Estrogen signaling selectively induces apoptosis of hematopoietic progenitors and myeloid neoplasms without harming steady-state hematopoiesis

Cell Stem Cell

Volumn 15, Issue 6, 2014, Pages 791-804

  Sánchez Aguilera, Abel ^a   Arranz, Lorena ^a   Martín Pérez, Daniel ^a   García García, Andrés ^a   Stavropoulou, Vaia ^b   Kubovcakova, Lucia ^b   Isern, Joan ^a   Martín Salamanca, Sandra ^a   Langa, Xavier ^a   Skoda, Radek C ^b   Schwaller, Jürg ^b   Méndez Ferrer, Simón ^a  

^a CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR ALPHA; FLUOROURACIL; JANUS KINASE 2; TAMOXIFEN; JAK2 PROTEIN, MOUSE; MLL-AF9 FUSION PROTEIN, MOUSE; ONCOPROTEIN; SELECTIVE ESTROGEN RECEPTOR MODULATOR;

ACUTE MYELOBLASTIC LEUKEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CELL DEATH; CELL FUNCTION; CELL MUTANT; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; FEMALE; GENE EXPRESSION PROFILING; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; LEUKOCYTE COUNT; LOW DRUG DOSE; MALE; MOUSE; MYELOID PROGENITOR CELL; MYELOPROLIFERATIVE NEOPLASM; NONHUMAN; NUCLEOTIDE SEQUENCE; SIGNAL TRANSDUCTION; STEADY STATE; THROMBOCYTE COUNT; THROMBOCYTOPENIA; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; DRUG EFFECTS; DRUG SCREENING; GENETICS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; KNOCKOUT MOUSE; LEUKEMIA; METABOLISM; MUTATION; PATHOLOGY; PHYSIOLOGY;

ANIMALIA; MUS;

ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; ESTROGEN RECEPTOR ALPHA; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; JANUS KINASE 2; LEUKEMIA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; MYELOID PROGENITOR CELLS; ONCOGENE PROTEINS, FUSION; SELECTIVE ESTROGEN RECEPTOR MODULATORS; SIGNAL TRANSDUCTION; TAMOXIFEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84919423731     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2014.11.002     Document Type: Article

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