Dis Sci 35: 80-85, 1990.
    • (1990) Dig Dis Sci , vol.35 , pp. 80-85
    • Uchida, M.1    Kawano, O.2    Misaki, N.3    Saitoh, K.4    Irino, O.5
  • 39
    • 9144266386 scopus 로고    scopus 로고
    • AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1: Involvement in the nuclear import of RNA-binding protein HuR
    • Wang W, Yang X, Kawai T, Lopez DS, I, Mazan-Mamczarz K, Chen P, Chook YM, Quensel C, Kohler M, Gorospe M. AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1: involvement in the nuclear import of RNA-binding protein HuR. J Biol Chem 279: 48376-48388, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 48376-48388
    • Wang, W.1    Yang, X.2    Kawai, T.3    Lopez I, D.S.4    Mazan-Mamczarz, K.5    Chen, P.6    Chook, Y.M.7    Quensel, C.8    Kohler, M.9    Gorospe, M.10


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