Neurokinin B and its receptor in hypogonadotropic hypogonadism

Frontiers of Hormone Research

Volumn 39, Issue , 2010, Pages 133-141

  Semple, Robert K ^a   Topaloglu, A Kemal ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b CUKUROVA UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN; NEUROKININ 3 RECEPTOR; NEUROKININ A; NEUROKININ B; SUBSTANCE P;

CHROMOSOME 4; CLINICAL FEATURE; CRYPTORCHISM; DISEASE SEVERITY; GENE IDENTIFICATION; GENE MUTATION; GENE SEQUENCE; GONADORELIN RELEASE; HOMOZYGOSITY; HUMAN; HYPOGONADOTROPIC HYPOGONADISM; HYPOTHALAMUS; IMMUNOREACTIVITY; ISOLATED HYPOGONADOTROPIC HYPOGONADISM; LOSS OF FUNCTION MUTATION; MICROPENIS; MISSENSE MUTATION; MUTATIONAL ANALYSIS; NEUROANATOMY; NONHUMAN; PHENOTYPE; PRIMARY AMENORRHEA; PRIORITY JOURNAL; PROTEIN FUNCTION; REPRODUCTION; REVIEW; SIGNAL TRANSDUCTION;

HUMANS; HYPOGONADISM; MUTATION, MISSENSE; NEUROKININ B; PHENOTYPE; RECEPTORS, NEUROKININ-3; RECEPTORS, TACHYKININ; REPRODUCTION; TACHYKININS;

EID: 84919351241     PISSN: 03013073     EISSN: None     Source Type: Book Series    
DOI: 10.1159/000312699     Document Type: Review

References (28)

1. Semple RK, Topaloglu AK: The recent genetics of hypogonadotrophic hypogonadism-novel insights and new questions. Clin Endocrinol (Oxf) 2009, Epub ahead of print.
2. Seminara SB, Messager S, Chatzidaki EE, et al: The GPR54 gene as a regulator of puberty. N Engl J Med 2003;349:1614-1627.
3. de Roux N, Genin E, Carel JC, Matsuda F, Chaussain JL, Milgrom E: Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci USA 2003;100: 10972-10976.
4. Crowley WF, Pitteloud N, Seminara SB: New genes controlling human reproduction and how you find them. Trans Am Clin Climatol Assoc 2008;119:29-38.
5. Topaloglu AK, Reimann F, Guclu M, Yalin AS, Kotan LD, Porter KM, Serin A, Mungan NO, Cook JR, Ozbek MN, Imamoglu S, Akalin NS, Yuksel B, O'Rahilly S, Semple RK: TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for neurokinin B in the central control of reproduction. Nat Genet 2009;41:354-358.
6. Guran T, Tolhurst G, Bereket A, Rocha N, Porter KM, Turan S, Gribble FM, Kotan LD, Akcay T, Atay Z, Canan H, Serin A, O'Rahilly S, Reimann F, Semple RK, Topaloglu AK: A novel missense mutation in the first extracellular loop of the neurokinin B receptor causes hypogonadotropic hypogonad-ism. J Clin Endocrinol Metab 2009;94:3633-3639.
7. Prigge ST, Mains RE, Eipper BA, Amzel LM: New insights into copper monooxygenases and peptide amidation: structure, mechanism and function. Cell Mol Life Sci 2000;57:1236-1259.
8. Siuciak JA, McCarthy SA, Martin AN, Chapin DS, Stock J, Nadeau DM, Kantesaria S, Bryce-Pritt D, McLean S: Disruption of the neurokinin-3 receptor (NK3) in mice leads to cognitive deficits. Psycho-pharmacology (Berl) 2007;194:185-195.
9. Nordquist RE, Delenclos M, Ballard TM, Savignac H, Pauly-Evers M, Ozmen L, Spooren W: Cognitive performance in neurokinin 3 receptor knockout mice. Psychopharmacology (Berl) 2008;198:211-220.
10. Spooren W, Riemer C, Meltzer H: Opinion: NK3 receptor antagonists: the next generation of antipsy-chotics? Nat Rev Drug Discov 2005;4:967-975.
11. Panocka I, Massi M, Lapo I, Swiderski T, Kowalczyk M, Sadowski B: Antidepressant-type effect of the NK3 tachykinin receptor agonist aminosenktide in mouse lines differing in endogenous opioid system activity. Peptides 2001;22:1037-1042.
12. Ribeiro SJ, Teixeira RM, Calixto JB, De Lima TC: Tachykinin NK(3)receptor involvement in anxiety. Neuropeptides 1999;33:181-188.
13. Stoessl AJ, Dourish CT, Iversen SD: Pharmacological characterization of the behavioural syndrome induced by the NK-3 tachykinin agonist senktide in rodents: evidence for mediation by endogenous 5-HT. Brain Res 1990;517:111-1116.
14. Sakamoto R, Osada H, Iitsuka Y, Masuda K, Kaku K, Seki K, Sekiya S: Profile of neurokinin B concentrations in maternal and cord blood in normal pregnancy. Clin Endocrinol (Oxf) 2003;58:597-600.
15. Page NM, Woods RJ, Gardiner SM, Lomthaisong K, Gladwell RT, Butlin DJ, Manyonda IT, Lowry PJ: Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia. Nature 2000;405:797-800.
16. Pennefather JN, Lecci A, Candenas ML, Patak E, Pinto FM, Maggi CA: Tachykinins and tachykinin receptors: a growing family. Life Sci 2004;74:1445-1463.
17. Pinto FM, Almeida TA, Hernandez M, Devillier P, Advenier C, Candenas ML: mRNA expression of tachykinins and tachykinin receptors in different human tissues. Eur J Pharmacol 2004;494:233-239.
18. Ding YQ, Lu BZ, Guan ZL, Wang DS, Xu JQ, Li JH: Neurokinin B receptor (NK3)-containing neurons in the paraventricular and supraoptic nuclei of the rat hypothalamus synthesize vasopressin and express Fos following intravenous injection of hypertonic saline. Neuroscience 1999;91:1077-1085.
19. Kung TT, Crawley Y, Jones H, Luo B, Gilchrest H, Greenfeder S, Anthes JC, Lira S, Wiekowski M, Cook DN, Hey JA, Egan RW, Chapman RW: Tachy-kinin NK3-receptor deficiency does not inhibit pulmonary eosinophilia in allergic mice. Pharmacol Res 2004;50:611-615.
20. Sahu A, Kalra SP: Effects of tachykinins on luteiniz-ing hormone release in female rats: potent inhibitory action of neuropeptide K. Endocrinology 1992; 130:1571-1577.
21. Goubillon ML, Forsdike RA, Robinson JE, Ciofi P, Caraty A, Herbison AE: Identification of neurokinin B-expressing neurons as a highly estrogen-receptive, sexually dimorphic cell group in the ovine arcuate nucleus. Endocrinology 2000;141:4218-4225.
22. Burke MC, Letts PA, Krajewski SJ, Rance NE: Coexpression of dynorphin and neurokinin B immunoreactivity in the rat hypothalamus: morphologic evidence of interrelated function within the arcuate nucleus. J Comp Neurol 2006;498:712-726.
23. Rance NE: Menopause and the human hypothala-mus: evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback. Peptides 2009;30:111-122.
24. Krajewski SJ, Anderson MJ, Iles-Shih L, Chen KJ, Urbanski HF, Rance NE: Morphologic evidence that neurokinin B modulates gonadotropin-releasing hormone secretion via neurokinin 3 receptors in the rat median eminence. J Comp Neurol 2005;489:372-386.
25. Sandoval-Guzman T, Rance NE: Central injection of senktide, an NK3 receptor agonist, or neuropep-tide Y inhibits LH secretion and induces different patterns of Fos expression in the rat hypothalamus. Brain Res 2004;1026:307-312.
26. Chan YM, Broder-Fingert S, Seminara SB: Reproductive functions of kisspeptin and Gpr54 across the life cycle of mice and men. Peptides 2009;30: 42-48.
27. Plant TM: Hypothalamic control of the pituitary-gonadal axis in higher primates: key advances over the last two decades. J Neuroendocrinol 2008;20: 719-726.
28. McManus CJ, Valent M, Connors JM, Lehman MN, Goodman R: A neurokinin-B agonist stimulates LT secretion in follicular, but not luteal, phase ewes (abstract 760.8). Soc Neurosci Annu Meet, 2005, Washington.