Desvenlafaxine prevents white matter injury and improves the decreased phosphorylation of the rate-limiting enzyme of cholesterol synthesis in a chronic mouse model of depression

Journal of Neurochemistry

Volumn 131, Issue 2, 2014, Pages 229-238

  Wang, Junhui ^a,b   Qiao, Jinping ^a,c,d   Zhang, Yanbo ^e   Wang, Hongxing ^f   Zhu, Shenghua ^d   Zhang, Handi ^a   Hartle, Kelly ^b   Guo, Huining ^b   Guo, Wei ^f   He, Jue ^b   Kong, Jiming ^d   Huang, Qingjun ^a   Li, Xin Min ^b  

^a SHANDONG MENTAL HEALTH CENTER   (China)

^b UNIVERSITY OF ALBERTA   (Canada)

^c ANHUI MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF MANITOBA   (Canada)

^e UNIVERSITY OF SASKATCHEWAN   (Canada)

^f CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Depression; Desvenlafaxine (DVS); Myelin; Oligodendrocyte; Unpredictable chronic mild stress (UCMS)

Indexed keywords

ADENYLATE KINASE; AMPK ALPHA PROTEIN; CHOLESTEROL; DESVENLAFAXINE; GLUTAMATE DECARBOXYLASE 65; GLUTAMATE DECARBOXYLASE 67; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MYELIN PROTEIN; UNCLASSIFIED DRUG; ANTIDEPRESSANT AGENT; CYCLOHEXANOL DERIVATIVE; O-DESMETHYLVENLAFAXINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL SYNTHESIS; CHRONIC STRESS; CONTROLLED STUDY; DEPRESSION; DRUG EFFICACY; DRUG MECHANISM; ELEVATED PLUS MAZE TEST; ENZYME PHOSPHORYLATION; FEMALE; FORCED SWIM TEST; IMMOBILITY; MOUSE; NEUROPROTECTION; NONHUMAN; OUTCOME ASSESSMENT; PROTEIN EXPRESSION; SUCROSE PREFERENCE TEST; TAIL SUSPENSION TEST; WHITE MATTER INJURY; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; RANDOMIZATION; WHITE MATTER;

DAPHNE VIRUS S; MUS;

ANIMALS; ANTIDEPRESSIVE AGENTS; CHOLESTEROL; CYCLOHEXANOLS; DEPRESSION; DISEASE MODELS, ANIMAL; FEMALE; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; RANDOM ALLOCATION; WHITE MATTER;

EID: 84919401182     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12792     Document Type: Article

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