Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 50, 2014, Pages 18007-18012

  Murphy, Patrick A ^a,e   Kim, Tyson N ^a   Huang, Lawrence ^a   Nielsen, Corinne M ^a   Lawton, Michael T ^b   Adams, Ralf H ^c   Schaffer, Chris B ^d   Wang, Rong A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d School of Operations Research and Industrial Engineering   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Angiogenesis; Hereditary hemorrhagic telangiectasia; Notch; Stroke; Vascular anomaly

Indexed keywords

NOTCH4 RECEPTOR; BROXURIDINE; NOTCH RECEPTOR; NOTCH4 PROTEIN, MOUSE; ONCOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIOVENOUS SHUNT; ARTICLE; BLOOD FLOW VELOCITY; BLOOD VESSEL DIAMETER; BRAIN ARTERIOVENOUS MALFORMATION; BRAIN CAPILLARY; CAPILLARY FLOW; CELL COUNT; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE COURSE; ENDOTHELIUM CELL; HEMODYNAMICS; MICROVASCULATURE; MOUSE; NONHUMAN; POSITIVE FEEDBACK; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TIME LAPSE IMAGING; ANIMAL; BLOOD FLOW; CAPILLARY; FLOW CYTOMETRY; INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; METABOLISM; MICRO-COMPUTED TOMOGRAPHY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

MUS;

ANIMALS; BROMODEOXYURIDINE; CAPILLARIES; ENDOTHELIAL CELLS; FLOW CYTOMETRY; INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; MICE; PROTO-ONCOGENE PROTEINS; RECEPTORS, NOTCH; REGIONAL BLOOD FLOW; SIGNAL TRANSDUCTION; X-RAY MICROTOMOGRAPHY;

EID: 84919360516     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1415316111     Document Type: Article

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