Serum microRNA profiling of hyperlipidemic and/or hyperglycemic patients reveals specifically increased levels of miR-122, miR-125a, miR-486 and miR-92a

Annals of the Romanian Society for Cell Biology

Volumn 19, Issue 1, 2014, Pages 55-66

  Simionescu, N ^a,b   Niculescu, L S ^a   Sanda, G M ^a   Margina, D ^c   Sima, Anca V ^a  

^a INSTITUTE OF CELLULAR BIOLOGY AND PATHOLOGY NICOLAE SIMIONESCU   (Romania)

^b PETRU PONI INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Romania)

^c CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

Circulating microRNAs; Hyperglycemia; Hyperlipidemia; Inflammation; TaqMan assay

Indexed keywords

EID: 84919387950     PISSN: 15836258     EISSN: None     Source Type: Journal    
DOI: 10.ANN/RSCB-2014-0004     Document Type: Article

References (28)

1. Aryal, B., Rotllan, N.Fernandez-Hernando, C.: Noncoding RNAs and atherosclerosis. Curr Atheroscler Rep, 16, 5, 407, 2014.
2. Balasubramanyam, M., Aravind, S., Gokulakrishnan, K., Prabu, P., Sathishkumar, C., Ranjani, H.Mohan, V.: Impaired miR-146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes. Mol Cell Biochem, 351, 1-2, 197-205, 2011.
3. Bartel, D.P.: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, 116, 2, 281-297, 2004.
4. Caroli, A., Cardillo, M.T., Galea, R.Biasucci, L.M.: Potential therapeutic role of microRNAs in ischemic heart disease. J Cardiol, 61, 5, 315-320, 2013.
5. Chen, T., Huang, Z., Wang, L., Wang, Y., Wu, F., Meng, S.Wang, C.: MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages. Cardiovasc Res, 83, 1, 131-139, 2009.
6. Cochain, C.Zernecke, A.: Noncoding RNAs in vascular inflammation and atherosclerosis: recent advances toward therapeutic applications. Curr Opin Lipidol, 25, 5, 380-386, 2014.
7. Creemers, E.E., Tijsen, A.J.Pinto, Y.M.: Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease? Circ Res, 110, 3, 483-495, 2012.
8. Eckel, R.H., Grundy, S.M.Zimmet, P.Z.: The metabolic syndrome. Lancet, 365, 9468, 1415-1428, 2005.
9. Gao, W., He, H.W., Wang, Z.M., Zhao, H., Lian, X.Q., Wang, Y.S., Zhu, J., Yan, J.J., Zhang, D.G., Yang, Z.J.Wang, L.S.: Plasma levels of lipometabolism-related miR-122 and miR-370 are increased in patients with hyperlipidemia and associated with coronary artery disease. Lipids Health Dis, 11, 55, 2012.
10. Grundy, S.M., Cleeman, J.I., Daniels, S.R., Donato, K.A., Eckel, R.H., Franklin, B.A., Gordon, D.J., Krauss, R.M., Savage, P.J., Smith, S.C., Jr., Spertus, J.A.Costa, F.: Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation, 112, 17, 2735-2752, 2005.
11. Guay, C.Regazzi, R.: Circulating microRNAs as novel biomarkers for diabetes mellitus. Nat Rev Endocrinol, 9, 9, 513-521, 2013.
12. Hao, L., Wang, X.G., Cheng, J.D., You, S.Z., Ma, S.H., Zhong, X., Quan, L.Luo, B.: The up-regulation of endothelin-1 and down-regulation of miRNA-125a-5p, -155, and -199a/b-3p in human atherosclerotic coronary artery. Cardiovasc Pathol, 23, 4, 217-223, 2014.
13. Jiang, Y., Wang, H.Y., Cao, H.M., Wang, C.Y., Zhang, L., Wang, H., Liu, L., Li, Y.Cai, J.H.: Peripheral blood miRNAs as a biomarker for chronic cardiovascular diseases. Sci Rep, 4, 5026, 2014.
14. Kato, M., Castro, N.E.Natarajan, R.: MicroRNAs: potential mediators and biomarkers of diabetic complications. Free Radic Biol Med, 64, 85-94, 2013.
15. Kirschner, M.B., Edelman, J.J., Kao, S.C., Vallely, M.P., van Zandwijk, N.Reid, G.: The Impact of Hemolysis on Cell-Free microRNA Biomarkers. Front Genet, 4, 94, 2013.
16. Kroh, E.M., Parkin, R.K., Mitchell, P.S.Tewari, M.: Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR). Methods, 50, 4, 298-301, 2010.
17. Madrigal-Matute, J., Rotllan, N., Aranda, J.F.Fernandez-Hernando, C.: MicroRNAs and atherosclerosis. Curr Atheroscler Rep, 15, 5, 322, 2013.
18. Mitchell, P.S., Parkin, R.K., Kroh, E.M., Fritz, B.R., Wyman, S.K., Pogosova-Agadjanyan, E.L., Peterson, A., Noteboom, J., O'Briant, K.C., Allen, A., Lin, D.W., Urban, N., Drescher, C.W., Knudsen, B.S., Stirewalt, D.L., Gentleman, R., Vessella, R.L., Nelson, P.S., Martin, D.B.Tewari, M.: Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A, 105, 30, 10513-10518, 2008.
19. Ono, K., Kuwabara, Y.Han, J.: MicroRNAs and cardiovascular diseases. FEBS J, 278, 10, 1619-1633, 2011.
20. Ortega, F.J., Mercader, J.M., Catalan, V., Moreno-Navarrete, J.M., Pueyo, N., Sabater, M., Gomez-Ambrosi, J., Anglada, R., Fernandez-Formoso, J.A., Ricart, W., Fruhbeck, G.Fernandez-Real, J.M.: Targeting the circulating microRNA signature of obesity. Clin Chem, 59, 5, 781-792, 2013.
21. Pirola, C.J., Fernandez Gianotti, T., Castano, G.O., Mallardi, P., San Martino, J., Mora Gonzalez Lopez Ledesma, M., Flichman, D., Mirshahi, F., Sanyal, A.J.Sookoian, S.: Circulating microRNA signature in non-alcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis. Gut, 2014.
22. Rayner, K.J., Fernandez-Hernando, C.Moore, K.J.: MicroRNAs regulating lipid metabolism in atherogenesis. Thromb Haemost, 107, 4, 642-647, 2012.
23. Schmittgen, T.D.Livak, K.J.: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc, 3, 6, 1101-1108, 2008.
24. Simionescu, N., Niculescu, L.S., Sanda, G.M., Margina, D.Sima, A.V.: Analysis of circulating microRNAs that are specifically increased in hyperlipidemic and/or hyperglycemic sera. Mol Biol Rep, 41, 9, 5765-5773, 2014.
25. Vickers, K.C., Palmisano, B.T., Shoucri, B.M., Shamburek, R.D.Remaley, A.T.: MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol, 13, 4, 423-433, 2011.
26. Wang, X., Sundquist, J., Zoller, B., Memon, A.A., Palmer, K., Sundquist, K.Bennet, L.: Determination of 14 circulating microRNAs in Swedes and Iraqis with and without diabetes mellitus type 2. PLoS One, 9, 1, e86792, 2014.
27. Yamada, H., Suzuki, K., Ichino, N., Ando, Y., Sawada, A., Osakabe, K., Sugimoto, K., Ohashi, K., Teradaira, R., Inoue, T., Hamajima, N.Hashimoto, S.: Associations between circulating microRNAs (miR-21, miR-34a, miR-122 and miR-451) and non-alcoholic fatty liver. Clin Chim Acta, 424, 99-103, 2013.
28. Zampetaki, A., Willeit, P., Drozdov, I., Kiechl, S.Mayr, M.: Profiling of circulating microRNAs: from single biomarkers to re-wired networks. Cardiovasc Res, 93, 4, 555-562, 2012.