A novel protein kinase D inhibitor attenuates early events of experimental pancreatitis in isolated rat acini

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 300, Issue 1, 2011, Pages

  Thrower, Edwin C ^a,b   Yuan, Jingzhen ^c   Usmani, Ashar ^a,b   Liu, Yannan ^c   Jones, Courtney ^a,b   Minervini, Samantha N ^a,b   Alexandre, Martine ^a,b   Pandol, Stephen J ^c   Guha, Sushovan ^d  

^a VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Amylase secretion; Cell injury; PKD PKD1 inhibitor CRT0066101; Zymogen activation

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; AMYLASE; BOMBESIN; CARBACHOL; CHOLECYSTOKININ; CRT 0066101; ENZYME PRECURSOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE; PROTEIN KINASE C; PROTEIN KINASE D; PROTEIN KINASE D INHIBITOR; PROTEIN KINASE D1; PROTEIN KINASE INHIBITOR; SERINE; UNCLASSIFIED DRUG;

ACINAR CELL; ACUTE PANCREATITIS; AMYLASE RELEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; AUTOPHOSPHORYLATION; CELL DAMAGE; CELL ISOLATION; CELL STIMULATION; CELL STRUCTURE; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME ACTIVITY; HYPOTHESIS; IC 50; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; CARBACHOL; CARBAZOLES; CATHEPSIN B; CHOLECYSTOKININ; MALE; NF-KAPPA B; PANCREATITIS; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 78650800667     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00300.2010     Document Type: Article

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