Role of kinase epidermal growth factor receptor and SRC in the caerulein-induced acute pancreatitis in mice

Pancreas

Volumn 44, Issue 1, 2015, Pages 152-157

  Huang, Yongming ^a   Xia, Weiliang ^a   Lu, Ming ^b   Gao, Bo ^a   Qiao, Xin ^b   Sun, Bei ^a   Zhang, Weihui ^a   Zhang, Yingmei ^a   Xue, Dongbo ^a  

^a THE FIRST AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acute pancreatitis; EGFR; Protein kinase; SRC

Indexed keywords

ACTIVIN RECEPTOR 1; APOPTOSIS SIGNAL REGULATING KINASE 1; CERULETIDE; EPIDERMAL GROWTH FACTOR RECEPTOR; HEAT SHOCK PROTEIN 22; HOMEODOMAIN INTERACTING PROTEIN KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE; NEUROTROPHIN; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN TYROSINE KINASE; S6 KINASE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M7; EGFR PROTEIN, MOUSE; MESSENGER RNA; PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; PROTEIN KINASE; PROTEIN KINASE P60; STRESS ACTIVATED PROTEIN KINASE;

ACINAR CELL; ACUTE PANCREATITIS; ADCK4 GENE; ADHERENS JUNCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRD2 GENE; CASK GENE; CLK3 GENE; CLK4 GENE; CONTROLLED STUDY; CSNK1D GENE; DDR1 GENE; DOWN REGULATION; ENZYME ANALYSIS; ENZYME REGULATION; GAP JUNCTION; GENE; GENE EXPRESSION; MAP2K3 GENE; MKNK1 GENE; MOUSE; NLK GENE; NONHUMAN; ONCOGENE SRC; PIM3 GENE; PRIORITY JOURNAL; RIOK3 GENE; RIPK4 GENE; ROR2 GENE; SLK GENE; TAOK3 GENE; TLK2 GENE; TRIB3 GENE; ULK2 GENE; UPREGULATION; ACUTE DISEASE; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; DISEASE MODEL; DNA MICROARRAY; ENZYMOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETIC DATABASE; GENETICS; METABOLISM; PANCREATITIS; PROCEDURES; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; DISEASE COURSE; GENETIC SCREENING; INTRACELLULAR SIGNALING; PREDICTION; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ACUTE DISEASE; ANIMALS; CERULETIDE; DATABASES, GENETIC; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE REGULATORY NETWORKS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PANCREATITIS; PROTEIN INTERACTION MAPS; PROTEIN KINASE INHIBITORS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, MESSENGER; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 84919444224     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0000000000000219     Document Type: Article

References (48)

1. Duan RD, Williams JA. Cholecystokinin rapidly activates mitogen-activated protein kinase in rat pancreatic acini. Am J Physiol. 1994;267:G401-G408.
2. DabrowskiA, Grady T, Logsdon CD, et al. Jun kinases are rapidly activated by cholecystokinin in rat pancreas both in vitro and in vivo. J Biol Chem. 1996;271:5686-5690.
3. Wagner AC, Metzler W, Hofken T, et al. p38 map kinaseis expressed in the pancreas and is immediately activated following cerulein hyperstimulation. Digestion. 1999;60:41-47.
4. Lupia E, Goffi A, De Giuli P, et al. Ablation of phosphoinositide 3-kinase-gamma reduces the severity of acute pancreatitis. Am J Physiol. 2004;165:2003-2011.
5. Yu JH, Kim H. Role of janus kinase/signal transducers and activators of transcription in the pathogenesis of pancreatitis and pancreatic cancer. Gut Liver. 2012;6:417-422.
6. Lu Z, Kolodecik TR, Karne S, et al. Effect of ligands that increase cAMP on caerulein-induced zymogen activation in pancreatic acini. Am J Physiol Gastrointest Liver Physiol. 2003;285:G822-G828.
7. Cosen-Binker LI, Lam PP, Binker MG, et al. Alcohol/cholecystokinin-evoked pancreatic acinar basolateral exocytosis is mediated by protein kinase C alpha phosphorylation of Munc18c. J Biol Chem. 2007;282:13047-13058.
8. Koh YH, Tamizhselvi R, Moochhala S, et al. Role of protein kinase C in caerulein induced expression of substance P and neurokinin-1-receptors in murine pancreatic acinar cells. J Cell Mol Med. 2011;15:2139-2149.
9. Berna MJ, Hoffmann KM, Tapia JA, et al. CCK causes PKD1 activation in pancreatic acini by signaling through PKC-delta and PKC-independent pathways. Biochim Biophys Acta. 2007;1773:483-501.
10. Thrower EC, Yuan J, Usmani A, et al. A novel protein kinase D inhibitor attenuates early events of experimental pancreatitis in isolated rat acini. Am J Physiol Gastrointest Liver Physiol. 2011;300:G120-G129.
11. Kanehisa M, Goto S, Furumichi M, et al. KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res. 2010;38:D355-D360.
12. Huang R, Wallqvist A, Covell DG. Comprehensive analysis of pathway or functionally related gene expression in the National Cancer Institute's anticancer screen. Genomics. 2006;87:315-328.
13. Mazzon E, Impellizzeri D, Di Paola R, et al. Effects of mitogen-activated protein kinase signaling pathway inhibition on the development of cerulein-induced acute pancreatitis in mice. Pancreas. 2012;41:560-570.
14. Wei S, Huang Q, Li J, et al. Taurine attenuates liver injury by downregulating phosphorylated p38 MAPK of Kupffer cells in rats with severe acute pancreatitis. Inflammation. 2012;35:690-701.
15. Samuel I, Zaheer A, Fisher RA. Invitro evidence for role of ERK, p38, and JNK in exocrine pancreatic cytokine production. J Gastrointest Surg. 2006; 10:1376-1383.
16. Rakonczay Z Jr, Hegyi P, Takacs T, et al. The role of NF-kappaB activation in the pathogenesis of acute pancreatitis. Gut. 2008;57:259-267.
17. Huang H, Liu Y, Daniluk J, et al. Activation of nuclear factor-kappaB in acinar cells increases the severity of pancreatitis in mice. Gastroenterology. 2013;144:202-210.
18. Bao J, Gur G, Yarden Y. Src promotes destruction of c-Cbl: implications for oncogenic synergy between Src and growth factor receptors. Proc Natl Acad Sci USA. 2003;100:2438-2443.
19. Ishizawar R, Parsons SJ. c-Src and cooperating partners in human cancer. Cancer Cell. 2004;6:209-214.
20. Biscardi JS, Maa MC, Tice DA, et al. c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function. J Biol Chem. 1999;274:8335-8343.
21. Tice DA, Biscardi JS, Nickles AL, et al. Mechanism of biological synergy between cellular Src and epidermal growth factor receptor. Proc Natl Acad Sci USA. 1999;96:1415-1420.
22. Sebastian S, Settleman J, Reshkin SJ, et al. The complexity of targeting EGFR signalling in cancer: from expression to turnover. Biochim Biophys Acta. 2006;1766:120-139.
23. Li Z, Ma B, Lu M, et al. Construction of network for protein kinases that play a role in acute pancreatitis. Pancreas. 2013;42:607-613.
24. Hu G, Shen J, Cheng L, et al. Reg4 protects against acinar cell necrosis in experimental pancreatitis. Gut. 2011;60:820-828.
25. Dembinski A, Warzecha Z, Konturek PC, et al. Epidermal growth factor accelerates pancreatic recovery after caerulein-induced pancreatitis. Eur J Pharmacol. 2000;398:159-168.
26. Lynch G, Kohler S, Leser J, et al. The tyrosine kinase Yes regulates actin structure and secretion during pancreatic acinar cell damage in rats. Pflugers Arch. 2004;447:445-451.
27. Pace A, Tapia JA, Garcia-Marin LJ, et al. The Src family kinase, Lyn, is activated in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters and growth factors which stimulate its association with numerous other signaling molecules. Biochim Biophys Acta. 2006;1763:356-365.
28. Bjorge JD, Pang AS, Funnell M, et al. Simultaneous siRNA targeting of Src and downstream signaling molecules inhibit tumor formation and metastasis of a human model breast cancer cell line. PLoS One. 2011;6:e19309.
29. Gupte RS, Vijay V, Marks B, et al. Upregulation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase activity increases oxidative stress in failing human heart. J Card Fail. 2007;13:497-506.
30. Yu JH, Lim JW, Kim H, et al. NADPH oxidase mediates interleukin-6 expression in cerulein-stimulated pancreatic acinar cells. Int J Biochem Cell Biol. 2005;37:1458-1469.
31. Hiraoka W, Vazquez N, Nieves-Neira W, et al. Role of oxygen radicals generated by NADPH oxidase in apoptosis induced in human leukemia cells. J Clin Invest. 1998;102:1961-1968.
32. Griendling KK, Sorescu D, Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res. 2000;86:494-501.
33. Bjork J, Arfors KE. Oxygen free radicals and leukotriene B4 induced increase in vascular leakage is mediated by polymorphonuclear leukocytes. Agents Actions Suppl. 1982;11:63-72.
34. Tamizhselvi R, Koh YH, Sun J, et al. Hydrogen sulfide induces ICAM-1 expression and neutrophil adhesion to caerulein-treated pancreatic acinar cells through NF-kappaB and Src-family kinases pathway. Exp Cell Res. 2010;316:1625-1636.
35. Singh VP, McNiven MA. Src-mediated cortactin phosphorylation regulates actin localization and injurious blebbing in acinar cells. Mol Biol Cell. 2008;19:2339-2347.
36. Mehta PK, Griendling KK. Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol. 2007;292:C82-C97.
37. Ito T, Ogoshi K, Nakano I, et al. Effect of Irsogladine on gap junctions in cerulein-induced acute pancreatitis in rats. Pancreas. 1997;15:297-303.
38. Frossard JL, Rubbia-Brandt L, Wallig MA, et al. Severe acute pancreatitis and reduced acinar cell apoptosis in the exocrine pancreas of mice deficient for the Cx32 gene. Gastroenterology. 2003;124:481-493.
39. Calautti E, Cabodi S, Stein PL, et al. Tyrosine phosphorylation and src family kinases control keratinocyte cell-cell adhesion. J Cell Biol. 1998; 141:1449-1465.
40. Hazan RB, Norton L. The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton. J Biol Chem. 1998; 273:9078-9084.
41. Leser J, Beil MF, Musa OA, et al. Regulation of adherens junction protein p120(ctn) by 10 nM CCK precedes actin breakdown in rat pancreatic acini. Am J Physiol Gastrointest Liver Physiol. 2000;278:G486-G491.
42. Wood ER, Truesdale AT, McDonald OB, et al. A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Cancer Res. 2004;64:6652-6659.
43. Xia W, Mullin RJ, Keith BR, et al. Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways. Oncogene. 2002;21:6255-6263.
44. Kim H, Lim HY. Novel EGFR-TK inhibitor EKB-569 inhibits hepatocellular carcinoma cell proliferation by AKT and MAPK pathways. J Korean Med Sci. 2011;26:1563-1568.
45. Burris HA 3rd, Hurwitz HI, Dees EC, et al. Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas. J Clin Oncol. 2005;23:5305-5313.
46. Karaman MW, Herrgard S, Treiber DK, et al. A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol. 2008;26:127-132.
47. Arcaroli JJ, Quackenbush KS, Powell RW, et al. Common PIK3CA mutants and a novel 3' UTR mutation are associated with increased sensitivity to saracatinib. Clin Cancer Res. 2012;18:2704-2714.
48. Rajeshkumar NV, Tan AC, De Oliveira E, et al. Antitumor effects and biomarkers of activity of AZD0530, a Src inhibitor, in pancreatic cancer. Clin Cancer Res. 2009;15:4138-4146.