Quetiapine enhances oligodendrocyte regeneration and myelin repair after cuprizone-induced demyelination

Schizophrenia Research

Volumn 138, Issue 1, 2012, Pages 8-17

  Zhang, Yanbo ^a,b   Zhang, Handi ^b   Wang, Lingyan ^c   Jiang, Wengao ^d   Xu, Haiyun ^e   Xiao, Lan ^f   Bi, Xiaoying ^g   Wang, Junhui ^b   Zhu, Shenghua ^b   Zhang, Ruiguo ^h   He, Jue ^b   Tan, Qingrong ^h   Zhang, Dai ⁱ   Kong, Jiming ^j   Li, Xin Min ^b,j  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c CHINA JAPAN UNION HOSPITAL OF JILIN UNIVERSITY   (China)

^d WENZHOU MEDICAL UNIVERSITY   (China)

^e SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^f THIRD MILITARY MEDICAL UNIVERSITY   (China)

^g SECOND MILITARY MEDICAL UNIVERSITY   (China)

^h FOURTH MILITARY MEDICAL UNIVERSITY   (China)

ⁱ PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^j UNIVERSITY OF MANITOBA   (Canada)

more..

Author keywords

Cuprizone; Olig2; Oligodendrocyte; Quetiapine; Remyelination; Schizophrenia

Indexed keywords

OLIGODENDROCYTE TRANSCRIPTION FACTOR 2; QUETIAPINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; CELL MATURATION; CELL REGENERATION; CONTROLLED STUDY; DEMYELINATION; DRUG MECHANISM; IMMUNOHISTOCHEMISTRY; LOCOMOTION; MALE; MAZE TEST; MOUSE; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; REMYELINIZATION; SPATIAL MEMORY; WORKING MEMORY;

ANIMALS; ANTIPSYCHOTIC AGENTS; CHELATING AGENTS; CUPRIZONE; DEMYELINATING DISEASES; DIBENZOTHIAZEPINES; DISEASE MODELS, ANIMAL; MEMORY, SHORT-TERM; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; MYELIN SHEATH; OLIGODENDROGLIA; REGENERATION; SCHIZOPHRENIA;

EID: 84861527299     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2012.04.006     Document Type: Article

References (51)

1. Alexiadis M., Whitehorn D., Woodley H., Kopala L. Prolactin elevation with quetiapine. Am. J. Psychiatry 2002, 159(9):1608-1609.
2. Bartzokis G., Lu P.H., Stewart S.B., Oluwadara B., Lucas A.J., Pantages J., Pratt E., Sherin J.E., Altshuler L.L., Mintz J., Gitlin M.J., Subotnik K.L., Nuechterlein K.H. In vivo evidence of differential impact of typical and atypical antipsychotics on intracortical myelin in adults with schizophrenia. Schizophr. Res. 2009, 113(2-3):322-331.
3. Bassett A.S., Chow E.W., AbdelMalik P., Gheorghiu M., Husted J., Weksberg R. The schizophrenia phenotype in 22q11 deletion syndrome. Am. J. Psychiatry 2003, 160(9):1580-1586.
4. Buckley P.F., Pillai A., Evans D., Stirewalt E., Mahadik S. Brain derived neurotropic factor in first-episode psychosis. Schizophr. Res. 2007, 91(1-3):1-5.
5. Coltman R., Spain A., Tsenkina Y., Fowler J.H., Smith J., Scullion G., Allerhand M., Scott F., Kalaria R.N., Ihara M., Daumas S., Deary I.J., Wood E., McCulloch J., Horsburgh K. Selective white matter pathology induces a specific impairment in spatial working memory. Neurobiol. Aging 2010, 32(12):2324.e7-12.
6. D'Agati E., Casarelli L., Pitzianti M.B., Pasini A. Overflow movements and white matter abnormalities in ADHD. Prog. Neuropsychopharmacol. Biol. Psychiatry 2010, 34(3):441-445.
7. de Leon J., Susce M.T., Johnson M., Hardin M., Pointer L., Ruano G., Windemuth A., Diaz F.J. A clinical study of the association of antipsychotics with hyperlipidemia. Schizophr. Res. 2007, 92(1-3):95-102.
8. Franklin R.J., Ffrench-Constant C. Remyelination in the CNS: from biology to therapy. Nat. Rev. Neurosci. 2008, 9(11):839-855.
9. Franklin K.B.J., Paxinos G. The Mouse Brain in Stereotaxic Coordinates 1997.
10. Gainetdinov R.R., Mohn A.R., Caron M.G. Genetic animal models: focus on schizophrenia. Trends Neurosci. 2001, 24(9):527-533.
11. Glahn D.C., Therman S., Manninen M., Huttunen M., Kaprio J., Lonnqvist J., Cannon T.D. Spatial working memory as an endophenotype for schizophrenia. Biol. Psychiatry 2003, 53(7):624-626.
12. Gregg C., Shikar V., Larsen P., Mak G., Chojnacki A., Yong V.W., Weiss S. White matter plasticity and enhanced remyelination in the maternal CNS. J. Neurosci. 2007, 27(8):1812-1823.
13. Gregg J.R., Herring N.R., Naydenov A.V., Hanlin R.P., Konradi C. Downregulation of oligodendrocyte transcripts is associated with impaired prefrontal cortex function in rats. Schizophr. Res. 2009, 113(2-3):277-287.
14. Hakak Y., Walker J.R., Li C., Wong W.H., Davis K.L., Buxbaum J.D., Haroutunian V., Fienberg A.A. Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc. Natl. Acad. Sci. U. S. A. 2001, 98(8):4746-4751.
15. Hikida T., Jaaro-Peled H., Seshadri S., Oishi K., Hookway C., Kong S., Wu D., Xue R., Andrade M., Tankou S., Mori S., Gallagher M., Ishizuka K., Pletnikov M., Kida S., Sawa A. Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. Proc. Natl. Acad. Sci. U. S. A. 2007, 104(36):14501-14506.
16. Hoffmann K., Lindner M., Groticke I., Stangel M., Loscher W. Epileptic seizures and hippocampal damage after cuprizone-induced demyelination in C57BL/6 mice. Exp. Neurol. 2008, 210(2):308-321.
17. Irvine K.A., Blakemore W.F. Age increases axon loss associated with primary demyelination in cuprizone-induced demyelination in C57BL/6 mice. J. Neuroimmunol. 2006, 175(1-2):69-76.
18. Jung R.E., Grazioplene R., Caprihan A., Chavez R.S., Haier R.J. White matter integrity, creativity, and psychopathology: disentangling constructs with diffusion tensor imaging. PLoS One 2010, 5(3):e9818.
19. Kessler R.M., Ansari M.S., Riccardi P., Li R., Jayathilake K., Dawant B., Meltzer H.Y. Occupancy of striatal and extrastriatal dopamine D2 receptors by clozapine and quetiapine. Neuropsychopharmacology 2006, 31(9):1991-2001.
20. Kozlov A.P., Druzin M.Y., Kurzina N.P., Malinina E.P. The role of D1-dependent dopaminergic mechanisms of the frontal cortex in delayed responding in rats. Neurosci. Behav. Physiol. 2001, 31(4):405-411.
21. Kuhlmann T., Miron V., Cui Q., Wegner C., Antel J., Bruck W. Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis. Brain 2008, 131(Pt 7):1749-1758.
22. Li X.M., Chlan-Fourney J., Juorio A.V., Bennett V.L., Shrikhande S., Keegan D.L., Qi J., Boulton A.A. Differential effects of olanzapine on the gene expression of superoxide dismutase and the low affinity nerve growth factor receptor. J. Neurosci. Res. 1999, 56(1):72-75.
23. Lindholm E., Jazin E. A possible link between dopamine action and myelin dysfunction in schizophrenia. Schizophr. Res. 2007, 96(1-3):271-272.
24. Lindner M., Fokuhl J., Linsmeier F., Trebst C., Stangel M. Chronic toxic demyelination in the central nervous system leads to axonal damage despite remyelination. Neurosci. Lett. 2009, 453(2):120-125.
25. Ludwin S.K., Sternberger N.H. An immunohistochemical study of myelin proteins during remyelination in the central nervous system. Acta Neuropathol. 1984, 63(3):240-248.
26. Mahon K., Burdick K.E., Szeszko P.R. A role for white matter abnormalities in the pathophysiology of bipolar disorder. Neurosci. Biobehav. Rev. 2010, 34(4):533-554.
27. Makinodan M., Yamauchi T., Tatsumi K., Okuda H., Takeda T., Kiuchi K., Sadamatsu M., Wanaka A., Kishimoto T. Demyelination in the juvenile period, but not in adulthood, leads to long-lasting cognitive impairment and deficient social interaction in mice. Prog. Neuropsychopharmacol. Biol. Psychiatry 2009, 33(6):978-985.
28. Mason J.L., Langaman C., Morell P., Suzuki K., Matsushima G.K. Episodic demyelination and subsequent remyelination within the murine central nervous system: changes in axonal calibre. Neuropathol. Appl. Neurobiol. 2001, 27(1):50-58.
29. Mason J.L., Toews A., Hostettler J.D., Morell P., Suzuki K., Goldman J.E., Matsushima G.K. Oligodendrocytes and progenitors become progressively depleted within chronically demyelinated lesions. Am. J. Pathol. 2004, 164(5):1673-1682.
30. McDonald C., Bullmore E., Sham P., Chitnis X., Suckling J., MacCabe J., Walshe M., Murray R.M. Regional volume deviations of brain structure in schizophrenia and psychotic bipolar disorder: computational morphometry study. Br. J. Psychiatry 2005, 186:369-377.
31. Menn B., Garcia-Verdugo J.M., Yaschine C., Gonzalez-Perez O., Rowitch D., Alvarez-Buylla A. Origin of oligodendrocytes in the subventricular zone of the adult brain. J. Neurosci. 2006, 26(30):7907-7918.
32. Miron V.E., Zehntner S.P., Kuhlmann T., Ludwin S.K., Owens T., Kennedy T.E., Bedell B.J., Antel J.P. Statin therapy inhibits remyelination in the central nervous system. Am. J. Pathol. 2009, 174(5):1880-1890.
33. Nait-Oumesmar B., Decker L., Lachapelle F., Avellana-Adalid V., Bachelin C., Van Evercooren A.B. Progenitor cells of the adult mouse subventricular zone proliferate, migrate and differentiate into oligodendrocytes after demyelination. Eur. J. Neurosci. 1999, 11(12):4357-4366.
34. Pappas C. CNS myelin and synapses in a spontaneous mouse ovarian teratoma showing neural differentiation. An immunohistochemical and electron microscopic study. J. Neuropathol. Exp. Neurol. 1981, 40(3):289-297.
35. Piskulic D., Olver J.S., Norman T.R., Maruff P. Behavioural studies of spatial working memory dysfunction in schizophrenia: a quantitative literature review. Psychiatry Res. 2007, 150(2):111-121.
36. Schlosser R.G., Nenadic I., Wagner G., Gullmar D., von Consbruch K., Kohler S., Schultz C.C., Koch K., Fitzek C., Matthews P.M., Reichenbach J.R., Sauer H. White matter abnormalities and brain activation in schizophrenia: a combined DTI and fMRI study. Schizophr. Res. 2007, 89(1-3):1-11.
37. Shibata M., Yamasaki N., Miyakawa T., Kalaria R.N., Fujita Y., Ohtani R., Ihara M., Takahashi R., Tomimoto H. Selective impairment of working memory in a mouse model of chronic cerebral hypoperfusion. Stroke 2007, 38(10):2826-2832.
38. Skihar V., Silva C., Chojnacki A., Doring A., Stallcup W.B., Weiss S., Yong V.W. Promoting oligodendrogenesis and myelin repair using the multiple sclerosis medication glatiramer acetate. Proc. Natl. Acad. Sci. U. S. A. 2009, 106(42):17992-17997.
39. Stidworthy M.F., Genoud S., Suter U., Mantei N., Franklin R.J. Quantifying the early stages of remyelination following cuprizone-induced demyelination. Brain Pathol. 2003, 13(3):329-339.
40. Tarazi F.I., Zhang K., Baldessarini R.J. Long-term effects of olanzapine, risperidone, and quetiapine on dopamine receptor types in regions of rat brain: implications for antipsychotic drug treatment. J. Pharmacol. Exp. Ther. 2001, 297(2):711-717.
41. Terwisscha van Scheltinga A.F., Bakker S.C., Kahn R.S. Fibroblast growth factors in schizophrenia. Schizophr. Bull. 2009, 36(6):1157-1166.
42. Tham M.W., Woon P.S., Sum M.Y., Lee T.S., Sim K. White matter abnormalities in major depression: evidence from post-mortem, neuroimaging and genetic studies. J. Affect. Disord. 2011, 132(1-2):26-36.
43. Thomason M.E., Thompson P.M. Diffusion imaging, white matter, and psychopathology. Annu. Rev. Clin. Psychol. 2011, 7:63-85.
44. Vana A.C., Flint N.C., Harwood N.E., Le T.Q., Fruttiger M., Armstrong R.C. Platelet-derived growth factor promotes repair of chronically demyelinated white matter. J. Neuropathol. Exp. Neurol. 2007, 66(11):975-988.
45. Verhoeven J.S., De Cock P., Lagae L., Sunaert S. Neuroimaging of autism. Neuroradiology 2010, 52(1):3-14.
46. Xiao L., Xu H., Zhang Y., Wei Z., He J., Jiang W., Li X., Dyck L.E., Devon R.M., Deng Y., Li X.M. Quetiapine facilitates oligodendrocyte development and prevents mice from myelin breakdown and behavioral changes. Mol. Psychiatry 2008, 13(7):697-708.
47. Xu H., Yang H.J., Zhang Y., Clough R., Browning R., Li X.M. Behavioral and neurobiological changes in C57BL/6 mice exposed to cuprizone. Behav. Neurosci. 2009, 123(2):418-429.
48. Xu H., Yang H.J., McConomy B., Browning R., Li X.M. Behavioral and neurobiological changes in C57BL/6 mouse exposed to cuprizone: effects of antipsychotics. Front. Behav. Neurosci. 2010, 4:8.
49. Xu H., Yang H.J., Rose G.M., Li X.M. Recovery of behavioral changes and compromised white matter in C57BL/6 mice exposed to cuprizone: effects of antipsychotic drugs. Front. Behav. Neurosci. 2011, 5:31.
50. Yang H.J., Wang H., Zhang Y., Xiao L., Clough R.W., Browning R., Li X.M., Xu H. Region-specific susceptibilities to cuprizone-induced lesions in the mouse forebrain: implications for the pathophysiology of schizophrenia. Brain Res. 2009, 1270:121-130.
51. Zhang Y., Xu H., Jiang W., Xiao L., Yan B., He J., Wang Y., Bi X., Li X., Kong J., Li X.M. Quetiapine alleviates the cuprizone-induced white matter pathology in the brain of C57BL/6 mouse. Schizophr. Res. 2008, 106(2-3):182-191.